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Constraints on signaling network logic reveal functional subgraphs on Multiple Myeloma OMIC data
2018
BMC Systems Biology
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This graph links Multiple Myeloma (MM) genes to known receptors for this blood cancer. ...
Existing methods are based on network distance measures among significantly measured species. ...
Conclusion In this study, we proposed a method that imposes constraints to model graph coloration on biological signaling and regulatory networks. ...
doi:10.1186/s12918-018-0551-4
pmid:29589566
pmcid:PMC5872385
fatcat:7do5ntrymzc73hggppsfkcwekm
Mathematical and Computational Modeling in Complex Biological Systems
2017
BioMed Research International
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A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Computational and mathematical models are gradually being used to help us understand the omics data produced by high-throughput experimental techniques. ...
The biological process and molecular functions involved in the cancer progression remain difficult to understand for biologists and clinical doctors. ...
DILP was then applied to infer osteoclasts-mediated myeloma cell-specific pathways under normoxic and hypoxic condition on time series proteomic data and finally revealed that how OC-myeloma interaction ...
doi:10.1155/2017/5958321
pmid:28386558
pmcid:PMC5366773
fatcat:e6pyjhqdyzfllk6q2l5yjzssf4
A Network-based Approach to Breast Cancer Systems Medicine
[article]
2015
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A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
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Through the application of a Systems Biology approach to reverse engineer Gene Regulatory Networks (GRNs) from gene expression data, we built GRNs around "hub" genes transcriptionally correlating with ...
Clinical heterogeneity of breast cancer is in part explained by the vast genetic and molecular heterogeneity of this disease, which is now emerging from large-scale screening studies using "-omics" technologies ...
constraints there are multiple solutions to ODEs system. ...
doi:10.13130/lusito-eleonora_phd2015-03-18
fatcat:dyawnspuczfmpkuniianpxgmry