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DYANA: An Environment for Embedded System Design and Analysis [chapter]

A. G. Bakhmurov, A. P. Kapitonova, R. L. Smeliansky
1999 Lecture Notes in Computer Science  
The results presented here are based on the experience of development and application of DYANA -an environment for analysis of multiprocessor computer systems operation.  ...  The architecture and basic features of such an environments are discussed. Main problems of such the environment design are highlighted and possible solutions are shown.  ...  The DYANA system was tested in the following areas: performance analysis of local area networks; -software design and development for embedded systems.  ... 
doi:10.1007/3-540-49059-0_27 fatcat:zonzwt7qpnezvpw5nk4u5hqewu

DYANA: an environment for embedded system design and analysis

R.L. Smeliansky, A.G. Bakhmurov, A.P. Kapitonova
Proceedings 32nd Annual Simulation Symposium  
The results presented here are based on the experience of development and application of DYANA -an environment for analysis of multiprocessor computer systems operation.  ...  The architecture and basic features of such an environments are discussed. Main problems of such the environment design are highlighted and possible solutions are shown.  ...  The DYANA system was tested in the following areas: performance analysis of local area networks; -software design and development for embedded systems.  ... 
doi:10.1109/simsym.1999.766454 dblp:conf/anss/SmelianskyBK99 fatcat:hb3yj26oyve77oddxbiaecremi

Integrated environment for the analysis and design of distributed real-time embedded computing systems

R. L. Smelyansky, A. G. Bakhmurov, D. Yu. Volkanov, E. V. Chemeritskii
2013 Programming and computer software  
Problems of analysis and design of embedded real time systems for controlling complex engineer ing systems are considered by an example of a DYANA simulation environment and its development at the Laboratory  ...  The key features of this environment are as follows: the use of a formal model of operation for distributed systems, and the analysis of various aspects of the behav ior of a system, both quantitative  ...  The work was partly supported by the Russian Foundation for Basic Research (project nos. 95 01 01590 a, 98 01 00151 a, 01 01 00263 a).  ... 
doi:10.1134/s0361768813050058 fatcat:fqrdbdqtvnh2nnoslpscvrauui

Antioxidant and Anti-Atherogenic Activities of Essential Oils from Myrtus communis L. and Laurus nobilis L. in Rat

Dyana Odeh, Nada Oršolić, Marija Berendika, Domagoj Đikić, Sandra Domjanić Drozdek, Sandra Balbino, Maja Repajić, Verica Dragović-Uzelac, Irena Landeka Jurčević
2022 Nutrients  
Laurel EO can be an excellent candidate for the treatment of drug-induced obesity and related diseases, since it affects lipid metabolism in the liver and inhibits the enzymes responsible for the metabolism  ...  Myrtle EO increases the permeability and instability of the erythrocyte membrane, resulting in a loss of selectivity for the entry of toxic substances into the cell.  ...  to ensure that myrtle EO is safe for human and animal health as well as the environment.  ... 
doi:10.3390/nu14071465 pmid:35406078 pmcid:PMC9003404 fatcat:xwkr4czbfngqfimztlidha5a3q

Ultrastructural Changes in Clinical and Microbiota Isolates ofKlebsiella pneumoniaeCarriers of GenesblaSHV,blaTEM,blaCTX-M, orblaKPCWhen Subject toβ-Lactam Antibiotics

Dyana Leal Veras, Ana Catarina de Souza Lopes, Grasielle Vaz da Silva, Gabriel Gazzoni Araújo Gonçalves, Catarina Fernandes de Freitas, Fernanda Cristina Gomes de Lima, Maria Amélia Vieira Maciel, Ana Paula Sampaio Feitosa, Luiz Carlos Alves, Fábio André Brayner
2015 The Scientific World Journal  
from the microbiota to ampicillin and amoxicillin, for analysis by means of scanning and transmission electron microscopy.  ...  ThreeK. pneumoniaeclinical isolates were selected for the study with resistance profiles for third-generation cephalosporins, aztreonam, and/or imipenem and with different resistance genes for extended-spectrumβ-lactamases  ...  The SEM analysis showed conserved rod-shaped bacterial morphology and an average cell length of 1.5 to 3 m (Figures 4(a) , 4(b), 5(a), and 6(a)). K16R Isolate.  ... 
doi:10.1155/2015/572128 pmid:26491715 pmcid:PMC4600873 fatcat:lvo24kz6yjcxvcqfy2toa5mene

Revealing hidden species diversity in closely related species using nuclear SNPs, SSRs and DNA sequences – a case study in the tree genus Milicia

Kasso Daïnou, Céline Blanc-Jolivet, Bernd Degen, Priscilla Kimani, Dyana Ndiade-Bourobou, Armel S. L. Donkpegan, Félicien Tosso, Esra Kaymak, Nils Bourland, Jean-Louis Doucet, Olivier J. Hardy
2016 BMC Evolutionary Biology  
Globally, our work highlights the importance of collecting samples in a systematic way and the need for combining different nuclear markers when dealing with species complexes.  ...  We genotyped SNP and SSR loci to identify genetic clusters, and sequenced two plastid regions (psbA-trnH, trnC-ycf6) and a nuclear gene (At103) to confirm species' divergence and compare species delimitation  ...  Nuclear SNP data belong to the Thünen Institute for Forest Genetics (Germany) and will be made available by Bernd Degen and Céline Blanc-Jolivet.  ... 
doi:10.1186/s12862-016-0831-9 pmid:27903256 pmcid:PMC5131513 fatcat:ws4hdkcyzbee5k57fubrbjzb3m

Preorganization of molecular binding sites in designed diiron proteins

O. Maglio, F. Nastri, V. Pavone, A. Lombardi, W. F. DeGrado
2003 Proceedings of the National Academy of Sciences of the United States of America  
De novo protein design provides an attractive approach to critically test the features that are required for metalloprotein structure and function.  ...  Previously we designed and crystallographically characterized an idealized dimeric model for the four-helix bundle class of diiron and dimanganese proteins [Dueferri 1 (DF1)].  ...  We thank Professors Bertini, Banci, and Luchinat for kindly allowing us to collect NMR data at the Large Scale Facility Magnetic Resonance European Center (University of Florence, Florence, Italy) and  ... 
doi:10.1073/pnas.0730771100 pmid:12655072 pmcid:PMC152997 fatcat:7ssmfvaikzcipnkyli7awrdyci

Length-dependent stability and strand length limits in antiparallel -sheet secondary structure

H. E. Stanger, F. A. Syud, J. F. Espinosa, I. Giriat, T. Muir, S. H. Gellman
2001 Proceedings of the National Academy of Sciences of the United States of America  
For example, autonomously folding model systems have been essential for establishing the relationship between ␣-helix length and ␣-helix stability, which would be impossible to probe with ␣-helices embedded  ...  for D P and c( D P) 2 by using a Bruker (Billerica, MA) AVANCE 750 MHz spectrometer, and for D P-TT 2 by using a Varian 600 MHz spectrometer at 277 K.  ...  Tom Record and Fleming Crim and all three reviewers for helpful comments.  ... 
doi:10.1073/pnas.211536998 pmid:11593011 pmcid:PMC59824 fatcat:7d5h57k7erhq5mpy4wzu7eruwq

Membrane charge dependent states of the β-amyloid fragment Aβ (16–35) with differently charged micelle aggregates

Manuela Grimaldi, Mario Scrima, Cinzia Esposito, Giuseppe Vitiello, Anna Ramunno, Vittorio Limongelli, Gerardino D'Errico, Ettore Novellino, Anna Maria D'Ursi
2010 Biochimica et Biophysica Acta - Biomembranes  
CD and NMR conformational analyses were performed in negatively charged pure SDS micelles and in zwitterionic DPC micelles "doped" with small amounts of SDS.  ...  To analyze the tendency of Aβ (16-35) to interact with these micellar systems, we performed EPR experiments on three spin-labeled analogues of Aβ (16-35), bearing the methyl 3-(2,2,5,5-tetramethyl-1-oxypyrrolinyl  ...  It is well known that the plasma membrane is an extremely complex bio-system.  ... 
doi:10.1016/j.bbamem.2009.12.012 pmid:20045392 fatcat:yfeelw2z3zaznlonmm6iz32gya

The α-to-β Conformational Transition of Alzheimer's Aβ-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of β Conformation Seeding

Simona Tomaselli, Veronica Esposito, Paolo Vangone, Nico A. J. van Nuland, Alexandre M. J. J. Bonvin, Remo Guerrini, Teodorico Tancredi, Piero A. Temussi, Delia Picone
2006 ChemBioChem  
Acknowledgements The 600 and 750 MHz 2D spectra were recorded at the SON NMR Large Scale Facility in Utrecht, which is funded by the "Access to Research Infrastructures" program of the European Union (  ...  Simulations with GROMACS, [28, 29] starting from the accurate NMR structure of Ab-(1-42), which was previously determined in an apolar environment, were run for [30] Analysis of the trajectories,  ...  [10] We deem that this structure could represent an ideal starting point for monitoring environment-induced conformational transitions.  ... 
doi:10.1002/cbic.200500223 pmid:16444756 fatcat:3gegdkado5gg3jjmf73ntofbey

Solid-State NMR Structure Determination of Melittin in a Lipid Environment

Y.H. Lam, S.R. Wassall, C.J. Morton, R. Smith, F. Separovic
2001 Biophysical Journal  
Solid-state 13 C NMR spectroscopy was used to investigate the three-dimensional structure of melittin as lyophilized powder and in ditetradecylphosphatidylcholine (DTPC) membranes.  ...  This study demonstrates an application of RR techniques to the structural analysis of membrane peptides and could be applied to more complex systems, including membrane-bound receptors (Williamson et  ...  more complex systems.  ... 
doi:10.1016/s0006-3495(01)75918-8 pmid:11606288 pmcid:PMC1301742 fatcat:5uvgmax6tjd5jaobavpdo2zuye

Structure-based Functional Discovery of Proteins: Structural Proteomics

Jin-Won Jung, Weon-Tae Lee
2004 BMB Reports  
research; however, an integration of these methodologies together with comparative modeling and electron microscopy would speed up the goal for completing a full dictionary of protein folding space in  ...  Structural proteomics (genomics), a research area for structure-based functional discovery, aims to complete the protein-folding universe of all gene products in a cell.  ...  Acknowledgments This study was supported by the Ministry of Science and Technology of the Korea/the Korea Science and Engineering Foundation through the NRL program of MOST NRDP (M1-0203-00-0020) and in  ... 
doi:10.5483/bmbrep.2004.37.1.028 pmid:14761300 fatcat:mtkhijvkdnbj7o2fr236ykqzcq

Temporin-SHf, a New Type of Phe-rich and Hydrophobic Ultrashort Antimicrobial Peptide

Feten Abbassi, Olivier Lequin, Christophe Piesse, Nicole Goasdoué, Thierry Foulon, Pierre Nicolas, Ali Ladram
2010 Journal of Biological Chemistry  
A new type of short antimicrobial peptide, designated temporin-SHf, was isolated and cloned from the skin of the frog Pelophylax saharica.  ...  The short length, compositional simplicity, and broad-spectrum activity of temporin-SHf make it an attractive candidate to develop new antibiotic agents.  ...  The structure of temporin-SHf in micellar environments was further investigated by analysis of intraresidual, sequential, and medium-range NOEs in DPC (Fig. 8) .  ... 
doi:10.1074/jbc.m109.097204 pmid:20308076 pmcid:PMC2878016 fatcat:trg7knmlovhvrnxo6445th2hsq

Expression, purification and structural studies of a short antimicrobial peptide

Mateja Zorko, Boštjan Japelj, Iva Hafner-Bratkovič, Roman Jerala
2009 Biochimica et Biophysica Acta - Biomembranes  
Overall structure explains the advantageous role of the N-terminal proline residue, which forms an integral part of the hydrophobic cluster.  ...  The peptide has antibacterial activity and neutralizes macrophage activation by LPS.  ...  Guillermo Martinez de Tejada, and Dr. Ignacio Moriyon for their collaboration and discussions within the ANEPID project developing the more effective antimicrobial peptide sequences.  ... 
doi:10.1016/j.bbamem.2008.10.015 pmid:19026609 fatcat:eblx3h5s6bep7jbexiyhhsazhq

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides

Ludovic Carlier, Pierre Joanne, Lucie Khemtémourian, Claire Lacombe, Pierre Nicolas, Chahrazade El Amri, Olivier Lequin
2015 Biophysical Chemistry  
Despite a high number of glycine, CD and NMR spectroscopy show that the two plasticins adopt mainly alpha-helical conformations in a wide variety of environments such as trifluoroethanol, detergent micelles  ...  and lipid vesicles.  ...  Acknowledgments The authors are grateful to Dr Christophe Piesse from the peptidic synthesis service of the IBPS/FR 3631 Institut de Biologie Paris-Seine (Université Pierre and Marie Curie, Paris).  ... 
doi:10.1016/j.bpc.2014.09.004 pmid:25291467 fatcat:xvz3mpor2rfzzij4och3q4pcju
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