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Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies

Anderson M. Winkler, Peter Kochunov, John Blangero, Laura Almasy, Karl Zilles, Peter T. Fox, Ravindranath Duggirala, David C. Glahn
2010 NeuroImage  
The results suggest that surface area and cortical thickness measurements should be considered separately and preferred over gray matter volumes for imaging genetic studies.  ...  Here we examine the relationship between brain volume, grey matter volume, cortical thickness and surface area, from a genetic standpoint.  ...  The authors thank the Athinoula Martinos Center for Biomedical Imaging and the FMRIB Imaging Analysis Group for providing software used for the analyses.  ... 
doi:10.1016/j.neuroimage.2009.12.028 pmid:20006715 pmcid:PMC2891595 fatcat:eqqwxupi6va47ftz4upbnxqnpq

Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia

Sheena F. Owens, Marco M. Picchioni, Ulrich Ettinger, Colm McDonald, Muriel Walshe, Anne Schmechtig, Robin M. Murray, Fruhling Rijsdijk, Timothea Toulopoulou
2012 Brain  
This study sought to systematically investigate whether prefrontal cortex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investigating their presence in unaffected  ...  Volumes of the prefrontal and orbital cortices were, however, moderately heritable, but neither shared a genetic overlap with schizophrenia.  ...  Acknowledgements The principal investigators of this project were Dr T.T., Dr M.P. and Prof R.  ... 
doi:10.1093/brain/aws138 pmid:22693145 pmcid:PMC3381723 fatcat:unqfskcxurh6ppbyct7l6g3ayq

Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls

Donna Cosgrove, David O. Mothersill, Laura Whitton, Denise Harold, Sinead Kelly, Laurena Holleran, Jessica Holland, Richard Anney, Alex Richards, Kiran Mantripragada, Michael Owen, Michael C. O'Donovan (+4 others)
2018 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
Multiple genome-wide association studies of schizophrenia have implicated genetic variants within the gene encoding microRNA-137.  ...  These measures included total brain volume, cortical thickness, cortical surface area, and hippocampal volume, in a sample of 216 individuals consisting of healthy participants (n= 171) and patients with  ...  Acknowledgements We wish to thank all patients and their support staff, and all healthy volunteers for participating in the data collection on which this manuscript is based.  ... 
doi:10.1002/ajmg.b.32620 pmid:29418072 fatcat:q67khjnumvguzcprzhj22y5674

No effect of obstetric complications on basal ganglia volumes in schizophrenia

Unn Kristin Haukvik, Thomas McNeil, Ragnar Nesvåg, Erik Söderman, Erik Jönsson, Ingrid Agartz
2010 Progress in Neuro-psychopharmacology and Biological Psychiatry  
Zahngir Mukut is acknowledged for the manual delineation of hippocampal volumes. We thank Dr.  ...  The staff at the MRI-lab at the Institute of Psychiatry section Vinderen, University of Oslo, is acknowledged for the preprocessing of MR images.  ...  volumes, cortical thickness, and cortical gyrification; or the gene*OCs interaction effect on hippocampal volume.  ... 
doi:10.1016/j.pnpbp.2010.02.024 pmid:20193725 fatcat:smybi5xr6jhnhf35rnzmzf3k5y

The effect of lifelong bilingualism on regional grey and white matter volume

Rosanna K. Olsen, Melissa M. Pangelinan, Cari Bogulski, M. Mallar Chakravarty, Gigi Luk, Cheryl L. Grady, Ellen Bialystok
2015 Brain Research  
We employed two analytic approaches: 1) we examined global differences in grey and white matter volumes; and, 2) we examined local differences in volume and cortical thickness of specific regions of interest  ...  We expected bilinguals would exhibit greater volume of the frontal lobe and temporal lobe (grey and white matter), given the importance of these regions in executive and language functions, respectively  ...  SciNet is funded by: the Canada Foundation for Innovation under the auspices of Compute Canada; the Government of Ontario; Ontario Research Fund -Research Excellence; and the University of Toronto.  ... 
doi:10.1016/j.brainres.2015.02.034 pmid:25725380 fatcat:j64jopmhrfbp3di55ahwldqp74

Vitamin D levels, brain volume, and genetic architecture in patients with psychosis

Akiah Ottesen Berg, Kjetil N. Jørgensen, Mari Nerhus, Lavinia Athanasiu, Alice B. Popejoy, Francesco Bettella, Linn Christin Bonaventure Norbom, Tiril P. Gurholt, Sandra R. Dahl, Ole A. Andreassen, Srdjan Djurovic, Ingrid Agartz (+2 others)
2018 PLoS ONE  
Even though vitamin D deficiency has been proposed as a risk mechanism for schizophrenia there exist no studies to date of the association between vitamin D levels and brain volume in this population.  ...  Conclusions This is the first study of the association between vitamin D levels and brain volume in patients with psychotic disorders that takes into account possible interaction with genetic polymorphisms  ...  Further, we would like to acknowledge the important contribution of the thorough and considerate reviews received upon submission to Plos One.  ... 
doi:10.1371/journal.pone.0200250 pmid:30142216 fatcat:nefodgmhnbem7mzas3cvlnqt4i

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Oana Georgiana Rus, Tim Jonas Reess, Gerd Wagner, Michael Zaudig, Claus Zimmer, Kathrin Koch
2017 Journal of Psychiatry & Neuroscience  
The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age-and sex-matched healthy controls.  ...  There were no differences in grey matter thickness between the groups.  ...  Acknowledgements: The authors thank the Windach Institute and Hospital of Neurobehavioural Research and Therapy, Windach, Germany, for the opportunity to recruit patients at their institution.  ... 
doi:10.1503/jpn.170030 pmid:28832321 pmcid:PMC5662461 fatcat:w37wmk5d4bdgdaztcxbhplcx5i

Grey matter volume and cortical structure in Prader-Willi syndrome compared to typically developing young adults

Katherine E. Manning, Roger Tait, John Suckling, Anthony J. Holland
2018 NeuroImage: Clinical  
, aged 19-27 years, underwent multiparameter mapping magnetic resonance imaging sequences, from which measures of grey matter volume, cortical thickness and magnetisation transfer saturation, as a proxy  ...  Analysis of cortical structure revealed that areas of increased volume in the PWS group were largely driven by greater cortical thickness.  ...  Genetic analysis was undertaken by the East Anglian Medical Genetics Service, Cambridge, UK.  ... 
doi:10.1016/j.nicl.2017.12.027 pmid:29527494 pmcid:PMC5842730 fatcat:arx5vmmgrnc3hmomntycrgb7hy

Sexual dimorphism of volume reduction but not cognitive deficit in fetal alcohol spectrum disorders: A combined diffusion tensor imaging, cortical thickness and brain volume study

Sarah Treit, Zhang Chen, Dongming Zhou, Lauren Baugh, Carmen Rasmussen, Gail Andrew, Jacqueline Pei, Christian Beaulieu
2017 NeuroImage: Clinical  
A significant effect of group, ageby-group, or sex-by-group was found for 9/9 volumes, 7/39 cortical thickness regions, 3/9 white matter tracts, and 9/10 cognitive tests, indicating group differences that  ...  Quantitative magnetic resonance imaging (MRI) has revealed abnormalities in brain volumes, cortical thickness and white matter microstructure in fetal alcohol spectrum disorders (FASD); however, no study  ...  We gratefully acknowledge the time and efforts of the families who participated in this study  ... 
doi:10.1016/j.nicl.2017.05.006 pmid:28560153 pmcid:PMC5440763 fatcat:qnhbxhfnqzf4dajlaxtdrk4tei

Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

Donald M. Lyall, Simon R. Cox, Laura M. Lyall, Carlos Celis-Morales, Breda Cullen, Daniel F. Mackay, Joey Ward, Rona J. Strawbridge, Andrew M. McIntosh, Naveed Sattar, Daniel J. Smith, Jonathan Cavanagh (+2 others)
2019 Brain Imaging and Behavior  
There were no associations with left or right hippocampal, total grey matter (GM) or WM volumes, or WM tract integrity indexed by fractional anisotropy (FA) and mean diffusivity (MD).  ...  We used brain magnetic resonance imaging (MRI) and genetic data from a general-population cohort: the UK Biobank (N = 8395 after exclusions).  ...  For example, we did not investigate some brain phenotypes that have been reported to underlie some cognitive deficits, such as cortical thickness (Karama et al. 2014 ) nor did we examine structural brain  ... 
doi:10.1007/s11682-019-00069-9 pmid:30903549 fatcat:muc6tggv55fsxlxu6wdl63vhi4

A Magnetic Resonance Imaging Study of Cerebellar Volume in Tuberous Sclerosis Complex

Neil I. Weisenfeld, Jurriaan M. Peters, Peter T. Tsai, Sanjay P. Prabhu, Kira A. Dies, Mustafa Sahin, Simon K. Warfield
2013 Pediatric Neurology  
A Magnetic Resonance Imaging Study of Cerebellar Volume in Tuberous Sclerosis Comp.  ...  Using a robust, automated image analysis procedure, we studied 36 patients with tuberous sclerosis complex and age-matched control subjects and observed significant volume loss among patients in the cerebellar  ...  Images for this study were acquired without contrast media. Data analysis The primary measure in this study was regional tissue volume.  ... 
doi:10.1016/j.pediatrneurol.2012.10.011 pmid:23337002 pmcid:PMC3763730 fatcat:6rhg23rnrnctrfi5fgkh2fzurq

Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: A preliminary study

Ke Wu, Gregory L. Hanna, Philip Easter, James L. Kennedy, David R. Rosenberg, Paul D. Arnold
2013 Psychiatry Research : Neuroimaging  
In this study, volumes of brain regions selected for a priori evidence of association with OCD (orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), thalamus, caudate, putamen, globus pallidus  ...  These genes were selected based on either previous reported association with OCD in humans or evidence from animal models of OCD.  ...  Genotyping data for this report was obtained thanks to the International OCD Foundation Genetics Collaborative  ... 
doi:10.1016/j.pscychresns.2012.07.003 pmid:23154099 pmcid:PMC4552325 fatcat:7bxerrvlfbeclmdreydlitbxue

Cerebellar grey matter volume in adolescence is associated with prodromal psychotic symptoms and norm-violating behavior [article]

Torgeir Moberget, Dag Alnaes, Tobias Kaufmann, Nhat Trung Doan, Aldo Cordova-Palomera, Linn Bonaventure Norbom, Jarek Rokicki, Dennis van der Meer, Ole A Andreassen, Lars T Westlye
2018 bioRxiv   pre-print
Associations with norm-violating behavior and prodromal psychotic symptoms were stronger for the cerebellum than for subcortical and cerebro-cortical regions, while anxiety and general cognitive function  ...  The association between cerebellar volume and prodromal psychotic symptoms, and to a lesser extent norm violating behavior, remained significant when adjusting for potentially confounding factors such  ...  Third, associations with psychotic symptoms and norm-violating behavior were stronger for the cerebellum than for subcortical volumes or regional cortical thickness.  ... 
doi:10.1101/288134 fatcat:upr6ulmazrafpjius7ymr2geri

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder

Alvi H Islam, Arron W S Metcalfe, Bradley J MacIntosh, Daphne J Korczak, Benjamin I Goldstein
2018 Journal of Psychiatry & Neuroscience  
We processed T1-weighted images of adolescents with BD and psychiatrically healthy controls using FreeSurfer to derive a priori region of interest (ROI) volumes/cortical thickness for the frontal lobe  ...  In the BD group only, BMI was negatively associated with FL, OFC and PFC cortical thickness.  ...  The purpose of this study was to ascertain the association between BMI and brain structure (volume and cortical thickness) of regions of interest (ROIs) selected a priori among adolescents with and without  ... 
pmid:29481319 pmcid:PMC5837884 fatcat:lfzm5a2snrdjpbezyb24bpo62q

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder

Alvi H. Islam, Arron W.S. Metcalfe, Bradley J. MacIntosh, Daphne J. Korczak, Benjamin I. Goldstein
2018 Journal of Psychiatry & Neuroscience  
Methods: We processed T 1 -weighted images of adolescents with BD and psychiatrically healthy controls using FreeSurfer to derive a priori region of interest (ROI) volumes/cortical thickness for the frontal  ...  In the BD group only, BMI was negatively associated with FL, OFC and PFC cortical thickness.  ...  The purpose of this study was to ascertain the association between BMI and brain structure (volume and cortical thickness) of regions of interest (ROIs) selected a priori among adolescents with and without  ... 
doi:10.1503/jpn.170041 pmid:29077553 fatcat:v4y5enjvcncv7hh2gk46y2rqz4
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