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Contribution of Exploratory Methods to the Investigation of Extended Large-Scale Brain Networks in Functional MRI: Methodologies, Results, and Challenges

V. Perlbarg, G. Marrelec
2008 International Journal of Biomedical Imaging  
A large-scale brain network can be defined as a set of segregated and integrated regions, that is, distant regions that share strong anatomical connections and functional interactions.  ...  We here review the rationale for such an investigation, the methods used, the results obtained, and also discuss some issues that have to be faced for an efficient exploration.  ...  ACKNOWLEDGMENTS The authors would like to thank the guest editors for providing them with the opportunity to submit an invited paper to this special issue of the International Journal of Biomedical Imaging  ... 
doi:10.1155/2008/218519 pmid:18497865 pmcid:PMC2386147 fatcat:5u5s42rckrbfjn4hf7mz2mx6cm

Functional and Pharmacological MRI in Understanding Brain Function at a Systems Level [chapter]

Angelo Bifone, Alessandro Gozzi
2011 Current topics in behavioral neurosciences  
Functional magnetic resonance imaging (fMRI) methods have been extensively applied to study the human brain and its functional organization in healthy and disease states.  ...  This chapter describes the methodological aspects of fMRI and phMRI in preclinical species, and some of the key findings, with a special emphasis on the translational potential of these methods in neuropharmacological  ...  Synapse 61:925-932 and James (2000) to indicate the 183 application of functional MRI methods to map the spatiotemporal patterns of brain activity elicited by acute pharmacological challenge.  ... 
doi:10.1007/7854_2010_103 pmid:21225416 fatcat:3cddqqdnkzdubharizfi57e5vu

Intrinsic network activity in tinnitus investigated using functional MRI

Amber M. Leaver, Ted K. Turesky, Anna Seydell-Greenwald, Susan Morgan, Hung J. Kim, Josef P. Rauschecker
2016 Human Brain Mapping  
In this magnetic resonance imaging (MRI) study, we used two resting-state functional connectivity (RSFC) approaches to better understand functional network disturbances in tinnitus.  ...  Tinnitus pathophysiology has been repeatedly shown to involve both auditory and non-auditory brain structures, making network-level studies of tinnitus critical.  ...  This work was supported by the National Institutes of Health (RC1-DC010720), American Tinnitus Association, and Tinnitus Research Consortium.  ... 
doi:10.1002/hbm.23204 pmid:27091485 pmcid:PMC4945432 fatcat:vuow3r56mnb7tiv6d6mmcgkmi4

The importance of combining MRI and large-scale digital histology in neuroimaging studies of brain connectivity and disease

Jacopo Annese
2012 Frontiers in Neuroinformatics  
In vivo and postmortem neuroimaging methodologies are still largely incompatible in terms of sample size, scale, and resolution.  ...  The direct correlation of MRI and histological features is possible, because registered images from different modalities represent the same regions in the same brain.  ...  ACKNOWLEDGMENTS The author would like to acknowledge the contribution of all the research staff of The Brain Observatory. In particular Mr. Paul Maechler and Dr.  ... 
doi:10.3389/fninf.2012.00013 pmid:22536182 pmcid:PMC3334523 fatcat:dfjg745nnrbd3cjtuybldvew4m

Spontaneous EEG-Functional MRI in Mesial Temporal Lobe Epilepsy: Implications for the Neural Correlates of Consciousness

Zheng Wang, Loretta Norton, R. Matthew Hutchison, John R. Ives, Seyed M. Mirsattari
2012 Epilepsy Research and Treatment  
The combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has been shown to have great potential for providing a greater understanding of normal and diseased states  ...  Spontaneous, coherent fluctuations of neuronal activity and the coupled hemodynamic responses have also been shown to provide diagnostic markers of disease, extending our understanding of intrinsically  ...  Acknowledgment This work was partly funded by The Physicians' Services Incorporated Foundation (SM).  ... 
doi:10.1155/2012/385626 pmid:22957230 pmcid:PMC3420502 fatcat:axi7owcbqzb4hfchdi7mqob7x4

The combination of EEG Source Imaging and EEG-correlated functional MRI to map epileptic networks

Serge Vulliemoz, Louis Lemieux, Jean Daunizeau, Christoph M. Michel, John S. Duncan
2010 Epilepsia  
Functional electrophysiologic techniques such as electroencephalography (EEG) and magnetoencephalography (MEG) give insights into the dynamics of the networks involved in the generation of interictal and  ...  By its ability to show hemodynamic changes time locked to epileptic activity in the whole brain, EEG-correlated functional magnetic  ...  We are grateful to the Big Lottery Fund, Wolfson Trust, and National Society for Epilepsy for supporting the 3T MRI scanner at NSE.  ... 
doi:10.1111/j.1528-1167.2009.02342.x pmid:19817805 fatcat:wkzeojfr5fge5drheubnqxoiiu

Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping

Lucas Miranda, Riya Paul, Benno Pütz, Nikolaos Koutsouleris, Bertram Müller-Myhsok
2021 Frontiers in Psychiatry  
Finally, whereas functional MRI is the best way of measuring brain function available to date, its low signal-to-noise ratio and elevated monetary cost make it a poor clinical alternative.  ...  disorder (5%), and the consequences of early exposure to violence (5%).Conclusions: The increased interest in personalized medicine and data-driven disease subtyping also extends to psychiatric disorders  ...  Functional MRI, and brain connectivity, in particular, is positioned as the best tool to date to acquire insights into brain function, and the interest in using it for uncovering subentities of brain disease  ... 
doi:10.3389/fpsyt.2021.665536 pmid:34744805 pmcid:PMC8569315 fatcat:jmcxqcdzjba5bhvcpcrj2zvv3i

Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?

Emilio Merlo Pich, Andreas Jeromin, Giovanni B Frisoni, Derek Hill, Andrew Lockhart, Mark E Schmidt, Martin R Turner, Stefania Mondello, William Z Potter
2014 Alzheimer's Research & Therapy  
Collecting evidence relevant for decision-making to support the development of a novel chemical entity (NCE) requires investment in methodologies that are reliable, valid, and clinically relevant.  ...  If the method has regulatory approval, the inclusion in a clinical trial is generally supported. If not, the quality of the scientific data, the simplicity in execution, the  ...  Acknowledgments We thank the participants of the Wellcome Trust meeting on Brain Disorders for discussion, the Wellcome Trust for support, and Treasan Creavin and Lucy Criddle for their help in organizing  ... 
doi:10.1186/alzrt276 pmid:25484927 pmcid:PMC4255417 fatcat:oauvmaotwvbepcbsjzgwtiyxhi

Towards Monitoring Parkinson's Disease Following Drug Treatment: CGP Classification of rs-MRI Data [article]

Amir Dehsarvi, Jennifer Kay South Palomares, Stephen Leslie Smith
2019 arXiv   pre-print
EAs to both map and predict the functional connectivity in participants using rs-fMRI data.  ...  Nevertheless, EAs enable us to decode the classifier, in terms of understanding the data inputs that are used, more easily than in ANN and SVM.  ...  Classification of Timeseries rs-fMRI is a widespread tool for exploring the functionality of the brain, using volume Classification was completed in 10 runs per combination of inputs and the mean across  ... 
arXiv:1911.03439v1 fatcat:end4l5mxu5hujnmnda62ohgyvi

Investigating the Blood Oxygenation Level-Dependent Functional MRI Response to a Verbal Fluency Task in Early Stroke before and after Hemodynamic Scaling

Veena A. Nair, Ryan V. Raut, Vivek Prabhakaran
2017 Frontiers in Neurology  
Discussion and conclusion: BOLD fMRI changes with aging and disease is confounded by changes in neurofunctional coupling leading to challenges in the straightforward interpretation of task fMRI results  ...  and objective: Blood oxygenation level-dependent (BOLD) functional MRI (fMRI) has been extensively used as a marker of brain dysfunction and subsequent recovery following stroke.  ...  Dynamic changes following stroke including structural, vascular, and perfusion changes all contribute to changes in brain activity as measured by BOLD fMRI making it challenging to directly interpret results  ... 
doi:10.3389/fneur.2017.00283 pmid:28674515 pmcid:PMC5474460 fatcat:cucdl6zfi5bphewsgtrxyzk37u

Functional MRI Biomarkers Predicting Cognitive Progression in Parkinson's Disease: Protocol for a Prospective Longitudinal Cohort Study (Preprint)

Brenda Hanna-Pladdy, Rao Gullapalli, Hegang Chen
2018 JMIR Research Protocols  
Cognitive, genetic, and structural and functional magnetic resonance imaging will characterize neural network changes predictive of cognitive progression in PD across 4 years.  ...  We will evaluate a cohort of early-stage PD patients with the following methods to predict cognitive progression: (1) serial neuropsychological evaluations including detailed visuoperceptual functioning  ...  and funding provided by the National Institute of Aging.  ... 
doi:10.2196/12870 pmid:31033450 pmcid:PMC6660119 fatcat:nrcnwkqtifcf3htjcrz6q3ewee

Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings

Melissa J.M. Walsh, Gregory L. Wallace, Stephen M. Gallegos, B. Blair Braden
2021 NeuroImage: Clinical  
This systematic review on MRI-based sex differences in ASD was conducted to elucidate variations across the lifespan and inform biomarker discovery of ASD in females We identified articles through two  ...  Possible relationships between behavior, sex hormones, and brain development in ASD remain largely unexamined.  ...  Acknowledgements: We thank our participants and the Submitters to the National Institute of Mental Health (NIMH) Data Archive (NDA) who made the analysis of sex differences in symptom severity age patterns  ... 
doi:10.1016/j.nicl.2021.102719 pmid:34153690 fatcat:4qs5mz6wtbdaxah2dvfx32fcqy

Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease

Bethany L. Sussman, Sarah N. Wyckoff, Jennifer Heim, Angus A. Wilfong, P. David Adelson, Michael C. Kruer, Maria Jose Gonzalez, Varina L. Boerwinkle
2022 Frontiers in Neurology  
Herein is a focused review of relevant resting state fMRI functional and effective connectivity of the human motor network across the lifespan in health and disease.  ...  The goal is to examine how the transition from functional connectivity to dynamic effective connectivity may be especially informative of network-targeted movement disorder therapies, with hopeful implications  ...  ACKNOWLEDGMENTS Article previously published in preprint server. This article was published as a preprint to 2021120119 as 20944/preprints202112.0119.v1.  ... 
doi:10.3389/fneur.2022.847834 pmid:35493815 pmcid:PMC9046695 fatcat:fc5qc3krkvfsvogkfyt4ilwqb4

Bridging the gap between MRI and postmortem research in autism

Cynthia Mills Schumann, Christine Wu Nordahl
2011 Brain Research  
In this review, we discuss the strengths, limitations, and major contributions of each approach to autism research. We then describe how they relate and what they can learn from each other.  ...  MRI studies of autism have provided important clues, describing an aberrant trajectory of growth during early childhood that is both present in total brain and marked in specific structures such as the  ...  We are grateful to Aaron Lee, Jeff Bennett, and Brian Moon for their help with manuscript and figure preparation. Dr. John Morgan and Dr.  ... 
doi:10.1016/j.brainres.2010.09.061 pmid:20869352 pmcid:PMC3050078 fatcat:xh5isv7nyvdjbnhcz24p7nfhru

Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI

Jerome J. Maller, Thomas Welton, Matthew Middione, Fraser M. Callaghan, Jeffrey V. Rosenfeld, Stuart M. Grieve
2019 Scientific Reports  
We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n  ...  The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain.  ...  SMG acknowledges the support of the Heart Research Institute, Sydney Medical School and the Parker-Hughes Bequest.  ... 
doi:10.1038/s41598-018-37905-9 pmid:30787303 pmcid:PMC6382767 fatcat:cuef5qjqr5d7zcqgsvb3tjbaoy
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