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Experiments in spoken document retrieval using phoneme n-grams

Corinna Ng, Ross Wilkinson, Justin Zobel
2000 Speech Communication  
Previous experiments by Wechsler [23, 24] , Ng and Zue [12, 13, 14] and Smeaton et al.  ...  Experiments by Wechsler [23] and Ng [12] using dynamic programming techniques have shown that the confusion matrix approach can be effective.  ... 
doi:10.1016/s0167-6393(00)00024-8 fatcat:2nczktoeuzfinijo7qeihgq6i4

The RMIT/CSIRO Ad Hoc, Q&A, Web, Interactive, and Speech Experiments at TREC 8

Michael Fuller, Marcin Kaszkiel, Sam Kimberley, Corinna Ng, Ross Wilkinson, Mingfang Wu, Justin Zobel
1999 Text Retrieval Conference  
Approximate matching methods like W echsler 14 and Ng 8 are similar to this technique but di erent because recognition information like confusion matrices are required to determine the approximate matches  ... 
dblp:conf/trec/FullerKKNWWZ99 fatcat:mo2neerv7zgcffyimr5qn3smrq

Speech retrieval using phonemes with error correction

Corinna Ng, Justin Zobel
1998 Proceedings of the 21st annual international ACM SIGIR conference on Research and development in information retrieval - SIGIR '98  
In speech retrieval, text queries are matched to spoken-word recordings. We undertook a series of retrieval experiments on such speech documents, using both phonemes and words for matching text to speech. We found that, given a reliable automatic word-based process for speech recognition, phoneme-based retrieval can be as effective as word-based retrieval. However, retrieval is v.!orse with phoneme-based speech recognition. Error correction techniques, such as manual error correction of phoneme
more » ... sequences and use of a standard string edit distance, did not improve the effectiveness of phoneme-based retrieval.
doi:10.1145/290941.291055 dblp:conf/sigir/NgZ98 fatcat:hmid5wlycjcnpjmgprv26umh5y

Cognitive Health Assessment and Establishment of a Virtual Cohort of Dementia Caregivers

Corinna Lathan, Angela S. Wallace, Rita Shewbridge, Nicole Ng, Glenn Morrison, Helaine E. Resnick
2016 Dementia and Geriatric Cognitive Disorders Extra  
Many factors impact caregivers' cognitive health and, by extension, their ability to provide care. This study examined the relationship between psychosocial factors and cognitive performance among dementia caregivers and established a virtual cohort of caregivers for future research. Data on 527 caregivers were collected via a Web-based survey that assessed cognitive performance. Caregiver data were compared to corresponding data from 527 age-, race-, gender-, and education-matched controls
more » ... a normative database. Caregiver self-reported sleep, stress, health, and social support were also assessed. Caregivers performed significantly worse than controls on 3 of 5 cognitive subtests. Stress, sleep, perceived support, self-rated health, years of caregiving, race, and gender were significant predictors of cognitive performance. In this sample of dementia caregivers, psychosocial factors interacted in complex ways to impact cognitive performance. Further investigation is needed to better understand how these factors affect cognitive performance among caregivers. This could be accomplished by the establishment of a virtual cohort that facilitates the development of digital tools to support the evaluation and management of caregiver needs in a manner that helps them remain effective in their caregiving roles.
doi:10.1159/000444390 pmid:27099613 pmcid:PMC4836114 fatcat:l3qwiyoq55gmdb76xc2nlek42m

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

Stefanie Sieste, Thomas Mack, Christopher V. Synatschke, Corinna Schilling, Christopher Meyer zu Reckendorf, Laura Pendi, Sean Harvey, Francesco S. Ruggeri, Tuomas P. J. Knowles, Christoph Meier, David Y. W. Ng, Tanja Weil (+1 others)
2018 Advanced Healthcare Materials  
Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. We demonstrate the peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing
more » ... alities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion.
doi:10.1002/adhm.201701485 pmid:29635761 fatcat:lm2jpr72tvavzlv6dbavfuuq6y

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Hao Zhu, Samar Shah, Ng Shyh-Chang, Gen Shinoda, William S Einhorn, Srinivas R Viswanathan, Ayumu Takeuchi, Corinna Grasemann, John L Rinn, Mary F Lopez, Joel N Hirschhorn, Mark R Palmert (+1 others)
2010 Nature Genetics  
doi:10.1038/ng.593 pmid:20512147 pmcid:PMC3069638 fatcat:bfqa6itvvvcf3obgahtlz62nw4

Association of single nucleotide polymorphisms of cytochrome P450 enzymes with experience of vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients: a systematic review

Carmen W. H. Chan, Bernard M. H. Law, Marques S. N. Ng, Corinna C. Y. Wong, Carissa W. Y. Wong, Morgan Quinley, Jessica M. Orgusyan, Ka Ming Chow, Mary M. Y. Waye
2021 BMC Cancer  
Background Adjuvant endocrine therapies are known to induce undesirable adverse effects such as vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients. Drugs used in these therapies are often metabolised by cytochrome P450 (CYP) enzymes, in which their metabolising activities can be modified by single nucleotide polymorphisms (SNP) in CYP genes and CYP genotypes. This review aims to explore whether SNPs or genotypes of CYP are associated with the occurrence, frequency and
more » ... everity of vasomotor, vaginal and musculoskeletal symptoms in breast cancer patients on adjuvant endocrine therapies. Methods A literature review was conducted using five electronic databases, resulting in the inclusion of 14 eligible studies, and their findings were presented narratively. Selected items from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist were used for critical appraisal of the reporting quality of the included studies. Results Most of the included studies showed that SNPs or genotypes of CYP that modify its metabolising activity have no effect on the occurrence, frequency or severity of vasomotor symptoms, including hot flashes. One study showed no correlation of these genetic variations in CYP with musculoskeletal symptoms, and no data were available on the association between such genetic variations and vaginal symptoms. Conclusions Overall, genetic variations in CYP have no effect on the experience of hot flashes among breast cancer patients. We recommend exploration of the link between the active metabolites of chemotherapeutic drugs and the molecules shown to affect the occurrence or severity of hot flashes, and the establishment of the relationship between such genetic variations and patients' experience of musculoskeletal and vaginal symptoms. Subgroup analyses based on patients' duration of adjuvant endocrine therapies in such studies are recommended.
doi:10.1186/s12885-021-08268-8 pmid:34006247 fatcat:zvn2i7sedrcolexfxh5pvybeka

UV-triggered Affinity Capture Identifies Interactions between thePlasmodium falciparumMultidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

Ralf Brunner, Caroline L. Ng, Hamed Aissaoui, Myles H. Akabas, Christoph Boss, Reto Brun, Paul S. Callaghan, Olivier Corminboeuf, David A. Fidock, Ithiel J. Frame, Bibia Heidmann, Amélie Le Bihan (+11 others)
2013 Journal of Biological Chemistry  
We have previously identified potent novel antimalarial compounds with an unknown mode of action. Results: A photo-reactive affinity capture method was used to identify parasite proteins that interact with these antimalarials. Conclusion: ACT-213615 interacts with Plasmodium falciparum multidrug resistance protein 1 (PfMDR1). Significance: This photo-reactive affinity capture method can be generally used to identify drug targets in live cells. A representative of a new class of potent
more » ... als with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reactive affinity capture method to find parasite proteins specifically interacting with the capture compound in living parasitized cells. The capture reagent retained the antimalarial properties of the parent molecule (ACT-213615) and accumulated within parasites. We identified several proteins interacting with the capture compound and established a functional interaction between ACT-213615 and PfMDR1. We surmise that PfMDR1 may play a role in the antimalarial activity of the piperazine-containing compound ACT-213615. Recently, we reported the synthesis of a new chemical class of antimalarials, discovered in a cell-based anti-proliferative screen (1). ACT-213615, a representative of this class of compounds, was shown to inhibit erythrocytic Plasmodium falciparum growth in vitro with IC 50 values in the low single digit nanomolar range. In vivo, the compound exhibited activity comparable with that of the reference drug chloroquine in the P. falciparum SCID mouse model. Furthermore, ACT-213615 Downloaded from 2 The abbreviations used are: Pf MDR, P. falciparum multidrug resistance protein; ENT, equilibrative nucleoside transporter; AzBCQ, azido-biotin-chloroquine; BisTris, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol.
doi:10.1074/jbc.m113.453159 pmid:23754276 pmcid:PMC3829344 fatcat:fqxyw6pnardajomtbldjr5vyra

Factors affecting speech retrieval

Corinna Ng, Ross Wilkinson, Justin Zobel
1998 5th International Conference on Spoken Language Processing (ICSLP 1998)   unpublished
Collections of speech documents can be searched using speech retrieval, in which the documents are processed by a speech recogniser to give text that can be searched by standard text retrieval techniques. Recognition is the translation of speech signals into either words or subword units such as phonemes. We investigated the use of a phoneme-based recogniser to obtain phoneme sequences. We found that phoneme recognition is worse than word recognition, because of lack of context and di culty in
more » ... honeme boundary detection. Comparing the transcriptions of two di erent phonemebased recogniser, we found that the e ects of training using well-de ned phoneme data, the lack of a language model, and lack of a context-dependent model a ected recognition performance. Retrieval was based on n-grams. We found that trigrams performed better than quadgrams because the longer n-gram features contained too many transcription errors. Comparing the phonetic transcriptions from a word recogniser to transcriptions from a phoneme recogniser, we found that using 61 phones modelled with an algorithmic approach were better than using 40 phones modelled with a dictionary approach.
doi:10.21437/icslp.1998-836 fatcat:7uphdod2vnhnbgwdwqni2fdwzy

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

Neelie Zacharias, Summer Park, Bing Zheng, Kelly M. Loyet, Min Xu, Katherine Ruth Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, J. Hiroshi Morisaki, Keyang Xu, Amrita Kamath (+29 others)
2022 Chemical Science  
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD)...
doi:10.1039/d1sc05243h pmid:35414872 pmcid:PMC8926172 fatcat:cvz5bzaptjhd5i6rjxijwpgdq4

Page 353 of The Weekly Entertainer, and West of England Miscellany Vol. 55, Issue [page]

1815 The Weekly Entertainer, and West of England Miscellany  
place he lodyed the maid with an aged $ sleep Darn well Gy x Celleny id it Wa 1e fal xX, ty Tow er Wa warks ) paits cult a ‘atory Jeayis; Who that Spot raries atels, , ad Can hiyet € Oi ited, anid Tse, ng  ...  Corinna had nota thonght but she gave it to thie breast of Myrtis, and M yrtis existed ouls in the presence of Corinna, In thegiove, on the shores of the foaming Euripas, in the baths, in the schools of  ... 

Page 43 of New McClure's Magazine Vol. 51A, Issue 8 [page]

1919 New McClure's Magazine  
or se er Zo ng McCLURE’S for AUGUST in front of a florist’s window. | Some roses in the display, delicate, gracious blossoms made him think of Corinna.  ...  For Corinna was — well, she was Corinna. In that moment he undoubtedly loved her the more because of her faults. “Oh, Corinna,” he said again.  ... 

Page 17 of New McClure's Magazine Vol. 50, Issue 14 [page]

1918 New McClure's Magazine  
Ise. hen ing in ver ‘by wht yur ad ng he he d, or McCLURE’S for DECEMBER NDY BENSON was in love with Corinna. At least, at times, Corinna was sure that he was.  ...  he said irrele- nice now and They seemed dimming gilt of so that Corinna mightn't “Sonie day vantly. Corinna turned startled dark eves. “Oh, no! You must never do that, Andy!” “Why not?”  ... 

Page 16 of New McClure's Magazine Vol. 51A, Issue 3 [page]

1919 New McClure's Magazine  
It might, on occasion. he Die ( ng a sig w lack of insight he often showed as to herself. expedient, proper . , Vi Chis last reflection made Corinna smile softly as she Meanwhile the party of the second  ...  and Corinna had a curious, own.  ... 

Page 287 of American Journal of Philology Vol. 77, Issue 3 [page]

1956 American Journal of Philology  
eXe uit vY- as the ng. eS- ude ries ng. art sed NOTES ON CORINNA. 287 362, and of ré ce weppixacr AcdvP ws pyxades aiyes, A 383; or to maternal instincts as in dies . . . éornKaow dpeAyopevat . . . alnxés  ... 
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