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Neuroimaging Auditory Hallucinations in Schizophrenia: From Neuroanatomy to Neurochemistry and Beyond

P. Allen, G. Modinos, D. Hubl, G. Shields, A. Cachia, R. Jardri, P. Thomas, T. Woodward, P. Shotbolt, M. Plaze, R. Hoffman
2012 Schizophrenia Bulletin  
However, some progress has been made with imaging studies in patients with AH consistently reporting altered structure and function in speech and language, sensory, and nonsensory regions.  ...  Despite more than 2 decades of neuroimaging investigations, there is currently insufficient evidence to fully understand the neurobiological substrate of auditory hallucinations (AH).  ...  Acknowledgments The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbs066 pmid:22535906 pmcid:PMC3406523 fatcat:fzdfi7r2g5d6rhhjylxasp7muu

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

Colleen P. E. Rollins, Jane R. Garrison, Maite Arribas, Aida Seyedsalehi, Zhi Li, Raymond C. K. Chan, Junwei Yang, Duo Wang, Pietro Liò, Chao Yan, Zheng-hui Yi, Arnaud Cachia (+5 others)
2020 Translational Psychiatry  
In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls.  ...  cortical folding covariance matrices organized by large-scale functional networks.  ...  The funders had no input in study design, data collection, data analysis, data interpretation, writing of the report, or the decision to submit for publication.  ... 
doi:10.1038/s41398-020-01075-y pmid:33159044 fatcat:25uba3kntbcjdpzxzhvsxnfsim

A Review of Studies Leveraging Multimodal TMS-fMRI Applications in the Pathophysiology and Treatment of Schizophrenia

Sachin Pradeep Baliga, Urvakhsh Meherwan Mehta
2021 Frontiers in Human Neuroscience  
Among studies examining treatment, low-frequency rTMS for the management of persistent auditory verbal hallucinations (AVH) was the most studied.  ...  The current review provides an overview of the existing literature on multimodal transcranial magnetic stimulation, and functional magnetic resonance imaging (TMS/fMRI) studies in individuals with schizophrenia  ...  For this study, patients of schizophrenia with resistant AVH were divided into continuous or intermittent hallucinators.  ... 
doi:10.3389/fnhum.2021.662976 fatcat:y35rn7fqvfdadoa75axiqvwbru

The neurodevelopment of anomalous perception: Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia [article]

Colleen P.E. Rollins, Jane R. Garrison, Maite Arribas, Aida Seyedsalehi, Zhi Li, Raymond C.K. Chan, Junwei Yang, Duo Wang, Pietro Lio, Chao Yan, Zheng-hui Yi, Arnaud Cachia (+5 others)
2020 medRxiv   pre-print
Results: In both ethnic groups, we replicated a significantly shorter left PCS in patients with hallucinations compared to those without, and healthy controls.  ...  Methods: We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T structural magnetic resonance (MR) imaging from the United Kingdom and Shanghai, China  ...  Localized deviations in the superior temporal sulcus (STS) in schizophrenia patients with auditory hallucinations have been reported (20, 21) , as well as global decreases in cortical sulcation in patients  ... 
doi:10.1101/2020.06.04.20122424 fatcat:wtsth33ugngjzitel6hm5gkwle

Understanding tDCS effects in schizophrenia: a systematic review of clinical data and an integrated computation modeling analysis

Andre R Brunoni, Pedro Shiozawa, Dennis Truong, Daniel C Javitt, Hélio Elkis, Felipe Fregni, Marom Bikson
2014 Expert Review of Medical Devices  
We also identified tDCS-induced electrical currents in cortical areas between the electrodes (frontoparietal network) and, to a lesser extent, in deeper structures involved in schizophrenia pathophysiology  ...  Mechanisms of tDCS effects in schizophrenia and the usefulness of computer modeling techniques for planning tDCS trials in schizophrenia are discussed.  ...  [37] investigated tDCS for the treatment of auditory hallucinations in schizophrenia by randomizing 30 patients with persistent auditory hallucinations to receive either active or sham tDCS.  ... 
doi:10.1586/17434440.2014.911082 pmid:24754366 fatcat:b554lid4v5eq7fhz66lsrebzoi

Abnormal Asymmetry of Brain Connectivity in Schizophrenia

Michele Ribolsi, Zafiris J. Daskalakis, Alberto Siracusano, Giacomo Koch
2014 Frontiers in Human Neuroscience  
The loss of the cerebral torque and the abnormalities of gyrification, with an increased or more complex cortical folding in the right hemisphere may provide an anatomical basis for such aberrant connectivity  ...  Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity  ...  Interestingly, schizophrenia patients (SCZ) with resistant auditory hallucinations show a greater local sulcal index decrease in the superior temporal sulcus bilaterally, and in a peculiar way, also in  ... 
doi:10.3389/fnhum.2014.01010 pmid:25566030 pmcid:PMC4273663 fatcat:eibhflcul5by7pgbd45t6abr6q

A Case for Thalamic Mechanisms of Schizophrenia: Perspective From Modeling 22q11.2 Deletion Syndrome

Yanbo Jiang, Mary H. Patton, Stanislav S. Zakharenko
2021 Frontiers in Neural Circuits  
We posit that synaptic dysfunction and oscillatory abnormalities in neural circuits involving projections from and within the thalamus, with a focus on the thalamocortical circuits, may underlie the psychotic  ...  Here we review the literature on the molecular, cellular, and circuitry findings in schizophrenia and discuss the leading theories in the field, which point to abnormalities within the thalamus as potential  ...  ACKNOWLEDGMENTS We thank Troy Hackett and the members of the Zakharenko lab for constructive comments, Angela McArthur for editing the manuscript, and Chris Fiveash for assistance with the figures.  ... 
doi:10.3389/fncir.2021.769969 pmid:34955759 pmcid:PMC8693383 fatcat:ppap5fojjfh5tmxo4fpgbm45la

Abnormalities of cortical thickness in postictal psychosis

J.M. DuBois, O. Devinsky, C. Carlson, R. Kuzniecky, B.T. Quinn, K. Alper, T. Butler, K. Starner, E. Halgren, T. Thesen
2011 Epilepsy & Behavior  
Comparison of patients with epilepsy and PIP with patients with epilepsy without PIP revealed increased cortical thickness in the right lateral prefrontal cortex, right anterior cingulate cortex, and right  ...  Here, we used quantitative MRI morphometry to identify structural abnormalities in the cortex of patients with PIP relative to patients with epilepsy without PIP and age-and gender-matched normal healthy  ...  Our findings of cortical thickening in specific anatomic regions in patients with PIP may help to focus attention on these structures and their role in abnormal behavior.  ... 
doi:10.1016/j.yebeh.2011.03.024 pmid:21543262 fatcat:rp3cjilvojaspb7hwfum75dvtm

Can we use mice to study schizophrenia?

Sarah Canetta, Christoph Kellendonk
2018 Philosophical Transactions of the Royal Society of London. Biological Sciences  
We will then discuss how circuit analysis in these specific examples can be used for testing hypotheses about neuronal mechanisms underlying symptoms of schizophrenia, which will then guide the development  ...  Focusing on schizophrenia, we will give four examples of rodent models that were generated based on genetic and environmental risk factors or pathophysiological evidence as entry points.  ...  in patients with schizophrenia.  ... 
doi:10.1098/rstb.2017.0032 pmid:29352031 fatcat:quoehv3eznflrp6wacmbnkkkwm

Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex

Arnaud Cachia, Grégoire Borst, Renaud Jardri, Armin Raznahan, Graham K. Murray, Jean-François Mangin, Marion Plaze
2021 Frontiers in Neuroanatomy  
that analysis of the sulcal patterns can provide information on prenatal dispositions to cognition (with a focus on cognitive control and academic abilities) and cognitive symptoms (with a focus on schizophrenia  ...  Indeed, as opposed to quantitative features of the cortical sheet (e.g., thickness, surface area or curvature) taking decades to reach the levels measured in adult, the qualitative sulcal patterns are  ...  In patients with auditory verbal hallucinations (AVH), abnormal sulcation have been found in the language-related cortex, including shorter STS (Cachia et al., 2008) and a higher number of duplicated  ... 
doi:10.3389/fnana.2021.712862 pmid:34650408 pmcid:PMC8505772 fatcat:f5vjsw275ffmtcnchkquif42ni

Distinct Hierarchical Alterations of Intrinsic Neural Timescales Account for Different Manifestations of Psychosis [article]

Kenneth Wengler, Andrew Goldberg, George Chahine, Guillermo Horga
2020 bioRxiv   pre-print
Next, we investigated differences in INT between 127 patients with schizophrenia and 152 age- and gender-matched controls, finding that patients exhibited a widespread INT reduction.  ...  and delusion severity in the auditory system.  ...  Rishidev Chaudhuri and Xiao-Jing Wang for their guidance in  ... 
doi:10.1101/2020.02.07.939520 fatcat:ujybmvqioneipazsyknntzt4p4

A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway

Didier Pinault
2017 Brain Sciences  
Schizophrenia patients are waiting for a treatment free of detrimental effects. Psychotic disorders are devastating mental illnesses associated with dysfunctional brain networks.  ...  Ongoing brain network gamma frequency (30-80 Hz) oscillations, naturally implicated in integrative function, are excessively amplified during hallucinations, in at-risk mental states for psychosis and  ...  However, tDCS applied over the left frontotemporal cortex of schizophrenia patients with disabling treatment-resistant symptoms reduces both the auditory verbal hallucinations (~30%) and the abnormal resting-state  ... 
doi:10.3390/brainsci7040034 pmid:28350371 pmcid:PMC5406691 fatcat:g2p6vidg2zgvvebsm6a6nzvhrq

Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading

Inkyung Park, Minah Kim, Tae Young Lee, Wu Jeong Hwang, Yoo Bin Kwak, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon
2021 npj Schizophrenia  
Although abnormal cortical gyrification has been consistently reported in patients with schizophrenia, whether gyrification abnormalities reflect a genetic risk for the disorder remains unknown.  ...  This study investigated differences in cortical gyrification between unaffected relatives (URs) with high genetic loading for schizophrenia and healthy controls (HCs) to identify potential genetic vulnerability  ...  A previous study in schizophrenia patients with medication-resistant auditory hallucinations also reported hypogyria in the posterior cingulate sulcus and anterior calcarine fissure as a trait feature  ... 
doi:10.1038/s41537-021-00148-1 pmid:33649350 fatcat:6m5vm36gjvdfxcw5lvikf7t4um

Schizophrenia: The Ambiguous Mechanism behind the Disorder

Mayasah Al-Nema, Anand Gaurav
2022 Jordan Journal of Pharmaceutical Sciences  
Regardless of its low prevalence, it negatively impacts the quality of life not only for patients but also for families and society.  ...  Methods: Four hypotheses which explain the possible mechanisms that might be involved in the development of schizophrenia have been discussed in this review.  ...  They induced auditory illusions in untreated patients with schizophrenia who experience varying degrees of hallucination and healthy volunteers to test a dopamine-dependent gain-control mechanism of hallucinations  ... 
doi:10.35516/jjps.v15i2.323 fatcat:ka2wv2py55btbb365fg7n2ege4

Translating Neurocognitive Models of Auditory-Verbal Hallucinations into Therapy: Using Real-time fMRI-Neurofeedback to Treat Voices

Thomas Fovet, Natasza Orlov, Miriam Dyck, Paul Allen, Klaus Mathiak, Renaud Jardri
2016 Frontiers in Psychiatry  
Auditory-verbal hallucinations (AVHs) are frequent and disabling symptoms, which can be refractory to conventional psychopharmacological treatment in more than 25% of the cases.  ...  Considering the potential cost necessary to implement fMRI-NF, proof-of-concept studies are urgently required to define the optimal strategy for application in patients with AVHs.  ...  Why Using fMRI-Neurofeedback for Auditory-Verbal hallucinations in schizophrenia?  ... 
doi:10.3389/fpsyt.2016.00103 pmid:27445865 pmcid:PMC4921472 fatcat:sltqqrnx4fakzgizewvsxsz3o4
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