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Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer
2019
Cancers
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Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is a potential therapeutic agent for a variety of diseases such as inflammatory diseases, chronic neurodegenerative diseases, and cancers. Here, we found that the combination of cannabidiol and TNF-related apoptosis-inducing ligand (TRAIL) produces synergistic antitumor effects in vitro. However, this synergistic effect was not observed in normal colonic cells. The levels of ER stress-related proteins, including
doi:10.3390/cancers11050642
pmid:31075907
pmcid:PMC6562873
fatcat:iv5rzrebr5cjjmo2orb2i4xfy4
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... P homologous protein (CHOP) and phosphorylated protein kinase RNA-like ER kinase (PERK) were increased in treatment of cannabidiol. Cannabidiol enhanced significantly DR5 expression by ER stress. Knockdown of DR5 decreased the combined effect of cannabidiol and TRAIL. Additionally, the combination of TRAIL and cannabidiol decreased tumor growth in xenograft models. Our studies demonstrate that cannabidiol enhances TRAIL-induced apoptosis by upregulating DR5 and suggests that cannabidiol is a novel agent for increasing sensitivity to TRAIL.
Science Comic Strips
2012
Journal of Education and Learning
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Science comic strips entitled Dr. Scifun were planned to promote science jobs and studies among professionals (scientists, graduate and undergraduate students) and children. To this end, the authors collected intriguing science stories as the basis of scenarios, and drew four-cut comic strips, first on paper and subsequently as computer files. Eighty three episodes of the cartoons in English are available on the homepage (anatomy.co.kr). The comics have been displayed in the on-line science
doi:10.5539/jel.v1n2p65
fatcat:eng4sew7pjgzfo7nfhfliheycy
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... zine and the science museum in Korea. The reception has been positive. The comic strips help inform graduate students and young scientists of the appropriate philosophy for their devotion to science. As well the comics demonstrate the fascinating and meaningful activities of scientists to juveniles. It is anticipated that competition between comics created by different scientists will improve the quality of the publications, benefiting readers worldwide.
FOXO3 induces ubiquitylation of AKT through MUL1 regulation
2017
OncoTarget
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Copyright: Kim et al. ...
CH), the Korean government (MSIP) (No. 2011-0030043 and 2017M3A9F7079339 to Kim CH and 2017R1C1B2005395 to Kim SY). ...
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (2015R1A2A1A01002968 to Kim ...
doi:10.18632/oncotarget.22793
pmid:29299162
pmcid:PMC5746397
fatcat:fwh4fhyx2jdddndzmwvhupw3le
FIGO stage IB clear cell carcinoma and adenocarcinoma of uterine cervix
2005
Korean Journal of Gynecologic Oncology
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Orbital Blowout Fracture: MR Findings
1996
Journal of the Korean Radiological Society
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Treatment of Atelectasis Dectected in the Recovery Room after General Anesthesia
2007
Yeungnam university journal of medicine
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Post-Traumatic Contrast Enhancing Brain Lesion
2014
Journal of the Korean Society of Radiology
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A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis
2017
Radiation Oncology
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This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m 2 ) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 (CYP2A6), uridine monophosphate synthetase (UMPS), and ATP-binding cassette B1 (ABCB1) on clinical outcome. Methods: Patients with cT3 or cT4 rectal cancer were enrolled and were given tegafur-uracil 400 mg/m 2 /day and leucovorin 90 mg/m 2 /day for 7 days a
doi:10.1186/s13014-017-0800-5
pmid:28347333
pmcid:PMC5369180
fatcat:afts6jhk3vb23odtnqoclbe7hq
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... eek during preoperative chemoradiation (50.4 Gy/28 fractions) in this phase II trial. Primary endpoint was pathologic complete response rate, and the secondary endpoint was to explore the association between clinical outcomes and genetic polymorphisms CYP2A6 (*4, *7, *9 and *10), UMPS G638C, and three ABCB1 genotypes (C1236T, C3435T, and G2677T). Results: Ninety-one patients were given study treatment, and 90 underwent surgery. Pathologic complete response was noted in 10 patients (11.1%). There was no grade 4 or 5 toxicity; 20 (22.0%) experienced grade 3 toxicities, including diarrhea (10, 11.0%), abdominal pain (2, 2.2%), and anemia (2, 2.2%). Relapse-free survival and overall survival at 5 years were 88.6% and 94.2%, respectively. Patients with the UMPS 638 CC genotype experienced significantly more frequent grade 2 or 3 diarrhea (p for trend = 0.018). Conclusions: Preoperative chemoradiation with tegafur-uracil 400 mg/m 2 /day with leucovorin was feasible, but did not meet the expected pathologic complete response rate. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer.
Making the LINC: SUN and KASH protein interactions
2015
Biological chemistry
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In this review, we provide a comprehensive analysis of the reported protein-protein interactions for KASH and SUN domain proteins. ...
Outer nuclear membrane KASH domain proteins and inner nuclear membrane SUN domain proteins interact to form the core of the LINC complex. ...
Evidence of unique roles for SUN protein variants remains limited. -SUN proteins-There are five conventional SUN proteins in mammals. ...
doi:10.1515/hsz-2014-0267
pmid:25720065
pmcid:PMC4386892
fatcat:62oc3qpav5epjd4lmirgj2nspm
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis
2020
Clinical Epigenetics
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Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying the development of atherosclerosis. We aimed to identify and validate specific genes that are differentially expressed through promoter methylation in atherosclerotic plaques. We performed the present study in four steps: (1) profiling and identification of gene-specific promoter
doi:10.1186/s13148-020-00846-0
pmid:32398127
fatcat:fyylcaetqnci7iyfvz65rm55wu
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... changes in atherosclerotic tissues; (2) validation of the promoter methylation changes of genes in plaques by comparison with non-plaque intima; (3) evaluation of promoter methylation status of the genes in vascular cellular components composing atherosclerotic plaques; and (4) evaluation of promoter methylation differences in genes among monocytes, T cells, and B cells isolated from the blood of ischemic stroke patients. Upon profiling, AIRE1, ALOX12, FANK1, NETO1, and SERHL2 were found to have displayed changes in promoter methylation. Of these, AIRE1 and ALOX12 displayed higher methylation levels in plaques than in non-plaque intima, but lower than those in the buffy coat of blood. Between inflammatory cells, the three genes were significantly less methylated in monocytes than in T and B cells. In the vascular cells, AIRE1 methylation was lower in endothelial and smooth muscle cells. ALOX12 methylation was higher in endothelial, but lower in smooth muscle cells. Immunofluorescence staining showed that co-localization of ALOX12 and AIRE1 was more frequent in CD14(+)-monocytes than in CD4(+)-T cell in plaque than in non-plaque intima. Promoter methylation changes in AIRE1 and ALOX12 occur in atherosclerosis and can be considered as novel epigenetic markers.
Hepatitis B Virus X Protein Regulates Hepatic Glucose Homeostasis via Activation of Inducible Nitric Oxide Synthase
2011
Journal of Biological Chemistry
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Dysregulation of liver functions leads to insulin resistance causing type 2 diabetes mellitus and is often found in chronic liver diseases. However, the mechanisms of hepatic dysfunction leading to hepatic metabolic disorder are still poorly understood in chronic liver diseases. The current work investigated the role of hepatitis B virus X protein (HBx) in regulating glucose metabolism. We studied HBx-overexpressing (HBxTg) mice and HBxTg mice lacking inducible nitric oxide synthase (iNOS).
doi:10.1074/jbc.m111.259978
pmid:21690090
pmcid:PMC3191028
fatcat:k4eea345dbe7hfkflstzxxbpyq
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... we show that gene expressions of the key gluconeogenic enzymes were significantly increased in HepG2 cells expressing HBx (HepG2-HBx) and in non-tumor liver tissues of hepatitis B virus patients with high levels of HBx expression. In the liver of HBxTg mice, the expressions of gluconeogenic genes were also elevated, leading to hyperglycemia by increasing hepatic glucose production. However, this effect was insufficient to cause systemic insulin resistance. Importantly, the actions of HBx on hepatic glucose metabolism are thought to be mediated via * 4 The abbreviations used are: HBV, hepatitis B virus; HBx, hepatitis B virus X protein; iNOS, inducible nitric oxide synthase; Tg, transgenic; PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; PGC1␣, peroxisome proliferator-activated receptor-␥ coactivator 1␣; qRT-PCR, quantitative real-time reverse-transcription polymerase chain reaction.
Perivascular Epithelioid Cell Tumor (PEComa) of Abdominal Cavity from Falciform Ligament: A Case Report
2009
Journal of Korean medical science
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The Recent Status of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea
2010
Tuberculosis and Respiratory Diseases
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국내 다제내성 및 광범위내성결핵의 최근 현황 The Recent Status of Multidrug-and Extensively Drug-Resistant Tuberculosis in Korea Sun Young Kim, M.D. 1
울산대학교 의과대학 서울아산병원 호흡기내과학교실,
2
결핵연구원,
3
서울의과학연구소,
4
녹십자의료재단 ...
doi:10.4046/trd.2010.68.3.146
fatcat:tzc2cw4zn5cs3ouddk6z7pgdey
Transient Acquired Hemophilia Associated with Mycoplasma Pneumoniae Pneumonia
2008
Journal of Korean medical science
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2018 KHRS guideline for the evaluation and management of syncope-Part 2
2018
International Journal of Arrhythmia
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Chronic sinus node disease: natural course and
Leitch JW KG, Yee R, Leather RA, Kim YH. Syncope associated with supraventricular tachycardia. ...
doi:10.18501/arrhythmia.2018.010
fatcat:melp4jpqhngbzl5yrpe2cagaje
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