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Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer

Jung Lim Kim, Bo Ram Kim, Dae Yeong Kim, Yoon A. Jeong, Soyeon Jeong, Yoo Jin Na, Seong Hye Park, Hye Kyeong Yun, Min Jee Jo, Bu Gyeom Kim, Han Do Kim, Dae Hyun Kim (+3 others)
2019 Cancers  
Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is a potential therapeutic agent for a variety of diseases such as inflammatory diseases, chronic neurodegenerative diseases, and cancers. Here, we found that the combination of cannabidiol and TNF-related apoptosis-inducing ligand (TRAIL) produces synergistic antitumor effects in vitro. However, this synergistic effect was not observed in normal colonic cells. The levels of ER stress-related proteins, including
more » ... P homologous protein (CHOP) and phosphorylated protein kinase RNA-like ER kinase (PERK) were increased in treatment of cannabidiol. Cannabidiol enhanced significantly DR5 expression by ER stress. Knockdown of DR5 decreased the combined effect of cannabidiol and TRAIL. Additionally, the combination of TRAIL and cannabidiol decreased tumor growth in xenograft models. Our studies demonstrate that cannabidiol enhances TRAIL-induced apoptosis by upregulating DR5 and suggests that cannabidiol is a novel agent for increasing sensitivity to TRAIL.
doi:10.3390/cancers11050642 pmid:31075907 pmcid:PMC6562873 fatcat:iv5rzrebr5cjjmo2orb2i4xfy4

Science Comic Strips

Dae Hyun Kim, Hae Gwon Jang, Dong Sun Shin, Sun-Ja Kim, Chang Young Yoo, Min Suk Chung
2012 Journal of Education and Learning  
Science comic strips entitled Dr. Scifun were planned to promote science jobs and studies among professionals (scientists, graduate and undergraduate students) and children. To this end, the authors collected intriguing science stories as the basis of scenarios, and drew four-cut comic strips, first on paper and subsequently as computer files. Eighty three episodes of the cartoons in English are available on the homepage ( The comics have been displayed in the on-line science
more » ... zine and the science museum in Korea. The reception has been positive. The comic strips help inform graduate students and young scientists of the appropriate philosophy for their devotion to science. As well the comics demonstrate the fascinating and meaningful activities of scientists to juveniles. It is anticipated that competition between comics created by different scientists will improve the quality of the publications, benefiting readers worldwide.
doi:10.5539/jel.v1n2p65 fatcat:eng4sew7pjgzfo7nfhfliheycy

FOXO3 induces ubiquitylation of AKT through MUL1 regulation

Sun-Yong Kim, Hyo Jeong Kim, Hyung Kwon Byeon, Dae Ho Kim, Chul-Ho Kim
2017 OncoTarget  
Copyright: Kim et al.  ...  CH), the Korean government (MSIP) (No. 2011-0030043 and 2017M3A9F7079339 to Kim CH and 2017R1C1B2005395 to Kim SY).  ...  This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (2015R1A2A1A01002968 to Kim  ... 
doi:10.18632/oncotarget.22793 pmid:29299162 pmcid:PMC5746397 fatcat:fwh4fhyx2jdddndzmwvhupw3le

FIGO stage IB clear cell carcinoma and adenocarcinoma of uterine cervix

Jin Hee Kim, Eun Sun Choi, Dae Yeon Kim, Dae Sik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam, Jung Eun Mok
2005 Korean Journal of Gynecologic Oncology  
doi:10.3802/kjgo.2005.16.4.307 fatcat:htstmzfczrdh3l2l7cphijvgsi

Orbital Blowout Fracture: MR Findings

Kyu Sun Kim, Dae Young Yoon, So Yeon Cho, Young Choon Kim, Ho Chul Kim, Jeong Geun Yi, Chul Sun Choi, Sang Hoon Bae, Jung Wook Kim
1996 Journal of the Korean Radiological Society  
doi:10.3348/jkrs.1996.34.4.463 fatcat:zjmdicdyzrdonapsyahkvfpgmq

Treatment of Atelectasis Dectected in the Recovery Room after General Anesthesia

Chang jae Hwang, Heung dae Kim, Dae pal Park, Il suk Seo, Sun ok Song, Sae yeon Kim, Dae lim Jee, Deok hee Lee
2007 Yeungnam university journal of medicine  
doi:10.12701/yujm.2007.24.2s.s696 fatcat:gets2k2wmjfb7kde2uucrvl5q4

Post-Traumatic Contrast Enhancing Brain Lesion

Dae Jung Kim, Hyun Sook Kim, Min Sun Jeong, Deok Ryeong Kim, Young Kwon Cho, Yun Sun Choi
2014 Journal of the Korean Society of Radiology  
doi:10.3348/jksr.2014.71.4.155 fatcat:nwwq4f6jwrcvlmsmcuymxgrhwq

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis

Sun Young Kim, Ji Yeon Baek, Jae Hwan Oh, Sung Chan Park, Dae Kyung Sohn, Min Ju Kim, Hee Jin Chang, Sun-Young Kong, Dae Yong Kim
2017 Radiation Oncology  
This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m 2 ) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 (CYP2A6), uridine monophosphate synthetase (UMPS), and ATP-binding cassette B1 (ABCB1) on clinical outcome. Methods: Patients with cT3 or cT4 rectal cancer were enrolled and were given tegafur-uracil 400 mg/m 2 /day and leucovorin 90 mg/m 2 /day for 7 days a
more » ... eek during preoperative chemoradiation (50.4 Gy/28 fractions) in this phase II trial. Primary endpoint was pathologic complete response rate, and the secondary endpoint was to explore the association between clinical outcomes and genetic polymorphisms CYP2A6 (*4, *7, *9 and *10), UMPS G638C, and three ABCB1 genotypes (C1236T, C3435T, and G2677T). Results: Ninety-one patients were given study treatment, and 90 underwent surgery. Pathologic complete response was noted in 10 patients (11.1%). There was no grade 4 or 5 toxicity; 20 (22.0%) experienced grade 3 toxicities, including diarrhea (10, 11.0%), abdominal pain (2, 2.2%), and anemia (2, 2.2%). Relapse-free survival and overall survival at 5 years were 88.6% and 94.2%, respectively. Patients with the UMPS 638 CC genotype experienced significantly more frequent grade 2 or 3 diarrhea (p for trend = 0.018). Conclusions: Preoperative chemoradiation with tegafur-uracil 400 mg/m 2 /day with leucovorin was feasible, but did not meet the expected pathologic complete response rate. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer.
doi:10.1186/s13014-017-0800-5 pmid:28347333 pmcid:PMC5369180 fatcat:afts6jhk3vb23odtnqoclbe7hq

Making the LINC: SUN and KASH protein interactions

Dae In Kim, Birendra KC, Kyle J. Roux
2015 Biological chemistry  
In this review, we provide a comprehensive analysis of the reported protein-protein interactions for KASH and SUN domain proteins.  ...  Outer nuclear membrane KASH domain proteins and inner nuclear membrane SUN domain proteins interact to form the core of the LINC complex.  ...  Evidence of unique roles for SUN protein variants remains limited. -SUN proteins-There are five conventional SUN proteins in mammals.  ... 
doi:10.1515/hsz-2014-0267 pmid:25720065 pmcid:PMC4386892 fatcat:62oc3qpav5epjd4lmirgj2nspm

Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis

Jee Yeon Kim, Bong-Geun Choi, Jaroslav Jelinek, Dae Hyun Kim, Seo Hyun Lee, Kwangjo Cho, Seo Hee Rha, Young Ho Lee, Hyo Sun Jin, Dae-Kyoung Choi, Geun-Eun Kim, Sun U. Kwon (+5 others)
2020 Clinical Epigenetics  
Atherosclerosis is the main cause of cardiovascular diseases such as ischemic stroke and coronary heart disease. Gene-specific promoter methylation changes have been suggested as one of the causes underlying the development of atherosclerosis. We aimed to identify and validate specific genes that are differentially expressed through promoter methylation in atherosclerotic plaques. We performed the present study in four steps: (1) profiling and identification of gene-specific promoter
more » ... changes in atherosclerotic tissues; (2) validation of the promoter methylation changes of genes in plaques by comparison with non-plaque intima; (3) evaluation of promoter methylation status of the genes in vascular cellular components composing atherosclerotic plaques; and (4) evaluation of promoter methylation differences in genes among monocytes, T cells, and B cells isolated from the blood of ischemic stroke patients. Upon profiling, AIRE1, ALOX12, FANK1, NETO1, and SERHL2 were found to have displayed changes in promoter methylation. Of these, AIRE1 and ALOX12 displayed higher methylation levels in plaques than in non-plaque intima, but lower than those in the buffy coat of blood. Between inflammatory cells, the three genes were significantly less methylated in monocytes than in T and B cells. In the vascular cells, AIRE1 methylation was lower in endothelial and smooth muscle cells. ALOX12 methylation was higher in endothelial, but lower in smooth muscle cells. Immunofluorescence staining showed that co-localization of ALOX12 and AIRE1 was more frequent in CD14(+)-monocytes than in CD4(+)-T cell in plaque than in non-plaque intima. Promoter methylation changes in AIRE1 and ALOX12 occur in atherosclerosis and can be considered as novel epigenetic markers.
doi:10.1186/s13148-020-00846-0 pmid:32398127 fatcat:fyylcaetqnci7iyfvz65rm55wu

Hepatitis B Virus X Protein Regulates Hepatic Glucose Homeostasis via Activation of Inducible Nitric Oxide Synthase

Hye-Jun Shin, Young-Ho Park, Sun-Uk Kim, Hyung-Bae Moon, Do Sim Park, Ying-Hao Han, Chul-Ho Lee, Dong-Seok Lee, In-Sung Song, Dae Ho Lee, Minhye Kim, Nam-Soon Kim (+8 others)
2011 Journal of Biological Chemistry  
Dysregulation of liver functions leads to insulin resistance causing type 2 diabetes mellitus and is often found in chronic liver diseases. However, the mechanisms of hepatic dysfunction leading to hepatic metabolic disorder are still poorly understood in chronic liver diseases. The current work investigated the role of hepatitis B virus X protein (HBx) in regulating glucose metabolism. We studied HBx-overexpressing (HBxTg) mice and HBxTg mice lacking inducible nitric oxide synthase (iNOS).
more » ... we show that gene expressions of the key gluconeogenic enzymes were significantly increased in HepG2 cells expressing HBx (HepG2-HBx) and in non-tumor liver tissues of hepatitis B virus patients with high levels of HBx expression. In the liver of HBxTg mice, the expressions of gluconeogenic genes were also elevated, leading to hyperglycemia by increasing hepatic glucose production. However, this effect was insufficient to cause systemic insulin resistance. Importantly, the actions of HBx on hepatic glucose metabolism are thought to be mediated via * 4 The abbreviations used are: HBV, hepatitis B virus; HBx, hepatitis B virus X protein; iNOS, inducible nitric oxide synthase; Tg, transgenic; PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; PGC1␣, peroxisome proliferator-activated receptor-␥ coactivator 1␣; qRT-PCR, quantitative real-time reverse-transcription polymerase chain reaction.
doi:10.1074/jbc.m111.259978 pmid:21690090 pmcid:PMC3191028 fatcat:k4eea345dbe7hfkflstzxxbpyq

Perivascular Epithelioid Cell Tumor (PEComa) of Abdominal Cavity from Falciform Ligament: A Case Report

Cheol Woong Choi, Tae Oh Kim, Kyung Yeob Kim, Sun Mi Lee, Gwang Ha Kim, Dae Hwan Kang, Geun Am Song, Suk Kim, Dae Hwan Kim
2009 Journal of Korean medical science  
doi:10.3346/jkms.2009.24.2.346 pmid:19399284 pmcid:PMC2672142 fatcat:gshdc5fpazctzjmaaxfj5t6lwi

The Recent Status of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea

Sun Young Kim, Hee Jin Kim, Chang Ki Kim, Hye Ryung Yoon, Hye-Gyung Bae, Sun-Hwa Lee, Nackmoon Sung, Dae Yeon Kim, Gang Young Lee, Young Soo Cho, Sang Do Lee, Woo Sung Kim (+2 others)
2010 Tuberculosis and Respiratory Diseases  
국내 다제내성 및 광범위내성결핵의 최근 현황 The Recent Status of Multidrug-and Extensively Drug-Resistant Tuberculosis in Korea Sun Young Kim, M.D. 1 울산대학교 의과대학 서울아산병원 호흡기내과학교실, 2 결핵연구원, 3 서울의과학연구소, 4 녹십자의료재단  ... 
doi:10.4046/trd.2010.68.3.146 fatcat:tzc2cw4zn5cs3ouddk6z7pgdey

Transient Acquired Hemophilia Associated with Mycoplasma Pneumoniae Pneumonia

Min Sun Kim, Paul E. Kilgore, Ju Sung Kang, Sun Young Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
2008 Journal of Korean medical science  
doi:10.3346/jkms.2008.23.1.138 pmid:18303215 pmcid:PMC2526493 fatcat:sr45oze4qfd57g7wvhsclkxgha

2018 KHRS guideline for the evaluation and management of syncope-Part 2

Yoo Ri Kim, Kwang Jin Chun, June Soo Kim, Hee Sun Mun, Junbeom Park, Dae Won Seo, Mi Kyoung Song, Jinhee Ahn, Hee Yoon, Dae In Lee, Young Soo Lee, Myung-jin Cha (+2 others)
2018 International Journal of Arrhythmia  
Chronic sinus node disease: natural course and Leitch JW KG, Yee R, Leather RA, Kim YH. Syncope associated with supraventricular tachycardia.  ... 
doi:10.18501/arrhythmia.2018.010 fatcat:melp4jpqhngbzl5yrpe2cagaje
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