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ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Q. Kaas, R. Yu, A.-H. Jin, S. Dutertre, D. J. Craik
2011 Nucleic Acids Research  
ConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails.  ...  Transcriptomics and proteomics have began generating massive numbers of new conopeptide sequences, and two dedicated tools have been recently implemented in ConoServer to standardize the analysis of conopeptide  ...  Two important missions of ConoServer are to help organize knowledge on conopeptides and to provide tools to help in the analysis and comparison of conopeptides.  ... 
doi:10.1093/nar/gkr886 pmid:22058133 pmcid:PMC3245185 fatcat:krh4bbghlbcqxfkwkr4q6d7wti

Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus

Han Zhang, Lei Wang, Xiang Yang, Zhiwei Lian, Yinbin Qiu, Zhanying Dong, Xuedong Wu, Xinghua Pan
2021 Frontiers in Marine Science  
The ConoServer database includes 8,134 conopeptides from 122 Conus species, yet many more natural conopeptides remain to be discovered.  ...  These discoveries accelerate our understanding of conopeptide diversity in the genus, Conus and supply promising materials for medical research.  ...  This work was in part supported by the grants from the National Key R&D Program of China (2018YFA0507800), the National Nature Science Foundation of China (81770173), the Guangdong Natural Science Foundation  ... 
doi:10.3389/fmars.2021.766792 fatcat:xe27zr5lrbbvzlatmnsoqlknze

Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes

Ronghua Li, Michaël Bekaert, Luning Wu, Changkao Mu, Weiwei Song, Herve Migaud, Chunlin Wang
2019 Marine Drugs  
This study provides reports of conopeptide genes in Buccinidae for the first time as well as genomic resources for further drug development, gene discovery and population resource studies of this species  ...  In the present study, we used high-throughput sequencing technologies to generate the first transcriptomic database of H. tuba.  ...  Possible use could be as biochemical tools in neurophysiological studies and for the discovery of new molecular targets in pharmacology [2] .  ... 
doi:10.3390/md17080466 fatcat:n6tyy5ccobdhdgjj5dsbp7kyyu

Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails

Anicet Ebou, Dominique Koua, Audrey Addablah, Solange Kakou-Ngazoa, Sébastien Dutertre
2021 Biomedicines  
Considering sequencing efficiency and affordability, cone snail venom gland transcriptome analyses could allow the discovery of new, promising antimicrobial peptides.  ...  Secondly, we review the current knowledge on cone snails as a source of antimicrobial peptides.  ...  To fill this gap in cone snail venom studies, we show here the need for novel compounds in the battle against antimicrobial resistance, update the knowledge on cone snails as a source of antimicrobial  ... 
doi:10.3390/biomedicines9040344 pmid:33805497 pmcid:PMC8066717 fatcat:kfgilsey7vacvlri3zkypy5v7e

Snails In Silico: A Review of Computational Studies on the Conopeptides

Rachael Mansbach, Timothy Travers, Benjamin McMahon, Jeanne Fair, S. Gnanakaran
2019 Marine Drugs  
This diversity arises in terms of variations both in amino acid sequence and length, and in posttranslational modifications, particularly the formation of multiple disulfide linkages.  ...  In this review, we will explore the chemical diversity of conopeptides from a computational perspective. First, we discuss current approaches used for classifying conopeptides.  ...  Acknowledgments: We thank Amy Migliori and Srirupa Chakraborty for fruitful discussions.  ... 
doi:10.3390/md17030145 fatcat:4mprqedl2fcxpepd5ru2rkopze

A perspective on toxicology of Conus venom peptides

Palanisamy Satheesh Kumar, Dhanabalan Senthil Kumar, Sundaresan Umamaheswari
2015 Asian Pacific Journal of Tropical Medicine  
A great number of research studies and large amount of data on conopeptides made way topool the database, ConoServer (http://www.conoserver.org), to help catalog the growing literature on conopeptide sequences  ...  This database has now grown substantially and provides a valuable resource for analyzing the sequence and structural features of conopeptides.  ... 
doi:10.1016/s1995-7645(14)60342-4 pmid:26003592 fatcat:dvymp7xsingtdaviiq5eb7sv4m

Peptide Toxicity Prediction [chapter]

Sudheer Gupta, Pallavi Kapoor, Kumardeep Chaudhary, Ankur Gautam, Rahul Kumar, Gajendra P. S. Raghava
2014 Msphere  
Also various in silico tools for peptide toxicity prediction and peptide designing have been developed, which facilitates designing of therapeutic peptides with desired toxicity.  ...  Therefore, considerable efforts have been made over the years both in wet and dry lab to overcome this limitation.  ...  ConoServer : It is a database [ 25 ] , specializing in the sequence and structures of conopeptides, which are peptides expressed by carnivorous marine cone snail.  ... 
doi:10.1007/978-1-4939-2285-7_7 pmid:25555724 fatcat:m3ly67t645alfbmf63vzuoyvwi

Key challenges for the creation and maintenance of specialist protein resources

Gemma L. Holliday, Amos Bairoch, Pantelis G. Bagos, Arnaud Chatonnet, David J. Craik, Robert D. Finn, Bernard Henrissat, David Landsman, Gerard Manning, Nozomi Nagano, Claire O'Donovan, Kim D. Pruitt (+8 others)
2015 Proteins: Structure, Function, and Bioinformatics  
feasible in the major reference databases.  ...  material of individual articles, all the way to major reference databases with professional staff and long-term funding.  ...  ACKNOWLEDGMENTS The participants of the inaugural SPRN meeting thank the Wellcome Trust for funding the meeting and Alex Bateman and Patricia Babbitt for organizing it.  ... 
doi:10.1002/prot.24803 pmid:25820941 pmcid:PMC4446195 fatcat:klsc6qmmlnhslkxd7swoifpeee

Bioinformatics tools to assist drug candidate discovery in venom gland transcriptomes

Dominique Kadio Koua, Ron David Appel, Frédérique Lisacek, Reto Stocklin
2012
Bioinformatics tools to assist drug candidate discovery in venom gland transcriptomes.  ...  The use of TATools is illustrated with the study of the Conus consors venom gland transcriptome and subsequent conopeptide identification and classification.  ...  Kaplinski and M. Remm were also supported by the EU through the European Regional Development Fund through the Estonian Centre of Excellence in Genomics.  ... 
doi:10.13097/archive-ouverte/unige:23951 fatcat:e4p2d7s3nve4dmutil7msltlpa

Venomics of the piscivorous cone snail C. consors: multidisciplinary techniques for drug discovery

Daniel Biasse, Denis Hochstrasser, Reto Stocklin
2015
Of course, one of the major goals of venomics projects is also the development of new compounds for pharmacological research and drug discovery.  ...  In the early 2000s, venoms were studied in a more and more comprehensive manner. Venom proteomics was launched.  ...  The Toxinomics Foundation office in Nouméa (Alain Gerbault and Jacques Pusset) and Robin Offord (Mintaka Foundation for Medical Research in Geneva, Switzerland) for their constant support.  ... 
doi:10.13097/archive-ouverte/unige:75353 fatcat:gbd5qv2ldja5bb32igc5nlpbsy

Poisons, toxungens, and venoms: redefining and classifying toxic biological secretions and the organisms that employ them

David R. Nelsen, Zia Nisani, Allen M. Cooper, Gerad A. Fox, Eric C. K. Gren, Aaron G. Corbit, William K. Hayes
2013 Biological Reviews  
ConoServer: updated content, kowledge, and discovery tools in the conopeptide database. Nuclei Acids Research 40, D325—D330. KARDONG, K. V. (1996).  ...  CONTENTS I. Introduction II. Toxins III.  ... 
doi:10.1111/brv.12062 pmid:24102715 fatcat:7kaera4jrjhjxc2qqut2yr5fri