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Cortical abnormalities in epilepsy revealed by local EEG synchrony

C.A. Schevon, J. Cappell, R. Emerson, J. Isler, P. Grieve, R. Goodman, G. Mckhann, H. Weiner, W. Doyle, R. Kuzniecky, O. Devinsky, F. Gilliam
2007 NeuroImage  
Measuring local synchrony in a subdural grid results in a map of the cortical surface that provides information not visually apparent on either EEG or structural imaging.  ...  Abnormally strong functional linkage between cortical areas has been postulated to play a role in the pathogenesis of partial epilepsy.  ...  A study of local and distant synchrony in MEG recordings of patients with generalized epilepsy and normal controls did not reveal significant spatial heterogeneity in either group (Dominguez, Wennberg  ... 
doi:10.1016/j.neuroimage.2006.11.009 pmid:17224281 pmcid:PMC1994936 fatcat:bvjigxpl4zbz3ix2e3yhs3mspy

Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy

Edward F. Chang, Srikantan S. Nagarajan, Mary Mantle, Nicholas M. Barbaro, Heidi E. Kirsch
2009 Journal of Neurosurgery  
kEy wordS • secondary bilateral synchrony • magnetic source imaging • epilepsy surgery • magnetoencephalography • epilepsy Abbreviations used in this paper: ECD = equivalent current dipole; EEG = electroencephalography  ...  ; MEG = magnetoencephalography; MS = magnetic source; PBS = primary bilateral synchrony; SBS = secondary bilateral synchrony; VNS = vagal nerve stimulator.  ...  The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.  ... 
doi:10.3171/2009.6.jns081376 pmid:19575574 pmcid:PMC3151560 fatcat:3k3pm37inrgz7dwugaqogt3zui

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods

Katarína Česká, Štefánia Aulická, Ondřej Horák, Pavlína Danhofer, Pavel Říha, Radek Mareček, Jan Šenkyřík, Ivan Rektor, Milan Brázdil, Hana Ošlejšková
2019 Epilepsy and Behavior Case Reports  
The functional connectivity analysis revealed higher local synchrony in the patient in the left temporal (middle temporal gyrus), left frontal (supplementary motor area, superior frontal gyrus), and left  ...  Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology.  ...  We acknowledge the core facility MAFIL of CEITEC, supported by the Czech-BioImaging large RI project (LM2015062 funded by MEYS CR), for their support with obtaining the scientific data presented in this  ... 
doi:10.1016/j.ebcr.2018.10.003 pmid:30619712 pmcid:PMC6313257 fatcat:lleoj3o6ajdcxmzw3ko4r4vw4i

Neural Synchrony in Brain Disorders: Relevance for Cognitive Dysfunctions and Pathophysiology

Peter J. Uhlhaas, Wolf Singer
2006 Neuron  
Studies employing these advanced techniques revealed that synchronization of oscillatory responses in the b-and g-band is involved in a variety of cognitive functions, such as perceptual grouping, attention-dependent  ...  Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization.  ...  Acknowledgments This research was supported by the Max Planck Society. Neuron  ... 
doi:10.1016/j.neuron.2006.09.020 pmid:17015233 fatcat:av72c6ln3fd4pl5ubz6oaiowby

Detecting seizure origin using basic, multiscale population dynamic measures: Preliminary findings

A.K. Roopun, R.D. Traub, T. Baldeweg, M.O. Cunningham, R.G. Whittaker, A. Trevelyan, R. Duncan, A.J.C. Russell, M.A. Whittington
2009 Epilepsy & Behavior  
fast oscillations (sometimes called ripples), excess gamma frequency oscillations, electroencephalographic/electrocorticographic flattening, and changes in global synchrony.  ...  Many types of electrographic seizures are readily identifiable by direct visual examination of electroencephalographic or electrocorticographic recordings.  ...  of abnormal EEG signatures of epilepsy [7, 8] .  ... 
doi:10.1016/j.yebeh.2008.09.008 pmid:18834957 pmcid:PMC2841527 fatcat:jqmxip6etvaazkdszyrw3holju

Enhanced Synchrony in Epileptiform Activity? Local versus Distant Phase Synchronization in Generalized Seizures

L. G. Dominguez,
2005 Journal of Neuroscience  
However, all seizures were characterized by enhanced local synchrony compared with distant synchrony.  ...  ) in local (neighboring) and distant cortical areas and to explore the ongoing temporal dynamics for particular ranges of frequencies at which synchrony occurs, during interictal and ictal activity.  ...  We observed higher local (in small neighboring cortical areas; see Results) synchrony in the recordings from the patients during the seizures; however, distant synchrony did not show a similar increase  ... 
doi:10.1523/jneurosci.1046-05.2005 pmid:16135765 fatcat:4h7j5sm6qja3zfzt7uzutgobyi

Pure Graphogenic Epilepsy - A Rare Form of Reflex Epilepsy

Shaik Afshan Jabeen, A. Haritha Chowdary, K. Rukmini Mridula, Ajith Cherian, P. Rakhee Kumar, Saileja Sarva, Chikkam V. V. S. N. Murty
2013 Canadian Journal of Neurological Sciences  
Several EEG abnormalities have been reported with writing epilepsy.  ...  A distinct neuroanatomical localization with left central focus in a patient with writing epilepsy has been described by Oshima et al, in 2003. 2 This is also analogous to the findings by Op de beeck  ... 
doi:10.1017/s0317167100014761 fatcat:r2x3flrr6fdpll4onphnjbo4ia

Page 623 of JAMA Neurology Vol. 5, Issue 6 [page]

1961 JAMA Neurology  
—An anal- ysis of our results reveals that when the cerebral hemisphere containing a cortical epileptogenic area is irrigated by intraca- rotid injection of amobarbital in doses of 50-100 mg., there is  ...  of cortical gray matter localized on the side of the injection.  ... 

Shaping pathological cortical dynamics with high-frequency neurostimulation

Jérémie Lefebvre, Micah M Murray
2015 BMC Neuroscience  
power expressed by synchronous cortical networks.  ...  Disrupted neural synchrony is a hallmark pattern observed in numerous pathological states, such as dementia, depression, Parkinson's disease, epilepsy, and schizophrenia.  ...  power expressed by synchronous cortical networks.  ... 
doi:10.1186/1471-2202-16-s1-p172 pmcid:PMC4697527 fatcat:o2qbchfyv5f3fgicwqefz27lou

Spontaneous EEG-Functional MRI in Mesial Temporal Lobe Epilepsy: Implications for the Neural Correlates of Consciousness

Zheng Wang, Loretta Norton, R. Matthew Hutchison, John R. Ives, Seyed M. Mirsattari
2012 Epilepsy Research and Treatment  
Simultaneous EEG-fMRI is particularly well suited for the study of epilepsy in that it may reveal the neurobiology of ictal and interictal epileptiform discharges and noninvasively localize epileptogenic  ...  and discusses the role and impact of spontaneous activity in the mesial temporal lobe epilepsies with particular emphasis on the neural and physiological correlates of consciousness.  ...  Acknowledgment This work was partly funded by The Physicians' Services Incorporated Foundation (SM).  ... 
doi:10.1155/2012/385626 pmid:22957230 pmcid:PMC3420502 fatcat:axi7owcbqzb4hfchdi7mqob7x4

Preoperative Electroencephalographic Investigation in Frontal Lobe Epilepsy: Electroencephalographic and Electrocorticographic Recordings

L.F. Quesney
1991 Canadian Journal of Neurological Sciences  
seizure onset localization commonly reported in patients with frontal lobe epilepsy.  ...  The localizing effectiveness of long term EEG monitoring was reviewed in four different groups of frontal lobe epileptic patients who underwent preoperative EEG investigation with extracranial and intracranial  ...  A good indicator of the localizing effectiveness provided by the interictal epileptic abnormality in frontal lobe epilepsy is available in the summary of Table I , comprising 113 patients belonging to  ... 
doi:10.1017/s0317167100032698 fatcat:ilnp6xwjvvbx5fvbsxsu5wezky

Epilepsy Surgery: Current Status and Ongoing Challenges

Kensuke KAWAI
2015 Neurologia medico-chirurgica  
Meanwhile, surgical outcome in nonlesional extratemporal lobe epilepsy is still to be improved using various approaches.  ...  Multiple subpial transection is still being modified expecting a better outcome by transection to the vertical cortices along the sulci-and multi-directional transection from a single entry point.  ...  We hypothesized that VNS-induced modulation of cortical activity be state-dependent in order to maintain neuronal synchrony within a normal range and investigated whether and how VNS modulates local synchrony  ... 
doi:10.2176/nmc.ra.2014-0414 pmid:25925752 pmcid:PMC4628163 fatcat:hdp3eyvowfht5mxwqmcs6dasiy

Pathophysiology of Neocortical Epileptic Seizures [chapter]

Igor Timofeev
2010 Atlas of Epilepsies  
Some neocortical epileptic seizures start with EEG flattening and changes in global synchrony.  ...  .), Atlas of Epilepsies, DOI 10.1007/978-1-84882-128-6_27, # Springer-Verlag London Limited 2010 conditions characterized by abnormal brain structure/organization, the hexalaminar structure of the cerebral  ...  Some neocortical epileptic seizures start with EEG flattening and changes in global synchrony.  ... 
doi:10.1007/978-1-84882-128-6_27 fatcat:f2pumv2morhhxjeoo3xmavedwa

Tuberous sclerosis complex: a review of neurological aspects

2002 European journal of paediatric neurology  
Clear localization of the most active epileptogenic focus and the zone of the cortical abnormality may lead to tuberectomy and improved seizure control in selective drug-resistant patients.  ...  Cortical tubers constitute the hallmark of the disease and are pathognomonic of cerebral tuberous sclerosis. Epilepsy is the most common neurological feature, occurring in 96% of patients.  ...  detect secondary bilateral synchrony, often originating in frontal regions and corresponding to prominent cortical tubers detected by MRI in the mesial surface of the frontal or anterotemporal lobes.  ... 
doi:10.1053/ejpn.2001.0538 pmid:11993952 fatcat:e6chtk7lrvfprofub5zdgis7om

Effects of levetiracetam on seizure frequency and neuropsychological impairments in children with refractory epilepsy with secondary bilateral synchrony

Hideaki Kanemura, Fumikazu Sano, Kanji Sugita, Masao Aihara
2013 Seizure  
slow sleep (CSWS), which is a representative epileptic syndrome of secondary bilateral synchrony (SBS), the urgent suppression of this electroencephalographic (EEG) abnormality may be necessary to prevent  ...  Secondary bilateral synchrony (SBS) Refractory epilepsy Continuous spikes and waves during slow sleep (CSWS) Frontal Children A B S T R A C T Purpose: In epilepsy with continuous spikes and waves during  ...  Acknowledgment This work was supported by Grants-in-Aid for Scientific Research (C) (22591124 and 22591123).  ... 
doi:10.1016/j.seizure.2012.10.003 pmid:23127775 fatcat:vlw2yapn2ja5vpoi7fkhdpryya
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