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Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

Rita Z. Goldstein, Nora D. Volkow
2011 Nature Reviews Neuroscience  
Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will.  ...  However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order  ...  Acknowledgements This study was supported by grants from the US National Institute on Drug Abuse (R01DA023579 to R.Z.G.), the Intramural NIAAA program and the Department of Energy, Office of Biological  ... 
doi:10.1038/nrn3119 pmid:22011681 pmcid:PMC3462342 fatcat:vrfpkzqyuvc3tdwno5ahxgqqiu

Genetics of impulsive behaviour

L. Bevilacqua, D. Goldman
2013 Philosophical Transactions of the Royal Society of London. Biological Sciences  
A negative association between D2/D3 receptor availability and impulsivity was detected in the group of addicts, consistent with the role of these dopamine receptors in impulsivity.  ...  [59] explored the association between scores on the BIS and striatal D2/D3 receptor availability assessed by positron emission tomography in both healthy controls and methamphetamine-dependent individuals  ... 
doi:10.1098/rstb.2012.0380 pmid:23440466 pmcid:PMC3638385 fatcat:5b32pevtsnbx5edgcizimhcady

The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directions

Marc Nicholas Potenza, Lorrin Michael Koran, Stefano Pallanti
2009 Psychiatry Research  
Impulse-control disorders (ICDs) constitute a heterogeneous group of conditions linked diagnostically by difficulties in resisting "the impulse, drive, or temptation to perform an act that is harmful to  ...  In this article, clinical, phenomenological and biological features of the formal ICDs are reviewed and compared and contrasted with those of OCD.  ...  Acknowledgments Supported in part by: (1) the National Institute on Drug Abuse (R01-DA019039); (2) Women's Health Research at Yale; and (3) the US Department of Veterans Affairs VISN1 MIRECC.and REAP.  ... 
doi:10.1016/j.psychres.2008.06.036 pmid:19811840 pmcid:PMC2792582 fatcat:m4a2flojbzcivcbvlfprngleey

The role of the orbitofrontal cortex in alcohol use, abuse, and dependence

David E. Moorman
2018 Progress in Neuro-psychopharmacology and Biological Psychiatry  
One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated behavior.  ...  Given the primary role that the OFC plays in controlling of flexible, goal directed behavior, as well as its association with reward identification and acquisition, it is likely that the OFC will emerge  ...  The density of neurons in OFC was inversely correlated with the duration of alcohol dependence, providing a particularly strong association between alcoholism in humans and OFC disruption at a cellular  ... 
doi:10.1016/j.pnpbp.2018.01.010 pmid:29355587 pmcid:PMC6072631 fatcat:o63l5yxiyrcmjo3id7y6clfqi4

Development of pharmacotherapies for drug addiction: a Rosetta Stone approach

George F. Koob, G. Kenneth Lloyd, Barbara J. Mason
2009 Nature reviews. Drug discovery  
Second, there is a dynamic approach to the process of validation, with changes being discovered and implemented at both ends.  ...  The addiction cycle A useful psychiatrybased motivational framework that integrates well with animal models of addiction is the concept that drug addiction has aspects of both impulse control disorders  ...  Acknowledgements This is manuscript number 19,996 authored from The Scripps Research Institute. The authors thank M. Arends for his assistance with manuscript preparation.  ... 
doi:10.1038/nrd2828 pmid:19483710 pmcid:PMC2760328 fatcat:mk3jbn2ppfcvdks43ofqwhbvra

Addictive behaviour in experimental animals: prospects for translation

Barry J. Everitt, Chiara Giuliano, David Belin
2018 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Whether or not these behavioural and molecular studies are viewed as modelling the underpinnings of addiction in humans, the discussion presented here highlights two areas -the impact of drug-associated  ...  mechanisms of drug reward and reinforcement and the neuroadaptations to chronic use.  ...  The review summarises research undertaken by many members of the Cambridge laboratory over many years and we thank them for their outstanding contributions.  ... 
doi:10.1098/rstb.2017.0027 pmid:29352026 fatcat:7l5tshkadjhsnct5v3cm2aveji

Poster Session I

2014 Neuropsychopharmacology  
Background: Contemporary theories of reward-based decision making posit that dopamine signaling updates cached values associated with stimuli or actions; and that these values are used to compare available  ...  Cue-induced nicotine relapse is associated with rapid synaptic potentiation, and NAC works to inhibit both nicotine relapse and relapse-associated NAcore plasticity.  ...  The orbitofrontal cortex (OFC) is implicated in associative learning and cognitive flexibility.  ... 
doi:10.1038/npp.2014.280 fatcat:xunw4pdn75hlnmhvvksgp2lsse

Neurophysiology of Performance Monitoring and Adaptive Behavior

Markus Ullsperger, Claudia Danielmeier, Gerhard Jocham
2014 Physiological Reviews  
Here, we review the neurophysiology of evaluating action course and outcome with respect to their valence, i.e., reward and punishment, and initiating short-and long-term adaptations, learning, and decisions  ...  A prerequisite for determining the necessity, type, and magnitude of adjustments is to continuously monitor the course and outcome of one's actions.  ...  Fischer for helpful comments on the manuscript.  ... 
doi:10.1152/physrev.00041.2012 pmid:24382883 fatcat:3lmbdfjb4jhnlc2ckfhtlers6m

Lipids in psychiatric disorders and preventive medicine

Miriam Schneider, Beth Levant, Martin Reichel, Erich Gulbins, Johannes Kornhuber, Christian P. Müller
2017 Neuroscience and Biobehavioral Reviews  
Here we review how brain lipids contribute to normal behaviour and to major psychiatric disorders with the focus on phospholipids/fatty acids, sphingolipids, and endocannabinoids.  ...  The lipid composition of the brain can be influenced by nutrition, environmental factors, and by behavioural activity.  ...  MS, by the Annika Liese Price 2014 (to EG and JK), and by funding from the Interdisciplinary Center for Clinical Research Erlangen, Project E13.  ... 
doi:10.1016/j.neubiorev.2016.06.002 pmid:27317860 fatcat:haywhj7duvcq7mzkwz2ab36sga

Neuronal Reward and Decision Signals: From Theories to Data

Wolfram Schultz
2015 Physiological Reviews  
These signals are found in dopamine neurons, which emit a global reward signal to striatum and frontal cortex, and in specific neurons in striatum, amygdala, and frontal cortex projecting to select neuronal  ...  Utility is the formal mathematical characterization of subjective value and a prime decision variable in economic choice theory. It is coded as utility prediction error by phasic dopamine responses.  ...  cingulate cortex (10) , and from odor rewards in human orbitofrontal cortex (190) .  ... 
doi:10.1152/physrev.00023.2014 pmid:26109341 pmcid:PMC4491543 fatcat:io5urzxu7rcttkaciaapilmkwe

The neurobiology of psychopathic traits in youths

R. James R. Blair
2013 Nature Reviews Neuroscience  
Psychopathic traits consist of a callous-unemotional component and an impulsive-antisocial component, which are associated with two core impairments.  ...  reinforcement learning, which reflects dysfunction in the ventromedial prefrontal cortex and striatum.  ...  Acknowledgements This work was supported by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health, USA, under grant number 1-ZIA-MH002860-08.  ... 
doi:10.1038/nrn3577 pmid:24105343 pmcid:PMC4418507 fatcat:4ubacbw7r5aefoxb7squryltj4

Applications of Radiotracer Imaging Poster Abstracts

2012 Journal of Cerebral Blood Flow and Metabolism  
The purpose of this study was to examine the relationships between age and both in vivo fibrillary amyloid deposition and glucose metabolism in AD.  ...  For [ 18 F]fluorodeoxyglucose, associations were found between parietal uptake with visuo-spatial (standardized b: 0.55), attention (standardized b: 0.39) and executive functioning (standardized b: 0.37  ...  This investigation suggests that the influence of dopamine on aggression is not directly linked with a reward-expectancy to harmful-behaviour but is inversely linked to the distractibility from goal/reward-directed  ... 
doi:10.1038/jcbfm.2012.78 fatcat:2uvqdqlwsfgexhr5qno2gjfmqe

The effect of exposure to drugs on the processing of natural rewards

Patrick Anselme
2009 Neuroscience and Biobehavioral Reviews  
Acknowledgements The author would like to thank Ezio Tirelli and Michel Hansenne for several informative discussions, as well as two anonymous reviewers for their helpful comments, on this paper.  ...  Fig. 7B indicates that alcoholic subjects do not process information in the same way as opiate-dependent subjects: they reacted faster to neutral sentences than to those semantically associated with alcohol  ...  This pathway is known to induce neuronal and behavioural sensitisations associated with rewarding and rewardassociated stimuli (e.g. Berridge and Robinson, 1998; Depue and Collins, 1999) .  ... 
doi:10.1016/j.neubiorev.2008.10.002 pmid:18955078 fatcat:famvliudwbeq5imxetjeworenu

Neuroscience of Psychoactive Substance Use and Dependence

2004 Addiction  
With long-term use of methamphetamine there is a decrease in dopamine D 2 receptor availability in the caudate and putamen, and a decrease in metabolic rate in the orbitofrontal cortex (Volkow et al.,  ...  The HTR 7 L279 variant was not significantly associated with alcohol dependence or impulsivity, however it may be a predisposing allele in a subgroup of people with alcohol dependence and multiple behavioural  ...  Hasegawa Y et al. (2002) Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. Journal of Neural Transmission, 109:513-521.  ... 
doi:10.1111/j.1360-0443.2004.00906.x fatcat:eyujrmtzbrbrlmr2x4rgkgdiem

Steps to a neurochemistry of personality

Andrew D. Lawrence, Matthias J. Koepp, Roger N. Gunn, Vincent J. Cunningham, Paul M. Grasby
1999 Behavioral and Brain Sciences  
Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation.  ...  A corticolimbic-striatal-thalamic network (1) integrates the salient incentive context in the medial orbital cortex, amygdala, and hippocampus; (2) encodes the intensity of incentive stimuli in a motive  ...  ACKNOWLEDGMENT Support for writing this commentary was provided by the Medical Research Council and the Wellcome Trust.  ... 
doi:10.1017/s0140525x99332040 fatcat:katsxmy4m5fj5hs2kq6lgondoe
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