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Conductance-based dendrites perform reliability-weighted opinion pooling [article]

Jakob Jordan, João Sacramento, Mihai A. Petrovici, Walter Senn
2020 arXiv   pre-print
Starting from a normative model we show that the dynamics of multi-compartment neurons with conductance-based dendrites naturally implement the required probabilistic computations.  ...  The associated error-driven plasticity rule allows neurons to learn the relative reliability of different pathways from data samples, approximating Bayes-optimal observers in multisensory integration tasks  ...  integration via conductance-based dendrites.  ... 
arXiv:2006.15099v1 fatcat:a23g7cko4ffnbcoj5d5jubkqxu

Learning Bayes-optimal dendritic opinion pooling [article]

Jakob Jordan, João Sacramento, Willem A.M. Wybo, Mihai A. Petrovici, Walter Senn
2021 arXiv   pre-print
Pooling different opinions and weighting them according to their reliability is conducive to making good decisions.  ...  We suggest that dendritic membrane potentials and conductances encode opinions and their associated reliabilities, on which the soma acts as a decision maker.  ...  decisions based on the pooled opinions.  ... 
arXiv:2104.13238v1 fatcat:gdis35qlhja6litbxdnujqotbm

Developmental Self-Construction and -Configuration of Functional Neocortical Neuronal Networks

Roman Bauer, Frédéric Zubler, Sabina Pfister, Andreas Hauri, Michael Pfeiffer, Dylan R. Muir, Rodney J. Douglas, Olaf Sporns
2014 PLoS Computational Biology  
Once initial axonal connection patterns are established, their synaptic weights undergo homeostatic unsupervised learning that is shaped by wave-like input patterns.  ...  Performed the experiments: RB SP. Analyzed the data: RB SP. Contributed reagents/ materials/analysis tools: RB FZ SP AH. Wrote the paper: RB FZ SP MP DRM RJD.  ...  This kind of reliability is useful for performing computation with states based on analog elements [8, 62] .  ... 
doi:10.1371/journal.pcbi.1003994 pmid:25474693 pmcid:PMC4256067 fatcat:2tfon7aqkvberk5ugta5zeg2ku

Risk Factors of Cytomegalovirus Reactivation in Ulcerative Colitis Patients: A Meta-Analysis

Yafei Qin, Grace Wang, Dejun Kong, Guangming Li, Hongda Wang, Hong Qin, Hao Wang
2021 Diagnostics  
This meta-analysis was performed to identify the risk factors for CMV reactivation in UC patients.  ...  The robustness and reliability of each outcome were evaluated by sensitivity analysis. Twenty studies were included in the final meta-analysis, comprising a total of 2099 patients with UC.  ...  Exclusion criteria: (I) Diagnosis of CMV reactivation only based on the positive serological antibody or endoscopic performance, but the serological test is negative; (II) abstract, letter, editorial,  ... 
doi:10.3390/diagnostics11111952 pmid:34829298 pmcid:PMC8625464 fatcat:7s7p7oi3jneulmf55ezkzycjge

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

Florent Ubelmann, Tatiana Burrinha, Laura Salavessa, Ricardo Gomes, Cláudio Ferreira, Nuno Moreno, Cláudia Guimas Almeida
2016 EMBO Reports  
Hence, Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites.  ...  When CD2AP levels are reduced, APP is trapped at the limiting membrane of early endosomes and fails to be sorted for degradation in dendrites.  ...  Given its weight for the paper, the authors should include more controls for their semi-quantitative immunofluorescence based Abeta42 assay, for instance using g-secretase and BACE1 inhibitors for an extended  ... 
doi:10.15252/embr.201642738 pmid:27895104 pmcid:PMC5210085 fatcat:o7kk3sfczvekdlgkobg5qjuxue

High-Temperature Protective Coatings Produced by EB-PVD

B.A. Movchan, Yakovchuk K. Yu
2014 Journal of Coating Science and Technology  
Heating and high-rate evaporation of initial inorganic substances is performed by electron beam (accelerated flow of electrons) generated by electron beam gun.  ...  Uwe Schulz (DRL, Germany) for providing the initial substrate samples and heat conductivity studies (Figure 7) .  ...  The main factor influencing thermal conductivity of 8YSZ layer, is its porosity, and in our opinion intercrystalline porosity plays the determinant role here.  ... 
doi:10.6000/2369-3355.2014.01.02.2 fatcat:rvninccmfvhmzjilpmstt64ziq

Immunotoxicity testing using human primary leukocytes: An adjunct approach for the evaluation of human risk

Ashwini S. Phadnis-Moghe, Norbert E. Kaminski
2017 Current Opinion in Toxicology  
Hence, this opinion piece aims to discuss new models used to assess the effects of environmental contaminants and immune modulators on the immune response in human cells, the advantages and challenges  ...  Many if not most of the current rodent-based immune function assays in the tier testing approach can also be performed using isolated human primary leukocytes.  ...  Conversely, a major drawback of conducting immunotoxicity testing in mice was that the majority of routine toxicity and carcinogenicity testing was and continues to be conducted in the rat.  ... 
doi:10.1016/j.cotox.2017.04.005 pmid:29619412 pmcid:PMC5880284 fatcat:5dfjruzanfhpfn3hgnljc7gcja

Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells

Michael Häausser, Arnd Roth
1997 Journal of Physiology  
The mean single-channel conductance of the GluR channels measured using non-stationary fluctuation analysis was •8 pS in dendritic and somatic patches, and the maximum open probability was at least 0·7  ...  Dendritic patches were isolated 40-130 ìm from the soma. 2.  ...  Pooled results from 9 dendritic patches.  ... 
doi:10.1111/j.1469-7793.1997.077bo.x pmid:9174996 fatcat:72otomlxvfhcpi7dngxmk2f2lu

Early detection of Ebola virus proteins in peripheral blood mononuclear cells from infected mice

Michael D. Ward, Tara Kenny, Ernie Bruggeman, Christopher D. Kane, Courtney L. Morrell, Molly M. Kane, Sandra Bixler, Sarah L. Grady, Rachel S. Quizon, Mekbib Astatke, Lisa H. Cazares
2020 Clinical Proteomics  
These results were confirmed via western blot which was performed on identical PBMC lysates from each post-infection time point.  ...  Blood samples pooled from animals at the post-infection time-points were used to determine the viral load by RT-PCR and purify PBMCs.  ...  Lou Altamura for his assistance in performing the RT-PCR for EBOV titer determination from the mouse blood samples. 1  ... 
doi:10.1186/s12014-020-09273-y pmid:32194356 pmcid:PMC7077124 fatcat:mh5cbicluncxzk5up5fj4peufe

Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis

Qiang Zhang, Zhijiang Qi, Bo-Liu, Chun-Sheng Li
2018 BioMed Research International  
Strict literature retrieval and data extraction were performed to extract relevant data. Data analysis was conducted using RevMan 5.3 software and Stata version 12.0.  ...  A fixed-effect model was selected to pool and a forest plot was used to display RRs. Results. Four studies involving 394 animals were finally included. Nine control groups are used to pool.  ...  We performed subgroup analysis to identify the sources of heterogeneity. A sensitivity analysis was performed using Stata version 12.0 to identify influence of an individual study on the pooled RR.  ... 
doi:10.1155/2018/1969474 pmid:30159323 pmcid:PMC6109543 fatcat:msjjl5uu7je5hpdwc24iejyj6a

Learning-guided automatic three dimensional synapse quantification for drosophila neurons

Jonathan Sanders, Anil Singh, Gabriella Sterne, Bing Ye, Jie Zhou
2015 BMC Bioinformatics  
The method developed a discriminative model based on 3D feature descriptors that detected the centers of synaptic markers.  ...  Algorithms were tested on lobula plate tangential cells (LPTCs) in the brain of Drosophila melanogaster, for GABAergic synaptic markers on axon terminals as well as dendrites.  ...  Central to our method is a multidimensional discriminative model learned from reliable 3D feature descriptors.  ... 
doi:10.1186/s12859-015-0616-y pmid:26017624 pmcid:PMC4445279 fatcat:ru46gcyn7zhqldqrukydcopv4m

A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease

Xiaoxue Fu, Yu Wang, Xiaofeng He, Hongyu Li, Hong Liu, Xiangyang Zhang
2020 Lipids in Health and Disease  
Then this article summarized the characteristics of all clinical studies and collected the corresponding data to perform pooled and sensitivity analyses.  ...  The meta-analysis was performed by using the RevMan 5.3 software after data extraction, quality assessment and analysis of publication bias.  ...  Forest plots pooled standard weighted mean difference (c) or odds ratios (d) for meta-analysis after excluding the study by Ikeda et al. [20] or Hu et al. [33] Fig. 3 3 Forest plots for pooled standard  ... 
doi:10.1186/s12944-020-01284-w pmid:32430016 fatcat:met27yg6lzanvmqdtvflvk45nm

CRISPR-based functional genomics in human dendritic cells

Marco Jost, Amy N Jacobson, Jeffrey A Hussmann, Giana Cirolia, Michael A Fischbach, Jonathan S Weissman
2021 eLife  
Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe communication at mucosal surfaces.  ...  Using this method, we perform genetic screens in moDCs, identifying mechanisms by which DCs tune responses to lipopolysaccharides from the human microbiome.  ...  CRISPR-based functional genomics in human dendritic cells Cited 1 Views 2,490 Annotations Abstract Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe  ... 
doi:10.7554/elife.65856 fatcat:j37hpxlldvfc3dj6wsplbyv6za

Information integration for nutritional decision-making in desert locusts [article]

Yannick Günzel, Felix B. Oberhauser, Einat Couzin-Fuchs
2022 bioRxiv   pre-print
We then predicted the decisions of individual locusts based on personally acquired and socially derived evidence by disentangling the relative contributions of each information class.  ...  At the same time, they reinforce congruent information to form stronger opinions when evidence aligns.  ...  Data were pooled across all group sizes (N = 5, 10, 15, 30 animals).  ... 
doi:10.1101/2022.05.16.492099 fatcat:xgpda36tffgpjmwqkjd7djnyoq

Extraction of spatio-temporal primitives of emotional body expressions

Lars Omlor, Martin A. Giese
2007 Neurocomputing  
synaptic integration is by adding voltage-gated dendritic conductances to models of passive dendrites, which incorporate sodium and potassium dendritic conductances.  ...  We performed computational simulations with NEURON using a novel stochastic dendrite generation algorithm to create ëgenericí neurons based on realistic morphological parameters for CA1 pyramidal dendrites  ... 
doi:10.1016/j.neucom.2006.10.100 fatcat:esivhljzsbcihdl5qbp756josu
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