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An Introductory Overview of Image-Based Computational Modeling in Personalized Cardiovascular Medicine
2020
Frontiers in Bioengineering and Biotechnology
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However, with the recent advancements made in biomedical scanning technologies and computer simulations, image-based modeling (IBM) has arisen as the next logical step in the evolution of non-invasive ...
Additionally, the imaging methods, the aspects of the unique cardiac anatomy derived from them, and their relation to the modeling algorithms are reviewed. ...
Ultimately, the microscopic sarcomere sliding velocity is related to the macroscopic strain along the myocardial fibers via a constitutive relationship (i.e., microscopic rate-of-strain depends on the ...
doi:10.3389/fbioe.2020.529365
pmid:33102452
pmcid:PMC7546862
fatcat:d3skbglp25avtopkcwkhsipawi
A mathematical model of the unidirectional block caused by the pulmonary veins for anatomically induced atrial reentry
2014
Journal of biological physics (Print)
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To understand this mechanism, a new analytic approach is proposed by adapting the geometric relative acceleration analysis from spacetime physics based on the hypothesis that a large relative acceleration ...
can translate to a dramatic increase in the curvature of a wavefront and subsequently to conduction failure. ...
Reentry in PVs was also simulated on an image-based model by Zhao et al. [29, 30] but was generated by repetitive stimulation with a reduced coupling interval; thus it is a functional reentry. ...
doi:10.1007/s10867-014-9340-5
pmid:24789612
pmcid:PMC4059837
fatcat:oamtmkwexvfuveosedklkt4nkm
Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones
2012
Europace
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It focuses on the contribution of cardiac modelling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction. ...
Reviewed are cardiac modelling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy ...
and Engineering Research Council of Canada (to PMB). ...
doi:10.1093/europace/eus277
pmid:23104919
pmcid:PMC3482619
fatcat:f5m2hzdulnhfjcz3tc6avjhmuq
Computational Cardiology: The Heart of the Matter
2012
ISRN Cardiology
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It focuses on the contribution of cardiac modeling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction. ...
Reviewed are cardiac modeling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy ...
Acknowledgments This research was supported by NIH R01 award HL103428, HL105216, and HL094610 and NSF awards CBET-0933029 and 1124804. ...
doi:10.5402/2012/269680
pmid:23213566
pmcid:PMC3505657
fatcat:rooe57zdzvcs3pgqks24rvffwq
Full Issue PDF
2020
JACC Cardiovascular Imaging
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OBJECTIVES The aim of this study was to assess the effect of congestion and decongestive therapy on left atrial (LA) mechanics and to determine the relationship between LA improvement after decongestive ...
LA function was assessed by strain (rate) imaging. ...
The authors are solely responsible for the design and conduct of this study; all study analyses; and the drafting and editing of the paper and its final contents. ...
doi:10.1016/s1936-878x(20)30301-6
fatcat:w765zpyw4neohdsuytjzyy4gtm
A Contemporary Look at Biomechanical Models of Myocardium
2019
Annual Review of Biomedical Engineering
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Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior. ...
We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium. ...
With the advent of diffusion tensor magnetic resonance imaging (DT-MRI) that can capture myofiber directions in full 3D, a tremendous amount of information has become available. ...
doi:10.1146/annurev-bioeng-062117-121129
pmid:31167105
pmcid:PMC6626320
fatcat:g4tjr6qxybembism7afcgnvrb4
Automatically Generated, Anatomically Accurate Meshes for Cardiac Electrophysiology Problems
2009
IEEE Transactions on Biomedical Engineering
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The method is very well suited for cardiac electrophysiological simulations. ...
To effectively make use of high-resolution imaging datasets for modeling purposes, the imaged objects have to be discretized. This procedure is trivial for structured grids. ...
Acknowledgments The authors thank the teams of Dr. P. Kohl and Dr. D. Gavaghan at the University of Oxford for access to data from their 3-D Heart Project, BBSRC Grant #E003443. ...
doi:10.1109/tbme.2009.2014243
pmid:19203877
pmcid:PMC2819345
fatcat:2ehdk6dp3fagfhekiyo3fzyvpy
Proceedings of the FEniCS Conference 2017
2017
Figshare
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of the FEniCS Conference 2017 ...
Proceedings of the FEniCS Conference 2017 that took place 12-14 June 2017 at the University of Luxembourg, Luxembourg.You can cite individual articles in the proceedings using the following bibtex as a ...
The FEniCS project has embraced the use of containers for Continuous Integration, and for distribution of pre-configured images for users. ...
doi:10.6084/m9.figshare.5086369.v1
fatcat:siyz4enqijbp5byzmdrvi75owm
Proceedings of the FEniCS Conference 2017
2017
Figshare
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of the FEniCS Conference 2017 ...
Proceedings of the FEniCS Conference 2017 that took place 12-14 June 2017 at the University of Luxembourg, Luxembourg.You can cite individual articles in the proceedings using the following bibtex as a ...
The FEniCS project has embraced the use of containers for Continuous Integration, and for distribution of pre-configured images for users. ...
doi:10.6084/m9.figshare.5086369
fatcat:iwajrgqf3nfgzgyloge3f7dz74
AI and Medical Imaging Informatics: Current Challenges and Future Directions
2020
IEEE journal of biomedical and health informatics
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It then provides a synopsis of contemporary and emerging algorithmic methods for disease classification and organ/ tissue segmentation, focusing on AI and deep learning architectures that have already ...
This paper reviews state-of-the-art research solutions across the spectrum of medical imaging informatics, discusses clinical translation, and provides future directions for advancing clinical practice ...
Important factors include the ability to simulate tumor microenvironment, as well as cell-to-cell interactions, the effectiveness of addressing body heterogeneity and anisotropy issues with diffusion tensors ...
doi:10.1109/jbhi.2020.2991043
pmid:32609615
pmcid:PMC8580417
fatcat:dcaefxwwqjfwla5asin34x2hxm
Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease
2016
Journal of the International Neuropsychological Society
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Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597. ...
Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, which receives funding from P41EB015896, a Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging ...
Depending on the severity of the TBI, axonal injury can manifest as microscopic diffuse injury or as macroscopic focal lesions superimposed on diffuse injury (Adams et al., 1989) . ...
doi:10.1017/s1355617716000047
fatcat:f2preenihbes5ftkrxbo7tgt64
Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology
2015
Frontiers in Pharmacology
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In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition ...
This review attempts to make the (bio)medical imaging, molecular medicine, and pharmaceutical communities aware of this productive ferment and its outstanding significance for anatomical and functional ...
., MDC) as well as Tim Wokrina and Daniel Marek (Bruker BioSpin). ...
doi:10.3389/fphar.2015.00255
pmid:26617515
pmcid:PMC4642111
fatcat:fejxorfcyzbivhwv6jndp5n36a
Nonlinear physics of electrical wave propagation in the heart: a review
2016
Reports on progress in physics (Print)
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In this review we focus on the nonlinear dynamics of wave propagation in the heart with an emphasis on the theory of pulses, spirals and scroll waves and their instabilities in excitable media and their ...
instabilities like negative line tension and sproing are reviewed in depth and discussed with emphasis on their impact in cardiac arrhythmias. ...
under grant numbers FIS2011-28820-C02-01 and SAF2014-58286-C2-2-R and MINECO of Spain under the Ramon y Cajal program with the grant number RYC-2012-11265. ...
doi:10.1088/0034-4885/79/9/096601
pmid:27517161
fatcat:rmqut4zmkzhfzdphvxnnbnypte
Perspectives on biological growth and remodeling
2011
Journal of the mechanics and physics of solids
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In this perspective paper we review the state of the field and highlight open questions, challenges, and avenues for further development. ...
Many aspects of these problems are now well-understood, yet there remain areas in need of significant development from the standpoint of experiments, theory, and computation. ...
Anisotropic growth based on microscopically-motivated growth laws. Cardiac wall thickening, stress-driven concentric growth, and transmural muscle thickening at constant cardiac size. ...
doi:10.1016/j.jmps.2010.12.011
pmid:21532929
pmcid:PMC3083065
fatcat:acbqdtdzjreiziij3vsle5vrdy
Female Pelvis: Genital Organs
[chapter]
2015
Medical Radiology
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Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. ...
of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. ...
Imaging of Gastrointestinal Complications and Toxicity Following Tumor Therapy ...
doi:10.1007/174_2015_1054
fatcat:3pptfpaakjcdjiz225n4lewejm
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