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Concurrent TMS to the primary motor cortex augments slow motor learning

Shalini Narayana, Wei Zhang, William Rogers, Casey Strickland, Crystal Franklin, Jack L. Lancaster, Peter T. Fox
2014 NeuroImage  
Healthy right-handed individuals were assigned to receive 5 Hz TMS (TMS group) or sham TMS (sham group) to the right primary motor cortex (M1) as they performed daily motor practice of a digit sequence  ...  We tested this hypothesis in the context of a slow motor learning paradigm.  ...  Acknowledgments This work was funded by grants from the Veterans Administration (Merit Award to Peter. T.  ... 
doi:10.1016/j.neuroimage.2013.07.024 pmid:23867557 pmcid:PMC4331120 fatcat:sj6l3375n5ewdc5s3ulaot6yja

A Framework for Combining rTMS with Behavioral Therapy

K. Zoe Tsagaris, Douglas R. Labar, Dylan J. Edwards
2016 Frontiers in Systems Neuroscience  
In the last decade, experimental enquiry has sought new ways to improve the therapeutic benefits of rTMS, intended to enhance underlying brain reorganization and functional recovery by combining it with  ...  Upon its inception, repetitive transcranial magnetic stimulation (rTMS) was delivered at rest, without regard to the potential impact of activity occurring during or around the time of stimulation. rTMS  ...  ACKNOWLEDGMENTS The authors would like to acknowledge Daniel Press MD for insight in psychiatric application of rTMS, and Gary Thickbroom Ph.D. for helpful comments during manuscript development.  ... 
doi:10.3389/fnsys.2016.00082 pmid:27895557 pmcid:PMC5108775 fatcat:ap266kqlvfhz7o3bdoezex7wki

Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications

Charles-Francois V. Latchoumane, Deborah A. Barany, Lohitash Karumbaiah, Tarkeshwar Singh
2020 Frontiers in Neurology  
Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted following stroke and traumatic brain injury (TBI).  ...  The high degree of homology in reach-to-grasp circuitry between humans and rodents further implies that the application of NIBS to brain injury could be better informed by findings from pre-clinical rodent  ...  Response to treatment also depends on the timing relative to the injury-whereas the goal of stimulation in the acute and subacute phases may be to augment motor learning during spontaneous recovery, in  ... 
doi:10.3389/fneur.2020.00835 pmid:32849253 pmcid:PMC7396659 fatcat:7ejeq32l3jbrrkhxesnodxd7uu

Adaptive Plasticity in the Healthy Language Network: Implications for Language Recovery after Stroke

Gesa Hartwigsen
2016 Neural Plasticity  
A large number of studies applied transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in the healthy brain to probe the functional relevance and interaction of specific  ...  NIBS is also increasingly being used to induce adaptive plasticity in motor and cognitive networks and shape cognitive functions.  ...  primary motor cortex [77] .  ... 
doi:10.1155/2016/9674790 pmid:27830094 pmcid:PMC5088318 fatcat:qqmwczphgneztao62jbi2stbkq

Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS)

Bruce Luber, Sarah H. Lisanby
2014 NeuroImage  
One technique, combining multiple sessions of TMS with concurrent TMS/task performance to induce Hebbian-like learning, appears to be promising for prolonging enhancement effects.  ...  While further refinements in the application of TMS to cognitive enhancement can still be made, and questions remain regarding the mechanisms underlying the observed effects, this appears to be a fruitful  ...  Overall, a great deal still needs to be learned about the interaction of TMS and cortex.  ... 
doi:10.1016/j.neuroimage.2013.06.007 pmid:23770409 pmcid:PMC4083569 fatcat:zb7zqobnkbg25baxc6nrr4qmii

Motor control and aging: Links to age-related brain structural, functional, and biochemical effects

Rachael D. Seidler, Jessica A. Bernard, Taritonye B. Burutolu, Brett W. Fling, Mark T. Gordon, Joseph T. Gwin, Youngbin Kwak, David B. Lipps
2010 Neuroscience and Biobehavioral Reviews  
Acknowledgements We thank Patti Reuter-Lorenz, Cindy Lustig, Jaime Hughes, Yun Ju Lee, and members of the Neuromotor Behavior Laboratory for discussion and critical comments on this work.  ...  Older adults are also able to learn to learn new motor skills (Seidler, 2007a,b) . That is, older adults learn a new task faster if they previously learn multiple other motor tasks.  ...  to the movement slowing seen with age.  ... 
doi:10.1016/j.neubiorev.2009.10.005 pmid:19850077 pmcid:PMC2838968 fatcat:rr3s5chiqfd3jfxglyg6g6heya

Applications of transcranial direct current stimulation for understanding brain function

Hannah L. Filmer, Paul E. Dux, Jason B. Mattingley
2014 Trends in Neurosciences  
These advances have allowed inferences to be made regarding the neural operations that shape perception, cognition, and action.  ...  Here we summarise how tDCS works, and show how research using this technique is expanding our understanding of the neural basis of cognitive and motor training.  ...  Motor evoked potentials (MEPs): activity in a muscle induced, in this context, by a TMS pulse applied to the primary motor cortex.  ... 
doi:10.1016/j.tins.2014.08.003 pmid:25189102 fatcat:ezef57jdwvgzvkats4y2u2ulmm

Non-Invasive Brain Stimulation: An Interventional Tool for Enhancing Behavioral Training after Stroke

Maximilian J. Wessel, Máximo Zimerman, Friedhelm C. Hummel
2015 Frontiers in Human Neuroscience  
The purpose of the present review is to provide a comprehensive overview of neuroplastic phenomena in the motor system during learning of a motor skill, recovery after brain injury, and of interventional  ...  Based on this and the development of novel non-invasive brain stimulation (NIBS) techniques, new adjuvant interventional approaches that augment the response to behavioral training have been proposed.  ...  Acknowledgments This research was supported by the German Research Foundation SFB 936-C4 to FCH.  ... 
doi:10.3389/fnhum.2015.00265 pmid:26029083 pmcid:PMC4432668 fatcat:xa5oisa4hjcatdif74aqtailoy

Combining Reward and M1 Transcranial Direct Current Stimulation Enhances the Retention of Newly Learnt Sensorimotor Mappings

Danny Spampinato, Zabina Satar, John Rothwell
2019 Brain Stimulation  
Reward-based feedback given during motor learning has been shown to improve the retention of the behaviour being acquired.  ...  Interestingly, applying transcranial direct current stimulation (tDCS) during learning over the primary motor cortex (M1), an area associated with motor retention, also results in enhanced retention of  ...  Since regions of the frontal lobe, specifically the ventromedial frontal cortex and ventral prefrontal cortex, have been implicated in strategic learning processes [44] that are critical to motor learning  ... 
doi:10.1016/j.brs.2019.05.015 pmid:31133478 pmcid:PMC6709642 fatcat:vlrn6swoxvhohkouj2kf3p3ir4

Sensory Abnormalities in Focal Hand Dystonia and Non-Invasive Brain Stimulation

Angelo Quartarone, Vincenzo Rizzo, Carmen Terranova, Demetrio Milardi, Daniele Bruschetta, Maria Felice Ghilardi, Paolo Girlanda
2014 Frontiers in Human Neuroscience  
In the present review, we examine the contribution of sensory-motor integration in the pathophysiology of primary dystonia.  ...  It can be postulated, according to the two factor hypothesis that dystonia is triggered and maintained by the concurrence of environmental factors such as repetitive training and subtle abnormal mechanisms  ...  There is considerable evidence suggesting that both the motor and sensory cortex in primary dystonia exhibits an exaggerated responsiveness to TMS conditioning protocols.  ... 
doi:10.3389/fnhum.2014.00956 pmid:25538594 pmcid:PMC4257013 fatcat:agae3pe7znfkfdhicrhohgdt7y

Weak but Critical Links between Primary Somatosensory Centers and Motor Cortex during Movement

Pengxu Wei, Ruixue Bao, Zeping Lv, Bin Jing
2018 Frontiers in Human Neuroscience  
thalamus to the left primary motor cortex (M1).  ...  Over the years, studies reported a small number of projections from the thalamus to the motor cortex. This is the first work to present functions of these pathways.  ...  Stimulation to the median or other nerves can modulate effects of TMS on motor cortex (Tokimura et al., 2000; Stefan et al., 2002) , and dorsal root inputs very shortly prior to TMS can facilitate motor  ... 
doi:10.3389/fnhum.2018.00001 pmid:29387003 pmcid:PMC5776089 fatcat:ebohfdtuhfgdblgglku4ivj3mi

Concurrent TMS-fMRI for causal network perturbation and proof of target engagement

Til Ole Bergmann, Rathiga Varatheeswaran, Colleen A Hanlon, Kristoffer H Madsen, Axel Thielscher, Hartwig Roman Siebner
2021 NeuroImage  
We will also discuss how concurrent TMS-fMRI during a behavioral task can help to link behavioral TMS effects to changes in neural network activity and to identify peripheral co-stimulation confounds.  ...  Concurrent TMS-fMRI allows the assessment of the neurovascular responses evoked by TMS with excellent spatial resolution and full-brain coverage.  ...  Acknowledgements T.O.B. and R.V. were supported by the Boehringer Ingelheim Foundation. A.T. received support by the Lundbeck foundation (grant R244-2017-196 and R313-2019-622 ). Hartwig R.  ... 
doi:10.1016/j.neuroimage.2021.118093 pmid:33940146 fatcat:5jdc2wnwsff5hkt7l4abilfko4

Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements - a neuro-navigated rTMS study

Stefanie Verstraelen, Kim van Dun, Siel Depestele, Sybren Van Hoornweder, Asif Jamil, Ensiyeh Ghasemian-Shirvan, Michael A Nitsche, Shanti Van Malderen, Stephan P Swinnen, Koen Cuypers, Raf L J Meesen
2021 Brain Stimulation  
The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking.  ...  The current findings support the growing evidence on PMdL dominance during motor planning, as PMdL was crucially involved in planning the speed of each hand, subserving bimanual coordination accuracy.  ...  Acknowledgements Authors are thankful to R. Clerckx for his support in programming the bimanual task and for his help in preprocessing the acquired performance data.  ... 
doi:10.1016/j.brs.2021.02.006 pmid:33621675 fatcat:dwmje4cvojhh7pfep5y5xpdqz4

Active versus Passive Training of a Complex Bimanual Task: Is Prescriptive Proprioceptive Information Sufficient for Inducing Motor Learning?

Iseult A. M. Beets, Marc Macé, Raf L. J. Meesen, Koen Cuypers, Oron Levin, Stephan P. Swinnen, Trevor Bruce Penney
2012 PLoS ONE  
Perceptual processes play an important role in motor learning.  ...  relative phasing between the limbs in the presence of augmented visual feedback.  ...  Transcranial magnetic stimulation (TMS) research in humans has revealed that observation of actions results in increased excitability in the primary motor cortex which receives input from the mirror neuron  ... 
doi:10.1371/journal.pone.0037687 pmid:22666379 pmcid:PMC3359339 fatcat:n4rvfllgzvcd7hrnsavywvzmxy

Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: Current approaches and future perspectives

Til Ole Bergmann, Anke Karabanov, Gesa Hartwigsen, Axel Thielscher, Hartwig Roman Siebner
2016 NeuroImage  
Firstly, neuroimaging and electrophysiology can inform subsequent NTBS, providing the required information to optimize where, when, and how to stimulate the brain.  ...  It is nowadays feasible to combine NTBS, either consecutively or concurrently, with a variety of neuroimaging and electrophysiological techniques.  ...  For instance, EEG-triggered TMS of the primary motor cortex has been successfully used during deep sleep to target the up-vs. down-state of the ongoing sleep slow oscillation (b 1 Hz) and investigate rapid  ... 
doi:10.1016/j.neuroimage.2016.02.012 pmid:26883069 fatcat:nuuocuimd5htvirqj6jyjur3a4
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