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Confirmation of functional zones within the human subthalamic nucleus: Patterns of connectivity and sub-parcellation using diffusion weighted imaging
2012
NeuroImage
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In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. ...
The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. ...
We thank all participants in our study and the radiographers at the Functional Imaging Laboratory for their assistance acquiring data. ...
doi:10.1016/j.neuroimage.2011.11.082
pmid:22173294
pmcid:PMC3315017
fatcat:7r332dafzrhn7f4vr25ekp2uce
Non-motor effects of subthalamic nucleus stimulation in Parkinson's patients
[article]
2019
bioRxiv
pre-print
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The existing white matter connectivity analyses of the subthalamic region have mainly included the motor effects of deep brain stimulation. ...
The subthalamic parcellation yielded a medio-lateral gradient with motor parcel being lateral and the non-motor parcels being medial. ...
Diffusion weighted images were acquired using an EPI sequence with inter-slice distance=0 mm; number of slices=71; voxel size=2.0 x 2.0 x2.0 mm, TR=8100 ms; TE=68 ms; matrix size 128x128; 60 directions ...
doi:10.1101/540328
fatcat:7h4qd7y53vfs7glvbeqtqctnni
Identifying and characterizing projections from the subthalamic nucleus to the cerebellum in humans
2020
NeuroImage
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A connection between the subthalamic nucleus (STN) and the cerebellum which has been shown to exist in non-human primates, was recently identified in humans. ...
Anatomical features and asymmetry index (AI) were explored using high definition fiber tractography data of 30 individuals from the Massachusetts General Hospital - Human Connectome Project adult diffusion ...
Confirmation of functional zones within the human subthalamic 31 nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging. 32 Neuroimage 60, 83-94. 33 Mallet, L., Polosan ...
doi:10.1016/j.neuroimage.2020.116573
pmid:31968232
fatcat:ootqx7yx55esrektk53ucasmmy
Functional segregation and integration within the human subthalamic nucleus from a micro- and meso-level perspective
2020
Cortex
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The subthalamic nucleus (STN) is a core basal ganglia structure involved in the control of motor, cognitive, motivational and affective functions. ...
Any functional segregation within the STN is expected to be reflected both at micro-level microscopy and meso-level neural population activity. ...
B) Winner-takes-all parcellation of the human STN by Ewert et al. (2016) based on diffusion-weighted images from 32 healthy adults and 90 people with Parkinson's disease. ...
doi:10.1016/j.cortex.2020.07.004
pmid:32823130
fatcat:7nooknoh4balviaxrqrmdddby4
Diverging prefrontal cortex fiber connection routes to the subthalamic nucleus and the mesencephalic ventral tegmentum investigated with long range (normative) and short range (ex-vivo high resolution) 7T DTI
2021
Brain Structure and Function
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AbstractUncertainties concerning anatomy and function of cortico-subcortical projections have arisen during the recent years. ...
Our work enfeebles previous anatomical criticism and strengthens the position of the slMFB DBS target for its use in MD and OCD. ...
Acknowledgements We would like to thank the body donor and her family for making the use of the brain sample possible. ...
doi:10.1007/s00429-021-02373-x
pmid:34482443
pmcid:PMC8741702
fatcat:2hbf5u5ipjaundp72heq3ugqpm
Cortico-basal white matter alterations occurring in Parkinson's disease
2019
PLoS ONE
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The present study utilizes Parkinson's disease and age-specific anatomical atlases of the subthalamic nucleus for diffusion tractography, assessing tracts that run between the subthalamic nucleus and a-priori ...
Contrary to that, Fractional Anisotropy values were shown to decrease in Parkinson's disease patients for connections between the subthalamic nucleus and the pars opercularis of the inferior frontal gyrus ...
Confirmation of functional zones within the human subthalamic nucleus: Patterns of connectivity and sub-parcellation using diffusion weighted imaging. ...
doi:10.1371/journal.pone.0214343
pmid:31425517
pmcid:PMC6699705
fatcat:mpid4cutcbfcljgqjk6ghr2qbq
In vivo 3D Reconstruction of the Human Pallidothalamic and Nigrothalamic Pathways With Super-Resolution 7T MR Track Density Imaging and Fiber Tractography
2021
Frontiers in Neuroanatomy
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In this study, track-density imaging (TDI) of the whole human brain was employed to overcome the limitations of observing the pallidothalamic and nigrothalamic tracts. ...
However, these connections in the human brain remain difficult to elucidate because of the resolution limit of current neuroimaging techniques. ...
In this study, we obtained ultra-high-resolution structural and diffusion-weighted MR images of the human brain in vivo at 7T. ...
doi:10.3389/fnana.2021.739576
pmid:34776880
pmcid:PMC8579044
fatcat:o35q6afcyraojjbs23kmcqxdxu
A Direct Cortico-Nigral Pathway as Revealed by Constrained Spherical Deconvolution Tractography in Humans
2016
Frontiers in Human Neuroscience
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diffusion weighted imaging data. ...
Substantia nigra is an important neuronal structure, located in the ventral midbrain, that exerts a regulatory function within the basal ganglia circuitry through the nigro-striatal pathway. ...
The antero-lateral zone, the "pars reticulata" (SNr), consists of GABAergic neurons which receive afferents from the striatum and subthalamic nucleus (STN) and in turn project to ventral-anterior (VA) ...
doi:10.3389/fnhum.2016.00374
pmid:27507940
pmcid:PMC4960230
fatcat:lumz5j2dx5cxbhg4gsvzve32km
Automatic target validation based on neuroscientific literature mining for tractography
2015
Frontiers in Neuroanatomy
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We applied textmining models to three structures: two well-studied structures, since validated deep brain stimulation targets, the internal globus pallidus and the subthalamic nucleus and, the nucleus ...
We ran probabilistic tractography on the nucleus accumbens and compared the output with the results of the text-mining models and literature review. ...
Acknowledgments We acknowledge our colleagues, Antoine Lutti, Sara Lorio, Anne Ruef and Lester Melie-Garcia for the validation and implementation of the structural imaging protocols at LREN. ...
doi:10.3389/fnana.2015.00066
pmid:26074781
pmcid:PMC4445321
fatcat:msidutnkrnfarjshm3iu5nfyua
Feasibility of Diffusion Tractography for the Reconstruction of Intra-Thalamic and Cerebello-Thalamic Targets for Functional Neurosurgery: A Multi-Vendor Pilot Study in Four Subjects
2016
Frontiers in Neuroanatomy
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The purpose of this pilot study was to evaluate the feasibility of diffusion tensor imaging (DTI) based probabilistic tractography of deep brain structures that are commonly used for pre-and perioperative ...
Compared to a 3D histological atlas of the human thalamus, moderate overlaps of 35-50% were measured between connectivity-and atlas based volumes, while the minimal distance between the centerpoints of ...
atlas of the human thalamus used in our study. ...
doi:10.3389/fnana.2016.00076
pmid:27462207
pmcid:PMC4940380
fatcat:opnmho3leva4hmmti52rehio7m
WIKIBrainStem: an online atlas to manually segment the human brainstem at the mesoscopic scale from ultrahigh field MRI
2021
NeuroImage
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Here, we scanned an ex vivo specimen using an ultra-high field (11.7T) preclinical MRI scanner providing data at a mesoscopic scale for anatomical T2-weighted (100µm and 185µm isotropic) and diffusion-weighted ...
The brainstem is one of the most densely packed areas of the central nervous system in terms of gray, but also white, matter structures and, therefore, is a highly functional hub. ...
Funding: this project/research has received funding from the European Union's Horizon 2020 Framework Program for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project ...
doi:10.1016/j.neuroimage.2021.118080
pmid:33882348
fatcat:zxbgrapwyfaxpdzhvoiujesway
Detecting stable individual differences in the functional organization of the human basal ganglia
2018
NeuroImage
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Still, the identification of functional units in the brain based on intrinsic functional connectivity and its dynamic variations between and within subjects remains challenging. ...
The functional parcellation revealed by stable clusters replicated previous divisions found in the basal ganglia based on intrinsic functional connectivity. ...
Acknowledgements The work presented here was supported by gifts from Phyllis Green, Randolph Cowen, and Joseph Healey, as well as support provided by U01 MH099059. ...
doi:10.1016/j.neuroimage.2017.07.029
pmid:28739120
pmcid:PMC7025720
fatcat:4vmvnfooevd3vd6cv4mixhar64
Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain
[article]
2021
bioRxiv
pre-print
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However, its mechanisms of action within the brain network are still poorly understood. ...
-Our simulations are based on a normative connectome including detailed tracts between the cortex and the basal ganglia regions combined with subject-specific optimized weights for a healthy control and ...
We are grateful to Julien Vitay for providing us with guidance concerning the usage of ANNarchy and being involved in initial discussions. ...
doi:10.1101/2021.05.05.442704
fatcat:sbhjxk37gjaflfznjkgbezaqiu
Clinical Applications of Magnetic Resonance Imaging Based Functional and Structural Connectivity
2021
NeuroImage
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of connectivity analytic approaches to present an encompassing and appropriate perspective. ...
In this review, we will highlight the current clinical uses of MRI connectomics in the diagnosis and treatment of neurological disorders; balancing emerging applications and technologies with limitations ...
JHG was supported by the National Institutes of Health ( 1KL2TR001444 , R01 ...
doi:10.1016/j.neuroimage.2021.118649
pmid:34648960
fatcat:6i536zz6mfertaortalbr5h7gi
Abstracts
2019
Stereotactic and Functional Neurosurgery
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The MRgFUS platform enables image-based targeting of the area of BBBD, real-time acoustic monitoring to account for tissue variability, intraoperative hemorrhage detection and confirmation of BBBD outcome ...
Methods: This is a prospective, single-arm study to establish the safety and feasibility of BBBD along the periphery of tumor resection cavity using the MRgFUS. ...
Methods: We used diffusion weighted imaging-based tractography acquired from 30 healthy subjects from the Human Connectome Project. ...
doi:10.1159/000501568
fatcat:pv2k5hzuindpdmffhvqlkl25ji
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