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Feasibility of creating a high-resolution 3D diffusion tensor imaging based atlas of the human brainstem: A case study at 11.7T

Manisha Aggarwal, Jiangyang Zhang, Olga Pletnikova, Barbara Crain, Juan Troncoso, Susumu Mori
2013 NeuroImage  
The DTI data revealed microscopic neuroanatomical details, allowing three-dimensional visualization and reconstruction of fiber pathways including the decussation of the pyramidal tract fibers, and interdigitating  ...  Additionally, strong grey-white matter contrasts in the apparent diffusion coefficient (ADC) maps enabled precise delineation of grey matter nuclei in the brainstem, including the cranial nerve and the  ...  Acknowledgments This study was supported by National Institutes of Health grants R01AG020012 and R01EB003543.  ... 
doi:10.1016/j.neuroimage.2013.01.061 pmid:23384518 pmcid:PMC3615045 fatcat:ysugrgsrwzh27appcprq6clv2y

High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy

Hatsuho Mamata, Yoshiaki Mamata, Carl-Fredrik Westin, Martha E Shenton, Ron Kikinis, Ferenc A Jolesz, Stephan E Maier
2002 American Journal of Neuroradiology  
We obtained a complete set of detailed white matter fiber anatomy maps of the normal brain by means of line scan diffusion tensor imaging at high resolution.  ...  Fiber directions derived from diffusion tensor imaging were consistent with known white matter fiber anatomy. The principal fiber tracts were well observed in all cases.  ...  Conclusion We have shown high-resolution white matter fiber anatomy in the human adult brain by using maps of the first diffusion eigenvector.  ... 
pmid:11827877 pmcid:PMC2845164 fatcat:ppsvzmniejhtnmtkrxcafqxcc4

Single-shot T1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy

Sabine Hofer, Xiaoqing Wang, Volkert Roeloffs, Jens Frahm
2015 Frontiers in Neuroanatomy  
A region-of-interest analysis revealed a tendency for the lowest T1 relaxation times in the genu and the highest T1 relaxation times in the somatomotor region of the CC.  ...  The results indicate that characteristic T1 relaxation times in callosal profiles provide an additional means to monitor differences in fiber anatomy, fiber density, and gray matter in respective neocortical  ...  Acknowledgment SH was supported by the Bundesministerium für Bildung und Forschung of the Federal Republic of Germany (grant 01 GQ 0432).  ... 
doi:10.3389/fnana.2015.00057 pmid:26029059 pmcid:PMC4426710 fatcat:zxgctkqmfnddxmqvyghvphmiwa

Measuring macroscopic brain connections in vivo

Saad Jbabdi, Stamatios N Sotiropoulos, Suzanne N Haber, David C Van Essen, Timothy E Behrens
2015 Nature Neuroscience  
Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain.  ...  In this review, we mostly focus on magnetic resonance imaging of the brain.  ...  , the US National Institutes of Health Blueprint for Neuroscience (1U54MH091657-01), the US National Institutes of Health (R01 MH-60974) and the National Institute of Mental Health (P50 MH106435).  ... 
doi:10.1038/nn.4134 pmid:26505566 fatcat:6tth5q3onfbjdehkmcxqbn22ku

Magnetic resonance imaging shows orientation and asymmetry of white matter fiber tracts

Sharon Peled, Hákon Gudbjartsson, Carl-Fredrik Westin, Ron Kikinis, Ferenc A. Jolesz
1998 Brain Research  
A comparison of corresponding anatomic regions in the white matter of both hemispheres in 24 healthy volunteers revealed that Ž . fiber tracts within the anterior limb of the internal capsule have a significantly  ...  Display of the orientation and directional uniformity of the water diffusion in the brain demonstrated most of the known major anatomical constituents of human white matter.  ...  vivo images of human white matter tracts.  ... 
doi:10.1016/s0006-8993(97)00635-5 pmid:9473573 fatcat:lfkqccf4gve3pi3nahjxidmotu

High-Resolution MR Imaging of the Human Brainstem In vivo at 7 Tesla

Andreas Deistung, Andreas Schäfer, Ferdinand Schweser, Uta Biedermann, Daniel Güllmar, Robert Trampel, Robert Turner, Jürgen R. Reichenbach
2013 Frontiers in Human Neuroscience  
The human brainstem, which comprises a multitude of axonal nerve fibers and nuclei, plays an important functional role in the human brain.  ...  We explored the potential of high-resolution magnetic resonance imaging (MRI) at 7 T for depicting the intricate anatomy of the human brainstem in vivo by acquiring and generating images with multiple  ...  ACKNOWLEDGMENTS We would like to thank Andrew Webb (Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center) for providing the dielectric pads as well as Penny  ... 
doi:10.3389/fnhum.2013.00710 pmid:24194710 pmcid:PMC3810670 fatcat:vi55pw3f2ndi7jlbvgtgyigxzm

Ex vivo visualization of the trigeminal pathways in the human brainstem using 11.7T diffusion MRI combined with microscopy polarized light imaging

Dylan J. H. A. Henssen, Jeroen Mollink, Erkan Kurt, Robert van Dongen, Ronald H. M. A. Bartels, David Gräβel, Tamas Kozicz, Markus Axer, Anne-Marie Van Cappellen van Walsum
2018 Brain Structure and Function  
Referring to a similar anatomic feature in primate brains, the dorsal and ventral tracts were named the dorsal and ventral trigeminothalamic tract (dtt and vtt), respectively.  ...  This study shows that both the dtt and vtt are present in humans, indicating that each hemiface has a bilateral projection, although the functional relevance of these tracts cannot be determined by the  ...  In this way, polarization-sensitive OCT has been used to image the fiber orientation and cyto-and myeloarchitecture of human nervous tissue and to visualize volumetric reconstructions of human brain tissue  ... 
doi:10.1007/s00429-018-1767-1 fatcat:ejdk4tioajegbb6cminefylivq

Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori, Walter E. Kaufmann, Christos Davatzikos, Bram Stieltjes, Laura Amodei, Kim Fredericksen, Godfrey D. Pearlson, Elias R. Melhem, Meiyappan Solaiyappan, Gerald V. Raymond, Hugo W. Moser, Peter C.M. van Zijl
2002 Magnetic Resonance in Medicine  
Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior  ...  As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.  ...  Paul Folkers (Philips Medical Systems, Best, The Netherlands) for helpful suggestions, Dr. Ryuta Ito for help in the patient study, and Dr.  ... 
doi:10.1002/mrm.10074 pmid:11810663 fatcat:h6kp7c4o4vegfegdgms63jmdva

The challenge of mapping the human connectome based on diffusion tractography

Klaus H. Maier-Hein, Peter F. Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E. Reddick, John O. Glass (+65 others)
2017 Nature Communications  
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies.  ...  Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups.  ...  In total the tracts occupy 71% of the white matter volume in the human brain.  ... 
doi:10.1038/s41467-017-01285-x pmid:29116093 pmcid:PMC5677006 fatcat:6s7zph3cdfd6xbb4aq3y6ur3my

Mapping brain anatomical connectivity using white matter tractography

Mariana Lazar
2010 NMR in Biomedicine  
Finally, we discuss white matter tractography applications to the study of brain disorders, including fiber tracts localization in brains affected by tumors and identifying impaired connectivity routes  ...  In this paper, the techniques for estimating fiber directions from diffusion measurements in the human brain are reviewed.  ...  tract information in regions of fiber crossing.  ... 
doi:10.1002/nbm.1579 pmid:20886567 pmcid:PMC4503207 fatcat:vxtc74ouufe35njl4wmwljldna

Tractography-based connectomes are dominated by false-positive connections [article]

Klaus Maier-Hein, Peter Neher, Jean-Christophe Houde, Marc-Alexandre Cote, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying Chia Lin, Qing Ji, Wilburn E. Reddick, John O. Glass (+65 others)
2016 bioRxiv   pre-print
Fiber tractography based on non-invasive diffusion imaging is at the heart of connectivity studies of the human brain.  ...  Based on a simulated human brain dataset with ground truth white matter tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups  ...  based on diffusion-weighted magnetic resonance imaging (DWI), attempts to reveal the white matter pathways of the human brain in vivo and to infer the underlying network structure, the structural connectome  ... 
doi:10.1101/084137 fatcat:c2s4nmf2kbdrrbpdde5y5afa44

Two fiber pathways connecting amygdala and prefrontal cortex in humans and monkeys [article]

Davide Folloni, Jérôme Sallet, Alexandre A. Khrapitchev, Nicola R. Sibson, Lennart Verhagen, Rogier B. Mars
2019 bioRxiv   pre-print
Using diffusion imaging techniques, we reconstructed connections between amygdala, anterior temporal and prefrontal cortex in human and macaque brains.  ...  Little, however, is known of the structural wiring linking amygdala and prefrontal cortex in humans.  ...  Passingham for valuable discussions on the results. The work of D.F. is supported by the Wellcome Trust [UK Grant  ... 
doi:10.1101/561811 fatcat:jko3dh7ep5gq7azlj37ckwxcza

Image Processing for Diffusion Tensor Magnetic Resonance Imaging [chapter]

C. -F. Westin, S. E. Maier, B. Khidhir, P. Everett, F. A. Jolesz, R. Kikinis
1999 Lecture Notes in Computer Science  
We show how filtering of the tensor data of a human brain can provide a description of macrostructural diffusion which can be used for measures of fiber-tract organization.  ...  The geometric nature of the diffusion tensors can quantitatively characterize the local structure in tissues such as bone, muscles, and white matter of the brain.  ...  Acknowledgements This work was funded in part by the Wenner-Gren Foundation, Sweden, the Whitaker Foundation, NIH grants P41-RR13218-01, R01-RR11747-01A, P01-CA67165-03.  ... 
doi:10.1007/10704282_48 fatcat:psdkw5aha5gxroll56wm4dgra4

Anatomical Characterization of Human Fetal Brain Development with Diffusion Tensor Magnetic Resonance Imaging

H. Huang, R. Xue, J. Zhang, T. Ren, L. J. Richards, P. Yarowsky, M. I. Miller, S. Mori
2009 Journal of Neuroscience  
DTI color maps and tractography revealed that important white matter tracts, such as the corpus callosum and uncinate and inferior longitudinal fasciculi, become apparent during this period.  ...  During the second trimester of human fetal development, neural structures in the brain undergo significant morphological changes.  ...  Results White matter tracts The DTI-derived images provide unique contrasts of white matter fiber bundles.  ... 
doi:10.1523/jneurosci.2769-08.2009 pmid:19339620 pmcid:PMC2721010 fatcat:be26edwe7faoxhamevfim7zj34

Tracking neuronal fiber pathways in the living human brain

T. E. Conturo, N. F. Lori, T. S. Cull, E. Akbudak, A. Z. Snyder, J. S. Shimony, R. C. McKinstry, H. Burton, M. E. Raichle
1999 Proceedings of the National Academy of Sciences of the United States of America  
We demonstrate diffusion tracking of fiber bundles in a variety of white matter classes with examples in the corpus callosum, geniculo-calcarine, and subcortical association pathways.  ...  This approach enhances the power of modern imaging by enabling study of fiber connections among anatomically and functionally defined brain regions in individual human subjects.  ...  This work was supported in part by the Major Grants Program of the McDonnell Center for Higher Brain Function, the Charles A.  ... 
doi:10.1073/pnas.96.18.10422 pmid:10468624 pmcid:PMC17904 fatcat:cetevrxgyzdmzg3xempbqw6zyi
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