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DNA Copy Number Aberrations in Breast Cancer by Array Comparative Genomic Hybridization

Jian Li, Kai Wang, Shengting Li, Vera Timmermans-Wielenga, Fritz Rank, Carsten Wiuf, Xiuqing Zhang, Huanming Yang, Lars Bolund
2009 Genomics, Proteomics & Bioinformatics  
Array comparative genomic hybridization (CGH) has been popularly used for analyzing DNA copy number variations in diseases like cancer.  ...  In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artif icial chromosome CGH arrays.  ...  In recent years, array comparative genomic hybridization (CGH) has proven its value for analyzing DNA copy number variations in diseases like cancer (3 ) .  ... 
doi:10.1016/s1672-0229(08)60029-7 pmid:19591788 pmcid:PMC5054221 fatcat:anktl3zoqndz3nkexeuaav3kpm

Array-based Comparative Genomic Hybridization and Its Application to Cancer Genomes and Human Genetics

Eun Kyung Cho
2011 Journal of Lung Cancer  
Array CGH can be used for analysis of DNA copy number aberrations that cause not only cancer and human genetic disease, but also normal human variation.  ...  Microarray comparative genomic hybridization (CGH) has proven to be a specific, sensitive, and rapid technique, with considerable advantages compared to other m ethods used for analysis of DNA copy num  ...  The DNA copy number aberrations are subsequently measured by detecting intensity differences in the hybridization patterns of Array CGH and the Application to Cancer Genomes 79 both DNAs.  ... 
doi:10.6058/jlc.2011.10.2.77 fatcat:7azzxzdzwzb53lthtukmrjbdna

Profiling Breast Cancer by Array CGH

Donna G. Albertson
2003 Breast Cancer Research and Treatment  
This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization.  ...  Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.  ...  Acknowledgements This work was supported by NIH grants CA80314, CA83040, CA84118, HD17665 and CA58207 by California BCRP grant 2RB-0225 and Vysis, Inc.  ... 
doi:10.1023/a:1023025506386 pmid:12755488 fatcat:wheh6rj4mfc4nclbjkbfxkszvq

SNP array technology: an array of hope in breast cancer research

C C Ho, K S Mun, R Naidu
2013 The Malaysian journal of pathology  
which combine the power of chromosomal comparative genomic hybridization (cCGH) and loss of heterozygosity (LOH) in the offering of higher-resolution mappings.  ...  Breast cancer is the most common malignancy in women worldwide.  ...  ACKNOWLEDGEMENTS This study was financially supported by E-ScienceFund grant (02-02-10-SF0016) from Ministry of Science, Technology and Innovation, Malaysia.  ... 
pmid:23817393 fatcat:unhsexozlnhtbmlaajlmczmhda

Page 399 of Cancer Science Vol. 98, Issue 3 [page]

2007 Cancer Science  
Screening of DNA copy-number Platzer P, Upender MB, Wilson K aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci 2005; 96: 100-10.  ...  Positional cloning of ZNF217 and NABCI: genes amplified at 20q13.2 and overexpressed in breast carcinoma. carcinoma revealed by array-based comparative genomic hybridization: Proc Natl Acad Sci USA 1998  ... 

Array-CGH and breast cancer

Erik H van Beers, Petra M Nederlof
2006 Breast Cancer Research  
However, application of array-CGH to breast cancer BAC = bacterial artificial chromosome; CESH = comparative expressed sequence hybridization; CGH = comparative genomic hybridization; CNA = copy number  ...  The introduction of comparative genomic hybridization (CGH) in 1992 opened new avenues in genomic investigation; in particular, it advanced analysis of solid tumours, including breast cancer, because it  ...  Acknowledgements We thank the Marie-Curie Foundation (meetings and course) that helped us to share CGH experiences with many researchers in this field.  ... 
doi:10.1186/bcr1510 pmid:16817944 pmcid:PMC1557735 fatcat:cjrhuz7u7zfrfogdf4y3tpebdm

Chromosome-breakage genomic instability and chromothripsis in breast cancer

Ewa Przybytkowski, Elizabeth Lenkiewicz, Michael T Barrett, Kathleen Klein, Sheida Nabavi, Celia MT Greenwood, Mark Basik
2014 BMC Genomics  
Results: We performed array comparative genomic hybridization in 29 primary tumors from high risk patients with breast cancer.  ...  However, the mere assessment of the extent of genomic changes, amplifications and deletions may reduce the complexity of genomic data observed by array comparative genomic hybridization (array CGH).  ...  Acknowledgements and funding We acknowledge financial support form AstraZeneca, the Reseau de Recherche sur le Cancer of the Fond Quebecois de Recherche en Santé, Genome Québec, The Québec Breast Cancer  ... 
doi:10.1186/1471-2164-15-579 pmid:25011954 pmcid:PMC4227294 fatcat:bvdz3t2fgjhyxlqy3j6wssgyti

Genomic microarrays in human genetic disease and cancer

D. G. Albertson, D. Pinkel
2003 Human Molecular Genetics  
Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation.  ...  Comparative genomic hybridization (CGH) can be used to detect and map these changes.  ...  Work in the authors' laboratories was supported by NIH grants CA80314, CA83040 and CA94407 and Vysis Abbott Inc.  ... 
doi:10.1093/hmg/ddg261 pmid:12915456 fatcat:dey3wz5iubbjfhsq5d5u23nucq

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues

Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki
2010 BMC Cancer  
Methods: Array-based comparative genomic hybridization (CGH) was employed with 4030 bacterial artificial chromosomes (BACs) that cover the genome at 1.0 megabase resolution to analyze DNA copy number aberrations  ...  (DCNAs) in 35 primary breast tumors and 24 breast cancer cell lines.  ...  Acknowledgements This work was supported in part by The Ministry of Education, Culture of Japan (19390102 and 20659055) and The New Energy and Industrial Technology Development Organization (NEDO) of Japan  ... 
doi:10.1186/1471-2407-10-15 pmid:20070913 pmcid:PMC2836299 fatcat:uks6t3rkmnbcdgozdlv4pojxtu

Lack of Genomic Heterogeneity at High-Resolution aCGH between Primary Breast Cancers and Their Paired Lymph Node Metastases

Marieke A. Vollebergh, Christiaan Klijn, Philip C. Schouten, Jelle Wesseling, Danielle Israeli, Bauke Ylstra, Lodewyk F.A. Wessels, Jos Jonkers, Sabine C. Linn, Paul J. van Diest
2014 PLoS ONE  
To date, no recurrent LNM-specific genomic aberrations have been identified using array comparative genomic hybridization (aCGH) analysis.  ...  In this study we used high-resolution aCGH to investigate DNA copy number differences between primary breast cancers and their paired LNMs.  ...  This work was supported by A Sister's Hope/Pink Ribbon. Author Contributions  ... 
doi:10.1371/journal.pone.0103177 pmid:25083859 pmcid:PMC4118860 fatcat:fbl6rodppfcxth5w5bfgjz5k4u

Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array

F. Andre, B. Job, P. Dessen, A. Tordai, S. Michiels, C. Liedtke, C. Richon, K. Yan, B. Wang, G. Vassal, S. Delaloge, G. N. Hortobagyi (+3 others)
2009 Clinical Cancer Research  
Purpose: We used high-resolution oligonucleotide comparative genomic hybridization (CGH) arrays and matching gene expression array data to identify dysregulated genes and to classify breast cancers according  ...  Nonnegative matrix factorization (NMF) clustering of DNA copy number aberrations revealed three distinct molecular classes in this data set.  ...  Genomic instability leads to DNA copy number abnormalities in cancer cells (1) .  ... 
doi:10.1158/1078-0432.ccr-08-1791 pmid:19147748 fatcat:6lfoz3pzkvchdef5s4zuixocrm

Genome changes and gene expression in human solid tumors

Joe W. Gray, Colin Collins
2000 Carcinogenesis  
LOH are now accelerating high-resolution genome aberration localization in human tumors.  ...  Abbreviations: CGH, comparative genomic hybridization; FISH, fluorescence in situ hybridization; LOH, loss of heterozygosity; RDA, representational difference analysis; RLGS, restriction landmark genome  ...  Alternately, cloned NotI/EcoRV boundary library elements can be mixed with the genomic DNA during An array CGH analysis of genome copy number changes along chromosome 20 in a human breast cancer (adapted  ... 
doi:10.1093/carcin/21.3.443 pmid:10688864 fatcat:xi245pvyh5eqdbnyxzgevoeuiu

Gene copy number variation in male breast cancer by aCGH

Stefania Tommasi, Anita Mangia, Giuseppina Iannelli, Patrizia Chiarappa, Elena Rossi, Laura Ottini, Marcella Mottolese, Wainer Zoli, Orsetta Zuffardi, Angelo Paradiso
2010 Analytical Cellular Pathology  
Array comparative genomic hybridization (aCGH) provides a method to quantitatively measure the changes of DNA copy number and to map them directly onto the complete linear genome sequences.  ...  The aim of this study was to investigate DNA imbalances by aCGH and compare them with a female breast cancer dataset.  ...  The present paper focuses on the characterization of DNA imbalances in a set of 25 MBC samples analyzed by high-resolution CGH arrays in order to detect DNA copy number aberrations (CNAs).  ... 
doi:10.3233/acp-clo-2010-0544 pmid:21045282 pmcid:PMC4605520 fatcat:uaaqjw6fyvh7bkq7dmizfxddha

Gene Copy Number Variation in Male Breast Cancer by aCGH

Stefania Tommasi, Anita Mangia, Giuseppina Iannelli, Patrizia Chiarappa, Elena Rossi, Laura Ottini, Marcella Mottolese, Wainer Zoli, Orsetta Zuffardi, Angelo Paradiso
2010 Analytical Cellular Pathology  
Array comparative genomic hybridization (aCGH) provides a method to quantitatively measure the changes of DNA copy number and to map them directly onto the complete linear genome sequences.  ...  The aim of this study was to investigate DNA imbalances by aCGH and compare them with a female breast cancer dataset.Methods: We used Agilent Human Genome CGH Microarray Kit 44B and 44K to compare genomic  ...  The present paper focuses on the characterization of DNA imbalances in a set of 25 MBC samples analyzed by high-resolution CGH arrays in order to detect DNA copy number aberrations (CNAs).  ... 
doi:10.1155/2010/468280 fatcat:ewwsyukz3vfsvgq2wr5jseo2ce

Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research

David S P Tan, Maryou B K Lambros, Rachael Natrajan, Jorge S Reis-Filho
2007 Laboratory Investigation  
for translational research by facilitating detailed analysis of entire cancer genomes in a single experiment.  ...  The development of high-resolution microarray-based comparative genomic hybridization (aCGH), using cDNA, bacterial artificial chromosome (BAC) and oligonucleotide probes, is providing tremendous opportunities  ...  RN, ML, and JSR-F are funded by Breakthrough Breast Cancer. DT is funded in part by a grant from Cancer Research UK.  ... 
doi:10.1038/labinvest.3700593 pmid:17558419 fatcat:44vjwn2odrg3bpk2r53jeesmby
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