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Creating and Exploiting the Intrinsically Disordered Protein Knowledge Graph (IDP-KG)

Alasdair J. G. Gray, Petros Papadopoulos, Imran Asif, Ivan Micetic, András Hatos
2022 Workshop on Semantic Web Applications and Tools for Life Sciences  
In this paper, we investigate using Bioschemas markup as a mechanism to populate the IDPcentral registry by constructing the Intrinsically Disordered Protein Knowledge Graph (idp-kg).  ...  We harvest the Bioschemas markup in three IDP sources and show the resulting idp-kg has the same breadth of proteins available as the original sources, and can be used to gain deeper insight into their  ...  This work was funded through the ELIXIR Strategic Implementation Study Exploiting Bioschemas Markup to Support ELIXIR Communities exploiting-bioschemas-markup-support-elixir-communities  ... 
dblp:conf/swat4ls/GrayPAMH22 fatcat:4drvy5pfdzdgpbl7ew2fiu24qa

The Eighth Central European Conference "Chemistry towards Biology": Snapshot

András Perczel, Atanas Atanasov, Vladimír Sklenář, Jiří Nováček, Veronika Papoušková, Pavel Kadeřávek, Lukáš Žídek, Henryk Kozłowski, Joanna Wątły, Aleksandra Hecel, Paulina Kołkowska, Jaroslav Koča (+27 others)
2016 Molecules  
The authors of this manuscript are plenary speakers and other participants of the symposium and members of their research teams.  ...  researchers of the respective areas that fall within the common scope of chemistry and biology.  ...  Acknowledgments: The 8th Central European Conference "Chemistry towards Biology" was supported by the  ... 
doi:10.3390/molecules21101381 pmid:27763518 pmcid:PMC5283649 fatcat:gp27ideg6jbaddtfwpkq3r4e2m

Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017

2017 Protein Science  
In the present study, we aimed to improve the ExM method for imaging of proteins in human clinical tissue samples, for diagnostic pathology and research.  ...  by imaging of the ACTN4 protein expression pattern with conventional light microscopy.  ...  Intrinsically disordered proteins (IDPs) are common in protein-protein interactions and are involved in numerous cellular processes.  ... 
doi:10.1002/pro.3349 pmid:29280217 fatcat:jrxtwzblare37gxsvc5szbwuhu

Androgen receptor condensates as drug targets [article]

Shaon Basu, Paula Martinez-Cristobal, Mireia Pesarrodona, Marta Frigole-Vivas, Elzbieta Szulc, Michael Lewis, Adriana Banuelos, Carolina Sanchez-Zarzalejo, Stase Bielskute, Jiaqi Zhu, Carla Garcia-Cabau, Cristina Batlle (+19 others)
2022 bioRxiv   pre-print
These results establish a generalizable framework to target the phase-separation capacity of intrinsically disordered regions in oncogenic transcription factors and other disease-associated proteins with  ...  We show that the phase separation capacity of the androgen receptor is driven by aromatic residues and short unstable helices in its intrinsically disordered activation domain.  ...  We acknowledge help and support from the advanced digital microscopy, high throughput protein expression and mass spectrometry, biostatistics/bioinformatics, and sequencing core facilities at MPI-MG and  ... 
doi:10.1101/2022.08.18.504385 fatcat:5py64md4lzgzva3g35c5ktta7q

13th EBSA congress, July 24–28, 2021, Vienna, Austria

2021 European Biophysics Journal  
Welcome from the President of EBSA The world is dealing with one of its greatest challenges, and thanks to the amazing contribution of science and the development, in record time, of vaccines against SARS-CoV  ...  and concepts related with the most recent research efforts during Covid-19 time.  ...  Using force spectroscopy to probe protein:protein interactions David J Brockwell School of Molecular and Cellular Biology, University of Leeds, UK Intrinsically disordered proteins (IDPs) or proteins with  ... 
doi:10.1007/s00249-021-01558-w pmid:34245338 pmcid:PMC8272448 fatcat:z2svytd4kbamrmvarle4lxwtxm

Behavioral Medicine, Clinical Nutrition, Education, and Exercise

2017 Diabetes  
The aim of the study was to 1) implement an SMA model that incorporated the rotation of medical, physician assistant, and undergraduate students, pharmacy residents, and an attending endocrinologist to  ...  Students involved in SMA gained exposure to novel models of care, the challenges of other aspects of diabetes care, and the complexities of the patient-perceived experience of diabetes.  ...  A1c and weight decreased in SDP compared to IDP (A1c -0.64 ± 0.9% vs. 0.01 ± 1.1%, p <0.01; weight -3.0 ± 4.2 kg vs. -0.9 ± 2.7 kg, p <0.05).  ... 
doi:10.2337/db17-664-889 fatcat:6qnwtkbmureypelwbk3hm763k4


2016 The FEBS Journal  
Intrinsically disordered proteins (IDPs) and complex multidomain proteins are characterized by a dynamic ensemble of conformations that cannot be unequivocally described by traditional static terms of  ...  We then assign a node to each residue and links between directly coordinating node-pairs, treating the protein as a graph.  ...  Material and Methods: The boron and mineral compounds tested were as follows: boric acid, borax, colemanite and ulexite. The study consisted of 78 Wistar-Albino male rats.  ... 
doi:10.1111/febs.13805 fatcat:5bh6wnb75nbijopqvhnzhv3bmi

E-Poster Presentations

2020 European psychiatry  
Estimated prevalence and incidence: 10 and 4 cases per 100.000 people. The female-to-male ratio was 1  ...  Objectives: Our aim was to empirically estimate prevalence and incidence of delusional disorder in an emergency department and to describe main sociodemographic and clinical features.  ...  In the study 155 IDPs were examined.  ... 
doi:10.1192/j.eurpsy.2020.5 fatcat:vslfruegm5f2jc5dl6hu6gqnom

Determinants of Anemia among Pregnant Women in Mali

Mohamed Ag Ayoya, Gerburg Maria Spiekermann-Brouwer, Abdel Kader Traoré, Rebecca Joyce Stoltzfus, Cutberto Garza
2006 Food and Nutrition Bulletin  
The authors thank Dhammika Menike of the Department of Applied Nutrition for assistance with the laboratory analysis and Dr.  ...  Financial support was provided by the Division of Nutritional Sciences at Cornell University and the Ithaca First Presbyterian Church.  ...  151 mg nitrogen or 0.94 g protein/kg/day for milk, and 162 mg nitrogen or 1.01 g protein/kg/day for soybean isolate.  ... 
doi:10.1177/156482650602700101 pmid:16572713 fatcat:lhhukqv2tfd4bggqenlq2bnwnm

Russian Journal of Infection and Immunity 2014. Special Issue. Theses

article Editorial
2015 Infekciâ i Immunitet  
Russian Journal of Infection and Immunity 2014. Special Issue. Theses  ...  of intrinsic disorder-based human colonic microbiota.  ...  disordered proteins (IDPs) lack stable of about 70 metabolite including low molecular carbonic tertiary and/or secondary structure under physiological and amino acids.  ... 
doaj:08842895fd39435bb5c4cfe1ed793459 fatcat:q52g5yn7o5gehbku2ns6pvrvqi

Evaluation of student perceptions of introductory pharmacy practice experiences

Jaclyn A. Boyle, Zachary N. Jenkins, Thaddeus T. Franz, Charles W. Cather, Nicole K. Deitschmann, Nicole G. Harper, Alison Dittmer, Christy Hartline
2020 Currents in Pharmacy Teaching and Learning  
Introductory pharmacy practice experiences (IPPEs) are focused on sharpening the student's knowledge, skills, abilities, and attitudes related to becoming an effective member of the healthcare team.  ...  and end of the 2017-2018 academic year.  ...  The item construction of MCQs and utilization of case-based questions were evaluated using best practices for item construction.  ... 
doi:10.1016/j.cptl.2020.01.029 pmid:32482264 fatcat:rh5hkqp3gnfqhczgeghtt3zxvm

Abstracts Presented at the 120th Annual Meeting of the American Association of Colleges of Pharmacy, Chicago, Illinois, July 13-17, 2019

2019 American Journal of Pharmaceutical Education  
and during the P4 year.  ...  , and the presence of a branch campus.  ...  Plans (IDPs).  ... 
doi:10.5688/ajpe7654 pmid:31333273 pmcid:PMC6630869 fatcat:q6mty63pk5ctfhypxwjkoogfce

Platelet membrane surface heterogeneity detected by partition in two-polymer phase systems

Timothy James Webber
platelet heterogeneity through the use of methods which reflect platelet properties, e.g., function, size, density, and membrane surface characteristics, which are believed to change during the survival  ...  Platelet surface property distributions were heterogeneous based on the shape and spread of the CCD curves for these blood elements in comparison to expected theoretical distributions for uniform particles  ...  In fond memory of the wealth of friendship in us and Canada.  ... 
doi:10.14288/1.0096599 fatcat:bpwuf7w4jfd43ifsduztns6uae

24(th) Annual Canadian Conference on HIV/AIDS Research/24(e) Congrès Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comités de l'ACRV

2015 Canadian Journal of Infectious Diseases and Medical Microbiology  
We now characterize the detailed mechanisms by which IL-7 suppresses CD127 transcription and protein expression.  ...  We show here that IL-7 suppresses CD127 expression by two mechanisms: transcriptional which is dependent on c-Myb and at the protein level by inducing expression of CIS protein which in turn binds to CD127  ...  APOBEC3 PROTEINS INFLUENCES THEIR POTENCy FOR HIV-1 GENE INACTIVATION Belanger, kasandra; Langlois, marc-André Ottawa, ON APOBEC3 (A3) proteins are host intrinsic restriction factors that hinder retroviral  ... 
pmid:26015799 pmcid:PMC4427862 fatcat:hjukjvydzna4pnrq2uzc2hbooi

Structural and biochemical studies of Sporosarcina pasteurii UreE: a nickel-chaperone involved in the urease activation process Coordinatore Dottorato Relatore

Presentata, Dott Ssa, Anna Merloni, Vincenzo Scarlato, Stefano Ciurli
SpUreE-SpUreG by NMR 102 -Assignment of the NMR spectra of SpUreE and intrinsic exchange rates -Secondary structure propensity of SpUreE from NMR chemical shifts -NMR studies of SpUreE dynamics -CSP analysis  ...  Ni(II) and Zn(II) competition for SpUreE 123 8. Conclusions 129 9. Supplementary information 135 Bibliography 141 Acnowledgements 149 6 7  ...  of α-synuclein: an intrinsically disordered hub.  ... 
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