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Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks

Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
2012 Brain Connectivity  
We have developed a functional connectivity toolbox Conn ( that implements the component-based noise correction method (CompCor) strategy for physiological and other noise source  ...  Resting state functional connectivity reveals intrinsic, spontaneous networks that elucidate the functional architecture of the human brain.  ...  The authors thank Shay Mozes for initial programming support and John Gabrieli for comments on the article.  ... 
doi:10.1089/brain.2012.0073 pmid:22642651 fatcat:cynvmokadjhf7eyqa4w32r7da4

Resting state functional connectivity in early post-anesthesia recovery is characterized by globally reduced anticorrelations [article]

Tommer Nir, Yael Jacob, Kuang-Han Huang, Arthur E. Schwartz, Jess W. Brallier, Helen Ahn, Prantik Kundu, Cheuk Y. Tang, Bradley N. Delman, Patrick J. McCormick, Mary Sano, Stacie G. Deiner (+2 others)
2019 bioRxiv   pre-print
This corresponded to a global reduction in anticorrelated functional connectivity post-anesthesia, seen across individual regions-of-interest.  ...  Positively correlated functional connectivity remained constant across peri-anesthetic states.  ...  Conn : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks. Brain Connect 2012; 2: 125-41 29. Greicius M, Krasnow B, Reiss A, Menon V.  ... 
doi:10.1101/669457 fatcat:fz4becpgf5d2plwrlr4mynu3we

Test-Retest Reliability of Emotion Regulation Networks in the Resting-State fMRI Functional Connectivity

Lucas Jeay-Bizot, Stella Berboth, Carmen Morawetz
2020 Zenodo  
Functional connectivity analysis was performed using the CONN Toolbox and by applying a seed-region approach.  ...  Whereas multiple brain areas have been implicated in ER, relatively little is known about the functionally connected networks during rest that are related to ER and their reliability.  ...  Whitfield-Gabrieli and A. Nieto-Castanon, "Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks," Brain Connect., Cicchetti, D.V., & Sparrow, S.A., (1981).  ... 
doi:10.5281/zenodo.4016697 fatcat:hgnyck4uqnbjzfxi5si3434cyi

Resting-State Functional Connectivity and Scholastic Performance in Preadolescent Children: A Data-Driven Multivoxel Pattern Analysis (MVPA)

Daniel R. Westfall, Sheeba A. Anteraper, Laura Chaddock-Heyman, Eric S. Drollette, Lauren B. Raine, Susan Whitfield-Gabrieli, Arthur F. Kramer, Charles H. Hillman
2020 Journal of Clinical Medicine  
This study examines resting-state functional connectivity (RsFc) associated with scholastic performance (reading and mathematics) in preadolescent children (7–9 years) using an unbiased whole-brain connectome-wide  ...  Of particular interest, anticorrelations were observed between the default mode network and the somatomotor, dorsal attention, ventral attention, and frontoparietal networks.  ...  Figure 3 . 3 Whole-brain functional connectivity correlations with reading composite score for MVPA cluster a.  ... 
doi:10.3390/jcm9103198 pmid:33023206 fatcat:k62rguggvvb2fagosdwtbqvgf4

The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network

Junkai Wang, Yachao Xu, Gopikrishna Deshpande, Kuncheng Li, Pei Sun, Peipeng Liang
2021 Brain Sciences  
Midazolam decreased functional connectivity of the dorsal attention network.  ...  It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness.  ...  April 2019) and the CONN-fMRI functional connectivity toolbox v18b (, accessed on 17 May 2019; [31] ).  ... 
doi:10.3390/brainsci11081107 fatcat:223upu736bgldhi7jxbn463u3a

Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment

Junkai Wang, Jianghong Liu, Zhiqun Wang, Pei Sun, Kuncheng Li, Peipeng Liang
2019 Aging  
An anticorrelated relationship in the spontaneous fluctuations between the default mode network (DMN) and dorsal attention network (DAN) is a robust feature of intrinsic brain organization in healthy individuals  ...  Our findings suggest that DMN-DAN anticorrelation may shed light on the understanding of the adaptations in brain function during the progression from MCI to AD and may serve as a potential biomarker to  ...  Functional connectivity analysis After data preprocessing, we first performed group spatial independent component analysis (ICA) to decompose the data into functional networks using the CONN toolbox and  ... 
doi:10.18632/aging.102380 pmid:31645482 pmcid:PMC6834429 fatcat:kz3ekdju5nbfpjfq7ip2oc5st4

Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness

Aaron D Boes, David Fischer, Joel C Geerling, Joel Bruss, Clifford B Saper, Michael D Fox
2018 Sleep  
These findings, while preliminary, may lend further insight into the neural basis of sleep-wake regulation in humans and the functional significance of anticorrelated networks.  ...  First, we identify a negative correlation (anticorrelation) between the anterior and posterior hypothalamus, two regions with opposing roles in sleep-wake regulation.  ...  Acknowledgments We thank Randy Buckner and the Brain Genomics Superstruct Project for contributing data and analysis tools.  ... 
doi:10.1093/sleep/zsy108 pmid:29850898 fatcat:bicomlb6frddbnkmjtaqw2vnzi

Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults

Chaleece W. Sandberg
2017 Frontiers in Human Neuroscience  
but also for the interaction of language and other cognitive functions.  ...  The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared  ...  AUTHOR CONTRIBUTIONS CS designed the study, carried out the acquisition, analysis, and interpretation of the data, drafted the manuscript, and is solely accountable for all aspects of the work.  ... 
doi:10.3389/fnhum.2017.00091 pmid:28293185 pmcid:PMC5329062 fatcat:wkkuzgtzw5clbdleqjuqjnkuum

Functional networks reemerge during recovery of consciousness after acute severe traumatic brain injury

Zachary D. Threlkeld, Yelena G. Bodien, Eric S. Rosenthal, Joseph T. Giacino, Alfonso Nieto-Castanon, Ona Wu, Susan Whitfield-Gabrieli, Brian L. Edlow
2018 Cortex  
However, the effects of acute severe traumatic brain injury (TBI) on DMN functional connectivity are poorly understood.  ...  Both intra-network DMN correlations and inter-network DMN anticorrelations may be necessary for full recovery of consciousness after acute severe TBI.  ...  We are grateful to the patients and families in this study for their participation and support. We acknowledge Dylan Tisdall and Andre van der Kouwe (Athinoula A.  ... 
doi:10.1016/j.cortex.2018.05.004 pmid:29871771 pmcid:PMC6120794 fatcat:sllpxpbekjesfk576i6gckbm2y

Attenuated Resting-State Functional Anticorrelation between Attention and Executive Control Networks in Schizotypal Personality Disorder

Ji-Won Hur, Taekwan Kim, Kang Ik K. Cho, Jun Soo Kwon
2021 Journal of Clinical Medicine  
Consequently, while there were no group differences in intra-network functional connectivity across DMN, FPN, DAN, and SN, the SPD participants exhibited attenuated anticorrelation between the right frontal  ...  This study, which links SPD pathology and social functioning deficits, is the first evidence of impaired large-scale intrinsic brain networks in SPD.  ...  Each connection denotes the correlation between two brain regions and has a threshold at the upper 25% of the strongest connections for visualization purposes.  ... 
doi:10.3390/jcm10020312 pmid:33467694 pmcid:PMC7829946 fatcat:2dc3lldedjailezwswvzozj23q

Anticorrelations in resting state networks without global signal regression

Xiaoqian J. Chai, Alfonso Nieto Castañón, Dost Öngür, Susan Whitfield-Gabrieli
2012 NeuroImage  
We examined positive and negative correlations in resting-state connectivity using two different preprocessing methods: a component base noise reduction method (CompCor, Behzadi et al., 2007), in which  ...  Specificity of the anticorrelations was similar between the two methods. Specificity and sensitivity for positive correlations were higher under CompCor compared to the global regression method.  ...  Öngür) from the National Institute of Mental Health and by the Poitras Center for Affective Disorders Research at the McGovern Institute for Brain Research at MIT.  ... 
doi:10.1016/j.neuroimage.2011.08.048 pmid:21889994 pmcid:PMC3230748 fatcat:hj4h7b4ztvfynh7mmgh2czv4sy

Mesocorticolimbic Interactions Mediate fMRI-Guided Regulation of Self-Generated Affective States

Andrea Caria
2020 Brain Sciences  
The fMRI and functional connectivity analysis revealed that the upper midbrain significantly contributes to emotion regulation in humans.  ...  Moreover, differential functional interactions between the dopaminergic mesocorticolimbic system and frontoparietal networks mediate up and down emotion regulatory processes.  ...  Multivariate and univariate connectivity analyses were performed using the CONN functional connectivity toolbox (Release 18.a, [62, 63] .  ... 
doi:10.3390/brainsci10040223 pmid:32276411 fatcat:yhpzhzfqvnhpta4mv766ypx72u

Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy

P. Flodin, S. Martinsen, K. Mannerkorpi, M. Löfgren, I. Bileviciute-Ljungar, E. Kosek, P. Fransson
2015 NeuroImage: Clinical  
In this study we investigated resting-state connectivity using functional magnetic resonance imaging (fMRI) before and after a 15 week standardized exercise program supervised by physical therapists.  ...  Although several brain regions showed a treatment-related change in connectivity, only the connectivity between the right anterior insula and the left primary sensorimotor area was significantly more affected  ...  Subject level SCA analyses were carried out using the Conn toolbox ( (Whitfield-Gabrieli & Nieto-Castanon, 2012).  ... 
doi:10.1016/j.nicl.2015.08.004 pmid:26413476 pmcid:PMC4556735 fatcat:3vs2262kzrgjnclh3n7px2hme4

Anticorrelations between Active Brain Regions: An Agent-Based Model Simulation Study

Fabrizio Parente, Alfredo Colosimo
2018 Neural Plasticity  
refine any brain functional model.  ...  Some evidence points to a possible physiological role for them, and simulation models showed that it is appropriate to explore such an issue.  ...  The SPM8 (Statistical Parametric Mapping) (Wellcome Department of Cognitive Neurology, London, UK) toolbox and the Functional Connectivity (CONN) toolbox were used in the preprocessing of data on a MATLAB  ... 
doi:10.1155/2018/6815040 pmid:29755515 pmcid:PMC5883988 fatcat:cde5xk4tzfd4deqxxuesinrpbu

Aberrant Coupling Within and Across the Default Mode, Task-Positive, and Salience Network in Subjects at Risk for Psychosis

Diana Wotruba, Lars Michels, Roman Buechler, Sibylle Metzler, Anastasia Theodoridou, Miriam Gerstenberg, Susanne Walitza, Spyros Kollias, Wulf Rössler, Karsten Heekeren
2013 Schizophrenia Bulletin  
Key words: resting-state fMRI/schizophrenia/anticorrel ated networks/functional connectivity/central executive network/anterior insula/prodrome/intrinsic connectivity/ brain  ...  Because abnormal functional connectivity in these networks has been related to schizophrenia, we tested whether alterations are also evident in subjects at risk for psychosis.  ...  The CONN-fMRI functional connectivity toolbox v13 (, accessed October 29, 2013) was used to apply band-pass filtering (0.008 Hz < f < 0.09 Hz) and to create individual  ... 
doi:10.1093/schbul/sbt161 pmid:24243441 pmcid:PMC4133671 fatcat:ml74un3iwjfbjewukcebyxdssm
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