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Coupling of cerebral blood flow and oxygen metabolism is conserved for chromatic and luminance stimuli in human visual cortex

Oleg Leontiev, Giedrius T. Buracas, Christine Liang, Beau M. Ances, Joanna E. Perthen, Amir Shmuel, Richard B. Buxton
2013 NeuroImage  
The ratio of the changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO 2 ) during brain activation is a critical determinant of the magnitude of the blood oxygenation level dependent  ...  We conclude that CBF-CMRO 2 coupling is conserved for the chromatic and luminance stimuli used, suggesting a consistent coupling for blob and inter-blob neuronal populations despite the difference in CO  ...  Highlights BOLD response is sensitive to blood flow/oxygen metabolism coupling Variability of flow/metabolism coupling in human primary visual cortex was tested Chromatic and luminance stimuli to excite  ... 
doi:10.1016/j.neuroimage.2012.11.050 pmid:23238435 pmcid:PMC3558279 fatcat:bkein4f5i5ga3ep6daqmq5ejpu

Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model

Richard D. Hoge, Jeff Atkinson, Brad Gill, G�rard R. Crelier, Sean Marrett, G. Bruce Pike
1999 Magnetic Resonance in Medicine  
The relationship between blood oxygenation level-dependent (BOLD) MRI signals, cerebral blood flow (CBF), and oxygen consumption (CMR O 2 ) in the physiological steady state was investigated.  ...  A quantitative model, based on flow-dependent dilution of metabolically generated deoxyhemoglobin, was validated by measuring BOLD signals and relative CBF simultaneously in the primary visual cortex (  ...  We are also grateful to Curtis Baker, Gareth Barnes, Joe Mandeville, and Bruce Rosen for discussion and critical reading of the manuscript.  ... 
doi:10.1002/(sici)1522-2594(199911)42:5<849::aid-mrm4>3.0.co;2-z pmid:10542343 fatcat:abzq4r5vxvgxpessln6ljk7gju

Functional localization of the human color center by decreased water displacement using diffusion-weighted fMRI

Rebecca J. Williams, David C. Reutens, Julia Hocking
2015 Brain and Behavior  
Spatial and temporal properties of DfMRI and BOLD activation were examined across regions of the visual cortex.  ...  Methods: Colored and achromatic Mondrian visual stimuli were statistically contrasted to functionally localize the human color center Area V4 in neurologically intact adults.  ...  Because of its sensitivity to deoxyhemoglobin concentration changes (Ogawa et al. 1990 ), which are dependent on neural activity-induced changes in cerebral blood flow, cerebral blood volume and cerebral  ... 
doi:10.1002/brb3.408 pmid:26664792 pmcid:PMC4667755 fatcat:inpcydkqnffwjjtwqz6p5ug27y

Feature-specific patterns of attention and functional connectivity in human visual cortex [article]

Kirstie Wailes-Newson, Antony B Morland, Richard J W Vernon, Alex R Wade
2019 biorxiv/medrxiv   pre-print
Attending to different features of a scene can alter the responses of neurons in early- and mid- level visual areas but the nature of this change depends on both the (top down) attentional task and the  ...  One outstanding question is the spatial scale at which cortex is modulated by attention to low-level stimulus features such as shape, contrast and orientation.  ...  Hence fMRI images make the assumption increased neural firing demands increased blood flow, which is taken to indicate metabolic activity in particular regions of the brain.  ... 
doi:10.1101/869552 fatcat:o4m4s43yhndmdnimefxqhgai34

Relating Macroscopic Measures of Brain Activity to Fast, Dynamic Neuronal Interactions

D. Chawla, E. D. Lumer, K. J. Friston
2000 Neural Computation  
PET measures blood flow distribution or regional cerebral blood flow (iCBF) in the human brain. PET relies on the intravenous administration o f radioactive water.  ...  More recently, a combination of laser Doppler flow imaging and electrode recordings has shown that there is a coupling between regional cerebral blood flow (rCBF), as measured in PET, and local field potentials  ... 
doi:10.1162/089976600300014737 pmid:11112256 fatcat:656c5u3mlfcozkca4dz73fdrxe

Poor glycemic control is associated with neuroretinal dysfunction in short-wavelength colour pathways in adolescents with type 1 diabetes

M. McFarlane, T. Wright, C. Westall
2010 Journal of Vision  
Poor glycemic control, as measured by hemoglobin A 1c (HbA 1c ), is a strong risk factor for DR.  ...  Studies demonstrate short-wavelength cone pathway dysfunction in patients with diabetes and no clinically visible DR.  ...  Chromatic VEPs Neurons in chromatic visual pathways have low chromatic thresholds and respond preferentially to chromatic stimuli of low temporal frequency since they respond in a sustained manner (Purves  ... 
doi:10.1167/10.15.70 fatcat:wdkzacackfezrbjk4tusfuz44i

Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I

R. H. Triepels, L. P. Van Den Heuvel, J. L. C. M. Loeffen, C. A. F. Buskens, R. J. P. Smeets, M. E. Rubio Gozalbo, S. M. S. Budde, E. C. Mariman, F. A. Wijburg, P. G. Barth, J. M. F. Trijbels, J. A. M. Smeitink
1999 Annals of Neurology  
Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I. Annals of Neurology, 45, 787-790.  ...  Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I Triepels, R.H.; van den Heuvel, L.P.; Loeffen, J.L.C.M.; Buskens, C.A.F.; Smeets, R.J.P.; Rubio Gozalbo  ...  This study was supported by research grants for cardiovascular disease (9A-2 and 9A-8) from the Ministry of Health and Welfare, Japan.  ... 
doi:10.1002/1531-8249(199906)45:6<787::aid-ana13>3.0.co;2-6 pmid:10360771 fatcat:orer7rilszhsjd5k7xmxmqhui4

Abstracts of the 11th Annual Meeting of the Israel Society for Neuroscience

2002 Neural Plasticity  
ordered congruent, incongruent and neutral stimuli.  ...  We relate these results also to the differentiated function of the anterior cingulated cortex in the verbal and motor domain.  ...  not immutable in adult cerebral cortex.  ... 
doi:10.1155/np.2002.65 pmid:12516548 pmcid:PMC2565399 fatcat:6o7uzh2mtfawdao4mzwue32m2y

27th Annual Computational Neuroscience Meeting (CNS*2018): Part One

2018 BMC Neuroscience  
Alliance through the Initiative and Networking Fund of the Helmholtz Association and the Helmholtz Portfolio theme "Supercomputing and Modeling for the Human Brain" and the European Union Seventh Framework  ...  Acknowledgements We acknowledge the Initiative and Networking Fund of the Helmholtz Association, the Helmholtz Association through the Helmholtz Portfolio Theme"Supercomputing and Modeling for the Human  ...  The computational modeling of the cerebral cortex may be useful to unravel the encoding mechanism for the given stimuli in the form of effective connectivity.  ... 
doi:10.1186/s12868-018-0452-x pmid:30373544 pmcid:PMC6205781 fatcat:xv7pgbp76zbdfksl545xof2vzy

Physiology of Astroglia

Alexei Verkhratsky, Maiken Nedergaard
2018 Physiological Reviews  
Helmut Kettenmann (Berlin) and Dr. Alexandr Chvatal (Prague) for providing us with materials on glial history and to Dr. Nadia Alling for helpful discussions.  ...  Pia Crine Christensen for critically reading the manuscript.  ...  Compelling evidence indicates a specific role of astrocytes in neurovascular coupling and regulation of local blood flow.  ... 
doi:10.1152/physrev.00042.2016 pmid:29351512 fatcat:yxumfuzbpja6thxbyvljfxzlqa

Academic Press is an imprint of Elsevier [chapter]

2009 Annual Reports in Medicinal Chemistry  
Academic Press is an imprint of Elsevier Cover photo credit: ß Corbis  ...  Alcohol consumption and cognitive performance in the Framingham Heart Study. American Journal of Epidemiology, 150, 580-589. Elias, P. K., Elias, M. F., D'Agostino, R. B., Sullivan, L.  ...  NIDDM and blood pressure as risk factors for poor cognitive performance: The Framingham Study. Diabetes Care, 20, 1388-1395. Elias, P. K., Elias, M. F., D'Agostino, R. B., Silbershatz, H., & Wolf, P.  ... 
doi:10.1016/s0065-7743(09)04435-2 fatcat:udugdegd4bhrzkgbbtzict2ed4

2017 ASCB Annual Meeting Abstracts

David G. Drubin
2017 Molecular Biology of the Cell  
The ubiquitin ligase Rsp5, the yeast homolog of human Nedd4, is a key mediator of protein quality control at the PM.  ...  The goal of our research is to uncover the unappreciated role for ubiquitination and ARRDC3 in regulation of GPCR biology, not limited to PAR1 but also for other members of the GPCR superfamily.  ...  dynamic pool of actin and its mode of coupling to inner-leaflet lipids is lacking.  ... 
doi:10.1091/mbc.e17-10-0618 pmid:29237772 pmcid:PMC5739290 fatcat:3msjrn3omzcybfanlagykayauy

Determination of a site-specific reference dose for methylmercury for fish-eating populations

Annette M. Shipp, P. Robinan Gentry, Greg Lawrence, Cynthia Van Landingham, Tammie Covington, Harvey J. Clewell, Kirk Gribben, Kenny Crump
2000 Toxicology and industrial health  
In cooperation with the Texas Natural Resource Conservation Commission and USEPA Region VI, Alcoa conducted a baseline risk assessment to assess potential risk to human health and the environment.  ...  estimate of the traditional NOAEL, and that it is superior to the use of "average" or "grouped" exposure estimates when dose -response information is available, as is the case for the Seychelles study  ...  The earliest noted critical effects were reduced sensitivity to visual stimuli of low luminance and an intention tremor upon reaching for a small object at a distance.  ... 
doi:10.1177/074823370001600901 pmid:11762928 fatcat:wycbdk5nfzbjjm7amw4lsgg4ki

Abstracts

1978 Kidney International  
site, (2) alteration by glucocurticoid of ionic transport at this site, thereby increasing luminal pressure in the tubule and, (3) alteration of luminal cell metabolism by glucocorticoid so as to increase  ...  Morbidity and mortality for patients in advanced coma as a result of drug intoxication Is significant when treated with conservative therapy.  ...  uremia did not appear for 1.0,1.2,1.8 & 2.5 yrs respectively. 5 of the 20 related grafts that did not fail had stable function for > 1 yr and 6 (all blood group A) for > 3 yrs after cessation of IT.  ... 
doi:10.1038/ki.1978.175 fatcat:zeudzt5hprcbxfv5e2ti7wexja

Abstracts of Current Literature

1957 Radiology  
The CO, in those tissues with a high blood flow equilibrates very rapidly with that of blood. Resting muscle and skin need at least five minutes for equilibration with the CO, of the blood.  ...  In 2 cases, blood vessels in the distribution of the artery were visualized in roentgenograms representing a later phase of the study; this is probably the result of retrograde flow through anastomatic  ... 
doi:10.1148/68.6.879 fatcat:fb3pe7ol6rhe3jdksadrhkepji
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