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DM-BLD: differential methylation detection using a hierarchical Bayesian model exploiting local dependency

Xiao Wang, Jinghua Gu, Leena Hilakivi-Clarke, Robert Clarke, Jianhua Xuan
2016 Bioinformatics  
Results: We have developed a novel probabilistic approach, differential methylation detection using a hierarchical Bayesian model exploiting local dependency (DM-BLD), to detect differentially methylated  ...  A hierarchical Bayesian model is developed to fully take into account the local dependency for differential analysis, in which differential states are embedded as hidden variables.  ...  In this article, we develop a novel method, differential methylation detection using a hierarchical Bayesian model exploiting local dependency (DM-BLD), to identify differentially methylated genes based  ... 
doi:10.1093/bioinformatics/btw596 pmid:27616707 pmcid:PMC5254079 fatcat:bx25i6qg7vbuvjmwt5vrtpyxwa