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Da Woon Jung, Yang Lee, Hyo Jin Sung
2014 Korean Journal of Mathematics  
The studies of reversible and 2-primal rings have done important roles in noncommutative ring theory. We in this note introduce the concept of quasi-reversible-over-prime-radical (simply, QRPR) as a generalization of the 2-primal ring property. A ring is called QRPR if ab = 0 for a, b ∈ R implies that ab is contained in the prime radical. In this note we study the structure of QRPR rings and examine the QRPR property of several kinds of ring extensions which have roles in noncommutative ring theory.
doi:10.11568/kjm.2014.22.2.279 fatcat:xcrqoorklfajbjhnudnx2kefbu

Structural insights into catalytic relevances of substrates' poses in ACC-1

Da-Woon Bae, Ye-Eun Jung, Young Jun An, Jung-Hyun Na, Sun-Shin Cha
2019 Antimicrobial Agents and Chemotherapy  
ACC-1 is a plasmid-encoded class C β-lactamase identified in clinical isolates of Klebsiella pneumoniae, Proteus mirabilis, Salmonella enterica, and Escherichia coli. ACC-1-producing bacteria are susceptible to cefoxitin whereas they are resistant to oxyimino cephalosporins. Here, we depict crystal structures of apo ACC-1, adenylylated ACC-1, and acylated ACC-1 complexed with cefotaxime and cefoxitin. ACC-1 has noteworthy structural alterations in the R2-loop, the Ω- loop, and the Phe119-loop
more » ... ong the active-site rim. The adenylate covalently bonded to the nucleophilic serine reveals a tetrahedral phosphorus mimicking the deacylation transition state. Cefotaxime in ACC-1 has a proper conformation for the substrate-assisted catalysis in that its C4 carboxylate and N5 nitrogen are adequately located to facilitate the deacylation reaction. In contrast, cefoxitin in ACC-1 has a distinct conformation in which those functional groups cannot contribute to catalysis. Furthermore, the orientation of the deacylating water relative to the acyl carbonyl group in ACC-1 is unfavorable for nucleophilic attack.
doi:10.1128/aac.01411-19 pmid:31451494 pmcid:PMC6811428 fatcat:ee7tfx2gzrabrhjwgcwwjzmgza

Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol

Hyun Jung Kim, Soon-Ho Yim, Fubo Han, Bok Yun Kang, Hyun Jin Choi, Da-Woon Jung, Darren R. Williams, Kirk R. Gustafson, Edward J. Kennelly, Ik-Soo Lee
2019 Molecules  
A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism of organic compounds in mammalian systems. The microbial biotransformation of isoxanthohumol (1), a major hop prenylflavanone in beer, has resulted in the production of three diastereomeric pairs of oxygenated metabolites (2–7). The microbial metabolites of 1 were formed by epoxidation or hydroxylation of the prenyl group, and HPLC, NMR, and CD analyses revealed that all of the
more » ... products were diastereomeric pairs composed of (2S)- and (2R)- isomers. The structures of these metabolic compounds were elucidated to be (2S,2"S)- and (2R,2"S)-4′-hydroxy-5-methoxy-7,8-(2,2-dimethyl-3-hydroxy-2,3-dihydro-4H-pyrano)-flavanones (2 and 3), (2S)- and (2R)-7,4′-dihydroxy-5-methoxy-8-(2,3-dihydroxy-3-methylbutyl)-flavanones (4 and 5) which were new oxygenated derivatives, along with (2R)- and (2S)-4′-hydroxy-5-methoxy-2"-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanones (6 and 7) on the basis of spectroscopic data. These results could contribute to understanding the metabolic fates of the major beer prenylflavanone isoxanthohumol that occur in mammalian system.
doi:10.3390/molecules24030394 fatcat:udm6pb4kgze6jgqrpehfhw6yym


Da Woon Jung, Nam Kyun Kim, Yang Lee, Sung Ju Ryu
2015 Bulletin of the Korean Mathematical Society  
We study the connections between idempotents and zerodivisors in several kinds of ring theoretic properties. We next study several ring theoretic properties and examples related to reversible rings.
doi:10.4134/bkms.2015.52.1.247 fatcat:l6bbl3gtkrcoroolotczxelfg4

The future is now: cutting edge science and understanding toxicology

JungIn Um, Da-Woon Jung, Darren R. Williams
2018 Cell Biology and Toxicology  
achieved by the application of master transcription factors for the cell type of interest or with small molecule-based approaches (Cao et al. 2016; Um et al. 2017; Qian et al. 2012; Julian et al. 2017; Jung  ... 
doi:10.1007/s10565-018-9421-5 pmid:29397478 fatcat:bnuj2ubjsjhtbkm2ha7nx2n2ri

Cervical Necrotizing Fasciitis Caused by Dental Infection

Chi-Woong Song, Hyun-Joong Yoon, Da-Woon Jung, Sang-Hwa Lee
2014 Maxillofacial Plastic and Reconstructive Surgery  
Necrotizing fasciitis (NF) is defined as rapidly progressive necrosis of subcutaneous fat and fascia. Although NF of the face is rare, its mortality rate is nearly 30%. It usually originates from dental infection and can lead to involvement of the neck, mediastinum, and chest wall. Complications resulting from pre-existing systemic diseases can increase the mortality rate. Known complication factors for NF include diabetes, malnutrition, advanced age, peripheral vascular disease, renal failure,
more » ... and obesity. Here, we report a case of NF originating from dental infection in an 88-year-old woman already diagnosed with hypertension, thoracic aortic aneurysm, and renal diseases. Such conditions limited adequate surgical and antibiotic treatment. However, interdisciplinary treatment involving multiple departments was implemented with good results.
doi:10.14402/jkamprs.2014.36.2.67 pmid:27489813 pmcid:PMC4281902 fatcat:w4k6cb64yzbgpmz52noplkviaa

A Case of Type 2 Hereditary Angioedema WithSERPING1Mutation

Da Woon Sim, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park
2017 Allergy Asthma and Immunology Research  
A Case of Type 2 Hereditary Angioedema With SERPING1 Mutation Da Woon Sim, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park* Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University  ... 
doi:10.4168/aair.2017.9.1.96 pmid:27826968 pmcid:PMC5102842 fatcat:cgqbq7wwdfdr7fchtwv2okjrim

Oral allergy syndrome associated with weed pollinosis

Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park
2016 Allergy Asthma & Respiratory Disease  
서 론 구강알레르기증후군(oral allergy syndrome)은 식품알레르기의 한 아형이며 성인에서 관찰되는 가장 흔한 음식물 알레르기이다. 호흡기를 통해 감작된 꽃가루 알레르기 환자에서 특정 식품을 섭 취한 후 입술, 구강, 인두부위에 가려움증, 두드러기, 부종 등의 증 상이 나타날 경우 의심할 수 있다. 1 이는 화분과 식품 항원 사이에 공통된 항원결정부위(Epitope)에 의한 교차반응이 원인이 되어 발 생하는 것으로 대개 IgE 매개 반응과 관련이 있다. 증상을 나타내 는 식품은 감작된 화분에 따라 차이가 있는데, 자작나무 화분에 감 작된 경우 사과나 체리, 복숭아를 먹을 때 구강 내 증상을 보이는 것이 가장 흔히 볼 수 있는 임상 양상이다. 외국에서는 celery-mugwort-spice 증후군, ragweed-melon-banana 증후군 등이 보고가 되 어 있다. 2-4 진단 방법으로는 병력 청취를 통한 의심이 가장 중요하 며, 이후 피부단자검사, 생과일이나 채소
more » ... 유발 식품을 이용한 prick-to-prick 검사, 혈청 특이 IgE 항체 검사 등이 있다. 병력상 특 정 식품 섭취 후 앞서 언급한 증상이 동반되면서 꽃가루 알레르기 의 병력이 있다면 구강알레르기증후군을 의심할 수 있겠으며 이후 검사에서 합당한 소견이 나올 경우 확진할 수 있다. 5 쑥(Mugwort)은 쑥(Artemisia)속에 속하는 잡초류의 한 종류이 며, 국내에서 시행한 잡초 화분에 감작된 환자의 13%에서 구강알 레르기증후군의 증상을 보인 바 있고, 일본에서 채소류로 유발된 구강알레르기증후군 환자의 24.1%에서 쑥에 대한 감작을 관찰한 바 있다. 4,6 국내의 쑥에 대한 감작과 관련한 식품알레르기 증례를 살펴보면, 쑥갓 의존성 운동유발성 아나필락시스 1예 5 와 celerymugwort-birch-spice 증후군에서 음식 의존성 운동유발성 아나필 락시스 1예 7 등이 있다. 이에 저자들은 전신 증상을 동반한 쑥을 포함한 잡초류에 의한 Allergy Asthma Respir Dis 4(6):458-461, November 2016 https://doi. Oral allergy syndrome (OAS) is caused by cross-reactivity between certain pollens and plant foods, including vegetables, nuts, or fruits. Here, we experienced 2 cases of OAS patients associated with mugwort pollinosis without sensitization to Fagales. A 54-yearold female repeatedly experienced skin rashes, perioral edema, nasal obstruction after eating fresh vegetables (celery, lettuce, chicory, radish sprouts, ginseng, etc.). She had suffered from allergic rhinitis worsening in autumn for 5 years. Specific IgE (sIgE) titers to ragweed and mugwort were elevated to 54.1 and 24.9 kU/L, respectively. With regard to the allergen component of pollens, sIgE to Art v 1 (mugwort) and Amb a 1 (ragweed) were elevated to 21.9 and 36.1 kU/L, respectively. Birch sIgE (including Bet v 1 and Bet v 2) was not detected. A 35-year-old male suffered from abdominal pain, skin rashes after eating mango and kiwi. In addition, systemic allergic reaction developed after consumption of tomato and ginseng. He had chronic rhinitis. The sIgE levels to ragweed, mugwort, and tomato were elevated to 0.55, 6.39, and 0.78 kU/L, respectively. The sIgE test results were all negative for Amb a 1, Bet v 1, and Bet v 2 sIgE. Specific IgE levels to Art v 1, Art v 2 sIgE were 3.51 and 4.46 kU/L, respectively. Based on the history and sIgE test results, 2 cases OAS were related to mugwort. We experienced 2 cases of weed pollinosis related to OAS. Culprit foods of OAS can vary depending on their cuisine cultures. (Allergy Asthma Respir Dis 2016:4:458-461)
doi:10.4168/aard.2016.4.6.458 fatcat:mcuhpuo635adzoyggdl7jtjs6i

Soluble CD93 in Serum as a Marker of Allergic Inflammation

Hye Jung Park, Heejae Han, Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Yoon Hee Park, Kyoung Yong Jeong, Jung-Won Park, Jae-Hyun Lee
2017 Yonsei medical journal  
2,3 , Young Woong Son 2,3 , Da Woon Sim 2,3 , Kyung Hee Park 2,3 , Yoon Hee Park 2 , Kyoung Yong Jeong 2 , Jung-Won Park 2,3 , and Jae-Hyun Lee 2, 3 as a marker of developing B cells, CD93 is now recognized  ...  While CD93 was originally described as a complement 1q receptor that enhances phagocytosis and Soluble CD93 in Serum as a Marker of Allergic Inflammation Hye Jung Park 1 , Heejae Han 2 , Sang Chul Lee  ... 
doi:10.3349/ymj.2017.58.3.598 pmid:28332366 pmcid:PMC5368146 fatcat:uzlumyru3rderl5c6vj4x5duzy

CO2Laser Application for Treatment of the Hairy Tongue
이산화탄소 레이저를 이용한 모설의 치료

Da-Woon Jung, Eunae Cho, Hyung-Joon Ahn
2013 Journal of Oral Medicine and Pain  
Key words : Carbondioxide laser, CO 2 laser, Hairy tongue ABSTRACT CO 2 2 Laser Application for Treatment of the Hairy Tongue Da-Woon Jung, D.D.S., Eunae Cho, D.D.S., Hyung-Joon Ahn, D.D.S.,Ph.D.  ... 
doi:10.14476/jomp.2013.38.2.097 fatcat:nqi6i563e5hibpynbnp3235qtq

The safety of endoscopic esophageal procedures under general anesthesia

Go Eun Kim, Duk Kyung Kim, Ji Won Choi, In Sun Chung, Da Woon Jung
2017 Korean Journal of Anesthesiology  
Endoscopic esophageal procedures such as endoscopic submucosal dissection (ESD) and peroral endoscopic myotomy (POEM) are increasingly being performed to avoid the considerable morbidity and mortality associated with esophageal surgery. With its wide application as one of the main therapeutic modalities for early gastric cancer, ESD is now accepted as a useful, minimally invasive procedure for the management of early esophageal cancer [1] . Although POEM is a relatively new procedure,
more » ... cal advances have led to its widespread use for Clinical Research Article Background: With the increasing demand for general anesthesia for endoscopic esophageal procedures, anesthesiologists should understand the clinical characteristics of post-procedural complications (PPCs). Methods: We retrospectively investigated the incidence of and risk factors associated with PPCs of endoscopic esophageal procedures performed under general anesthesia from July 2013 to November 2016. The final analysis included 129 patients; 114 who underwent esophageal endoscopic dissection for esophageal tumors and 15 cases of peroral endoscopic myotomy for achalasia. Frank perforation during the procedure was defined as an endoscopically recognizable or clinically detected perforation during the procedures. A multivariable logistic regression analysis was conducted to identify independent risk factors for PPCs. Results: The overall incidence of PPCs was 19.4% (25/129). All of the PPCs were managed successfully with conservative measures. The most common PPC was symptomatic, radiologically documented atelectasis (11/25, 44.0%), followed by esophageal perforation-related PPCs (symptomatic pneumomediastinum or pneumoperitoneum; 9/25, 36.0%). In the multivariable analysis, frank perforation during the procedure was the only independent risk factor for PPCs (odds ratio, 8.470, 95% CI, 2.051-34.974, P = 0.003). Although frank perforation during the procedure occurred in 13 patients, 38.5% (5/13) of them did not develop any clinical sequelae after their procedures. Compared with patients without PPCs, patients who developed PPCs took longer to their first oral intake and had prolonged hospital stays (P = 0.047 and 0.026, respectively). Conclusions: Iatrogenic perforation during endoscopic esophageal procedures under general anesthesia was the only independent risk factor for PPCs; therefore, proactive measures and close follow-up are necessary.
doi:10.4097/kjae.2017.70.5.555 pmid:29046776 pmcid:PMC5645589 fatcat:jzvdlvy3svaytlht7qqcuy67na

Cytoskeletal alteration modulates cancer cell invasion through RhoA-YAP signaling in stromal fibroblasts

Do Kyeong Kim, Eun Kyoung Kim, Da-Woon Jung, Jin Kim, Cheng-Chia Yu
2019 PLoS ONE  
Cancer-associated fibroblasts(CAFs) participate in carcinogenesis through interaction with cancer cells. This study aimed to investigate the mechanism of cytoskeletal alteration of CAFs and its role in invasion of oral squamous cell carcinoma(OSCC).Immortalized normal fibroblasts(hTERT-hNOFs) co-cultured with OSCC cells showed myofibroblastic and senescent phenotypes like CAFs. Thus, this study substituted hTERT-hNOFs for CAFs. Next, the cytoskeletal alteration and its molecular mechanism were
more » ... nvestigated in hTERT-hNOFs co-cultured with OSCC. As results, we found that RhoA regulated cytoskeletal organization in fibroblasts surrounding OSCC cells. Furthermore, as a downstream transcriptional factor of RhoA, YAP was mainly localized in the nucleus of hTERT-hNOFs co-cultured with OSCC. Consequently, we examined whether nuclear YAP localization of fibroblasts could influence cancer progression. YAPS127A fibroblasts manifesting nuclear localization of YAP induced cytoskeletal alteration and increased gel contractility and matrix stiffness, and thereby enhances the invasiveness of OSCC cells. In conclusion, the modification of tumor microenvironment, such as cytoskeletal change and matrix remodeling via RhoA-YAP in CAFs, modulates OSCC invasion. These understandings will provide the development of novel approaches for CAFs-based cancer therapy.
doi:10.1371/journal.pone.0214553 pmid:30921404 pmcid:PMC6438594 fatcat:rdvmk46v3vfdhpfn46oy3iyraa

Interaction Augmented Reality System using a Hand Motion
손동작을 이용한 상호작용 증강현실 시스템

Kwang-Woon Choi, Da-Un Jung, Suk-Han Lee, Jong-Soo Choi
2012 Journal of Korea Multimedia Society  
In this paper, We propose Augmented Reality (AR) System for the interaction between user's hand motion and virtual object motion based on computer vision. The previous AR system provides inconvenience to user because the users have to control the marker and the sensor like a tracker. We solved the problem through hand motion and provide the convenience to the user. Also the motion of virtual object using a physical phenomenon gives a reality. The proposed system obtains geometrical information
more » ... y the marker and hand. The system environments like virtual space of moving virtual ball and bricks are made by using the geometrical information and user's hand motion is obtained from the hand's information with extracted feature point through the taping hand. And it registers a virtual plane stably by getting movement of the feature points. The movement of the virtual ball basically is parabolic motion with a parabolic equation. When the collision occurs either the planes or the bricks, we show movement of the virtual ball with ball position and normal vector of plane and the ball position is faulted. So we showed corrected ball position through experiment. and we proved that this system can replaced the marker system to compare to jitter of augmented virtual object and progress speed with it.
doi:10.9717/kmms.2012.15.4.425 fatcat:q3x7fpmokvggrj6mjrhdsbbs5q

Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications

Woong Hee Kim, Jinho Lee, Da-Woon Jung, Darren R. Williams
2012 Sensors  
Jung).  ...  National Research Foundation funded by the Korean government (MEST basic science research program (NRF-2010-0006002) to Darren Reece Williams and MEST basic science research program (NRF-2009-0067894) to Da-Woon  ... 
doi:10.3390/s120405005 pmid:22666073 pmcid:PMC3355456 fatcat:iadipskpzvg7dg3fbc5syghmju

Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea

Kyung Hee Park, Young Woong Son, Sang Chul Lee, Kyunguk Jeong, Da Woon Sim, Hye Jung Park, Sooyoung Lee, Jae-Hyun Lee, Jung-Won Park
2016 Allergy Asthma and Immunology Research  
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic
more » ... in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. Methods: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined.
doi:10.4168/aair.2016.8.6.505 pmid:27582401 pmcid:PMC5011050 fatcat:cekugtfn65hy7ip7nxhkr6e2uy
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