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Whole-body PET parametric imaging employing direct 4D nested reconstruction and a generalized non-linear Patlak model
2014
Medical Imaging 2014: Physics of Medical Imaging
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Recently, we proposed a multi-bed dynamic acquisition framework enabling clinically feasible whole-body parametric PET imaging by employing post-reconstruction parameter estimation. ...
We have developed a novel whole-body PET parametric reconstruction framework in the STIR platform, a widely employed open-source reconstruction toolkit, a) enabling accelerated convergence of direct 4D ...
Charalampos Tsoumpas for the guidance they provided regarding the usage of the basic STIR package. This work was in part supported by the NIH grant 1S10RR023623. ...
doi:10.1117/12.2043918
fatcat:66kzytc6tfffzetylbawup7p6y
Validation of a Fast Block-Iterative Spatio-temporal Reconstruction Algorithm for Small Animal Dynamic PET Data
2014
Advanced Biomedical Engineering
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Spatio-temporal reconstruction methods for positron emission tomography estimate the tissue timeactivity curves that are required for functional imaging. ...
A parametric image of regional glucose metabolism reconstructed from the proposed method was almost identical to those obtained from conventional reconstruction algorithms. ...
From the reconstructed tTACs, we produced parametric images by means of the Patlak graphic plot analysisz1|that generates parametric images of 18 F-FDGinflux values Ki. ...
doi:10.14326/abe.3.7
fatcat:bvkmfnyhwraj3h2kg4z4owucay
Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation–maximization reconstruction
2016
Physics in Medicine and Biology
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In the present study, we implemented, within the open-source software for tomographic image reconstruction platform, a clinically adoptable 4D WB reconstruction framework enabling efficient estimation ...
Post-reconstruction standard Patlak (sPatlak) WB graphical analysis utilizes multi-bed multi-pass PET acquisition to produce quantitative WB images of the tracer influx rate K i as a complimentary metric ...
Acknowledgments The authors would like to thank Drs Kris Thielemans and Charalampos Tsoumpas for their feedback regarding the software versioning and control procedures to facilitate integration of our ...
doi:10.1088/0031-9155/61/15/5456
pmid:27383991
pmcid:PMC5884686
fatcat:xd42t4yxbfdepcixkmjw4qd4fe
Quantitative PET image reconstruction employing nested expectation-maximization deconvolution for motion compensation
2017
Computerized Medical Imaging and Graphics
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In addition, metabolic uptake rate K i parametric images were generated with the standard Patlak method. ...
Subsequently, we replaced the integrated model component with a nested iterative Richardson-Lucy (RL) imagebased deconvolution method to accelerate the MLEM algorithm convergence rate (RL-3D-MCIR). ...
The proof for those solutions has been previously discussed in MLEM applications of the optimization transfer theory and in analogous work for nested PSF-3D-MLEM algorithms [29] , [30] . ...
doi:10.1016/j.compmedimag.2016.11.006
pmid:27887989
fatcat:toa7hafrwnbsffx62yzhyp3fzu
Direct 4D parametric imaging for linearized models of reversibly binding PET tracers using generalized AB-EM reconstruction
2012
Physics in Medicine and Biology
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As such, the focus of this work has been to develop a novel direct 4D parametric image reconstruction scheme for such tracers. ...
As validation, the means of parameters estimated from 55 human 11 C-raclopride dynamic PET studies were 0031-9155/12/030733+23$33.00 ...
The authors also wish to thank Andrew Crabb for computational support, and Hiroto Kuwabara and Anil Kumar for help with delineation of ROIs in patient study. ...
doi:10.1088/0031-9155/57/3/733
pmid:22252120
pmcid:PMC3434225
fatcat:npyf4fqc5rcbji4ctb2vfvbshu
Evaluation of a direct 4D reconstruction method using generalised linear least squares for estimating nonlinear micro-parametric maps
2014
Annals of Nuclear Medicine
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Methods In this work we employed a recently proposed direct parametric image reconstruction algorithm to estimate the parametric maps of all micro-parameters of a two-tissue compartment model, used to ...
Conclusions The proposed direct parametric reconstruction algorithm is a promising approach towards the estimation of all individual microparameters of any compartment model. ...
The optimal number of internal iterations depends on two factors: (a) the initial estimate for the weights and (b) the level of noise in the TAC to be fitted. ...
doi:10.1007/s12149-014-0881-2
pmid:25073760
fatcat:nkz5m6ycqncqzjogsz3ok6rkdq
Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET
2015
Physics in Medicine and Biology
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Validation on patient datasets demonstrated clinical feasibility for all Patlak methods, while TBR and CNR evaluations confirmed our simulation findings, and suggested presence of non-negligible k loss ...
Institute of Physics and Engineering in Medicine for gPatlak. Bias of sPatlak was found to be 16-18% and 20-40% poorer than gPatlak for ROIs A and B, respectively. ...
Acknowledgments The authors would like to thank Dr Abdel K Tahari and John Crandall for assistance in recruiting patients. ...
doi:10.1088/0031-9155/60/22/8643
pmid:26509251
pmcid:PMC4710061
fatcat:g2fv3nnekjfx7e3qxebm7jqbqa
STIR: Software for Tomographic Image Reconstruction Release 2
2006
2006 IEEE Nuclear Science Symposium Conference Record
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We present a new version of STIR, an Open Source object-oriented library implemented in C++ for 3D PET reconstruction. ...
This second release enhances its flexibility and modular design and includes additional features such as Compton scatter simulation, an additional iterative reconstruction algorithm and parametric image ...
Dr Tsoumpas wishes to express his gratitude to Dr Loudos (Technological Educational Institute of Athens) for longstanding inspiring discussions. ...
doi:10.1109/nssmic.2006.354345
fatcat:j2euobthibdardbidrqbezu43e
Dynamic PET Image Reconstruction Incorporating Multiscale Superpixel Clusters
2021
IEEE Access
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The curves were plotted by varying the iteration number from 20 to 100 for the MLEM algorithm and kernel method and varying the regularization parameter for the Bowsher method and proposed method. ...
L x x y x (3) However, the ML estimate can be very noisy at convergence. ...
doi:10.1109/access.2021.3058807
fatcat:y4l3owpq4fagpeezc23mjnrbqm
Towards enhanced PET quantification in clinical oncology
2018
British Journal of Radiology
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(4D) parametric imaging methods in clinical oncology. ...
avenues for clinical diagnosis, assessment of response to treatment and therapy planning. ...
iterative reconstruction routine within each iteration step of the frame-by-frame dynamic PET tomographic reconstruction method for accelerated convergence. 71, 98 Moreover, direct 4D parametric imaging ...
doi:10.1259/bjr.20170508
pmid:29164924
fatcat:7gtiavdgtzad3g6q7sos2orhx4
Direct parametric reconstruction in dynamic PET myocardial perfusion imaging:in vivostudies
2017
Physics in Medicine and Biology
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Direct 4D PET MLEM reconstruction of parametric images using the simplified reference tissue model with the basis function method for [11C]raclopride Paul Gravel and Andrew J Reader Abstract An overview ...
By viewing 4D image reconstruction as a matter of either linear or non-linear parameter estimation for a set of spatiotemporal functions chosen to approximately represent the radiotracer distribution, ...
Finally, the authors acknowledge Karl Herholz and Matthew Jones (University of Manchester, Wolfson Molecular Imaging Centre) for the raw PET list-mode data acquired with the HRRT used for figure 13. ...
doi:10.1088/1361-6560/aa6394
pmid:28379843
pmcid:PMC5739089
fatcat:gokrwq2x25hrthjjqdcbgaesnq
4D image reconstruction for emission tomography
2014
Physics in Medicine and Biology
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Finally, the authors acknowledge Karl Herholz and Matthew Jones (University of Manchester, Wolfson Molecular Imaging Centre) for the raw PET list-mode data acquired with the HRRT used for figure 13. ...
The authors gratefully acknowledge the use of time activity curve data supplied by Paul Gravel for the simulation section, and previous informal discussions with Julian Matthews regarding the expectation ...
Results of direct parametric reconstruction of the K i macro-parameter using the linear Patlak model and simulated brain data for [ 18 F]FDG can be found in Tsoumpas et al (2008b) (averaged reduction ...
doi:10.1088/0031-9155/59/22/r371
pmid:25361380
fatcat:dbhq74hapvbcfkkwjn2tkulumi
High Temporal-Resolution Dynamic PET Image Reconstruction Using A New Spatiotemporal Kernel Method
[article]
2018
bioRxiv
pre-print
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Current clinical dynamic PET has an effective temporal resolution of 5-10 seconds, which can be adequate for traditional compartmental modeling but is inadequate for exploiting the benefit of more advanced ...
However, reconstruction of these short-time frames from tomographic data is extremely challenging as the count level of each frame is very low and high noise presents in both spatial and temporal domains ...
(13) Note that the EM solution converges to the ML estimate when n is large, which however can result in noisy reconstruction. ...
doi:10.1101/323394
fatcat:lnud4th2yjds5ojmqb6dqg537y
Direct 4-D PET List Mode Parametric Reconstruction With a Novel EM Algorithm
2012
IEEE Transactions on Medical Imaging
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This paper presents a direct 4-D method for producing 3-D images of kinetic parameters from list mode PET data. ...
image reconstruction. ...
[10] proposed direct parametric image reconstruction methods, whose compartment model is linear (Patlak plot), and is thus limited to irreversible tracers such as FDG. Furthermore, Rahmim et al. ...
doi:10.1109/tmi.2012.2212451
pmid:22929383
pmcid:PMC3660152
fatcat:npymfjhia5hszlwrredvtfup2e
4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties
2018
Physics in Medicine and Biology
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Compared to conventional MAP reconstruction, spline-residue-based 4D reconstruction achieved >50% improvements for five of the eight combinations of the four kinetics parameters for which parametric maps ...
(TACs) during the reconstruction, though the optimal choice of function remains an open question. ...
The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, HEE or the Department of Health. ...
doi:10.1088/1361-6560/aabb62
pmid:29616663
pmcid:PMC5983307
fatcat:4n4v4uxzyvho5acf2ouxrr35gi
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