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Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment

C. Metzler-Baddeley, S. Hunt, D. K. Jones, A. Leemans, J. P. Aggleton, M. J. O'Sullivan
2012 Neurology  
Microstructure of uncinate and PHC also correlated with recognition memory, and recognition confidence, in MCI.  ...  Three temporal pathways were reconstructed by tractography: fornix, parahippocampal cingulum (PHC), and uncinate fasciculus.  ...  ACKNOWLEDGMENT The authors thank the staff of the Llandough Memory Clinic, Cardiff, for their assistance with patient recruitment.  ... 
doi:10.1212/wnl.0b013e31827689e8 pmid:23175726 pmcid:PMC3542350 fatcat:vnicht64jbce7g4opuwnvydqvu

The relationship between uncinate fasciculus white matter integrity and verbal memory proficiency in children

David J. Schaeffer, Cynthia E. Krafft, Nicolette F. Schwarz, Lingxi Chi, Amanda L. Rodrigue, Jordan E. Pierce, Jerry D. Allison, Nathan E. Yanasak, Tianming Liu, Catherine L. Davis, Jennifer E. McDowell
2014 NeuroReport  
These findings suggest that a greater degree of myelination and cohesiveness of axonal fibers in uncinate fasciculus underlie better verbal memory proficiency in children.  ...  The present study sought to test the relationship between fronto-temporal white matter integrity and verbal memory proficiency in children.  ...  than individual level tractography.  ... 
doi:10.1097/wnr.0000000000000204 pmid:24949818 pmcid:PMC4107309 fatcat:klu6gn3akfhxdhnyqwdwg2vp74

Altered white matter integrity in temporal lobe epilepsy: Association with cognitive and clinical profiles

Jeffrey D. Riley, David L. Franklin, Vicky Choi, Ronald C. Kim, Devin K. Binder, Steven C. Cramer, Jack J. Lin
2010 Epilepsia  
Mean FA was positively correlated with delayed memory, in anterior temporal lobe; immediate memory, in mesial temporal lobe.  ...  Purpose-Diffusion tensor imaging (DTI) studies have reported substantial white matter abnormalities in patients with temporal lobe epilepsy (TLE).  ...  Acknowledgments We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.  ... 
doi:10.1111/j.1528-1167.2009.02508.x pmid:20132296 pmcid:PMC2929974 fatcat:agckc3k5dzhg7kpfqywqw6sjcq

Longitudinal changes of structural connectivity in traumatic axonal injury

J. Y. Wang, K. Bakhadirov, H. Abdi, M. D. Devous, C. D. Marquez de la Plata, C. Moore, C. J. Madden, R. Diaz-Arrastia
2011 Neurology  
Conclusions: Diffusion tensor tractography is a valuable tool for identifying structural connectivity changes occurring between the acute and chronic stages of traumatic brain injury and for predicting  ...  Importantly, the amount of change in tractography measurements correlated with patients' long-term outcome.  ...  ACKNOWLEDGMENT The authors thank the patients and volunteers who participated in this study, the nursing staff at Parkland Health and Hospital System, and the imaging staff, in particular Dr.  ... 
doi:10.1212/wnl.0b013e31822c61d7 pmid:21813787 pmcid:PMC3162636 fatcat:rsce26h5t5dzfaya4rhkxojlje

White matter disruption at the prodromal stage of Alzheimer's disease: Relationships with hippocampal atrophy and episodic memory performance

Florence Rémy, Nathalie Vayssière, Laure Saint-Aubert, Emmanuel Barbeau, Jérémie Pariente
2015 NeuroImage: Clinical  
Within the patient group, significant intra-hemispheric correlations were notably found between hippocampal grey matter volume and FA in the uncinate fasciculus, suggesting a relationship between atrophy  ...  Performance in various episodic memory tasks was also evaluated in each participant.  ...  We thank Patrice Péran for his help with image analysis, and Hélène Gros, Lucette Foltier and Jean-Pierre Désirat for their help with participants3 scanning at the MRI platform of the 'Institut des Sciences  ... 
doi:10.1016/j.nicl.2015.01.014 pmid:25685715 pmcid:PMC4326466 fatcat:vifuy46qrrh4zg3cooquf22etu

White-matter tract integrity in late-life depression: associations with severity and cognition

R. A. Charlton, M. Lamar, A. Zhang, S. Yang, O. Ajilore, A. Kumar
2013 Psychological Medicine  
White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus.  ...  Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function  ...  We acknowledge the assistance of the Mood Disorders Team for participant screening and assessment. Declaration of Interest None.  ... 
doi:10.1017/s0033291713001980 pmid:24041297 pmcid:PMC4310501 fatcat:nnckun2vuffcrndj45mb2j5h7i

Diffusion Tensor Imaging Biomarkers for Traumatic Axonal Injury: Analysis of Three Analytic Methods

Carlos D. Marquez de la Plata, Fanpei Gloria Yang, Jun Yi Wang, Kamini Krishnan, Khamid Bakhadirov, Christopher Paliotta, Sina Aslan, Michael D. Devous, Carol Moore, Caryn Harper, Roderick McColl, C. Munro Cullum (+1 others)
2010 Journal of the International Neuropsychological Society  
Histogram analysis of fractional anisotropy (FA) and mean diffusivity showed global WM integrity differences between patients and controls.  ...  Novel imaging modalities such as diffusion tensor imaging (DTI) can detect microstructural compromise in white matter (WM) in various clinical populations including TAI.  ...  ACKNOWLEDGEMENTS We also thank Ana Arenivas, Carlee Culver, and Matthew Warner for their assistance with data analysis.  ... 
doi:10.1017/s1355617710001189 pmid:21070694 pmcid:PMC3097093 fatcat:qwt6ysqhuvfuzfmfn4vkx7iwey

Assessing the effects of age on long white matter tracts using diffusion tensor tractography

Simon W. Davis, Nancy A. Dennis, Norbou G. Buchler, Leonard E. White, David J. Madden, Roberto Cabeza
2009 NeuroImage  
The present study investigated specific predictions of the myelodegeneration hypothesis using diffusion tensor tractography.  ...  Specifically, FA in anterior tracts was shown to be primarily associated with executive tasks and FA in posterior tracts mainly associated with visual memory tasks.  ...  The authors would like to thank Amber Baptiste-Tarter for the assistance in participant recruitment, Jared Stokes, Vanessa A.  ... 
doi:10.1016/j.neuroimage.2009.01.068 pmid:19385018 pmcid:PMC2775533 fatcat:qbv34c3l4vbrrlgj5vlyzrspja

Limbic Tract Integrity Contributes to Pattern Separation Performance Across the Lifespan

Ilana J. Bennett, Derek J. Huffman, Craig E.L. Stark
2014 Cerebral Cortex  
In this study, healthy adults (20-89 years) underwent diffusion tensor imaging and completed the Behavioral Pattern Separation Task-Object Version (BPS-O) and Rey Auditory Verbal Learning Test (RAVLT).  ...  ; but not mode) was significantly related to pattern separation (measured using BPS-O and RAVLT tasks), but not to recognition memory.  ...  We thank Shauna Stark and Samantha Rutledge for their assistance in data collection and Avital Fisher for her help with data quality control. Conflict of Interest: None declared.  ... 
doi:10.1093/cercor/bhu093 pmid:24825784 pmcid:PMC4553719 fatcat:r4i25vd6fbgdriutq2wxi6zjjy

Influence of the BDNF Genotype on Amygdalo-Prefrontal White Matter Microstructure is Linked to Nonconscious Attention Bias to Threat

Joshua M. Carlson, Jiook Cha, Eddie Harmon-Jones, Lilianne R. Mujica-Parodi, Greg Hajcak
2013 Cerebral Cortex  
For 40 normative adults, we reconstructed the entire amygdalo-prefrontal white matter tract (uncinate fasciculus) using diffusion tensor weighted MRI and probabilistic tractography to test the hypothesis  ...  We used path analysis to investigate the relationship between brain-derived nerve growth factor genotype, uncinate fasciculus integrity, and attention bias behavior.  ...  (c) Scatter plots depicting correlations between attention bias and left uncinate fasciculus fractional anisotropy and (d) axial diffusivity. Figure 2 . 2 Variability map of the reconstructed UF.  ... 
doi:10.1093/cercor/bht089 pmid:23585520 fatcat:e4j6rpn5k5c3rmh3uaxdedhu4i

A General Factor of Brain White Matter Integrity Predicts Information Processing Speed in Healthy Older People

L. Penke, S. M. Maniega, C. Murray, A. J. Gow, M. C. Valdes Hernandez, J. D. Clayden, J. M. Starr, J. M. Wardlaw, M. E. Bastin, I. J. Deary
2010 Journal of Neuroscience  
Based on diffusion MRI scans of 132 healthy individuals with a narrow age range around 72 years, the integrity of eight major white matter tracts was quantified using probabilistic neighborhood tractography  ...  Principal component analyses (PCAs) were conducted on the correlations between the eight tracts, separately for four tract-averaged integrity parameters: fractional anisotropy, mean diffusivity, and radial  ...  Furthermore, after statistically controlling for the common tract integrity factor in correlations between the processing speed factor and integrity of the eight individual tracts, only left uncinate fasciculus  ... 
doi:10.1523/jneurosci.1553-10.2010 pmid:20519531 pmcid:PMC6632368 fatcat:5gztqx5trfdz7lnejyvz2oysye

Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story

J. Acosta-Cabronero, K. Patterson, T. D. Fryer, J. R. Hodges, G. Pengas, G. B. Williams, P. J. Nestor
2011 Brain  
At a less conservative threshold, tensor abnormalities in the semantic dementia group mapped onto the tractographies for the uncinate and arcuate bundles well beyond the rostral temporal lobe; this was  ...  Using an unbiased voxel-wise approach known as tract-based spatial statistics, we compared results of whole-brain diffusion tensor imaging-absolute metrics of axial, radial and mean diffusion as well as  ...  Acknowledgements We are grateful for the support from our patients and healthy volunteers.  ... 
doi:10.1093/brain/awr119 pmid:21646331 fatcat:4lhedwug3vgg3g7rv64dlsicya

Frontotemporal Connections in Episodic Memory and Aging: A Diffusion MRI Tractography Study

C. Metzler-Baddeley, D. K. Jones, B. Belaroussi, J. P. Aggleton, M. J. O'Sullivan
2011 Journal of Neuroscience  
Diffusion-weighted MRI tractography was used to reconstruct three candidate fasciculi known to link components of memory networks: the fornix, the parahippocampal cingulum, and the uncinate fasciculus.  ...  The relationships between aging, microstructure, and episodic memory were assessed for each individual tract.  ...  For the uncinate fasciculus, a significant negative correlation between the error ratio in the Paired-Associate Learning task and FA averaged across hemispheres was found (Fig. 5, Table 3 ).  ... 
doi:10.1523/jneurosci.2317-11.2011 pmid:21917806 pmcid:PMC6623273 fatcat:embbxlgptnfw7c76mjnwmxu32y

MR Diffusion Tensor Imaging: A Window into White Matter Integrity of the Working Brain

Sandra Chanraud, Natalie Zahr, Edith V. Sullivan, Adolf Pfefferbaum
2010 Neuropsychology Review  
Here we present an overview of the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and pathological brain function.  ...  The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white matter fiber integrity in health and disease, has served to strengthen Geschwind's proposal.  ...  Acknowledgments All authors were involved in drafting the article or revising it critically, and they read and approved the final version of the manuscript.  ... 
doi:10.1007/s11065-010-9129-7 pmid:20422451 pmcid:PMC2910550 fatcat:pkx5s4lrmngwxliz5vujlptcna

Prefrontal cortex white matter tracts in prodromal Huntington disease

Joy T. Matsui, Jatin G. Vaidya, Demian Wassermann, Regina Eunyoung Kim, Vincent A. Magnotta, Hans J. Johnson, Jane S. Paulsen
2015 Human Brain Mapping  
Within each of these tracts, tensor scalars for fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity coefficients were calculated.  ...  The primary objective of this research was to conduct a large-scale analysis using multisite diffusion-weighted imaging (DWI) tractography data to quantify diffusivity properties along major prefrontal  ...  ACKNOWLEDGMENTS The authors would like to acknowledge Norman Williams, David Welch, Jessica Forbes, Eric Axelson, Jacquie Marietta, Kathryn Jones, and Daniel Langstraat for their assistance in completing  ... 
doi:10.1002/hbm.22835 pmid:26179962 pmcid:PMC4583330 fatcat:tzhr6yfd4nbazcwtd3bd7etv6y
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