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Prognostic significance of genome-wide DNA methylation profiles within the randomised, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma

C M S Tesileanu, M J van den Bent, M Sanson, W Wick, A A Brandes, P M Clement, S C Erridge, M A Vogelbaum, A K Nowak, J F Baurain, W P Mason, H Wheeler (+26 others)
2021 Neuro-Oncology  
Two DNA methylation-based tumour classifiers were used for risk stratification. Next-generation sequencing (NGS) was performed using one of two glioma-tailored NGS panels.  ...  The primary endpoint was overall survival measured from date of randomization. Full analysis (genome-wide DNA methylation and NGS) was successfully performed on 654 tumours.  ...  Two classification systems have been reported that make use of the epigenetic profile to diagnose brain tumour subtypes: 1. a DNA methylation-based classification of all central nervous system (CNS) tumours  ... 
doi:10.1093/neuonc/noab088 pmid:33914057 pmcid:PMC8408862 fatcat:xldhsr74l5fv5linvfwdxfnoea

Diffuse Glioneuronal tumour with Oligodendroglioma‐like features and Nuclear Clusters (DGONC) – a molecularly‐defined glioneuronal CNS tumour class displaying recurrent monosomy 14

Maximilian Y. Deng, Martin Sill, Dominik Sturm, Damian Stichel, Hendrik Witt, Jonas Ecker, Andreas Wittmann, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Dominique Figarella‐Branger, Eleonora Aronica (+27 others)
2019 Neuropathology and Applied Neurobiology  
DNA methylation-based central nervous system (CNS) tumour classification has identified numerous molecularly-distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that  ...  DNA methylation-based tumour classification is an objective method of assessing tumour origins, which may aid in diagnosis, especially for atypical cases.  ...  & Laura Doerner (Department of Neuropathology, Institute of Pathology at the University Hospital Heidelberg).  ... 
doi:10.1111/nan.12590 pmid:31867747 fatcat:6ahqvx6ntrdhrizd55supmbpvq

Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types

Ed. C. Schwalbe, James T. Hayden, Hazel A. Rogers, Suzanne Miller, Janet C. Lindsey, Rebecca M. Hill, Sarah-Leigh Nicholson, John-Paul Kilday, Martyna Adamowicz-Brice, Lisa Storer, Thomas S. Jacques, Keith Robson (+5 others)
2013 Acta Neuropathologica  
These included medulloblastomas of defined molecular subgroup (n = 60; 15 representative examples each from the WNT (MB WNT ), sHH (MB sHH ), Central nervous system primitive neuro-ectodermal tumours (  ...  To investigate the potential of DNA methylation profiles to enhance the molecular classification of CNs-pNeTs, we assessed 1,505 CpG residues across 807 genes in a series of 29 archival CNs-pNeTs using  ...  Tumours investigated in this study include samples provided by the UK Children's Cancer and Leukaemia Group (CCLG) as part of CCLGapproved biological study Bs-2007-04.  ... 
doi:10.1007/s00401-013-1206-6 pmid:24212602 pmcid:PMC4313077 fatcat:li7se6dbwbaojfl4u3jbzukore

MOMC-1. Employing the Zika Virus to kill paediatric nervous system tumour cells

Matthew Sherwood, Robert Ewing, Carolini Kaid, Thiago Giove Mitsugi, Keith Okamoto
2021 Neuro-Oncology Advances  
These collectively will inform our understanding of how we can employ a future ZIKV-based virotherapy against paediatric nervous system tumours.  ...  The Zika virus (ZIKV) is capable of infecting and destroying neural stem-like cancer cells from human embryonal Central Nervous System (CNS) tumours in vitro and in vivo.  ...  These collectively will inform our understanding of how we can employ a future ZIKV-based virotherapy against paediatric nervous system tumours. MOMC-2.  ... 
doi:10.1093/noajnl/vdab070.011 fatcat:u5vndyr7gjcjtapfrknkx2psqa

Primary Central Nervous System Neuroblastoma: An Enigmatic Entity [chapter]

Rakesh Mishra, Amit Agrawal
2021 Pheochromocytoma, Paraganglioma and Neuroblastoma [Working Title]  
Central nervous system (CNS) involvement in neuroblastoma is commonly due to metastasis from the extracranial primary.  ...  Recent update in knowledge is seen in 2016 WHO classification of CNS tumours with reclassification of CNS neuroblastoma.  ...  Most of the cases of central nervous system neuroblastoma are due to metastasis from the extracranial site.  ... 
doi:10.5772/intechopen.98244 fatcat:sawcspn3arcpvn2depeuzqu55m

ECOA-9. Integration of molecular and methylation classifications yields three meningioma groups and suggests chromosome 1p loss may be critical to the aggressive group

James Bayley, Caroline Hadley, Arif Harmanci, Akdes Harmanci, Tiemo Klisch, Akash Patel
2021 Neuro-Oncology Advances  
Classifications using either DNA methylation profiling or RNA-sequencing predict tumor behavior more reliably than WHO grade, and segregate common meningioma features similarly, implying possible overlap  ...  In this study, we performed DNA methylation profiling, RNA-sequencing, and whole-exome sequencing on 110 primary meningiomas (90 WHO I, 20 WHO II).  ...  These collectively will inform our understanding of how we can employ a future ZIKV-based virotherapy against paediatric nervous system tumours. MOMC-2.  ... 
doi:10.1093/noajnl/vdab070.009 fatcat:j5qeyb6flnc7lmg3y6t5vygiuy

The potential for epigenetic analysis of paediatric CNS tumours to improve diagnosis, treatment and prognosis

A. Sexton-Oates, D. MacGregor, A. Dodgshun, R. Saffery
2015 Annals of Oncology  
Tumours of central nervous system (CNS) origin are the second most prevalent group of cancers in children, yet account for the majority of childhood cancer-related deaths.  ...  epigenomics (DNA methylation and non-coding RNA analysis), offers tremendous promise to (i) inform treatment approach, (ii) facilitate accurate early identification ( preferably at diagnosis) of variable  ...  The 2007 WHO Classification of Central Nervous System Tumours described medulloblastoma as a single entity, and the next imminent edition will describe clinically and molecularly distinct subgroups.  ... 
doi:10.1093/annonc/mdv024 pmid:25605740 fatcat:mb3zn2jp7vef7gjvvlahnojshq

In the literature: April 2018

Valentina Gambardella, Gemma Bruixola, Andrés Cervantes
2018 ESMO Open  
nervous system tumours diagnosis by Combining dna methylation Profiles and maChinelearning-based methods Accurate diagnosis remains challenging in central nervous system (CNS) tumours even with the implementation  ...  with all scope of CNS tumours by using DNA arrays.  ... 
doi:10.1136/esmoopen-2018-000362 pmid:29682333 pmcid:PMC5905831 fatcat:65xmsek545dlrmzyu3hyb7elje

Abstracts from the Conference "What is new in the diagnostics and treatment of the nervous system tumours"

2017 Folia Neuropathologica  
Abstracts from the Conference "What is new in the diagnostics and treatment of the nervous system tumours" Folia Neuropathologica 2017; 55/4 the only one which gives the opportunity for cortical and subcortical  ...  The histopathological study of the tumour showed relativly numerous dysplastic ganglion cells within astrocytic glial component of pleomorphic cells, with increased number of pathological mitotic figures  ...  Taking into account these discoveries, recent 4 th revision of WHO Classification of Tumours of the Central Nervous System (WHO 2016) introduced molecular findings to the current classification of brain  ... 
doi:10.5114/fn.2017.72425 doaj:fb47388ac59d43f6b4455f3b73c5eeb9 fatcat:2ea3vd5lpvghxdkw4kaijt4e6y

Brain tumour diagnostics using a DNA methylation‐based classifier as a diagnostic support tool

L.P. Priesterbach‐Ackley, H.B. Boldt, J.K. Petersen, N. Bervoets, D. Scheie, B.P. Ulhøi, M. Gardberg, T. Brännström, S.H. Torp, E. Aronica, B. Küsters, W.F.A. den Dunnen (+4 others)
2020 Neuropathology and Applied Neurobiology  
Methylation profiling (MP) is increasingly incorporated in the diagnostic process of central nervous system (CNS) tumours at our centres in The Netherlands and Scandinavia.  ...  In 1% of cases (5/502), the suggested class based on MP was initially disregarded/interpreted as misleading, but in retrospect the MP result predicted the right diagnosis for 3 of these cases.  ...  Author contributions Conflict of interest The authors declare that they have no conflict of interest.  ... 
doi:10.1111/nan.12610 pmid:32072658 fatcat:xfeju24igvd45idao5czoxwbqa

Adult WHO grade II ependymomas: is Ki67 a sex-specific proliferation marker?

Asfand Baig Mirza, José Pedro Lavrador, Marco Mancuso-Marcello, Shami Acharya, Timothy Martyn Boardman, Istvan Bodi, Richard Gullan, Francesco Vergani, Ranj Bhangoo, Keyoumars Ashkan
2021 Journal of Surgical Case Reports  
Age, gender, location, extent of resection, chemotherapy, radiotherapy and histological markers were not associated with tumour progression.  ...  Seventeen patients were included, seven had supratentorial and 10 had infratentorial tumours. Three patients died and eight had recurrent disease.  ...  INTRODUCTION Ependymomas are the most common type of spinal cord tumours, however are relatively rare neoplasms of the brain, especially in adults, comprise 3% of all primary central nervous system (CNS  ... 
doi:10.1093/jscr/rjab333 fatcat:vxjcgnvnh5amfisje6ocpzswkq

ECOA-10. Integrated genomic and clinical analysis of BRAF-mutated glioma in adults

Pinky Langat, Taibo Li, Wenya Linda Bi, Karisa C Schreck
2021 Neuro-Oncology Advances  
We characterized the molecular and clinical features of a multi-institutional cohort of adults with BRAF-mutated gliomas.  ...  This cohort of BRAF-altered adult gliomas demonstrates a broad range of molecular alterations with implications for treatment sensitivity and patient risk stratification.  ...  These collectively will inform our understanding of how we can employ a future ZIKV-based virotherapy against paediatric nervous system tumours. MOMC-2.  ... 
doi:10.1093/noajnl/vdab070.010 fatcat:ofbvmnp34fbgrfafbd7wudeedm

MOMC-2. Glioblastoma Metabolic Symbiosis: When Lactate Takes The Lead

Joris Guyon, Claire Larrieu, Cyrielle Bouchez, Ignacio Fernandez Moncada, Aurelien Coffe, Macha Nikolski, Andreas Bikfalvi, Thomas Daubon
2021 Neuro-Oncology Advances  
Most of differentiated cells convert glucose into pyruvate that enters into the Krebs cycle to maximize energy production in the presence of oxygen.  ...  For cancer cells, glucose uptake and catabolism are increased regardless of oxygen level.  ...  These collectively will inform our understanding of how we can employ a future ZIKV-based virotherapy against paediatric nervous system tumours. MOMC-2.  ... 
doi:10.1093/noajnl/vdab070.012 fatcat:54sz7viwwbagzh5xgebecil7xe

The 2016 World Health Organization Classification of tumours of the Central Nervous System: what the paediatric neuroradiologist needs to know

Sahil Chhabda, Olivia Carney, Felice D'Arco, Thomas S. Jacques, Kshitij Mankad
2016 Quantitative Imaging in Medicine and Surgery  
The recently published 2016 World Health Organization (WHO) classification of tumours of the Central Nervous System (CNS) introduces a number of significant changes from the previous edition.  ...  Based on an improved understanding of the genetic and molecular basis of tumorigenesis there has been a shift towards defining tumours by means of these characteristics in addition to their histological  ...  There remain a group of embryonal tumours of the nervous system that do not have one of these characteristic features and these are described as CNS neuroblastoma, CNS ganglioneuroblastoma or embryonal  ... 
doi:10.21037/qims.2016.10.01 pmid:27942466 pmcid:PMC5130574 fatcat:sb5ttmqojbdjtigxihvcfpju3y

The case for DNA methylation based molecular profiling to improve diagnostic accuracy for central nervous system embryonal tumors (not otherwise specified) in adults

Gail C. Halliday, Reimar C. Junckerstorff, Jacqueline M. Bentel, Andrew Miles, David T.W. Jones, Volker Hovestadt, David Capper, Raelene Endersby, Catherine H. Cole, Tom van Hagen, Nicholas G. Gottardo
2018 Journal of clinical neuroscience  
We report the case of a 45-year-old woman who was diagnosed with a central nervous system embryonal tumor (NOS) based on immunohistochemical analysis of the patient's tumor at diagnosis.  ...  Central nervous system primitive neuro-ectodermal tumors (CNS-PNETs), have recently been reclassified in the most recent 2016 WHO Classification into a standby catch all category, "CNS Embryonal Tumor,  ...  According to the revised 4th edition of the WHO Classification of Tumors of the Central Nervous System [6] , the tumor would be classified as an anaplastic astrocytoma, IDHmutant, ATRX mutant.  ... 
doi:10.1016/j.jocn.2017.09.013 pmid:28993028 fatcat:hslh3szxivdh5avtpbtwhzp7ue
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