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An Introductory Overview of Image-Based Computational Modeling in Personalized Cardiovascular Medicine

Thanh Danh Nguyen, Olufemi E. Kadri, Roman S. Voronov
2020 Frontiers in Bioengineering and Biotechnology  
However, with the recent advancements made in biomedical scanning technologies and computer simulations, image-based modeling (IBM) has arisen as the next logical step in the evolution of non-invasive  ...  Additionally, the imaging methods, the aspects of the unique cardiac anatomy derived from them, and their relation to the modeling algorithms are reviewed.  ...  Ultimately, the microscopic sarcomere sliding velocity is related to the macroscopic strain along the myocardial fibers via a constitutive relationship (i.e., microscopic rate-of-strain depends on the  ... 
doi:10.3389/fbioe.2020.529365 pmid:33102452 pmcid:PMC7546862 fatcat:d3skbglp25avtopkcwkhsipawi

A mathematical model of the unidirectional block caused by the pulmonary veins for anatomically induced atrial reentry

Sehun Chun
2014 Journal of biological physics (Print)  
To understand this mechanism, a new analytic approach is proposed by adapting the geometric relative acceleration analysis from spacetime physics based on the hypothesis that a large relative acceleration  ...  can translate to a dramatic increase in the curvature of a wavefront and subsequently to conduction failure.  ...  Reentry in PVs was also simulated on an image-based model by Zhao et al. [29, 30] but was generated by repetitive stimulation with a reduced coupling interval; thus it is a functional reentry.  ... 
doi:10.1007/s10867-014-9340-5 pmid:24789612 pmcid:PMC4059837 fatcat:oamtmkwexvfuveosedklkt4nkm

Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones

N. A. Trayanova, T. O'Hara, J. D. Bayer, P. M. Boyle, K. S. McDowell, J. Constantino, H. J. Arevalo, Y. Hu, F. Vadakkumpadan
2012 Europace  
It focuses on the contribution of cardiac modelling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction.  ...  Reviewed are cardiac modelling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy  ...  and Engineering Research Council of Canada (to PMB).  ... 
doi:10.1093/europace/eus277 pmid:23104919 pmcid:PMC3482619 fatcat:f5m2hzdulnhfjcz3tc6avjhmuq

Computational Cardiology: The Heart of the Matter

Natalia A. Trayanova
2012 ISRN Cardiology  
It focuses on the contribution of cardiac modeling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction.  ...  Reviewed are cardiac modeling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy  ...  Acknowledgments This research was supported by NIH R01 award HL103428, HL105216, and HL094610 and NSF awards CBET-0933029 and 1124804.  ... 
doi:10.5402/2012/269680 pmid:23213566 pmcid:PMC3505657 fatcat:rooe57zdzvcs3pgqks24rvffwq

Full Issue PDF

2020 JACC Cardiovascular Imaging  
OBJECTIVES The aim of this study was to assess the effect of congestion and decongestive therapy on left atrial (LA) mechanics and to determine the relationship between LA improvement after decongestive  ...  LA function was assessed by strain (rate) imaging.  ...  The authors are solely responsible for the design and conduct of this study; all study analyses; and the drafting and editing of the paper and its final contents.  ... 
doi:10.1016/s1936-878x(20)30301-6 fatcat:w765zpyw4neohdsuytjzyy4gtm

A Contemporary Look at Biomechanical Models of Myocardium

Reza Avazmohammadi, João S. Soares, David S. Li, Samarth S. Raut, Robert C. Gorman, Michael S. Sacks
2019 Annual Review of Biomedical Engineering  
Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior.  ...  We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium.  ...  With the advent of diffusion tensor magnetic resonance imaging (DT-MRI) that can capture myofiber directions in full 3D, a tremendous amount of information has become available.  ... 
doi:10.1146/annurev-bioeng-062117-121129 pmid:31167105 pmcid:PMC6626320 fatcat:g4tjr6qxybembism7afcgnvrb4

Automatically Generated, Anatomically Accurate Meshes for Cardiac Electrophysiology Problems

A.J. Prassl, F. Kickinger, H. Ahammer, V. Grau, J.E. Schneider, E. Hofer, E.J. Vigmond, N.A. Trayanova, G. Plank
2009 IEEE Transactions on Biomedical Engineering  
The method is very well suited for cardiac electrophysiological simulations.  ...  To effectively make use of high-resolution imaging datasets for modeling purposes, the imaged objects have to be discretized. This procedure is trivial for structured grids.  ...  Acknowledgments The authors thank the teams of Dr. P. Kohl and Dr. D. Gavaghan at the University of Oxford for access to data from their 3-D Heart Project, BBSRC Grant #E003443.  ... 
doi:10.1109/tbme.2009.2014243 pmid:19203877 pmcid:PMC2819345 fatcat:2ehdk6dp3fagfhekiyo3fzyvpy

Proceedings of the FEniCS Conference 2017

Jack S. Hale
2017 Figshare  
of the FEniCS Conference 2017  ...  Proceedings of the FEniCS Conference 2017 that took place 12-14 June 2017 at the University of Luxembourg, Luxembourg.You can cite individual articles in the proceedings using the following bibtex as a  ...  The FEniCS project has embraced the use of containers for Continuous Integration, and for distribution of pre-configured images for users.  ... 
doi:10.6084/m9.figshare.5086369.v1 fatcat:siyz4enqijbp5byzmdrvi75owm

Proceedings of the FEniCS Conference 2017

Jack S. Hale
2017 Figshare  
of the FEniCS Conference 2017  ...  Proceedings of the FEniCS Conference 2017 that took place 12-14 June 2017 at the University of Luxembourg, Luxembourg.You can cite individual articles in the proceedings using the following bibtex as a  ...  The FEniCS project has embraced the use of containers for Continuous Integration, and for distribution of pre-configured images for users.  ... 
doi:10.6084/m9.figshare.5086369 fatcat:iwajrgqf3nfgzgyloge3f7dz74

AI and Medical Imaging Informatics: Current Challenges and Future Directions

Andreas S. Panayides, Amir Amini, Nenad Filipovic, Ashish Sharma, Sotirios Tsaftaris, Alistair Young, David J. Foran, Nhan Do, Spyretta Golemati, Tahsin Kurc, Kun Huang, Konstantina S. Nikita (+4 others)
2020 IEEE journal of biomedical and health informatics  
It then provides a synopsis of contemporary and emerging algorithmic methods for disease classification and organ/ tissue segmentation, focusing on AI and deep learning architectures that have already  ...  This paper reviews state-of-the-art research solutions across the spectrum of medical imaging informatics, discusses clinical translation, and provides future directions for advancing clinical practice  ...  Important factors include the ability to simulate tumor microenvironment, as well as cell-to-cell interactions, the effectiveness of addressing body heterogeneity and anisotropy issues with diffusion tensors  ... 
doi:10.1109/jbhi.2020.2991043 pmid:32609615 pmcid:PMC8580417 fatcat:dcaefxwwqjfwla5asin34x2hxm

Introduction to JINS Special Issue on Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease

Deanna M. Barch, Mieke Verfaellie, Stephen M. Rao
2016 Journal of the International Neuropsychological Society  
Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597.  ...  Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, which receives funding from P41EB015896, a Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging  ...  Depending on the severity of the TBI, axonal injury can manifest as microscopic diffuse injury or as macroscopic focal lesions superimposed on diffuse injury (Adams et al., 1989) .  ... 
doi:10.1017/s1355617716000047 fatcat:f2preenihbes5ftkrxbo7tgt64

Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology

Thoralf Niendorf, Andreas Pohlmann, Henning M. Reimann, Helmar Waiczies, Eva Peper, Till Huelnhagen, Erdmann Seeliger, Adrian Schreiber, Ralph Kettritz, Klaus Strobel, Min-Chi Ku, Sonia Waiczies
2015 Frontiers in Pharmacology  
In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition  ...  This review attempts to make the (bio)medical imaging, molecular medicine, and pharmaceutical communities aware of this productive ferment and its outstanding significance for anatomical and functional  ...  ., MDC) as well as Tim Wokrina and Daniel Marek (Bruker BioSpin).  ... 
doi:10.3389/fphar.2015.00255 pmid:26617515 pmcid:PMC4642111 fatcat:fejxorfcyzbivhwv6jndp5n36a

Nonlinear physics of electrical wave propagation in the heart: a review

Sergio Alonso, Markus Bär, Blas Echebarria
2016 Reports on progress in physics (Print)  
In this review we focus on the nonlinear dynamics of wave propagation in the heart with an emphasis on the theory of pulses, spirals and scroll waves and their instabilities in excitable media and their  ...  instabilities like negative line tension and sproing are reviewed in depth and discussed with emphasis on their impact in cardiac arrhythmias.  ...  under grant numbers FIS2011-28820-C02-01 and SAF2014-58286-C2-2-R and MINECO of Spain under the Ramon y Cajal program with the grant number RYC-2012-11265.  ... 
doi:10.1088/0034-4885/79/9/096601 pmid:27517161 fatcat:rmqut4zmkzhfzdphvxnnbnypte

Perspectives on biological growth and remodeling

D. Ambrosi, G.A. Ateshian, E.M. Arruda, S.C. Cowin, J. Dumais, A. Goriely, G.A. Holzapfel, J.D. Humphrey, R. Kemkemer, E. Kuhl, J.E. Olberding, L.A. Taber (+1 others)
2011 Journal of the mechanics and physics of solids  
In this perspective paper we review the state of the field and highlight open questions, challenges, and avenues for further development.  ...  Many aspects of these problems are now well-understood, yet there remain areas in need of significant development from the standpoint of experiments, theory, and computation.  ...  Anisotropic growth based on microscopically-motivated growth laws. Cardiac wall thickening, stress-driven concentric growth, and transmural muscle thickening at constant cardiac size.  ... 
doi:10.1016/j.jmps.2010.12.011 pmid:21532929 pmcid:PMC3083065 fatcat:acbqdtdzjreiziij3vsle5vrdy

Female Pelvis: Genital Organs [chapter]

Rosemarie Forstner, Teresa Margarida Cunha
2015 Medical Radiology  
Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice.  ...  of radiation eff ects, with the emphasis on maximizing cure and minimizing complications.  ...  Imaging of Gastrointestinal Complications and Toxicity Following Tumor Therapy  ... 
doi:10.1007/174_2015_1054 fatcat:3pptfpaakjcdjiz225n4lewejm
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