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Broadband Local Field Potentials Correlate with Spontaneous Fluctuations in Functional Magnetic Resonance Imaging Signals in the Rat Somatosensory Cortex Under Isoflurane Anesthesia

Wen-Ju Pan, Garth Thompson, Matthew Magnuson, Waqas Majeed, Dieter Jaeger, Shella Keilholz
2011 Brain Connectivity  
in the low-frequency LFP bands and the BOLD signal increases.  ...  Peak correlation occurred between neural and hemodynamic activity when the BOLD signal was delayed by *4 sec relative to the LFP signal.  ...  Acknowledgment The work was supported by NIH R21NS057718-01. Author Disclosure Statement No competing financial interests exist.  ... 
doi:10.1089/brain.2011.0014 pmid:22433008 pmcid:PMC3621847 fatcat:ozbs4hrmmvgndgj6zd75zaapji

Early patterns of activity in the developing cortex: Focus on the sensorimotor system

Roustem Khazipov, Mathieu Milh
2018 Seminars in Cell and Developmental Biology  
During this period, the sensorimotor cortex expresses transient patterns of correlated neuronal activity including delta waves, gamma-and spindle-burst oscillations.  ...  Early development of somatotopic cortical maps occurs during the fetal period in humans and during the postnatal period in rodents.  ...  Interspecies and intersystems comparisons Dependence of the activity in the somatosensory system on the signals from the environment involving passive stimulation by the littermates and mother and tactile  ... 
doi:10.1016/j.semcdb.2017.09.014 pmid:28899717 fatcat:cfgzsbh6lzdg5fwpra26wt6fja

Structural and functional, empirical and modeled connectivity in the cerebral cortex of the rat

Antonio Díaz-Parra, Zachary Osborn, Santiago Canals, David Moratal, Olaf Sporns
2017 NeuroImage  
In this work, we investigate the relationship between structural and functional connectivity in the rat brain cortex using a directed anatomical network generated from a carefully curated meta-analysis  ...  We found a high correspondence between the strength of functional connections, measured as blood oxygen level dependent (BOLD) signal correlations between cortical regions, and the weight of the corresponding  ...  With the aim of investigating the relationship between the SC and the rs-fMRI-measured FC in the rat cortex, we first calculated the association between anatomical and functional matrices (Fig. 2 ).  ... 
doi:10.1016/j.neuroimage.2017.07.046 pmid:28739119 pmcid:PMC5724396 fatcat:6r3k5ubvrfd5rakfk7afbf24iq

Effects of the α2-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex

Mitsuhiro Fukuda, Alberto L. Vazquez, Xiaopeng Zong, Seong-Gi Kim
2012 European Journal of Neuroscience  
These measurements were obtained from the rat somatosensory cortex during 10 s of forepaw stimulation.  ...  We found that the continuous intravascular systemic infusion of DEX (50 lg/kg/h, doses typically used in fMRI studies) caused epileptic activities, and that supplemental isoflurane (ISO) administration  ...  Acknowledgements We thank Ping Wang for his valuable assistance with the experiments. This work was supported by NIH grants R21-EB006571, K01-NS066131, R01-NS044589, and R01-EB003375.  ... 
doi:10.1111/ejn.12024 pmid:23106361 pmcid:PMC3538949 fatcat:j3qs2ojzf5ec7iczk5fcvzmwbi

Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

Miriam Schwalm, Florian Schmid, Lydia Wachsmuth, Hendrik Backhaus, Andrea Kronfeld, Felipe Aedo Jury, Pierre-Hugues Prouvot, Consuelo Fois, Franziska Albers, Timo van Alst, Cornelius Faber, Albrecht Stroh
2017 eLife  
However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm.  ...  We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats.  ...  nster (Fa3/ 1603, PIX) and the Excellence Cluster Cells in Motion (DFG EXEC 1003).  ... 
doi:10.7554/elife.27602 pmid:28914607 pmcid:PMC5658067 fatcat:fsg4svw5hfbwbhhdpcn7frxysu

Spatiotemporal frequency tuning of BOLD and gamma band MEG responses compared in primary visual cortex

Suresh D. Muthukumaraswamy, Krish D. Singh
2008 NeuroImage  
In this study, the spatial and temporal frequency tuning characteristics of the MEG gamma (40-60 Hz) rhythm and the BOLD response in primary visual cortex were measured and compared.  ...  The gamma rhythm showed a clear increase in induced power for the high spatial frequency stimulus while BOLD showed no difference in activity for the two spatial frequencies used.  ...  Evidence in rat somatosensory cortex suggests that spiny stellate cells in layer IV represent local signal processing modules whereas pyramidal cell activity the integration of columnar activity (Staiger  ... 
doi:10.1016/j.neuroimage.2008.01.052 pmid:18337125 fatcat:bvdkzlfmjnef3lsriiq4ewrbja

Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex

Qingguang Zhang, Kyle W. Gheres, Patrick J. Drew, Simon Hanslmayr
2021 PLoS Biology  
We found that oxygen signal recorded from the cortex of mice had 1/f-like spectra. However, band-limited power in the local field potential did not show corresponding 1/f-like fluctuations.  ...  The concentration of oxygen in the brain spontaneously fluctuates, and the distribution of power in these fluctuations has a 1/f-like spectra, where the power present at low frequencies of the power spectrum  ...  Acknowledgments We thank Nanyin Zhang and Yuncong Ma for comments on this manuscript.  ... 
doi:10.1371/journal.pbio.3001298 pmid:34264930 pmcid:PMC8282088 fatcat:zv6wyacy3ze45eup5hmly2ju3a

Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies

Kwangyeol Baek, Woo Hyun Shim, Jaeseung Jeong, Harsha Radhakrishnan, Bruce R. Rosen, David Boas, Maria Franceschini, Bharat B. Biswal, Young R. Kim
2015 Brain Structure and Function  
We investigated the characteristics of bihemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by a-chloralose.  ...  Both neuroelectric and rsfMRI signals were interhemispherically correlated in a layer-specific manner, suggesting that there are independent neural inputs to infragranular and granular/supragranular layers  ...  Seven laminar ROIs were defined for each side of the somatosensory cortex (a) and resting state BOLD fMRI signals from the laminar ROIs were extracted (b).  ... 
doi:10.1007/s00429-015-1073-0 pmid:26077581 pmcid:PMC4681693 fatcat:f6ovcrie6fbz3brpv4d5xwvzxe

Pelvic Pain Alters Functional Connectivity Between Anterior Cingulate Cortex and Hippocampus in Both Humans and a Rat Model

Wenjun Yu, Xiaoyan Wu, Yunan Chen, Zhiying Liang, Jinxiang Jiang, Afzal Misrani, Yun Su, Yigang Peng, Jian Chen, Binliang Tang, Mengyao Sun, Cheng Long (+2 others)
2021 Frontiers in Systems Neuroscience  
Similarly, model rats demonstrate significantly increased ACC-HIPP synchronization in the gamma band, associating with reduced modulation by ACC-theta on HIPP-gamma and increased levels of receptor proteins  ...  connectivity between ACC and HIPP in resting-state fMRI, and a smaller reduction in connectivity during social exclusion in PDM females with periovulatory phase.  ...  All the authors contributed to the article and approved the submitted version.  ... 
doi:10.3389/fnsys.2021.642349 pmid:34149369 pmcid:PMC8210850 fatcat:fjumbt7gr5hfvhl4ahmamazdyy

Model-Predicted Balance Between Neural Excitation and Inhibition Was Maintained Despite of Age-Related Decline in Sensory Evoked Local Field Potential in Rat Barrel Cortex

Sungmin Kang, Yurie Hayashi, Michael Bruyns-Haylett, Evangelos Delivopoulos, Ying Zheng
2020 Frontiers in Systems Neuroscience  
This study investigated the effect of aging on the temporal dynamics of the somatosensory evoked local field potential (LFP) in rats and tested the hypothesis that excitatory and inhibitory post-synaptic  ...  We found an age-dependent slowing of the temporal dynamics in the somatosensory-evoked post-synaptic activity, as well as a significant age-related decrease in the amplitude of the excitatory component  ...  ACKNOWLEDGMENTS We would like to thank the BioResource Unit at the University of Reading.  ... 
doi:10.3389/fnsys.2020.00024 pmid:32528256 pmcid:PMC7247833 fatcat:l6ypikgbdfg33abjdfdfd4r2t4

Locus coeruleus phasic discharge is essential for stimulus-induced gamma oscillations in the prefrontal cortex

Ricardo M. Neves, Silvia van Keulen, Mingyu Yang, Nikos K. Logothetis, Oxana Eschenko
2018 Journal of Neurophysiology  
NEW & NOTEWORTHY Our study shows linear relationships between locus coeruleus phasic excitation and the amplitude of gamma oscillations in the prefrontal cortex.  ...  Locus coeruleus phasic discharge is essential for stimulus-induced gamma oscillations in the prefrontal cortex.  ...  ACKNOWLEDGMENTS We thank Nelson Totah and Vishal Kapoor for valuable comments on the manuscript, Stefano Panzeri for expert advice on data analyses, and Axel Oeltermann and Joachim Werner for technical  ... 
doi:10.1152/jn.00552.2017 pmid:29093170 fatcat:w3o26y4tbrawljzmsaifrfjyrq

Dynamic causal modelling of lateral interactions in the visual cortex

D.A. Pinotsis, D.S. Schwarzkopf, V. Litvak, G. Rees, G. Barnes, K.J. Friston
2013 NeuroImage  
parameterised in terms of horizontal connections, implicit in the cortical micro-architecture and its synaptic parameters.  ...  We also considered cortical excitability and assessed its relative influence on observed gamma activity.  ...  Acknowledgments This work was funded by the Wellcome Trust. We thank W. Penny and A. Bastos for useful discussions.  ... 
doi:10.1016/j.neuroimage.2012.10.078 pmid:23128079 pmcid:PMC3547173 fatcat:ghi7v5kyybfjhjq4hix2uiklie

Control of Functional Connectivity in Cerebral Cortex by Basal Ganglia Mediated Synchronization [article]

Daniel Pouzzner
2020 arXiv   pre-print
More recently, they have been identified not only in the cerebral cortex and thalamus, but pervasively in the healthy basal ganglia.  ...  Other structural arrangements in the basal ganglia show further specialization for this role, with convergence in the inputs from cortex, and divergence in many of the return paths to cortex, that systematically  ...  nucleus (STN) couples coherently to gamma oscillations in motor cortex, in apparent preparation for action, with performance improving with increased anticipatory phase coupling (Fischer et al. 2020)  ... 
arXiv:1708.00779v2 fatcat:3mbrakwdgfewpcdggox5v6mwme

Noise and non-neuronal contributions to the BOLD signal: applications to and insights from animal studies

Shella D. Keilholz, Wen-Ju Pan, Jacob Billings, Maysam Nezafati, Sadia Shakil
2017 NeuroImage  
Motion and physiological cycles have long been known to affect the BOLD signal and are present in both humans and animal models.  ...  The use of anesthesia, common in animal studies, alters neural activity, vascular tone, and neurovascular coupling.  ...  and Improved Cognition (BIONIC), and the Center for Systems Imaging at Emory.  ... 
doi:10.1016/j.neuroimage.2016.12.019 pmid:28017922 pmcid:PMC5481494 fatcat:cfjnbrsikzhglpfgml4mmikq24

Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans

S. D. Muthukumaraswamy, R. A.E. Edden, D. K. Jones, J. B. Swettenham, K. D. Singh
2009 Proceedings of the National Academy of Sciences of the United States of America  
concentration in the visual cortex, MEG to measure stimulus-induced visual gamma oscillations and fMRI to measure the BOLD response to a simple visual grating stimulus.  ...  Our results are therefore supportive of recent theories suggesting that these functional neuroimaging metrics are dependent on the excitation/inhibition balance in an individual's cortex and have important  ...  A need also exists to test the generality of these results across the cortex, although recent data in human anterior cingulate (32) and rat somatosensory cortex (31) suggest the dependence of BOLD  ... 
doi:10.1073/pnas.0900728106 pmid:19416820 pmcid:PMC2688873 fatcat:blkdc5dvrngh3brshdotnm2xta
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