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Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T

Hongxia Lei, Y. Pilloud, A. W. Magill, R. Gruetter
2011 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
This study evaluates the feasibility of performing continuous arterial spin labeling (CASL) on all cranial arteries for mapping murine cerebral blood flow at 9.4T.  ...  We showed that with an active-detuned two-coil system, a labeling efficiency of 0.82±0.03 was achieved with minimal magnetization transfer residuals in brain.  ...  ACKNOWLEDGMENT This study was supported by Centre d'Imagerie BioMédicale (CIBM) of the UNIL, UNIGE, HUG, CHUV, EPFL and the Leenaards and Jeantet Foundations.  ... 
doi:10.1109/iembs.2011.6091768 pmid:22255948 dblp:conf/embc/LeiPMG11 fatcat:bx7e47s73zfypmpxnsk7klx7tu

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Hongxia Lei, Frédéric Preitner, Gwenaël Labouèbe, Rolf Gruetter, Bernard Thorens
2018 Journal of Cerebral Blood Flow and Metabolism  
We aimed to determine if Glut2-positive cells can influence another response to hypoglycemia, i.e. increased cerebral blood flow (CBF).  ...  hypoglycemia using quantitative perfusion magnetic resonance imaging at 9.4 T.  ...  In order to measure CBF, we used the arterial spin labeling (ASL) magnetic resonance imaging (MRI) technique, which provides a non-invasive measurement of the blood flow in the brain 21, 22 that is superior  ... 
doi:10.1177/0271678x18766743 pmid:29561214 fatcat:hm6yuwhqbnbvvbj7xynob4t46a

Proton diffusion spectroscopy and modeling of brain metabolism at 14.1T

Masoumeh Dehghani Moghadam
The experimentally obtained 13 C labelling curves are analyzed using suitable mathematical models to provide an estimation of cerebral metabolic rates.  ...  The detection of an acetate and NAA signal at large diffusion weighting provided direct experimental evidence of intracellular cerebral acetate and NAA, although a substantial fraction of acetate was extracellular  ...  Two arteries were cannulated for the continuous monitoring of physiology (blood pressure, heart rate) and periodic blood sampling for blood gas, plasma lactate and glucose concentration measurements.  ... 
doi:10.5075/epfl-thesis-7275 fatcat:jdjtwaxeira63nfr2uyisnz36e