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Contributions of dynamic venous blood volume versus oxygenation level changes to BOLD fMRI

Xiaopeng Zong, Tae Kim, Seong-Gi Kim
2012 NeuroImage  
Keywords: CBV BOLD BOLD undershoot Cerebral arterial blood volume Cerebral venous blood volume Venous oxygenation level Blood-oxygenation-level-dependent (BOLD) fMRI has contributions from venous oxygenation  ...  Our data indicates that the contribution of venous oxygenation change to BOLD fMRI is dominant for short stimulations.  ...  Despite its name, BOLD fMRI signal is dependent not only on blood oxygenation level (Y), but also on venous cerebral blood volume (CBV v ) changes.  ... 
doi:10.1016/j.neuroimage.2012.02.052 pmid:22401759 pmcid:PMC3339492 fatcat:le3k45vhxvdtnbrb63k3o2buoq

Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals

Seong-Gi Kim, Seiji Ogawa
2012 Journal of Cerebral Blood Flow and Metabolism  
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional magnetic resonance imaging (fMRI) has been widely used to map brain activation in humans and animals.  ...  and intrinsic hemodynamic responses, (4) BOLD signal contributions from functional changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral metabolic rate of O 2 utilization (CMRO  ...  Disclosure/conflict of interest The authors declare no conflict of interest.  ... 
doi:10.1038/jcbfm.2012.23 pmid:22395207 pmcid:PMC3390806 fatcat:ysnuzc5tjrbkhn34p2ar22flda

Diffusion-weighted spin-echo fMRI at 9.4 T: Microvascular/tissue contribution to BOLD signal changes

Sang-Pil Lee, Afonso C. Silva, Kamil Ugurbil, Seong-Gi Kim
1999 Magnetic Resonance in Medicine  
The nature of vascular contribution to blood oxygenation level dependent (BOLD) contrast used in functional MRI (fMRI) is poorly understood.  ...  In comparison, the T 2 of venous blood at an oxygenation level of 79.6 ؎ 6.1% was 9.2 ؎ 2.3 msec (n ‫؍‬ 11).  ...  Blood oxygenation level was altered by changing respiration rate, volume, and the oxygen concentration of the gas mixture.  ... 
doi:10.1002/(sici)1522-2594(199911)42:5<919::aid-mrm12>3.0.co;2-8 pmid:10542351 fatcat:lju3bs4eknalpi7qlfunybvlqa

The Spatial Dependence of the Poststimulus Undershoot as Revealed by High-Resolution BOLD- and CBV-Weighted fMRI

Essa Yacoub, Kamil Ugurbil, Noam Harel
2005 Journal of Cerebral Blood Flow and Metabolism  
The hemodynamic response to neural activity consists of changes in blood flow, blood volume and oxygen metabolism.  ...  This poststimulus undershoot has been modeled and investigated to characterize the physiological mechanisms (cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral oxygen consumption) associated  ...  Acknowledgements The authors would like to thank Drs Peter Andersen and Gregor Adriany for hardware support.  ... 
doi:10.1038/sj.jcbfm.9600239 pmid:16222242 fatcat:plmvp4kofrdfrcb7dzkyb2tuti

The spatial dependence of the post-stimulus undershoot as revealed by high resolution bold and CBV weighted fMRI

Essa Yacoub, Kamil Ugurbil, Noam Harel
2005 Journal of Cerebral Blood Flow and Metabolism  
The hemodynamic response to neural activity consists of changes in blood flow, blood volume and oxygen metabolism.  ...  This poststimulus undershoot has been modeled and investigated to characterize the physiological mechanisms (cerebral blood flow (CBF), cerebral blood volume (CBV), and cerebral oxygen consumption) associated  ...  Acknowledgements The authors would like to thank Drs Peter Andersen and Gregor Adriany for hardware support.  ... 
doi:10.1038/sj.jcbfm.9591524.0335 fatcat:3kxph5wndnhs3iw27rwj3b242y

Increases in Oxygen Consumption without Cerebral Blood Volume Change during Visual Stimulation under Hypotension Condition

Tsukasa Nagaoka, Fuqiang Zhao, Ping Wang, Noam Harel, Richard P Kennan, Seiji Ogawa, Seong-Gi Kim
2005 Journal of Cerebral Blood Flow and Metabolism  
The magnitude of the blood oxygenation level-dependent (BOLD) signal depends on cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO 2 ).  ...  To detect the BOLD signal changes induced only by CMRO 2 responses without significant evoked CBF and CBV changes, BOLD and CBV functional magnetic resonance imaging (fMRI) responses to visual stimulation  ...  Acknowledgements SG Kim thanks Drs C Iadecola, I Kanno, O Paulson, and L Sokoloff for a helpful discussion of low blood pressure conditions.  ... 
doi:10.1038/sj.jcbfm.9600251 pmid:16395284 fatcat:ajmqzjj33vce3e6tthgjkbcvrq

Temporal Dynamics and Spatial Specificity of Arterial and Venous Blood Volume Changes during Visual Stimulation: Implication for Bold Quantification

Tae Kim, Seong-Gi Kim
2010 Journal of Cerebral Blood Flow and Metabolism  
Determination of compartment-specific cerebral blood volume (CBV) changes is important for understanding neurovascular physiology and quantifying blood oxygenation level-dependent (BOLD) functional magnetic  ...  Our finding implies that the contribution of CBV v changes to BOLD signals is significant for long, but not short, stimulation periods.  ...  Disclosure/conflict of interest The authors declare no conflict of interest.  ... 
doi:10.1038/jcbfm.2010.226 pmid:21179068 pmcid:PMC3099637 fatcat:j4i5a5bbp5akddbxk7ejnrr7ai

IRON fMRI measurements of CBV and implications for BOLD signal

Joseph B. Mandeville
2012 NeuroImage  
Changes in cerebral blood volume (CBV) and blood magnetization each induce changes in the transverse relaxation rate of MRI signal that are associated with changes in cerebral activity.  ...  The temporal response of blood plasma volume is quite different from blood flow and BOLD signal; thus, CBV has been identified as a prominent source of transient features of the BOLD response.  ...  Many coinvestigators contributed to this work.  ... 
doi:10.1016/j.neuroimage.2012.01.070 pmid:22281669 pmcid:PMC3971916 fatcat:ai4vz2k3kfgxfcrf65ugpobabu

Cortical layer-dependent arterial blood volume changes: Improved spatial specificity relative to BOLD fMRI

Tae Kim, Seong-Gi Kim
2010 NeuroImage  
The spatial specificity of functional hemodynamic responses was examined by simultaneous mapping of BOLD changes and quantitative changes in cerebral arterial blood volume (ΔCBV a ) across the cortical  ...  Time-dependencies of the ΔCBV a cortical profiles are similar to total CBV responses previously measured during visual stimulation in cats with a susceptibility contrast agent indicating, that blood volume  ...  in arterial blood oxygenation, venous blood volume and tissue MT level, and we expect (1) a very small increase in tissue T 2 ⁎ (=1/R 2,tissue ⁎ ); (2) an increase in arterial blood volume; and (3) a  ... 
doi:10.1016/j.neuroimage.2009.09.061 pmid:19800013 pmcid:PMC2819732 fatcat:4g3zegszlbgfhe3rlpa6lveapi

Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signals

Hanzhang Lu, Chenguang Zhao, Yulin Ge, Kelly Lewis-Amezcua
2008 Magnetic Resonance in Medicine  
TRUST MRI is a useful measurement for fMRI studies to control for the modulatory effects of baseline oxygenation that are unique to each subject.  ...  Second, if a pathologic condition or a drug treatment is shown to change fMRI responses, monitoring this modulatory parameter is useful in correctly interpreting the fMRI changes to neuronal deficits/recruitments  ...  Peter van Zijl of Johns Hopkins University for providing the in vitro blood T2 calibration plot.  ... 
doi:10.1002/mrm.21686 pmid:18666103 pmcid:PMC2597505 fatcat:semsvodeivgsfobf7cbn7vd5yu

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

Laurentius Huber, Jozien Goense, Aneurin J. Kennerley, Dimo Ivanov, Steffen N. Krieger, Jöran Lepsien, Robert Trampel, Robert Turner, Harald E. Möller
2014 NeuroImage  
Abbreviations: BOLD = blood oxygenation level dependent; CBF = cerebral blood flow; CBV = cerebral blood volume; CBV a = 'arterial' CBV; CBV tot = total CBV; CBV v = 'venous' CBV; CMRO 2 = cerebral metabolic  ...  Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in 'arterial' and 'venous' blood compartments in macro-and microvasculature.  ...  Estimation of venously oxygenated CBV change can be intuitively understood as follows; with the procedure of dynamic division, SS-SI-VASO is sensitive to volume changes of the blood component that is nulled  ... 
doi:10.1016/j.neuroimage.2014.04.022 pmid:24742920 fatcat:7l2twvtig5ffnmtc7rm5vubnva

Arterial versus Total Blood Volume Changes during Neural Activity-Induced Cerebral Blood Flow Change: Implication for BOLD fMRI

Tae Kim, Kristy S Hendrich, Kazuto Masamoto, Seong-Gi Kim
2006 Journal of Cerebral Blood Flow and Metabolism  
, and help to identify the origins of neurovascular responses in conventional blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI).  ...  changes may be negligible in BOLD fMRI.  ...  An increase in venous oxygenation level induced by an increase in CBF produces an increase in BOLD signals, while an increase in venous blood volume decreases the BOLD effect.  ... 
doi:10.1038/sj.jcbfm.9600429 pmid:17180136 fatcat:ugbypx3shndnrhwdwik6igergm

Effect of Basal Conditions on the Magnitude and Dynamics of the Blood Oxygenation Level-Dependent fMRI Response

Eric R. Cohen, Kamil Ugurbil, Seong-Gi Kim
2002 Journal of Cerebral Blood Flow and Metabolism  
Thus, the hemodynamic response to visual stimulation was measured using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in human subjects in a 7-T magnetic field under  ...  Measures of the dynamics of the visually evoked BOLD response (onset time, full-width-at-half-maximum, and time-to-peak) increased linearly with the basal fMRI signal and the end-tidal CO 2 level.  ...  Effect of PaCO 2 on the dynamics of the stimulus-induced blood oxygenation level-dependent response We demonstrated a consistent slowing of the BOLD response to visual stimulation as the ETCO 2 and global  ... 
doi:10.1097/00004647-200209000-00002 pmid:12218410 fatcat:vicuzxk2wvacznds4fnyynfeee

A statistical 3D model of the human cortical vasculature to compute the hemodynamic fingerprint of the BOLD fMRI signal [article]

Mario Gilberto Baez-Yanez, Jeroen C.W. Siero, Natalia Petridou
2020 bioRxiv   pre-print
The proposed model considers also the biophysical interactions and the intrinsic magnetic properties of the nearby tissue in order to compute a dynamic BOLD fMRI signal response.  ...  Using this model, we simulated hemodynamic changes triggered by a neuronal activation and local magnetic field disturbances created by the vascular topology and the blood oxygenation changes.  ...  oxygenation changes, i.e. the dynamic BOLD fMRI signal response.  ... 
doi:10.1101/2020.10.05.326512 fatcat:mhtsm7do35h4bibvnupd7j3bxa

Dynamics of Changes in Blood Flow, Volume, and Oxygenation: Implications for Dynamic Functional Magnetic Resonance Imaging Calibration

Ikuhiro Kida, Douglas L Rothman, Fahmeed Hyder
2006 Journal of Cerebral Blood Flow and Metabolism  
Changes in cerebral blood flow (CBF), volume (CBV), and oxygenation (blood-oxygenation level dependent (BOLD)) during functional activation are important for calculating changes in cerebral metabolic rate  ...  For dynamic fMRI calibration, it is important to know if the value of γ varies after stimulation onset.  ...  This research is supported by grants from the National Institutes of Health (DC-03710 to FH, MH-67528 to FH) and National Science Foundation (DBI-0095173 to FH).  ... 
doi:10.1038/sj.jcbfm.9600409 pmid:17033688 pmcid:PMC2854582 fatcat:y67nkj2rdfegfe5q2xxfml5axu
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