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DNA Computing in Microreactors
[chapter]
2002
Lecture Notes in Computer Science
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The goal of this research is to improve the programmability of DNA-based computers. ...
Novel clockable microreactors can be connected in various ways to solve combinatorial optimisation problems, such as Maximum Clique or 3-SAT. ...
Acknowledgement The authors wish to acknowledge the support of the GMD for DNA computing and the German Ministry of Science (BMBF) for BioMIP's start-up grant (#01SF9952). ...
doi:10.1007/3-540-48017-x_4
fatcat:rvwodb3l6fft3on4wffjnl6m3u
DNA computing in microreactors
2001
BioMEMS and Smart Nanostructures
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The goal of this research is to improve the programmability of DNA-based computers. ...
Novel clockable microreactors can be connected in various ways to solve combinatorial optimisation problems, such as Maximum Clique or 3-SAT. ...
Acknowledgement The authors wish to acknowledge the support of the GMD for DNA computing and the German Ministry of Science (BMBF) for BioMIP's start-up grant (#01SF9952). ...
doi:10.1117/12.454623
fatcat:qwg7zryacfhexotsgnjjyu5or4
Simulation and Visualization of Flow Pattern in Microarrays for Liquid Phase Oligonucleotide and Peptide Synthesis
2008
Biotechnology progress (Print)
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By proper design geometry, flow uniformity could be obtained in every microreactor in the microarrays. ...
Computational fluid dynamics (CFD) is used to model and simulate the microfluidic microarrays to study geometrical effects on flow patterns. ...
DNA Synthesis Chip Experiment DNA was synthesized in-situ on a microfluidic device in which the microreactor depth was intentionally increased. ...
doi:10.1021/bp060363o
pmid:17480053
pmcid:PMC2531222
fatcat:xqq37ngz75dyzdy7qrdggookiy
Optically programming DNA computing in microflow reactors
2001
Biosystems (Amsterdam. Print)
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The programmability and the integration of biochemical processing protocols are addressed for DNA computing using photochemical and microsystem techniques. ...
The specific problem is encoded in an initial labeling pattern of each module with one of 2N DNA oligonucleotides, identical for all instances of maximal clique. ...
beads in the microreactor. ...
doi:10.1016/s0303-2647(01)00099-5
pmid:11267740
fatcat:ewyjbpdzdjhlnfcmugk2rhsepy
Fluorogenic DNA sequencing in PDMS microreactors
2011
Nature Methods
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We immobilized primed dnA templates in the microreactors, then sequentially introduced one of the four identically labeled tPlFns, sealed the microreactors and recorded a fluorescence image after template-directed ...
phosphatase, primer extension by dnA polymerase using nonfluorescent tPlFns generates fluorophores, which are confined in the microreactors and detected. ...
This work was performed in part at the Center for Nanoscale Systems, which is a part of Harvard University and a member of the National Nanotechnology Infrastructure Network, which is supported by the ...
doi:10.1038/nmeth.1629
pmid:21666670
pmcid:PMC3414871
fatcat:ji5qfkqitjffvm6gia5unzxcuq
Another expert system rule inference based on DNA molecule logic gates
2013
Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2013
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It requires the unique representation of signals by DNA molecules. The main part of this work includes the concept of logic gates based on typical genetic engineering reactions. ...
With the help of silicon industry microfluidic processors were invented utilizing nano membrane valves, pumps and microreactors. ...
He used the miniaturization labon-a-chip methodology to solve in microreactors computational problems, which were previously computed in genetic engineering laboratory tubes [3] [4] [5] . ...
doi:10.1117/12.2032392
fatcat:ctao4i3dijcxdeooijxra7huaq
Microreactor Array Device
2015
Scientific Reports
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The device is validated by protein expressed in situ directly from DNA in a microarray of ,10,000 spots with no diffusion during three hours incubation. ...
Proteins can also be expressed outside of living cells by subjecting gene DNA to 'cell-free' in vitro coupled transcription and translation (IVTT) reagent. ...
Figure 6 | 6 Image rendered with proteins expressed from DNA in microreactors. ...
doi:10.1038/srep08736
pmid:25736721
pmcid:PMC4348619
fatcat:7w72qomdw5cs3awbfv7mqk7yyy
3D Printed Monolithic Microreactors for Real-Time Detection of Klebsiella pneumoniae and the Resistance Gene blaNDM-1 by Recombinase Polymerase Amplification
2020
Micromachines
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Singleplex assays for both khe and blaNDM-1 achieved a limit of detection of 2.5 × 101 DNA copies while the duplex assay achieved 2.5 × 101 DNA copies for khe and 2.5 × 102 DNA copies for blaNDM-1. ...
We 3D printed monolithic rtRPA microreactors and subjected the devices to different post curing protocols. ...
In addition, the authors would like to thank the National reference laboratory for multidrug-resistant Gram-negative bacteria at the Ruhr-University Bochum for providing Klebsiella pneumoniae strains. ...
doi:10.3390/mi11060595
pmid:32560308
fatcat:zgww65cfwfgdjbakrps7ooin7i
Handheld Continuous-flow Real-time Fluorescence qPCR System with PVC Microreactor
2020
The Analyst
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The polymerase chain reaction (PCR) has unique advantages of sensitivity, specificity and rapidity in pathogen detection, which makes it at the forefront of academia and application in molecular biology ...
in which the concentration of template DNA was 10 6 copies per μL in each set. ...
The bar plots represent the fluorescence intensity of the DNA template amplified products in the PVC and PTFE microreactors, respectively. ...
doi:10.1039/c9an01894h
pmid:32095799
fatcat:dviiiflvdfavdbsxxitsr6g5mm
Noise-Induced Stability Analysis of a Capillary Flow Microreactor with Mixing by Radial Diffusion of Laminar Flow Profiles
2015
International Journal of Chemoinformatics and Chemical Engineering
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Simulations showed that although the aim of RDLFP is to improve mixing, poorly mixed microreactors are more robust to the influx of noise than well-mixed tubes. ...
Multi-component noise in multi-fluid systems can also induce stochastic resonance, which may either enhance or reduce stability. ...
Mixing is an inherent problem because the flow in capillary microreactors is predominantly laminar (Wirth, 2008) . ...
doi:10.4018/ijcce.2015010101
fatcat:ysxf3pq2afdspnmtjx2zqshs2m
Microfluidic reactor array device for massively parallel in situ synthesis of oligonucleotides
2009
Sensors and actuators. B, Chemical
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Depending on the design parameters, it is possible to achieve uniform flow and synthesis reaction in all of the reactors by proper design of the microreactors and the microchannels. ...
The device is made of glass anodically bonded to silicon consisting of three level features: microreactors, microchannels and through inlet/outlet holes. ...
Computer software, written in C ++ , was developed in-house to generate light patterns based on predetermined oDNA chip layout. ...
doi:10.1016/j.snb.2009.04.071
pmid:20161215
pmcid:PMC2716077
fatcat:aet2wequn5gctlvdk7nvq5si6i
Automated Design and Programming of a Microfluidic DNA Computer
2006
Natural Computing
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Previously, we described ways to implement the functions AND and OR in a DNA computer consisting of microreactors with attached heating elements that control annealing of DNA. ...
Reducing the number of reactors in a DNA computer reduces the loss of DNA through binding to the surfaces of the system. ...
Introduction One of the primary goals in the field of DNA computing is to reduce the time and space necessary to perform a computation. ...
doi:10.1007/s11047-005-3803-3
fatcat:2uhugizejzbyzb52z3sbode7te
PDMS valves in DNA computers
2005
Biomedical Applications of Micro- and Nanoengineering II
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One form of DNA computing is performed in microfluidics. A network of microreactors decides the computational aspects and DNA is the tool for selection procedures. ...
To control complex microflow systems like this, a series of pneumatic valves are used to control the flow direction, i.e. the information direction, and to contain DNA functionalised beads in the microreactors ...
We have applied the field of microfluidics to biomolecular computing, or better known as DNA computing [1] . ...
doi:10.1117/12.582170
fatcat:7qhthpp7fra53gooxwgctz5hdq
Fluorogenic pyrosequencing in microreactors
2011
Nature Methods
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s clustering algorithm holds great promise as a game-changer in the field of computational proteomics. ...
(a) Clonally amplified DNA beads are deposited into a microreactor, and dNTPs are sequentially washed over the wells. ...
doi:10.1038/nmeth.1634
pmid:21716283
fatcat:iym5w3isbnb5jg52bzsqmjkwda
Integrated microfluidic reactors
2009
Nano Today
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of radiolabeled imaging probes for positron emission tomography (PET), (iii) sequential preparation of individually addressable conducting polymer nanowire (CPNW), and (iv) solid-phase synthesis of DNA ...
In this review, we summarize recent progresses on the development of integrated microfluidics-based chemical reactors for (i) parallel screening of in situ click chemistry libraries, (ii) multistep synthesis ...
To fully utilize the automation performance of the integrated microfluidic system, a computer-controlled interface was employed to operate this screening microreactor for preparation of 32 reaction mixtures ...
doi:10.1016/j.nantod.2009.10.007
pmid:20209065
pmcid:PMC2832182
fatcat:5wo674py3rbajicne3no3aikmm
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