Meanwhile, recent next-generation volume reconstruction algorithms that combine generative modeling with end-to-end unsupervised deep learning techniques have shown promising results on simulated data,  ...  Recent breakthroughs in high resolution imaging of biomolecules in solution with cryo-electron microscopy (cryo-EM) have unlocked new doors for the reconstruction of molecular volumes, thereby promising  ...  However, observations of 3D molecules (also called particles) are limited to their raw 2D projections relative to an incoming electron beam, with no information on their 3D orientation or position -see  ... 

Meanwhile, recent next-generation volume reconstruction algorithms that combine generative modeling with end-to-end unsupervised deep learning techniques have shown promising results on simulated data,  ...  Recent breakthroughs in high resolution imaging of biomolecules in solution with cryo-electron microscopy (cryo-EM) have unlocked new doors for the reconstruction of molecular volumes, thereby promising  ...  However, observations of 3D molecules (also called particles) are limited to their raw 2D projections relative to an incoming electron beam, with no information on their 3D orientation or position -see  ...