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DREIMT: a drug repositioning database and prioritization tool for immunomodulation [article]

Kevin Troulé, Hugo López-Fernández, Santiago García-Martín, Miguel Reboiro-Jato, Carlos Carretero-Puche, Jordi Martorell-Marugán, Guillermo Martín-Serrano, Pedro Carmona-Sáez, Daniel González-Peña, Fátima Al-Shahrour, Gonzalo Gómez-López
2020 bioRxiv   pre-print
DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation.  ...  DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ~2,6K immune gene expression signatures.  ...  Here we introduce DREIMT (Drug REpositioning for IMmune Transcriptome), a tool for hypothesis generation of drugs capable of modulating (boosting or inhibiting) the immune cells activity.  ... 
doi:10.1101/2020.06.24.168468 fatcat:oahz45vy7feyzpg7hrwz75wf64

DREIMT: a drug repositioning database and prioritization tool for immunomodulation

Kevin Troulé, Hugo López-Fernández, Santiago García-Martín, Miguel Reboiro-Jato, Carlos Carretero-Puche, Jordi Martorell-Marugán, Guillermo Martín-Serrano, Pedro Carmona-Sáez, Daniel González-Peña, Fátima Al-Shahrour, Gonzalo Gómez-López, Pier Luigi Martelli
2020 Bioinformatics  
Results DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation.  ...  DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ∼2,6K immune gene expression signatures.  ...  Acknowledgements José Antonio López for the fruitful discussions for the development of the DREIMT concept. BU staff for beta testing and DREIMTdb curation. Conflict of Interest: none declared.  ... 
doi:10.1093/bioinformatics/btaa727 pmid:32818254 fatcat:uy7at5cz7rhtth27pq2xv33lrq

FAIR, ethical, and coordinated data sharing for COVID-19 response: a review of COVID-19 data sharing platforms and registries [article]

Lauren Maxwell, Priya Shreedhar, Delphine Dauga, Peter McQuilton, Robert F Terry, Alisa Denisiuk, Fruzsina Molnar-Gabor, Abha Saxena, Susanna-Assunta Sansone
2021 Zenodo  
In the context of COVID-19, there has been a rush to share data, marked by an explosion of population- and discipline-specific resources for collecting, curating, and disseminating participant-level data  ...  We present a comprehensive overview of COVID-19-related platforms and registries that harmonize and share participant-level clinical, OMICs, and imaging data and metadata, and describe how these initiatives  ...  : a drug repositioning database and prioritization tool for immunomodulation Does not collect, harmonize, share COVID-19 participant-level data 64 Comprehensive mapping of local and diaspora scientists  ... 
doi:10.5281/zenodo.5642634 fatcat:6iafdybbw5dd7ojjxzmlieckxq