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Economic analyses of genetic tests in personalized medicine: clinical utility first, then cost utility

Scott D. Grosse
2013 Genetics in Medicine  
ACKNOWLEDGMENTS The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.  ...  tests in personalized medicine.  ...  The authors report that 20% (n = 12) of the 59 CUA studies in their sample (including a CUA of phenotypic cascade screening for hemochromatosis) 2 reported negative incremental direct medical costs, i.e  ... 
doi:10.1038/gim.2013.158 pmid:24232411 pmcid:PMC4454889 fatcat:fufhcu7hhbetdcya3qzf2jxch4

Internet of Things with Deep Learning-Based Face Recognition Approach for Authentication in Control Medical Systems

Tahir Hussain, Dostdar Hussain, Israr Hussain, Hussain AlSalman, Saddam Hussain, Syed Sajid Ullah, Suheer Al-Hadhrami, Shakeel Ahmad
2022 Computational and Mathematical Methods in Medicine  
We use Raspberry Pi (RPi) because it has low cost and acts as the main controller in this system.  ...  The installation of a smart control system using general-purpose input/output (GPIO) pins of RPi also enhanced the antitheft for smart locks, and the RPi is connected to smart doors.  ...  Acknowledgments This research was supported by the Researchers Supporting Project number (RSP-2021/244), King Saud University, Riyadh, Saudi Arabia.  ... 
doi:10.1155/2022/5137513 pmid:35190751 pmcid:PMC8858039 fatcat:mdaiqgr5wzfk3jtisfknvmxb3u

Precision Subtypes of T Cell-Mediated Rejection Identified by Molecular Profiles

Paul Ostrom Kadota, Zahraa Hajjiri, Patricia W. Finn, David L. Perkins
2015 Frontiers in Immunology  
Histological examination of the renal allograft is considered the gold standard in the diagnosis of acute rejection.  ...  Our results suggest approaches to identify more precise molecular diagnoses of TCMR, which could form the basis for personalized treatments.  ...  RESULTS Defining Subtypes of T Cell-Mediated Rejection To identify subtypes of TCMR rejection in kidney allografts, we analyzed all samples classified as TCMR rejection (and nephrectomy controls) using  ... 
doi:10.3389/fimmu.2015.00536 pmid:26594210 pmcid:PMC4635852 fatcat:zrbx7nzlhzfslhcqitlbabsq6q

Urinary Peptidomic Biomarkers in Kidney Diseases

Sirolli, Pieroni, Liberato, Urbani, Bonomini
2019 International Journal of Molecular Sciences  
In order to effectively develop personalized medicine for kidney diseases we urgently need to develop highly accurate biomarkers for use in the clinic, since current biomarkers of kidney damage (changes  ...  assessment, and prediction of response to treatment.  ...  Acknowledgments: The authors thank Giuseppina Malandra for the technical support in the preparation of the manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms21010096 pmid:31877774 pmcid:PMC6982248 fatcat:5b4polagsjdwxpnmbw4g7b3gam

Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area

Aihua Li, David Meyre
2014 Current Psychiatry Reviews  
The rapid decline of sequencing costs brings hope that personal genome sequencing will become a common feature of medical practice.  ...  We also address the challenges that currently limit the use of personalized medicine to its full potential.  ...  ACKNOWLEDGEMENTS We thank Arkan Al Abadi for his suggestions at the early stage of this manuscript and his editing of the manuscript. We also thank the reviewers for their helpful comments.  ... 
doi:10.2174/1573400510666140630170549 pmid:25598768 pmcid:PMC4287884 fatcat:anyckaaldfajbhrmwa3lnzmlj4

Robust clinical outcome prediction based on Bayesian analysis of transcriptional profiles and prior causal networks

Kourosh Zarringhalam, Ahmed Enayetallah, Padmalatha Reddy, Daniel Ziemek
2014 Computer applications in the biosciences : CABIOS  
Motivation: Understanding and predicting an individual's response in a clinical trial is the key to better treatments and cost-effective medicine.  ...  These regulators and their corresponding posterior probabilities of activity are used in a regularized regression framework to predict response.  ...  Conflict of Interest: none declared.  ... 
doi:10.1093/bioinformatics/btu272 pmid:24932007 pmcid:PMC4058945 fatcat:iuf7adxt3vajpmbzd3ksntuwly

Identifying biomarkers as diagnostic tools in kidney transplantation

Valeria R Mas, Thomas F Mueller, Kellie J Archer, Daniel G Maluf
2011 Expert Review of Molecular Diagnostics  
There is a critical need for biomarkers for early diagnosis, treatment response, and surrogate end point and outcome prediction in organ transplantation, leading to a tailored and individualized treatment  ...  However, there is still no routine application of any of these markers in clinical transplantation.  ...  Moreover, a classifier to distinguish rejection from nonrejection using predictive analysis of microarrays (PAM) was built.  ... 
doi:10.1586/erm.10.119 pmid:21405969 pmcid:PMC3116652 fatcat:rivexgj3ojhxdakcaj7wyeuda4

Towards implementation of AI in New Zealand national diabetic screening program: Cloud-based, robust, and bespoke

Li Xie, Song Yang, David Squirrell, Ehsan Vaghefi, Gianni Virgili
2020 PLoS ONE  
The implementation of 'cascading thresholds' and 'max margin' techniques led to significant improvements in the DRCNN's sensitivity, while also enhancing the specificity of other grades.  ...  Grading Diabetic Retinopathy (DR) has been at the forefront of the development of AI for ophthalmology.  ...  Cascading thresholds The cascading thresholds technique has been used previously in the literature, in order to boost the sensitivity of a given CNN [35] .  ... 
doi:10.1371/journal.pone.0225015 pmid:32275656 fatcat:wxstxzj3wzhrxkcir7qk2z3oui

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

Jan Brabek, Daniel Rosel, Michael Fernandes
2016 OncoTargets and Therapy  
The lag in therapeutics relative to diagnostics is a cause for confusion. Overdiagnosis adds to fear and harm, especially in the absence of effective interventions.  ...  The precision medicine (PM) initiative is a response to the dismal outlook in solid cancer. Despite heterogeneity, common mechanistic denominators may exist across the spectrum of solid cancer.  ...  MF is at Medbase, an independent think tank focused on pragmatic innovation in pharmaceutical products and medical devices. The authors report no other conflicts of interest in this work.  ... 
doi:10.2147/ott.s103832 pmid:27103822 pmcid:PMC4827419 fatcat:azcgltnbkjezrahtniwnlzts5y

The role of complement in kidney disease

Jamie Willows, Matthew Brown, Neil S Sheerin
2020 Clinical medicine (London)  
While the complement cascade is an important component of the innate immune system, uncontrolled activation can cause severe disease.  ...  Complement activation is also implicated in the pathogenesis of many other renal and non-renal diseases, necessitating an understanding of complement biology and diagnostics.  ...  Conflicts of interest Neil Sheerin has given lectures on behalf of and served on advisory boards for Alexion Pharmaceuticals.  ... 
doi:10.7861/clinmed.2019-0452 pmid:32188650 pmcid:PMC7081808 fatcat:ghwjgwwgofaxjkdtybom44bvwe

EMG-based Real Time Facial Gesture Recognition for Stress Monitoring

S. Orguc, H. S. Khurana, K. M. Stankovic, H.S. Leel, A.P. Chandrakasan
2018 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)  
A support vector machine (SVM) is used for the classification.  ...  A custom-designed sensor interface integrated circuit (IC) consisting of an amplifier and an ADC, implemented in 65nm CMOS technology, has been used for signal acquisition [1].  ...  ACKNOWLEDGMENT The authors acknowledge the funding support of Delta Electronics, Siebel Fellowship, MIT Center for Integrated Circuits and Systems, Lauer Tinnitus Research Center and the TSMC University  ... 
doi:10.1109/embc.2018.8512781 pmid:30440952 fatcat:ts7zsiwnczakrj3zz46ocprf7e

A Practical Animal Detection and Collision Avoidance System Using Computer Vision Technique

Sachin Umesh Sharma, Dharmesh J. Shah
2017 IEEE Access  
In this paper, a simple and a low-cost approach for automatic animal detection on highways for preventing animal-vehicle collision using computer vision techniques are proposed.  ...  A method for finding the distance of the animal in real-world units from the camera mounted vehicle is also proposed.  ...  ACKNOWLEDGMENT The authors would like to thank all who were involved directly or indirectly in the data collection, experiment conduction, and analysis stage of the project.  ... 
doi:10.1109/access.2016.2642981 fatcat:k7kokyxt55cwnnfamkynfn3t3a

Learning from the Behavior of Others: Conformity, Fads, and Informational Cascades

Sushil Bikhchandani, David Hirshleifer, Ivo Welch
1998 Journal of Economic Perspectives  
They use tract-level socioeconomic data, land-use data, and crime statistics to control for expected tract profitability.  ...  If the next person draws a Low signal, then a Down cascade is started. But if the next person draws a High signal, then it may take several more draws before a cascade reasserts itself.  ... 
doi:10.1257/jep.12.3.151 fatcat:nixqx6vbijcgnd6aliqofdmbii

Preventive and Predictive Genetics: A perspective [chapter]

Godfrey Grech, Christian Scerri, Jeanesse Scerri, Tomris Cesuroglu
2015 Advances in Predictive, Preventive and Personalised Medicine  
Preventive genetics can be defined as using genetics for the prevention of a future disease that has a genetic component either in the individual tested or in future offspring.  ...  Genetic tests can be classified into carrier, diagnostic and predictive testing.  ...  The routine use of family history or personal genomics alone as a measure of risk of common complex conditions does not generate sufficient evidence in the primary care setting; however, when used together  ... 
doi:10.1007/978-3-319-15344-5_2 fatcat:d5yl6olyfjcj3iqywpymhwxcwy

Pragmatic medicine in solid cancer: a translational alternative to precision medicine

Brábek J, Rosel D, Fernandes M
2016 OncoTargets and Therapy  
The lag in therapeutics relative to diagnostics is a cause for confusion. Overdiagnosis adds to fear and harm, especially in the absence of effective interventions.  ...  medicine (PM) initiative is a response to the dismal outlook in solid cancer.  ...  Whatever happened to N-of-1 trials? Insiders’ perspectives and a look to the future. Schork, NJ. Personalized medicine: time for one-person trials. Collette L, Tombal B. N-of-1 trials in oncology.  ... 
doaj:ab6b8a281b684a63b5acc5efbe82e3c2 fatcat:xwiirmddejhknmkc6uj646veze
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