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Systematic review of outcome measures following chemoradiotherapy for the treatment of anal cancer (CORMAC)

R. Fish, C. Sanders, N. Ryan, S. Van der Veer, A. G. Renehan, P. R. Williamson
2018 Colorectal Disease  
Acknowledgements We thank the members of the CORMAC study advisory group: Richard Adams, Julie Brewer, Jill DeNardo, Rohit Kochhar, Mark Saunders and David Sebag-Montefiore.  ...  The standardized outcome term and domain assigned to each verbatim outcome were reviewed and agreed at a meeting of the CORMAC Study Advisory Group (SAG), composed of experts in the field of anal cancer  ... 
doi:10.1111/codi.14103 pmid:29566456 pmcid:PMC5969105 fatcat:rv3eavnzxnbzlk2gecqlph3s4a

Advances in Interventional Radiology in the Treatment of Primary and Metastatic Liver Cancer

Cormac Farrelly, Mark Ryan
2007 European Oncology & Haematology  
30-day mortality rate of 2.4%. 25 It is thought that the soft Advances in Interventional Radiology in the Treatment of Primary and Metastatic Liver Cancer © T O U C H B R I E F I N G S 2 0 0 7 Cormac  ... 
doi:10.17925/eoh.2007.0.2.68 fatcat:cphavzqmqndptgurleqv355ptm

Sitting patterns at work: objective measurement of adherence to current recommendations

Cormac G. Ryan, Philippa M. Dall, Malcolm H. Granat, P. Margaret Grant
2011 Ergonomics  
The data for this article was collected by; Sebastien Chastin, Elaine Coulter, Philippa Dall, Margaret Grant, Gillian MacLellan, and Cormac Ryan.  ... 
doi:10.1080/00140139.2011.570458 fatcat:ucx7sw7bkvaklcofcm2xml4foe

Trends in the Level of Evidence in Clinical Hand Surgery Research

Conor M. Sugrue, Cormac W. Joyce, Ryan M. Sugrue, Sean M. Carroll
2016 Hand  
The application of evidence-based medicine (EBM) to the practice of hand surgery has been limited. Production of high-quality research is an integral component of EBM. With considerable improvements in the quality evidence in both orthopedic and plastic and reconstructive surgery, it is imperative that hand surgery research emulates this trend. Methods: A systematic review was performed on all hand surgery articles published in 6 journals over a 20year period. The level of evidence of each
more » ... le was determined using the Oxford level of evidence. The quality of methodology of randomized controlled trials (RCTs) was assessed using Jadad scale. Statistical analysis involved chi-squares and Student t test (P < .05). Results: A total of 972 original hand surgery research articles were reviewed. There was a significant increase in the average level of evidence of articles published between1993 and 2013. High-quality evidence only accounted for 11.2% of evidence published, with a significant increase over the study period (P = 0.001). Quantitative evaluation of the 26 published RCTs, using Jadad scale, revealed a progressive improvement in study design from 0.3 in 1993 to 3.33 in 2013. Conclusions: Hand surgery research has mirrored trends seen in other surgical specialties, with a significant increase in quality of evidence over time. Yet, high-quality evidence still remains infrequent.
doi:10.1177/1558944715627619 pmid:27390565 pmcid:PMC4920534 fatcat:bt6yzwqqkbf67c576xunafeq44

Left/right limb judgement task performance following total knee replacement

Crystal A. Rosser, T. David Punt, Cormac G. Ryan
2018 Journal of Back and Musculoskeletal Rehabilitation  
doi:10.3233/bmr-171104 pmid:30149438 fatcat:jli3oquyrbgrznvokbqdq6v6zm

Tactile acuity training for patients with chronic low back pain: a pilot randomised controlled trial

Cormac Ryan, Nicholas Harland, Benjamin T Drew, Denis Martin
2014 BMC Musculoskeletal Disorders  
The transcripts were read and reread a number of times by one of the research team (Ryan) and emergent themes identified using thematic analysis.  ...  Randomisation & blinding Randomisation was performed by a member of the research team (Ryan) using a computerised random number generator and participants were assigned to either group using pre prepared  ... 
doi:10.1186/1471-2474-15-59 pmid:24571855 pmcid:PMC3942257 fatcat:o4kzebjicfgrfh26njynp7exb4

The role of pain in pulmonary rehabilitation: a qualitative study

Samantha Harrison, Annemarie Lee, Helene Button, Rebecca Shea, Roger Goldstein, Dina Brooks, Cormac Ryan, Denis Martin
2017 International Journal of COPD  
doi:10.2147/copd.s145442 pmid:29184398 pmcid:PMC5685149 fatcat:v2bny3bubzgwzninhrq65acbu4

The Value of Pain Coping Constructs in Subcategorising Back Pain Patients according to Risk of Poor Outcome

Nicholas Harland, Cormac Gerard Ryan
2013 BioMed Research International  
Background.Subcategorising patients with chronic low back pain (CLBP) could improve patient outcomes and facilitate prioritisation of treatment resources.Objective.This study aimed to develop a subcategorising method for individuals with CLBP using the Coping Strategies Questionnaire 24 (CSQ24) and to investigate the methods potential validity.Methods.196 patients were recruited from a physiotherapy outpatients department. All participants completed a battery of questionnaires before and after
more » ... reatment including the CSQ24 and a measure of pain, disability, and mood. At discharge participants also completed a global subjective outcomes scale consisting of a 6-point Likert scale. All participants received usual physiotherapy.Results.Cut-off values for the CSQ24 were calculated using triangulation of the findings from three different statistical methods. Cut-off values were identified for the Catastrophising and Cognitive Coping subscales of the CSQ24. Participants were categorised into low, medium, and high risk of a poor outcome. The cut-off values for these were ≥21 on Cognitive Coping and ≤9 on Catastrophising for low risk and ≤15 on Cognitive Coping for high risk, with all other patients being classified as being at moderate risk.Conclusion.Further validation is required before this approach can be recommended for clinical practice.
doi:10.1155/2013/898573 pmid:24260746 pmcid:PMC3821903 fatcat:wjzl6bd2arcaxbywxeo7xzunp4

The translation, validity and reliability of the German version of the Fremantle Back Awareness Questionnaire

Katja Ehrenbrusthoff, Cormac G. Ryan, Christian Grüneberg, Benedict M. Wand, Denis J. Martin, Roger Hilfiker
2018 PLoS ONE  
The Fremantle Back Awareness Questionnaire (FreBAQ) claims to assess disrupted selfperception of the back. The aim of this study was to develop a German version of the Fre-BAQ (FreBAQ-G) and assess its test-retest reliability, its known-groups validity and its convergent validity with another purported measure of back perception. Methods The FreBaQ-G was translated following international guidelines for the transcultural adaptation of questionnaires. Thirty-five patients with non-specific CLBP
more » ... nd 48 healthy participants were recruited. Assessor one administered the FreBAQ-G to each patient with CLBP on two separate days to quantify intra-observer reliability. Assessor two administered the FreBaQ-G to each patient on day 1. The scores were compared to those obtained by assessor one on day 1 to assess inter-observer reliability. Known-groups validity was quantified by comparing the FreBAQ-G score between patients and healthy controls. To assess convergent validity, patient's FreBAQ-G scores were correlated to their two-point discrimination (TPD) scores. Results Intra-and Inter-observer reliability were both moderate with ICC 3.1 = 0.88 (95%CI: 0.77 to 0.94) and 0.89 (95%CI: 0.79 to 0.94), respectively. Intra-and inter-observer limits of agreement (LoA) were 6.2 (95%CI: 5.0-8.1) and 6.0 (4.8-7.8), respectively. The adjusted mean difference between patients and controls was 5.4 (95%CI: 3.0 to 7.8, p<0.01). Patient's FreBAQ-G scores were not associated with TPD thresholds (Pearson's r = -0.05, p = 0.79).
doi:10.1371/journal.pone.0205244 fatcat:s5gny4ia6ba2pimdf3x6vwhvi4

Do medical student attitudes towards patients with chronic low back pain improve during training? a cross-sectional study

Hayley Morris, Cormac Ryan, Douglas Lauchlan, Max Field
2012 BMC Medical Education  
2012) Do medical student attitudes towards patients with chronic low back pain improve during training?: a cross-sectional study. BMC Medical Education, 12 Abstract Background: Health care professionals with positive attitudes towards the functional abilities of patients with low back pain are more likely to encourage activity and avoidance of rest as per recommended guidelines. This study investigated whether medical student training fosters positive attitudes towards patients with back pain
more » ... d their ability to function. Methods: First (n = 202) and final (n = 146) year medical students at the University of Glasgow completed the Health Care Professionals' Pain and Impairment Relationship Scale (HC-PAIRS) questionnaire. This measures attitudes of clinicians towards the functional ability of patients with back pain. A group of first (n = 62) and final year (n = 61) business students acted as non-health care controls. Attitudes were compared using two-way ANOVA with year of study and discipline of degree as independent variables. Results: Both year of study [F(1,465) = 39.5, p < 0.01] and discipline of degree [F(1,465) = 43.6, p < 0.01] had significant effects on total HC-PAIRS scores and there was a significant interaction effect [F(1,465) = 9.5, p < 0.01]. Medical students commenced their course with more positive attitudes than non-health care students (65.7 vs. 69.2 respectively; p < 0.01) -lower scores translating into more positive attitudes. In their final year, the difference between the two student groups had widened (56.4 vs. 65.3; p < 0.01). Conclusions: Undergraduate medical training promotes positive attitudes towards the functional ability of patients with back pain, suggesting that students may be more likely to develop an evidence-based approach to this patient group after qualification. Some adjustments to training may be warranted to encourage a more positive shift in attitudes.
doi:10.1186/1472-6920-12-10 pmid:22429317 pmcid:PMC3359250 fatcat:ydefe3mzmjg7xdk6oejtb5lzcm

Point-of-Choice Prompts to Reduce Sitting Time at Work

Rhian E. Evans, Henrietta O. Fawole, Stephanie A. Sheriff, Philippa M. Dall, P. Margaret Grant, Cormac G. Ryan
2012 American Journal of Preventive Medicine  
Prolonged sitting is prevalent in the workplace and is associated with adverse health markers. Purpose: Investigate the effects of point-of-choice (PoC) prompting software, on the computer used at work (PC), to reduce long uninterrupted sedentary periods and total sedentary time at work. Design: Assessor-blinded, parallel group, active-controlled randomized trial. Setting/participants: A convenience sample of offıce workers from Glasgow, United Kingdom. Intervention: The education group (nϭ14)
more » ... eceived a brief education session on the importance of reducing long sitting periods at work. The PoC group (nϭ14) received the same education along with prompting software on their PC for 5 workdays, which reminded them to stand up every 30 minutes. Main outcome measures: Sitting time was measured objectively using the activPAL™ activity monitor for 5 workdays at baseline and 5 workdays during the intervention. The number and time spent sitting in events Ͼ30 minutes' duration were the main outcome measures. Results: At baseline, participants spent 5.7Ϯ1.0 hours/day (76%Ϯ9%) of their time at work sitting. Of that time, 3.3Ϯ1.3 hours/day was spent sitting in 3.7Ϯ1.4 events Ͼ30 minutes. There was a signifıcant difference between the groups in the change (intervention to baseline) of both the number (ANCOVA; Ϫ6.8%, pϭ0.014) and duration (Ϫ15.5%, pϭ0.007) of sitting events Ͼ30 minutes. During the intervention, compared with baseline, the PoC group reduced the number (paired t-test; Ϫ0.11 events/hour, pϭ0.045) and duration (Ϫ12.2%, pϭ0.035) of sitting events Ͼ30 minutes. However, there was no signifıcant difference in total sitting time between groups (Ϫ4.4%, pϭ0.084). Conclusions: Point-of-choice prompting software on work computers recommending taking a break from sitting plus education is superior to education alone in reducing long uninterrupted sedentary periods at work. Trial registration: This trial was registered at NCT01628861. (Am J Prev Med 2012;43(3):293-297)
doi:10.1016/j.amepre.2012.05.010 pmid:22898122 fatcat:txxkynp2xjbulkhuodxsjtruom

Pain neurophysiology education for the management of individuals with chronic low back pain: A systematic review and meta-analysis

Clare Louise Clarke, Cormac Gerard Ryan, Denis J. Martin
2011 Manual Therapy  
doi:10.1016/j.math.2011.05.003 pmid:21705261 fatcat:gbooeqgstzfcfhcpktbp4vc7em

Effect of education on non-specific neck and low back pain: A meta-analysis of randomized controlled trials

John Hurley, Mary O'Keeffe, Peter O'Sullivan, Cormac Ryan, Karen McCreesh, Kieran O'Sullivan
2016 Manual Therapy  
doi:10.1016/j.math.2016.02.009 pmid:27026111 fatcat:3edrzgrbxbgnldna2bj3i2l7mq

My Foot? Motor Imagery-Evoked Pain, Alternative Strategies and Implications for Laterality Recognition Tasks

Rick King, Mark I Johnson, Cormac G Ryan, Victoria Robinson, Denis J Martin, T David Punt
2015 Pain medicine (Malden, Mass.)  
Rick King 1 , Mark I Johnson 2 , Cormac G Ryan 3 , Victoria Robinson 1 , Denis J Martin 3 and T David Punt 4  ... 
doi:10.1111/pme.12646 pmid:25580587 fatcat:hjz47k4ozzf3dnbjjerwgeqayq

A qualitative exploration of people's experiences of pain neurophysiological education for chronic pain: The importance of relevance for the individual

Victoria Robinson, Richard King, Cormac G. Ryan, Denis J. Martin
2016 Manual Therapy  
are consistent with of the findings in the quantitative literature that PNE imparts a positive change in pain cognitions, attitudes, behaviour and physical performance (Moseley, 2003a (Moseley, , 2004 Ryan  ... 
doi:10.1016/j.math.2015.10.001 pmid:26511524 fatcat:5d4dnmmm3vc4rjbhvcujgjawyq
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