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Correction to: miRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease

Xiaoting Liu, Jinhu Chen, Tianyuan Guan, Hui Yao, Wenpei Zhang, Zhenlong Guan, Yanqin Wang
2019 BMC Systems Biology  
AbstractIt was highlighted that the original article [1] contained some typesetting mistakes in the first paragraph of the Background section.  ...  Early identification of PD molecular biomarkers is critical for initiating timely treatment prior to the onset of motor symptoms.  ...  Early identification of PD molecular biomarkers is critical for initiating timely treatment prior to the onset of motor symptoms.  ... 
doi:10.1186/s12918-019-0701-3 pmid:30755197 pmcid:PMC6372997 fatcat:ffctzh3dx5e7pkumr2nug44xqe

Corrective GUSB Transfer to the Canine Mucopolysaccharidosis VII Brain

Aurelie Cubizolle, Nicolas Serratrice, Nadia Skander, Marie-Anne Colle, Sandy Ibanes, Aurelie Gennetier, Neus Bayo-Puxan, Khalil Mazouni, Franck Mennechet, Beatrice Joussemet, Yan Cherel, Yaouen Lajat (+5 others)
2014 Molecular Therapy  
There have been encouraging gene transfer studies in the MPS VII mouse brain, but this is the first study attempting the correction of the >200-fold larger and challenging canine MPS VII brain.  ...  At the cellular level, deficiency in β-glu activity leads to abnormal accumulation of glycosaminoglycans (GAGs), and secondary accumulation of GM2 and GM3 gangliosides, which have been linked to neuroinflammation  ...  Inherited NeuRoMetabolic Diseases Information Network (InNerMeD-I-network) Scarpa M 1 , D'Avanzo F 1 , Barić I 2 , Ceci A 3 , Garcia Cazorla A 4 , i Dali C 5 , Lampe C 6 . on behalf of all InNerMeD partners  ... 
doi:10.1038/mt.2013.283 pmid:24343103 pmcid:PMC3983960 fatcat:6umq3j2d4nh77os77lgutxlyxi

Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer's Disease in Clinical Practice and to Assist Human Clinical Trials [chapter]

Francois Bernier, Pavan Kumar, Yoshiaki Sato, Yoshiya Oda
2015 Alzheimer's Disease - Challenges for the Future  
In conclusion, blood tests or other non-invasive tests as biomarkers for AD are appealing as they could be applied to many uses such as patient screening, disease prognosis, diagnosis and aid to support  ...  This suggested that these signature miRNAs were potentially related to early events in the disease and could be valuable for the early identification of AD/MCI patients for potential stratification in  ... 
doi:10.5772/60008 fatcat:73jpghtjffhzvf33xdiyzfvpki

Elevated Plasma microRNA-105-5p Level in Patients With Idiopathic Parkinson's Disease: A Potential Disease Biomarker

Zhaofei Yang, Tianbai Li, Yanhua Cui, Song Li, Cheng Cheng, Bairong Shen, Weidong Le
2019 Frontiers in Neuroscience  
Parkinson's disease (PD) is the second most common neurodegenerative disease, which still lacks a biomarker to aid in diagnosis and to differentiate diagnosis at the early stage of the disease. microRNAs  ...  Several miRNAs have been proposed as potential biomarkers in several diseases.  ...  , China Parkinson’s disease (PD) is the second most common neurodegenerative disease, which still lacks a biomarker to aid in diagnosis and to differentiate diagnosis at the early stage of the disease.  ... 
doi:10.3389/fnins.2019.00218 pmid:30936821 pmcid:PMC6431626 fatcat:yeixgl5xizbxjmqted6clwzkju

MicroRNA-Seq Data Analysis Pipeline to Identify Blood Biomarkers for Alzheimer's Disease from Public Data

Jun-ichi Satoh, Yoshihiro Kino, Shumpei Niida
2015 Biomarker Insights  
Increasing evidence indicated that various miRNAs, released extracellularly to biological fluids, serve as novel biomarkers for diagnosis and prediction of prognosis of AD, Parkinson's disease (PD), and  ...  Increasing evidence indicates that miRNAs circulating in biological fluids serve as non-invasive biomarkers for diagnosis of AD. 14 Recently, small RNA-Seq has been utilized as a powerful approach to the  ...  The expression profile of 14 miRNAs downregulated in AD blood. By omiRas, we identified the set of 27 miRNAs differentially expressed in blood samples of AD (blue) and NC (red).  ... 
doi:10.4137/bmi.s25132 pmid:25922570 pmcid:PMC4401249 fatcat:xmbfncask5euza4hpvbqlwswq4

A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson's patients is associated with the early stage onset of disease

Soudabeh Fazeli, Majid Motovali-Bashi, Maryam Peymani, Motahare-Sadat Hashemi, Masoud Etemadifar, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi, Hiroyoshi Ariga
2020 PLoS ONE  
The aim of this study was to assess whether SRRM2 and miR-27a/b-3p could act as early diagnostic biomarkers for PD.  ...  Blood-based biomarkers, which are minimally invasive, potentially used for diagnosis of PD, including miRNAs.  ...  MicroRNAs and target genes as biomarkers for the diagnosis of early onset of parkinson disease.  ... 
doi:10.1371/journal.pone.0240855 pmid:33171483 fatcat:ujssaxplenaovbnqgqbc6ghzpy

MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease

Yimeng Chen, Chao Gao, Qian Sun, Hong Pan, Pei Huang, Jianqing Ding, Shengdi Chen
2017 Frontiers in Aging Neuroscience  
However, there is a lack of effective biomarkers for early diagnosis, and the mechanisms of PD pathogenesis remain obscure. microRNAs (miRNAs) are post-transcriptional gene regulators and can be easily  ...  Here, we aimed to explore a peripheral biomarker, which not only can be applied for early diagnosis of PD but also has the potential to be a therapeutic target.  ...  It is highly imperative to explore biomarkers that allow for accurate diagnosis at the early stage of PD.  ... 
doi:10.3389/fnagi.2017.00232 pmid:28785216 pmcid:PMC5519626 fatcat:6div6u2oavfgpdn5kd7777aki4

Emerging Biomarkers in Vascular Cognitive Impairment and Dementia: From Pathophysiological Pathways to Clinical Application

Virginia Cipollini, Fernanda Troili, Franco Giubilei
2019 International Journal of Molecular Sciences  
of biomarkers to use for differential diagnosis among types of dementia.  ...  Firstly, we will discuss the role of endothelial dysfunction, blood-brain barrier disruption and neuroinflammation in its pathogenesis.  ...  In this exploratory study, deregulated miRNAs in seem to be associated with target genes related to AD pathology, suggesting that miRNAs are interesting candidates for AD biomarkers in the future.  ... 
doi:10.3390/ijms20112812 fatcat:3qvxvwapdrfvtiaysbtusqwopu

MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure

Costa Chiara, Teodoro Michele, Carmela Alessandra Rugolo, Alibrando Carmela, Giambò Federica, Briguglio Giusi, Fenga Concettina
2020 Toxicology Reports  
However, the application of miRNAs as diagnostic and therapeutic biomarkers in the clinical field is extremely challenging.  ...  The evaluation of miRNA expression levels may be used to develop new non-invasive strategies for the prediction and prognosis of many diseases, including cancer.  ...  as early biomarkers for the diagnosis of this pathology.  ... 
doi:10.1016/j.toxrep.2020.05.003 pmid:32612936 pmcid:PMC7322123 fatcat:eucmojt2bnd3limdanwkyvdori

MicroRNAs, Parkinson's Disease, and Diabetes Mellitus

Hsiuying Wang
2021 International Journal of Molecular Sciences  
Therefore, exploring the common miRNA biomarkers of both PD and DM can shed a light on how these two diseases are correlated, and targeting miRNAs is a potential therapeutic opportunity for both diseases  ...  They are also involved in the pathology of many diseases. miRNAs can mediate the insulin pathway and glucose absorption. miRNAs can also regulate PD-related genes.  ...  The tripartite regulatory network identified miR-18a,-92a,-200a,-200c,-17, and -20a as hub miRNAs that can be considered as possible biomarkers for PD [44] . miR-92a may serve to correct diabetes-associated  ... 
doi:10.3390/ijms22062953 pmid:33799467 pmcid:PMC8001823 fatcat:zyvsdytrkjhwtcbdbnceizscny

Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs Associated With Alzheimer's Disease Using Post-mortem Brain Tissue Samples

Qingqin S. Li, Diana Cai
2021 Frontiers in Neuroscience  
Our results support the finding of dysregulated miRNAs previously implicated in AD and propose additional miRNAs that appear to be dysregulated in AD for experimental follow-up.  ...  Alzheimer's disease (AD), the leading form of dementia, is associated with abnormal tau and β-amyloid accumulation in the brain.  ...  More experiments are needed to shed light on the role of miR-4446-3p. miRNAs seems to be promising biomarkers for early detection of disease, risk assessment, and prognosis especially if detected in non-invasive  ... 
doi:10.3389/fnins.2021.620899 pmid:33833661 pmcid:PMC8021900 fatcat:2sahmzrbmbevrfjnorlmb6wmza

The biomarker potential of cell-free microRNA from cerebrospinal fluid in Parkinsonian Syndromes

Charlotte Starhof, Anne-Mette Hejl, Niels H.H. Heegaard, Anting L. Carlsen, Mark Burton, Berit Lilje, Kristian Winge
2018 Movement Disorders  
MicroRNAs are small noncoding RNAs involved in the post-transcriptional regulation of protein synthesis. Extracellular microRNAs are accessible in a stable form in biofluids.  ...  We thank the team at Statens Serum Institute for advice and guidance and especially Ewa Kogutowska for valuable assistance with laboratory analysis of α-synuclein. Authors' roles:  ...  Acknowledgements Foremost, the authors would like to thank all participating patients.  ... 
doi:10.1002/mds.27542 pmid:30557454 fatcat:yfylalh6cjdzrj5uphfpuuvqoy

An Overview of Next Generation Sequencing and its Application in Neurodegenerative Diseases

Kritika Sehgal, Stuti Agarwal, Avantika Mishra, Aarushi Tandon, Chakresh Kumar Jain
2017 International Journal of Engineering Research and  
With the advent of NGS, it has been possible to sequence and study genomes at a much faster rate and in a much shorter span of time.  ...  Neurodegenerative diseases are least curative in nature when compared to others and the only measures that can be taken are at the onset stages which are easy to treat.  ...  MiRNA detection in blood has been seen as advantageous for early diagnosis; however differential miRNA expression may not accurately represent deregulation in neuronal tissues related to neurodegenerative  ... 
doi:10.17577/ijertv6is020059 fatcat:fa4uqzuwh5g75pkd6gxrpkzpja

Plasma-based circulating MicroRNA biomarkers for Parkinson's disease

Sok Kean Khoo, David Petillo, Un Jung Kang, James H Resau, Brian Berryhill, Jan Linder, Lars Forsgren, Leslie A Neuman, Aik Choon Tan
2012 Journal of Parkinson's Disease  
The current "gold-standard" for Parkinson's disease (PD) diagnosis is based primarily on subjective clinical rating scales related with motor features.  ...  This proof-of-concept study demonstrates the feasibility of using plasma-based circulating miRNAs as biomarkers for neurodegenerative disorders such as PD and shows the challenges of molecular biomarker  ...  In contrast, blood is an ideal source for biomarkers due to its propensity to contain biological and chemical signals from relevant sources such as cells associated with a disease [7] .  ... 
doi:10.3233/jpd-012144 pmid:23938262 fatcat:wier4ioi3faonc7nyhbqjvgnhe

Deep sncRNA-seq of the PPMI cohort to study Parkinson's disease progression [article]

Fabian Kern, Tobias Fehlmann, Ivo Violich, Eric Alsop, Elizabeth Hutchins, Mustafa Kahraman, Nadja Liddy Grammes, Pedro Guimaraes, Christina Backes, Kathleen Poston, Bradford Casey, Rudi Balling (+9 others)
2020 biorxiv/medrxiv   pre-print
First, we sequenced sncRNAs in 5,450 blood samples of 1,614 individuals in PPMI. The majority of 323 billion reads (59 million reads per sample) mapped to miRNAs.  ...  De-regulated miRNAs were associated with the disease and disease progression and occur in two distinct waves in the third and seventh decade of live.  ...  We highly appreciate the encouragement and support of Karoly Nikolich in setting up and performing the study.  ... 
doi:10.1101/2020.06.01.127092 fatcat:ykt66kdjszhahgavkqw3inu2a4
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