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Consolidating drug data on a global scale using Linked Data

Milos Jovanovik, Dimitar Trajanov
2017 Journal of Biomedical Semantics  
Defining methodological guidelines and specialized tools for generating Linked Data in the drug domain, applicable on a global scale, is a crucial step to achieving the necessary levels of data consolidation  ...  Using them, we generated the LinkedDrugs dataset by seamlessly transforming, consolidating and publishing high-quality, 5-star Linked Drug Data from twenty-three countries, containing over 248,000 drug  ...  Cyril and Methodius" University in Skopje, as part of the "SemBigData: Using Semantic Web Technologies to Connect and Explore Big Data" research project.  ... 
doi:10.1186/s13326-016-0111-z pmid:28109310 pmcid:PMC5251285 fatcat:klrd2u7g6vd3vnxdlmx5yzpft4

The Global Drug Facility and its role in the market for tuberculosis drugs

Nimalan Arinaminpathy, Thierry Cordier-Lassalle, Anant Vijay, Christopher Dye
2013 The Lancet  
We assess the scale of GDF drug supplies worldwide and fi nd that the GDF commands a substantial proportion of the market for drugs for fi rst-line and second-line treatment regimens, having supplied,  ...  The Global Drug Facility (GDF) was launched in 2001 to help to achieve this goal, through services including the supply of aff ordable, quality-assured drugs to countries in need.  ...  (C) Plot of the ratios of data in (A) and (B), on a regional basis, with smoothed GDF data. Uncertainty intervals have been omitted for clarity. GDF=Global Drug Facility. AFR=WHO African Region.  ... 
doi:10.1016/s0140-6736(13)60896-x pmid:23726162 fatcat:cepq75rejfde3dknok3nymnyve

A Generic, Service-based Data Integration Framework Applied to Linking Drugs & Clinical Trials

Chris Borckholder, Andreas Heinzel, Yuriy Kaniovskyi, Siegfried Benkner, Arno Lukas, Bernd Mayer
2013 Procedia Computer Science  
The infrastructure consists of diverse service types, which in an example scenario are used to expose and link several open drug and clinical trials data sources under a unified interface.  ...  This paper presents an integrated framework, the Vienna Cloud Environment, for building a generic, service-based data infrastructure for biomedical data integration needs.  ...  Among a manifold of specific scopes, the link between drugs and clinical trials in order to consolidate information on drug use in specific clinical phenotype context, together with reports on drug efficacy  ... 
doi:10.1016/j.procs.2013.10.005 fatcat:5c3g2dtvsrgkhasl32hv7xh534

Epidemiology of tuberculosis in WHO European Region and public health response

Masoud Dara, Andrei Dadu, Kristin Kremer, Richard Zaleskis, Hans H. P. Kluge
2012 European spine journal  
Purpose To provide an overview of the tuberculosis (TB) and multi-drug resistant tuberculosis (MDR-TB) in the WHO European Region and evolution of public health response with focus on extra-pulmonary tuberculosis  ...  Conclusions There is a need to further analyze country data to document the extent of Pott's disease and develop specific guidelines for timely diagnosis and treatment of Pott's disease.  ...  In 1993, because of resurgence of TB globally, WHO took an unprecedented step and declared TB a global emergency.  ... 
doi:10.1007/s00586-012-2339-3 pmid:22565803 pmcid:PMC3691406 fatcat:u77vm6qopndwzfump3kveyeaqi

Longitudinal virological outcomes and factors associated with virological failure in behaviorally HIV-infected young adults on combination antiretroviral treatment in the Netherlands, 2000 to 2015

Annouschka M. Weijsenfeld, Charlotte Blokhuis, Martijn M. Stuiver, Ferdinand W.N.M. Wit, Dasja Pajkrt
2019 Medicine  
Longitudinal data provide valuable insight on dynamics of viral suppression and variables of potential influence on HIV virological failure (VF), but is scarce in young adults living with HIV on combination  ...  We evaluated longitudinal virological outcomes of behaviorally young adults (18-24 years) living with HIV in the Netherlands over a period of 15 years.We analyzed data from the Dutch national HIV database  ...  High levels of retention on ART are critical to the long-term success of global ART scale-up.  ... 
doi:10.1097/md.0000000000016357 pmid:31393344 pmcid:PMC6709178 fatcat:mwbraxxngngnnlgdju67ydeax4

Scalable and Distributed Methods for Entity Matching, Consolidation and Disambiguation Over Linked Data Corpora

Aidan Hogan, Antoine Zimmermann, JJrgen Umbrich, Axel Polleres, Stefan Decker
2012 Social Science Research Network  
With respect to large-scale, static, Linked Data corpora, in this paper we discuss scalable and distributed methods for entity consolidation (aka. smushing, entity resolution, object consolidation, etc  ...  We investigate (i) a baseline approach, which uses explicit owl:sameAs relations to perform consolidation; (ii) extended entity consolidation which additionally uses a subset of OWL 2 RL/RDF rules to derive  ...  Domain-Specific Consolidation Various authors have looked at applying consolidation over domain-specific RDF corpora: e.g., Sleeman and Finin look at using machine learning techniques to consolidate FOAF  ... 
doi:10.2139/ssrn.3198933 fatcat:rkewnbi6rvbyzj4zbczjkb2y5u

Scalable and distributed methods for entity matching, consolidation and disambiguation over linked data corpora

Aidan Hogan, Antoine Zimmermann, Jürgen Umbrich, Axel Polleres, Stefan Decker
2012 Journal of Web Semantics  
With respect to large-scale, static, Linked Data corpora, in this paper we discuss scalable and distributed methods for entity consolidation (aka. smushing, entity resolution, object consolidation, etc  ...  We investigate (i) a baseline approach, which uses explicit owl:sameAs relations to perform consolidation; (ii) extended entity consolidation which additionally uses a subset of OWL 2 RL/RDF rules to derive  ...  Domain-Specific Consolidation Various authors have looked at applying consolidation over domain-specific RDF corpora: e.g., Sleeman and Finin look at using machine learning techniques to consolidate FOAF  ... 
doi:10.1016/j.websem.2011.11.002 fatcat:gekxu2bqarbt5h2mkbtpedbj5m

When technology precedes regulation: the challenges and opportunities of e-pharmacy in low-income and middle-income countries

Rosalind Miller, Francis Wafula, Chima A Onoka, Prasanna Saligram, Anita Musiega, Dosila Ogira, Ikedichi Okpani, Ufuoma Ejughemre, Shrutika Murthy, Surekha Garimella, Marie Sanderson, Stefanie Ettelt (+6 others)
2021 BMJ Global Health  
This will require exploration of a range of innovative regulatory options, collaboration with larger, more compliant businesses, and engagement with global regulatory bodies.  ...  Drawing on existing literature and a set of key informant interviews in Kenya, Nigeria and India, we examine the e-pharmacy regulatory systems in LMICs.  ...  The drug regulatory authority, the Pharmacy BMJ Global Health and Poisons Board, was navigating this gap by using an informal system whereby e-pharmacies sought a 'letter of no objection' to operate and  ... 
doi:10.1136/bmjgh-2021-005405 pmid:34016578 pmcid:PMC8141442 fatcat:glhr474pobc2rbdhh2c7ssar7u

Bio2RDF Release 2: Improved Coverage, Interoperability and Provenance of Life Science Linked Data [chapter]

Alison Callahan, José Cruz-Toledo, Peter Ansell, Michel Dumontier
2013 Lecture Notes in Computer Science  
Bio2RDF currently provides the largest network of Linked Data for the Life Sciences.  ...  This work forms a strong foundation for increased coverage and continuous integration of data in the life sciences.  ...  We also acknowledge technical support from Marc-Alexandre Nolin, constructive but anonymous peer-reviewers, and useful discussions from the Bio2RDF community.  ... 
doi:10.1007/978-3-642-38288-8_14 fatcat:3c5a5y3dxnfsleapwbcz6qenr4

Effects of combination approach on harm reduction programs: the Taiwan experience

Ting Lin, Chang-Hsun Chen, Pesus Chou
2016 Harm Reduction Journal  
Collected data from relevant agencies were used to explore the impact of the harm reduction programs on HIV and illicit drug use.  ...  Facing a severe HIV epidemic among injection drug users, quickly scaling up and promoting comprehensive harm reduction programs is a good strategy that can be used to simultaneously reverse the HIV epidemic  ...  Databases and all relevant raw data are freely available to any scientist wishing to use them. Their original sources can be found in references [13] [14] [15] [16] [17] [18] .  ... 
doi:10.1186/s12954-016-0112-3 pmid:27377896 pmcid:PMC4932706 fatcat:v2klfnn47ffvho3nd2aoqatxxm

Managing Information Technology In Transnational Enterprises

Siew Kien Sia, Christina Soh, Jet Olfato
2011 Pacific Asia Conference on Information Systems  
By analyzing a set of 15 published cases on global IT management, we found that these MNEs deployed distinct architectural and structural initiatives to achieve IT scale, responsiveness and innovation.  ...  Our theorizing and empirical findings led us to propose a framework for global IT management, as well as to identify the critical gaps for future research.  ...  Wyeth implemented a global data warehouse to create the "global glass pipeline".  ... 
dblp:conf/pacis/SiaSO11 fatcat:pnjkxun7abfgbjvsitqv7lis3q

Tracking 20 Years of Compound-to-Target Output from Literature and Patents

Christopher Southan, Peter Varkonyi, Kiran Boppana, Sarma A.R.P. Jagarlapudi, Sorel Muresan, Vladimir N. Uversky
2013 PLoS ONE  
Further analysis of the type we present here can provide unique insights into the process of drug discovery based on the data it actually generates.  ...  We have used this database to analyse published compounds cumulatively linked to nearly 4000 protein target identifiers from multiple species over the last 20 years.  ...  Further analysis and prediction of how drug discovery operates based on the data it actually generates will be important as this global undertaking adapts to the challenges and opportunities of the future  ... 
doi:10.1371/journal.pone.0077142 pmid:24204758 pmcid:PMC3812171 fatcat:qilhpxcoozgofkjoz7ozzxl7hi

Predictors of mortality among multidrug-resistant tuberculosis patients in central Ethiopia; a retrospective follow-up study

G. M. Kassa, A. T Woldetsadik, Y. A Gelaw, T. T Alemayehu, A. T Tsegaye, K. S Tamirat, T. Y. Akalu
2020 Epidemiology and Infection  
Data were fitted to a parametric frailty model and survival was expressed as an adjusted hazard ratio (AHR) with a 95% confidence interval (CI).  ...  A retrospective follow-up study was conducted at three hospitals in the Amhara region on 451 patients receiving treatment for MDR-TB from September 2010 to January 2017.  ...  We are also grateful for the data collectors who participated in this study for their commitment without which the study would not have materialised. Financial support.  ... 
doi:10.1017/s0950268820002514 pmid:33054897 pmcid:PMC7689597 fatcat:giaj6e4335geljvs4axlk2e5cu

Laboratory Medicine: Challenges and Opportunities

X. Bossuyt, K. Verweire, N. Blanckaert
2007 Clinical Chemistry  
We reflect on how current developments may affect the future of laboratory medicine and how to deal with these changes.  ...  We argue that to be prepared for the future, clinical laboratories should enhance efficiency and reduce costs by forming alliances and networks; consolidating, integrating, or outsourcing; and more importantly  ...  Information on laboratory services is globally available, and clinical laboratories worldwide face international competition and a huge pressure to reduce costs.  ... 
doi:10.1373/clinchem.2007.093989 pmid:17885139 fatcat:65x5y6epurff7llgl4sc7c77ua

Surveillance for antiviral resistance

Maria C. Zambon
2012 Influenza and Other Respiratory Viruses  
Experience now indicates that factors which influence the emergence of high level resistance include the nature of drug binding to target, viral subtype, the use of post exposure prophylaxis and a lack  ...  In the 10 years since licensure of neuraminidase inhibitor drugs, their use has steadily increased, especially during the pandemic of 2009.  ...  For the first time, consolidated laboratory resistance surveillance data, from all WHO regions, were available in one place on the WHO website 19 in real time, with a massive increase in the number of  ... 
doi:10.1111/irv.12050 pmid:23279895 pmcid:PMC5978627 fatcat:ob4zwjb74ne2ng4bhgbuzu5pmu
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