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Experimental models for analysis of oligodendrocyte pathophysiology in stroke

Ken Arai, Eng H Lo
2009 Experimental & Translational Stroke Medicine  
Whole-animal platforms comprise in vivo models of cerebral ischemia that attempt to target white matter brain areas.  ...  However, compared to the mechanisms of neuronal injury in gray matter, white matter pathophysiology remains relatively understudied and poorly understood.  ...  Acknowledgements and Funding Supported in part by P01-NS55104, P50-NS10828, R01-NS37074, R01-NS48422, R01-NS53560, the American Heart Association and the Deane Institute.  ... 
doi:10.1186/2040-7378-1-6 pmid:20150984 pmcid:PMC2820444 fatcat:kv6gevefzzckhosv4de522engm

Manifold Learning Techniques in Image Analysis of High-dimensional Diffusion Tensor Magnetic Resonance Images

Parmeshwar Khurd, Sajjad Baloch, Ruben Gur, Christos Davatzikos, Ragini Verma
2007 2007 IEEE Conference on Computer Vision and Pattern Recognition  
Diffusion Tensor magnetic resonance imaging (DT-MRI) provides a comprehensive characterization of white matter (WM) in the brain and therefore, plays a crucial role in the investigation of diseases in  ...  This in turn requires voxel-based statistical analysis of spatially normalized brain DT images, as in the case of conventional MR images.  ...  The hypothesis was that there were differences induced by maturation of white matter and gray matter that will be demonstrated by a group-based analysis.  ... 
doi:10.1109/cvpr.2007.383403 dblp:conf/cvpr/KhurdBGDV07 fatcat:rwl4yxabjbahjj5px77firzbda

Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy

Qi Li, Charlton Cheung, Ran Wei, Vinci Cheung, Edward S. Hui, Yuqi You, Priscilla Wong, Siew E. Chua, Grainne M. McAlonan, Ed. X. Wu
2010 NeuroImage  
We describe a novel application of voxel-based analysis to evaluate fractional anisotrophy (FA).  ...  Therefore this study directly tested the effect of early or late gestation maternal immune activation on post-natal white matter microstructure in the mouse.  ...  Table 1 Voxel-based analysis of white matter FA GD9, GD17 are mice exposed to PolyI:C on either gestation day 9 or day 17. x,y,z are co-ordinates based on the Allen C57/B6 Allen mouse brain atlas. z indicates  ... 
doi:10.1016/j.neuroimage.2010.04.015 pmid:20399275 fatcat:qg2rg64dzbd37n4mtvgvmfi2ma

A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain

Ruslan Rust, Tunahan Kirabali, Lisa Grönnert, Berre Dogancay, Yanuar D. P. Limasale, Andrea Meinhardt, Carsten Werner, Bàrbara Laviña, Luka Kulic, Roger M. Nitsch, Christian Tackenberg, Martin E. Schwab
2020 Frontiers in Neuroscience  
In particular, we developed a practical guide to reliably measure aspects of growth, repair and maturation of the brain's vasculature during development and neurovascular disease in mice and humans.  ...  Moreover, the procedure is expandable to blood vessels of other organs and vascular in vitro models.  ...  No white matter lesions were observed in AD samples.  ... 
doi:10.3389/fnins.2020.00244 pmid:32265643 pmcid:PMC7099171 fatcat:j5pxlxk2fzgmxmzdakihyx3de4

Principal component analysis-based unsupervised feature extraction applied to single-cell gene expression analysis [article]

Y-h. Taguchi
2018 bioRxiv   pre-print
In this paper, we applied principal component analysis (PCA)-based unsupervised feature extraction (FE) to identify biologically relevant genes from mouse and human embryonic brain development expression  ...  as well as bimodal genes in addition to the recently proposed dpFeature.  ...  In this paper, PCA-based unsupervised FE was applied to single-cell gene expression analysis.  ... 
doi:10.1101/312892 fatcat:arnfzrzfebfnbodzhrglsebf2q

Morphometric analysis of the C57BL/6J mouse brain

A. Badea, A.A. Ali-Sharief, G.A. Johnson
2007 NeuroImage  
The brains were scanned within the cranium vault to preserve the brain morphology, avoid shape distortions, and to allow an unbiased shape analysis.  ...  Using MRM, we imaged in situ the fixed, actively stained brains of C57BL/6J mice in order to characterize the neuroanatomical phenotype and produce a digital atlas.  ...  All experiments were conducted at the Duke Center for In Vivo Microscopy, an NCRR/NCI National Biomedical Technology Resource Center (P41 RR005959 and R24CA092656 to GAJ).  ... 
doi:10.1016/j.neuroimage.2007.05.046 pmid:17627846 pmcid:PMC2176152 fatcat:vv7xnlzj6nag5ato5qgac2ww3a

Multimodal Analysis of STRADA Function in Brain Development

Louis T. Dang, Katarzyna M. Glanowska, Philip H. Iffland II, Allan E. Barnes, Marianna Baybis, Yu Liu, Gustavo Patino, Shivanshi Vaid, Alexandra M. Streicher, Whitney E. Parker, Seonhee Kim, Uk Yeol Moon (+5 others)
2020 Frontiers in Cellular Neuroscience  
Ectopic neurons were seen in all five Strada-/- brains within the subcortical white matter mirroring what is observed in human PS brain tissue.  ...  To study the cellular mechanisms of STRADA loss, we generated CRISPR-edited Strada mouse N2a cells, a germline mouse Strada knockout (KO-/-) strain, and induced pluripotent stem cell (iPSC)-derived neurons  ...  Strada KD in fetal mouse brain by in utero electroporation at embryonic day 14-15 causes a cortical lamination defect with heterotopic neurons in the white matter, an effect that can be prevented with  ... 
doi:10.3389/fncel.2020.00122 pmid:32457579 pmcid:PMC7227375 fatcat:zhtizdb4mvbwfce6taunz3w6b4

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment

Tonny Lagerweij, Sophie A. Dusoswa, Adrian Negrean, Esther M. L. Hendrikx, Helga E. de Vries, Jeroen Kole, Juan J. Garcia-Vallejo, Huibert D. Mansvelder, W. Peter Vandertop, David P. Noske, Bakhos A. Tannous, René J. P. Musters (+4 others)
2017 Angiogenesis  
any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ...  distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative, which permits unrestricted use, distribution, and reproduction in  ...  Intravital confocal imaging Application of a cranial window for intravital imaging of the mouse brain was based on the method as described by Mostany et al. [26] .  ... 
doi:10.1007/s10456-017-9565-6 pmid:28699046 pmcid:PMC5660146 fatcat:rllb7324qreffm66wb7zd3i34m

Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo

Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J. Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini (+5 others)
2020 International Journal of Molecular Sciences  
In addition to missing information on active ingredients, the degree to which MSC-dependent lineage instruction is functional in vivo also remains to be established.  ...  However, the nature of MSC-derived differentiation and maturation factors acting on the oligodendroglial lineage has not been identified thus far.  ...  While transplantation of aNSCs into grey or white matter of the brain showed no difference in survival, most of the transplanted cells were found in white matter after spinal cord transplantation.  ... 
doi:10.3390/ijms21124350 pmid:32570968 pmcid:PMC7352621 fatcat:2oam5nqzovco3gq7g4zjqqewn4

Rich-Club in the Brain's Macrostructure: Insights from Graph Theoretical Analysis

Dae-Jin Kim, Byoung-Kyong Min
2020 Computational and Structural Biotechnology Journal  
We describe the concepts of the rich-club behind network construction in the brain using graph theoretical analysis.  ...  may be relevant to the rich-club phenomenon in the brain network.  ...  First, the DTI technique is specialized for extracting white matter connections and is suitable for macroscale network analysis to investigate larger functional and structural brain subregions (e.g., Brodmann  ... 
doi:10.1016/j.csbj.2020.06.039 pmid:32695269 pmcid:PMC7355726 fatcat:xd3o2bqpijakbktgtshythucy4

Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis

Raquel Sanchez-Varo, Marina Mejias-Ortega, Juan Jose Fernandez-Valenzuela, Cristina Nuñez-Diaz, Laura Caceres-Palomo, Laura Vegas-Gomez, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan Antonio Garcia-Leon, Ines Moreno-Gonzalez, Marisa Vizuete, Javier Vitorica (+2 others)
2022 International Journal of Molecular Sciences  
biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability.  ...  However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease  ...  Although white matter abnormalities have been long reported in AD brains [353] , the involvement of OLs in this pathology has received little attention.  ... 
doi:10.3390/ijms23105404 pmid:35628216 pmcid:PMC9142061 fatcat:5djcv232p5ghne57ntyjuoi3ai

The Translational Role of Diffusion Tensor Image Analysis in Animal Models of Developmental Pathologies

Ipek Oguz, Matthew S. McMurray, Martin Styner, Josephine M. Johns
2012 Developmental Neuroscience  
In addition to an in-depth review of translational analysis techniques, we present a number of relevant clinical and animal studies using DTI to investigate developmental insults in order to further illustrate  ...  tion about the analysis of data resulting from small animal DTI studies to facilitate the translation of these studies to clinical data.  ...  Acknowledgements We are grateful to Ashley Rumple for editorial assistance. We would also like to acknowledge the financial support of the  ... 
doi:10.1159/000336825 pmid:22627095 pmcid:PMC3566876 fatcat:bxq7w2bs7faurcgxfordlot3se

Synergy of Image Analysis for Animal and Human Neuroimaging Supports Translational Research on Drug Abuse

Guido Gerig, Ipek Oguz, Sylvain Gouttard, Joohwi Lee, Hongyu An, Weili Lin, Matthew McMurray, Karen Grewen, Josephine Johns, Martin Andreas Styner
2011 Frontiers in Psychiatry  
We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and  ...  This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal  ...  NICHD P30 HD03110 awarded to J. Piven.  ... 
doi:10.3389/fpsyt.2011.00053 pmid:22013425 pmcid:PMC3189614 fatcat:ljxxmkx6orazbivhuuclyjnchq

Hippocampal Shape Analysis in Alzheimer's Disease and Frontotemporal Lobar Degeneration Subtypes

Olof Lindberg, Mark Walterfang, Jeffrey C.L. Looi, Nikolai Malykhin, Per Östberg, Bram Zandbelt, Martin Styner, Beatriz Paniagua, Dennis Velakoulis, Eva Örndahl, Lars-Olof Wahlund
2012 Journal of Alzheimer's Disease  
Tracing began from the anterior at the first slice in which the corpus callosum white matter connected the two hemispheres.  ...  brain regions, the cortical cell structures or the integrity of sub-cortical white matter.  ... 
doi:10.3233/jad-2012-112210 pmid:22414571 pmcid:PMC4862006 fatcat:kwegbnd4kzdixnqjaynkt6x2b4

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

Meixiang Huang, Erica Modeste, Eric Dammer, Paola Merino, Georgia Taylor, Duc M. Duong, Qiudong Deng, Christopher J. Holler, Marla Gearing, Dennis Dickson, Nicholas T. Seyfried, Thomas Kukar
2020 Acta Neuropathologica Communications  
We find that lysosomal dysregulation is exacerbated with age in the Grn−/− mouse brain leading to neuroinflammation, synaptic loss, and decreased markers of oligodendrocytes, myelin, and neurons.  ...  To gain insight into the mechanisms of FTD pathogenesis, we utilized Tandem Mass Tag isobaric labeling mass spectrometry to perform an unbiased quantitative proteomic analysis of whole-brain tissue from  ...  white matter.  ... 
doi:10.1186/s40478-020-01037-x pmid:33028409 fatcat:tbe2pvpadrec3f4is4zibkdn3i
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