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Cyclin H Regulates Lung Cancer Progression as a Carcinoma Inducer

Lili Mao, Xu Ling, Ji Chen, Tao Huang
2021 Computational and Mathematical Methods in Medicine  
Studies have previously shown that Cyclin H (CCNH) is involved in the tumorigenesis and development of many cancers.  ...  Our study suggested that CCNH was a promising biomarker and target in the treatment of lung cancer.  ...  Introduction Lung cancer is the primary inducer of cancer mortality worldwide and has changed from a rare disease to a global problem and a public health problem [1] .  ... 
doi:10.1155/2021/6646077 pmid:33777168 pmcid:PMC7969110 fatcat:o3o2f46jobe6ja6akgsp7jgpby

Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin�D1

Wei Zhao, Jin‑Xia Hu, Rui‑Min Hao, Qian Zhang, Jun‑Qi Guo, You‑Jie Li, Ning Xie, Lu‑Ying Liu, Ping‑Yu Wang, Can Zhang, Shu‑Yang Xie
2018 Oncology Reports  
Furthermore, let-7a significantly inhibited cell growth by directly regulating cyclin D1 signals.  ...  Lung cancer is the most common cause of cancer-associated mortality.  ...  Cyclin D1 is a positive regulator of cell cycle progression (11) , and these results indicated that let-7a suppresses lung cancer cell growth by regulating the pathway of cyclin D1.  ... 
doi:10.3892/or.2018.6593 pmid:30066899 pmcid:PMC6111629 fatcat:74keqcf2rjfuxfot3ovy5ahoiq

Curcumin induces apoptosis in lung cancer cells via mitochondria-dependent signal pathways

Hui Wang, Wei Qiao
2019 Tropical Journal of Pharmaceutical Research  
Curcumin treatment also enhanced the expressions of Bax, cleavage-caspase-8 and PARP in A-549 cells. Conclusion: Curcumin inhibits lung cancer growth by inducing apoptosis and cell cycle arrest.  ...  Thus, curcumin has a promising potential for the treatment of lung cancer.  ...  Progression to S phase is regulated by A/cdk2 activation, while that of G2/M is regulated by activation of A and B/cdk1 cyclins [18, 19] .  ... 
doi:10.4314/tjpr.v17i10.6 fatcat:d3girendfvahhoibpopxdokpzy

Putative Tumor-Suppressive Function of Kruppel-Like Factor 4 in Primary Lung Carcinoma

W. Hu, W. L. Hofstetter, H. Li, Y. Zhou, Y. He, A. Pataer, L. Wang, K. Xie, S. G. Swisher, B. Fang
2009 Clinical Cancer Research  
The effect of KLF4 in regulating p21 and cyclin D1 was also evaluated.  ...  Conclusions: Our results suggest that KLF4 plays an important role in suppressing the growth of lung carcinoma. (Clin Cancer Res 2009;15(18):5688-95)  ...  Together, our data suggest that KLF4 functions as a tumor suppressor in lung cancer and that its down-regulation may contribute to the development and/or progression of lung cancer.  ... 
doi:10.1158/1078-0432.ccr-09-0310 pmid:19737957 pmcid:PMC2745510 fatcat:durm6tcronfz7i3uoxhlgqpca4

Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression

Jianan Pang, Xu Yan, He Cao, Lei Qian, Hua He, Huimin Tian, Fujun Han, Guanjun Wang, Xiao Chen, Yuguang Zhao, Ji-Fan Hu, Jiuwei Cui
2017 Journal of Cancer  
In lung adenocarcinoma A549 cells, shRNA-knockdown of COPS3 induced cell cycle arrest at G0/G1 phase by upregulating the cell cycle regulator protein P21 and downregulating cyclin B1 and CDK4.  ...  We found that COPS3 was overexpressed in most of the lung cancer samples examined, particularly in small cell carcinoma and squamous cell carcinoma.  ...  Acknowledgements This work was supported by g r a n t s f r o m the National Science  ... 
doi:10.7150/jca.16201 pmid:28607586 pmcid:PMC5463426 fatcat:gb2czdq4rnhbtf3aqer3m22svy

Cell cycle actions of parathyroid hormone-related protein in non-small cell lung carcinoma

Randolph H. Hastings, Philippe R. Montgrain, Rick Quintana, Yvette Rascon, Leonard J. Deftos, Erin Healy
2009 American Journal of Physiology - Lung cellular and Molecular Physiology  
Parathyroid hormone-related protein (PTHrP), a paraneoplastic protein expressed by two-thirds of human non-small cell lung cancers, has been reported to slow progression of lung carcinomas in mouse models  ...  Slower cancer cell proliferation could contribute to slower tumor progression and increased survival of patients with PTHrP-positive lung cancer. cyclin-dependent kinase inhibitor proteins; extracellular  ...  The mechanisms that PTHrP could engage to regulate lung cancer progression have not been established.  ... 
doi:10.1152/ajplung.90560.2008 pmid:19633068 pmcid:PMC2770787 fatcat:m6bel2m5q5fmxofuhor7lubazm

The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

Il-Man Kim, Timothy Ackerson, Sneha Ramakrishna, Maria Tretiakova, I-Ching Wang, Tanya V. Kalin, Michael L. Major, Galina A. Gusarova, Helena M. Yoder, Robert H. Costa, Vladimir V. Kalinichenko
2006 Cancer Research  
In this study, we show that human Foxm1 protein is abundantly expressed in highly proliferative human nonsmall cell lung cancers (NSCLC) as well as in mouse lung tumors induced by urethane.  ...  Expression of Foxm1 is found in a variety of distinct human cancers including hepatocellular carcinomas, intrahepatic cholangiocarcinomas, basal cell carcinomas, ductal breast carcinomas, and anaplastic  ...  These data suggest that Foxm1 directly regulates distinct pulmonary pathways that promote both S-phase progression and entry into the M phase during the progression of lung cancer.  ... 
doi:10.1158/0008-5472.can-05-3003 pmid:16489016 fatcat:4yoy37ym75agzomtxozqvb7cbi

Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

Haiying Li, Liangliang Sun, Zhongping Tang, Lin Fu, Ying Xu, Zixuan Li, Wenting Luo, Xueshan Qiu, Enhua Wang, Rana Pratap Singh
2012 PLoS ONE  
Western blotting analysis revealed that knockdown of TRIM24 decreased the protein levels of Cyclin A, Cyclin B, Cyclin D1, cyclin E and p-Rb and increased P27 expression.  ...  TRIM24 was found to be overexpressed in 81 of 113 (71.7%) human lung cancer samples and correlated with p-TNM stage (p = 0.0006), poor differentiation (p = 0.004), Ki67 index (p,0.0001), cyclin D1(p =  ...  in lung cancer progression.  ... 
doi:10.1371/journal.pone.0037657 pmid:22666376 pmcid:PMC3364288 fatcat:ei6jv6z2xraqno6ryvzbnw547i

FOXM1 induced by E6 oncoprotein promotes tumor invasion and chemoresistance in HPV-infected lung cancer

2015 Cancer Cell & Microenvironment  
FOXM1 induced by E6 oncoprotein promotes tumor invasion and chemoresistance in HPV-infected lung cancer. Can Cell Microenviron 2015; 2: e541.  ...  Therefore, we suggest that FOXM1 may potentially represent a therapeutic target in HPV-positive oral or and lung cancer patients with HPV16/18-positive tumors.  ...  FOXM1 also regulates cell cycle-related gene expression, such as cyclin B1, cyclin D1 and cdc25 expression, so as to promote cervical tumor progression [19] .  ... 
doi:10.14800/ccm.541 fatcat:q2v4rbrarrb5xjntagdrf633gq

β-sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells

Shanthi Sri Vundru, Raosaheb K Kale, Rana P Singh
2013 BMC Complementary and Alternative Medicine  
While exploring the molecular changes associated with strong ST efficacy in breast cancer cells, we observed that ST induced cell cycle arrest as well as cell death.  ...  Here, we evaluated the efficacy of ST on three different human cancer cell lines including skin epidermoid carcinoma A431 cells, lung epithelial carcinoma A549 cells and breast adenocarcinoma MDA-MB-231  ...  These results suggested better antiproliferative and cell death inducing effect of ST on MDA-MB-231 breast cancer cells as compared to skin carcinoma A431 and lung carcinoma A549 cells.  ... 
doi:10.1186/1472-6882-13-280 pmid:24160369 pmcid:PMC3819702 fatcat:y5yajohhdfdezgn2gqplmu7lhq

miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non–Small Cell Lung Cancer

Nora Bandi, Samuel Zbinden, Mathias Gugger, Marlene Arnold, Verena Kocher, Lara Hasan, Andreas Kappeler, Thomas Brunner, Erik Vassella
2009 Cancer Research  
In non-small cell lung cancer (NSCLC) cell lines, cyclins D1, D2, and E1 are directly regulated by physiologic concentrations of miR-15a/miR-16.  ...  Here, we show that miR-15a/miR-16 are frequently deleted or down-regulated in squamous cell carcinomas and adenocarcinomas of the lung.  ...  Lung cancer comprises several histologic types including small cell lung cancer and nonsmall cell lung cancer (NSCLC); the latter can be further subdivided into two major types, squamous cell carcinoma  ... 
doi:10.1158/0008-5472.can-08-4277 pmid:19549910 fatcat:3nisbmmew5cijf4s6jtgt6ljru

IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review)

YUXIN XIE, KEQI XIE, QIHENG GOU, NIANYONG CHEN
2015 Oncology Reports  
Recent studies have shown that IκB kinase α (IKKα) plays an important role in human skin cancer and acts as a major regulator for keratinocyte terminal differentiation and proliferation.  ...  In the present study, we discussed the role of IKKα as a tumor suppressor in IKKα-mediated epithelial-derived tumors and its activation pathway, which is different from the traditional NF-κB pathway.  ...  Acknowledgements The present study was supported by a grant from the National Natural Science Foundation of China (no. 81072217) (to C.N.).  ... 
doi:10.3892/or.2015.4229 pmid:26323241 fatcat:cisbr7kz4bhslcwxzrx2fzmgpe

Function of miRNAs in Tumor Cell Proliferation [chapter]

Zuoren Yu, Aydin Tozeren, Richard G. Pestell
2012 MicroRNA in Cancer  
The mature miRNA is assembled into a ribonucleoprotein complex known as RNA-induced silencing complex (RISC) that includes Argonaute protein [1] .  ...  MicroRNAs (miR) are a class of multifunctional, small, non-coding, singled-stranded molecules that regulate the stability or translational efficiency of targeted messenger RNAs.  ...  Work conducted at the Kimmel Cancer Center was supported by the NIH Cancer Center Core grant [P30CA56036 to R.G.P.]. This project is supported by a generous grant from the Dr. Ralph and Marian C.  ... 
doi:10.1007/978-94-007-4655-8_2 fatcat:c6qd7ex6enehxc6qwivobz33qm

CCDC106 promotes non-small cell lung cancer cell proliferation

Xiupeng Zhang, Qin Zheng, Chen Wang, Haijing Zhou, Guiyang Jiang, Yuan Miao, Yong Zhang, Yang Liu, Qingchang Li, Xueshan Qiu, Enhua Wang
2017 OncoTarget  
These results suggest that CCDC106 may be a novel target for lung cancer treatment.  ...  Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis.  ...  We hypothesized that CCDC106 is involved in human cancer progression and cell cycle regulation.  ... 
doi:10.18632/oncotarget.15792 pmid:28460455 pmcid:PMC5432287 fatcat:pths77chm5a3tnzuy2czbhqztq

CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity

Patrizia Bonelli, Franca Maria Tuccillo, Antonella Borrelli, Antonietta Schiattarella, Franco Maria Buonaguro
2014 BioMed Research International  
The cell cycle regulators are involved in tumor progression given their association with cancers characterized by higher incidence of relapses and chemotherapy resistance.  ...  This paper aims to correlate alterations of cell cycle regulators with human cancers and therapeutic responsivity.  ...  Introduction The recent progress in the field of molecular medicine has identified several molecular markers involved in the regulation of the cell cycle as a target for prognosis and cancer treatment.  ... 
doi:10.1155/2014/361020 pmid:24605326 pmcid:PMC3925518 fatcat:3c45an3p4zf2bdx5bberm2dtma
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