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Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth

Dustin Scheinost, Javid Dadashkarimi, Emily S. Finn, Caroline G. Wambach, Caroline MacGillivray, Alexandra L. Roule, Tara A. Niendam, Daniel S. Pine, Melissa A. Brotman, Ellen Leibenluft, Wan-Ling Tseng
2021 Neuropsychopharmacology  
(n = 14), anxiety disorder (n = 12), and controls (n = 23).  ...  This study included 69 youths (mean age = 14.55 years) with varying levels of irritability across diagnostic groups: disruptive mood dysregulation disorder (n = 20), attention-deficit/hyperactivity disorder  ...  ACKNOWLEDGEMENTS The authors would like to thank the children and families for their participation in this study as well as the staff and research assistants of the Emotion and Development Branch at the  ... 
doi:10.1038/s41386-020-00954-8 pmid:33479511 fatcat:hjdmyikbsvacpowpfeuvpew7ky

No evidence for morphometric associations of the amygdala and hippocampus with the five-factor model personality traits in relatively healthy young adults

Joshua C. Gray, Max M. Owens, Courtland S. Hyatt, Joshua D. Miller, Hengyi Rao
2018 PLoS ONE  
Using the new FreeSurfer amygdala and hippocampus segmentation pipelines with the full Human Connectome Project sample (N = 1105), the current study investigated whether the morphometry of these structures  ...  Exploratory analyses were conducted investigating potential associations between all of the FFM traits and the structure of the hippocampus and amygdala and their subregions.  ...  in uncertain direction given the conflicting findings across negative emotionality and depression/anxiety research [35, 36, 41, 42] .  ... 
doi:10.1371/journal.pone.0204011 pmid:30235257 pmcid:PMC6147458 fatcat:3wa5g6kwpnadlpgzfzbh3ood2i

Opposing relationships of childhood threat and deprivation with stria terminalis white matter

Layla Banihashemi, Christine W. Peng, Timothy Verstynen, Meredith L. Wallace, Daniel N. Lamont, Hussain M. Alkhars, Fang‐Cheng Yeh, Joseph E. Beeney, Howard J. Aizenstein, Anne Germain
2021 Human Brain Mapping  
Human Connectome Project data was used to perform ST and MFB tractography; these tracts were used as ROIs to extract generalized fractional anisotropy (gFA) from each participant.  ...  and disorders.  ...  Stria Terminalis Human Connectome Project Group Tractography.  ... 
doi:10.1002/hbm.25378 pmid:33739544 pmcid:PMC8090789 fatcat:2b4fy3ozn5errmhaquys5gzxry

Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis

Luigi A. Maglanoc, Tobias Kaufmann, Rune Jonassen, Eva Hilland, Dani Beck, Nils Inge Landrø, Lars T. Westlye
2019 Human Brain Mapping  
We used univariate and machine learning approaches to assess the relationship between age, sex, case-control status, and symptom loads for depression and anxiety with the resulting brain components.  ...  In contrast, there were no significant associations with case-control status, nor symptom loads for depression and anxiety with the brain components, nor any interaction effects with age and sex.  ...  ), the Department of Psychology, University of Oslo and the KG Jebsen Stiftelsen (223723).  ... 
doi:10.1002/hbm.24802 pmid:31571370 fatcat:g7y765irerdihhx4mx64nehug4

Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies

Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan (+40 others)
2021 Frontiers in Human Neuroscience  
There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer's  ...  DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry.  ...  The Human Connectome Project has enabled the generation of publicly available normative connectomes, which has proven invaluable for neuromodulation research (Yeo et al., 2011; Frontiers in Human Neuroscience  ... 
doi:10.3389/fnhum.2021.644593 pmid:33953663 pmcid:PMC8092047 fatcat:ixlexjcljjd7njuiuiphkjelz4

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Recent progress has been made on probes to study interactions between the opioid neuropeptide dynorphin and the kappa opioid receptor, which are implicated in the negative aversive states associated with  ...  What activity patterns and molecular mechanisms govern release? What is the extent of volume transmission, and how long do peptidergic signals last?  ...  the Human Connectome Project (HCP) multiband rsfMRI protocols.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

Resting State Functional Connectivity Biomarkers of Treatment Response in Mood Disorders: A Review

Joseph J. Taylor, Hatice Guncu Kurt, Amit Anand
2021 Frontiers in Psychiatry  
We discuss RSFC limitations and future directions in biomarker development.  ...  Resting State Functional Connectivity (RSFC) is a popular method for investigating the neural correlates of mood disorders, but the breadth of the field makes it difficult to assess progress toward treatment  ...  Despite these current limitations, there are several future direction that could facilitate the identification of treatment response biomarkers in mood disorders.  ... 
doi:10.3389/fpsyt.2021.565136 pmid:33841196 pmcid:PMC8032870 fatcat:t7p63cjrvzbulotft7y7nlloce

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  human.  ...  We validated PACE on the Human Connectome Project (HCP) and the 1000 Functional Connectomes (F1000) resting state connectome datasets, by comparing PACE to six Q-based methods (five weighted and one binarized  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

Poster Session II

2015 Neuropsychopharmacology  
and ''mood or anxiety disorders.''  ...  Future directions to be presented will include relationship of the PET findings to depression status/scales for some of the TS with OCD and TS alone.  ...  been investigated using a whole-brain approach and such brain-behavior studies are yet to be performed in individuals with cocaine use disorder (iCUD).  ... 
doi:10.1038/npp.2015.326 pmid:26632287 pmcid:PMC4672311 fatcat:ib64i5qmzngvxcpn5hznkcagie

ACNP 57th Annual Meeting: Poster Session II

2018 Neuropsychopharmacology  
Increasing evidence suggests a role for systemic and neurological inflammation in the pathophysiology of fear and trauma exposure based psychiatric disorders (Micholpoulos et al., 2017; Haroon et al.,  ...  Post-traumatic stress disorder (PTSD) remains a growing and often debilitating psychiatric disorder resulting from severe trauma.  ...  associated with mood and anxiety disorders.  ... 
doi:10.1038/s41386-018-0267-6 fatcat:febeq6uwefgdzm65ccmzrmjwjy

Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy

Yanan Sui, Ye Tian, Wai Kin Daniel Ko, Zhiyan Wang, Fumin Jia, Andreas Horn, Dirk De Ridder, Ki Sueng Choi, Ausaf A. Bari, Shouyan Wang, Clement Hamani, Kenneth B. Baker (+9 others)
2021 Frontiers in Neurology  
We specifically addressed new clinical approaches and challenges in DBS for movement disorders (Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress  ...  and challenges toward DBS for neuropsychiatric disorders.  ...  Preliminary analysis of outcomes data shows significantly improved outcomes using the new procedure and four-lead DBS.  ... 
doi:10.3389/fneur.2020.597451 pmid:33584498 pmcid:PMC7876228 fatcat:hqypmsxmpjaezfllq62zlyagje

ACNP 59th Annual Meeting: Poster Session II

2020 Neuropsychopharmacology  
Preliminary analyses also assessed the relationship  ...  LICA returns a participant-specific value for the loading of each component, with each component representing shared variance across the feature modalities.  ...  Resting state sequences were preprocessed using the Human Connectome Project pipelines v3.4.  ... 
doi:10.1038/s41386-020-00891-6 pmid:33279935 pmcid:PMC7735200 fatcat:5nfeakhcfnhpnjyuvli34vyxxq

Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank

Adolfo Ramirez-Zamora, James J. Giordano, Aysegul Gunduz, Peter Brown, Justin C. Sanchez, Kelly D. Foote, Leonardo Almeida, Philip A. Starr, Helen M. Bronte-Stewart, Wei Hu, Cameron McIntyre, Wayne Goodman (+25 others)
2018 Frontiers in Neuroscience  
Each section of this overview of the meeting provides insight to the critical elements of discussion, current challenges, and identified future directions of scientific and technological development and  ...  , essential tremor, Tourette syndrome, obsessive compulsive disorder, epilepsy and cognitive, and motor disorders.  ...  Highlights and Future DirectionsThe Anterior limb of the internal capsule (ALIC) is a frequent DBS target for treatment of psychiatric diseases. • Using a DTI-based template from the Human Connectome  ... 
doi:10.3389/fnins.2017.00734 pmid:29416498 pmcid:PMC5787550 fatcat:24zvpf5ndbcrhhcy7xdrcinaby

Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy

Matthew A. Scult, David M. Fresco, Faith M. Gunning, Conor Liston, Saren H. Seeley, Emmanuel García, Douglas S. Mennin
2019 Frontiers in Behavioral Neuroscience  
in connectivity of nodes of the DMN and SN networks to regions across the brain.  ...  This study examined 21 generalized anxiety disorder (GAD) patients [with and without major depressive disorder (MDD)] drawn from a larger intervention trial (Renna et al., 2018a), who completed resting  ...  Knodt for feedback on the analyses.  ... 
doi:10.3389/fnbeh.2019.00010 pmid:30778290 pmcid:PMC6369363 fatcat:ohrfp6uqqzdz7jl5qegj4vr4zq

Disrupted insula-based neural circuit organization and conflict interference in trauma-exposed youth

Hilary A. Marusak, Amit Etkin, Moriah E. Thomason
2015 NeuroImage: Clinical  
Emerging research suggests that aberrant saliency processing underlies the link between early trauma exposure and later cognitive and socioemotional deficits that are hallmark of several psychiatric disorders  ...  We find that trauma-exposed youth are more susceptible to conflict interference and this correlates with higher fronto-insular responses during conflict.  ...  Investigator Award to MET.  ... 
doi:10.1016/j.nicl.2015.04.007 pmid:26199869 pmcid:PMC4477108 fatcat:ldwpehkmgrag3erzsbrssyfcxu
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