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Application of zirconium MOFs in drug delivery and biomedicine

Isabel Abánades Lázaro, Ross S. Forgan
2019 Coordination chemistry reviews  
The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives  ...  on their future applications and analogous hafnium MOFs are given.  ...  (cis-platin IC 50 = 53.9 ± 4.7, 53.2 ± 4.4 and 45.1 ± 7.0 µM for free cis-platin, UiO-Cis and free cis-platin/pool siRNA respectively), whereas when cells were incubated with siRNA-UiO-Cis or free cis-platin  ... 
doi:10.1016/j.ccr.2018.09.009 fatcat:vqdquybppbgfpfvixm6ddlc7ie

Monofunctional Platinum(II) Anticancer Agents

Suxing Jin, Yan Guo, Zijian Guo, Xiaoyong Wang
2021 Pharmaceuticals  
However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs.  ...  the defects of current platinum drugs.  ...  Photodynamic therapy (PDT) is a minimally invasive method that produces selective cytotoxicity to malignant tumor cells.  ... 
doi:10.3390/ph14020133 pmid:33562293 pmcid:PMC7915149 fatcat:ynzizvalovcu3nxpkstebfjcse

Inorganic Nanoparticles in Cancer Therapy

Sanjib Bhattacharyya, Rachel A. Kudgus, Resham Bhattacharya, Priyabrata Mukherjee
2010 Pharmaceutical Research  
Herein, we will focus on gold, silver and platinum nanoparticles, discussing recent developments for therapeutic applications with regard to cancer in terms of nanoparticles being used as a delivery vehicle  ...  Nanotechnology is an evolving field with enormous potential for biomedical applications.  ...  Acknowledgments Partly supported by NIH CA135011 and CA136494 grants to PM  ... 
doi:10.1007/s11095-010-0318-0 pmid:21104301 pmcid:PMC3072278 fatcat:djgfxwl7afam5i5b65k3r45dbu

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

Ignacio Leon, Juan Cadavid-Vargas, Ana Di Virgilio, Susana Etcheverry
2017 Current Medicinal Chemistry  
The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications  ...  On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications.  ...  ALDV, IEL and SBE are members of the Carrera del Investigador CONICET, Argentina.  ... 
doi:10.2174/0929867323666160824162546 pmid:27554807 fatcat:iztfg2jjcngdvno5ahw4lxxswu

Targeted delivery of platinum-based anticancer complexes

Jennifer S Butler, Peter J Sadler
2013 Current Opinion in Chemical Biology  
Interestingly, use of these new delivery and targeting systems for platinum drugs can lead to species with unusual reactivity which can kill cancer cells by new mechanisms.  ...  Comprehensive review focussing on targeted delivery of platinum anticancer complexes since 2006. Summarises both active and passive drug delivery with focus on platinum drug carriers.  ...  Acknowledgements We thank the ERC (award no. 247450), EPSRC (EP/G006792/1) and Science City (AWM/ERDF) for support, our collaborators and the members of EC COST CM1105 for stimulating discussions.>  ... 
doi:10.1016/j.cbpa.2013.01.004 pmid:23395452 fatcat:umuvnloejfhd5pugcc5pmpespa

Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy

Luke K. McKenzie, Helen E. Bryant, Julia A. Weinstein
2018 Coordination chemistry reviews  
2018) Transition metal complexes as photosensitisers in one-and two-photon photodynamic therapy. Coordination Chemistry Reviews.  ...  Abstract Photodynamic therapy (PDT) exploits light-activated compounds for therapeutic use. It relies on a photosensitiser (PS) that is inactive in the absence of light.  ...  Photodynamic therapy (PDT) is built on the concept of light-activatable compounds known as photosensitisers (PS) which can be 'switched on' at the target site by localised irradiation with light.  ... 
doi:10.1016/j.ccr.2018.03.020 fatcat:cazicoz7xfendnzgfskxrxa7ke

Binding and beyond: what else can G-quadruplex ligands do?

Michael O'Hagan, Juan Carlos Morales, M. Carmen Galan
2019 European Journal of Organic Chemistry  
Hundreds of G4 ligands are reported to bind these sequences with high specificity and affinity, but such ligands can also be engineered to do more than simply associate with G4 in a straightforward host-guest  ...  Herein we survey the main themes of such "value-added" G4 ligands and consider the opportunities and challenges of their potential applications.  ...  cells kept in the dark, suggesting a mechanism of action involving the photogeneration of singlet oxygen and pointing to applications of G4 ligands in targeted photodynamic therapy  ... 
doi:10.1002/ejoc.201900692 fatcat:lgtoemqcc5e6fmr4gpml2fcuoi

Exploration of the medical periodic table: towards new targets

Nicolas P. E. Barry, Peter J. Sadler
2013 Chemical Communications  
Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry.  ...  We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anticancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative  ...  developments, Thomas Ward for providing Fig. 4 , and Eduardo Sousa for discussion of Fig. 10 .  ... 
doi:10.1039/c3cc41143e pmid:23636600 fatcat:6fu5xoycpbh25fdiskhw5nsu44

Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives

Manja Kubeil, Irma Ivette Santana Martínez, Michael Bachmann, Klaus Kopka, Kellie L. Tuck, Holger Stephan
2022 Pharmaceuticals  
In this review article, dual-labelled systems for bimodal nuclear and optical imaging based on both modular ligands and nanomaterials are discussed.  ...  Due to the comparably high sensitivity and provided complementary information, the combination of nuclear and optical probes has taken on a special significance.  ...  Informed Consent Statement: Not applicable. Data Availability Statement: Data sharing not applicable. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ph15040432 pmid:35455430 pmcid:PMC9028399 fatcat:minlrptrizeihplzdrpelqdcuy

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

Anupa R. Menjoge, Rangaramanujam M. Kannan, Donald A. Tomalia
2010 Drug Discovery Today  
(c) Dendrimers incorporated into various delivery systems for enhancing permeation, solubility and so on. (d) Dendrimers as complexing agents.  ...  Numbers 5/6 March 2010 FIGURE 1 Potential applications of dendrimers.  ...  Funding supports from Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS and the Dryer Foundation (for A.R.M.) are appreciated  ... 
doi:10.1016/j.drudis.2010.01.009 pmid:20116448 fatcat:s6utp2kapnhi7j4w2ptjybxy7u

Critical appraisals of approaches for predictive designs in anticancer drugs

C. T. Gnewuch, G. Sosnovsky
2002 Cellular and Molecular Life Sciences (CMLS)  
The combinations of etoposide-cis- platin and bleomycin-etoposide-cisplatin became stan- dard therapies for small-cell lung cancer and advanced testicular cancer, respectively [1].  ...  to the usual 7- system of porphyrins [319].  ... 
doi:10.1007/s00018-002-8483-x pmid:12169026 fatcat:2wrpqicvabgrrmsaz5kjtssdym

Targeted Cancer Therapy Using Compounds Activated by Light

Petra Dunkel, Janez Ilaš
2021 Cancers  
In this review, we focus on the anticancer applications of two light-activated approaches still in the experimental phase: photoremovable protecting groups ("photocages") and photoswitches.  ...  Among novel approaches to overcome this limitation and to bring to therapy more potent and selective agents is the use of light for selective activation of anticancer compounds.  ...  Author Contributions: Conceptualization, P.D. and J.I.; writing-review and editing, P.D. and J.I. All authors have read and agreed to the published version of the manuscript.  ... 
doi:10.3390/cancers13133237 pmid:34209493 pmcid:PMC8269035 fatcat:asskkodxenao3om6lvaok2eqfy

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Jacek Zielonka, Joy Joseph, Adam Sikora, Micael Hardy, Olivier Ouari, Jeannette Vasquez-Vivar, Gang Cheng, Marcos Lopez, Balaraman Kalyanaraman
2017 Chemical Reviews  
(ATP). 1,2 Over the last two decades, research focusing on mitochondria-dependent cellular signaling and cell death has flourished. 3-5 Mitochondrial defects or dysfunctions are associated with the onset  ...  Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases.  ...  More recently, she has focused on mitochondrial biochemistry in the phenotypical changes in the heart and hematopoietic stem cell phenotype.  ... 
doi:10.1021/acs.chemrev.7b00042 pmid:28654243 pmcid:PMC5611849 fatcat:lz64lxsi7rbtxjvd53kcgsu7fa

Nanoparticles and DNA – a powerful and growing functional combination in bionanotechnology

Anirban Samanta, Igor L. Medintz
2016 Nanoscale  
We focus on selected and representative nanoparticle-DNA materials and highlight their myriad applications using examples from the literature.  ...  Additionally, DNA aptamers can also provide specific recognition capabilities against many diverse non-nucleic acid targets across a range of size scales from ions to full protein and cells.  ...  Acknowledgements The authors acknowledge the Naval Research Laboratory Nanosciences Institute and DTRA JSTO MIPR # B112582M.  ... 
doi:10.1039/c5nr08465b pmid:27080924 fatcat:a4trnz546bcxrgvbhqayysegdu

Plasminogen-Activating System [chapter]

Salvatore Ulisse, Massimino D'Armiento, Sarah Bocchini, Enke Baldini
2011 Encyclopedia of Cancer  
O 2 -• OH -• Oxidation of Substrates Photodynamic Therapy. Fig. 1 Basic principle of photodynamic therapy.  ...  Photosensitizer 2881 P P This may be an adverse effect of many drugs or a desired effect in photodynamic therapy.  ...  Moreover, the ability of tumor cells to activate the coagulation system and to generate thrombin has been shown to enhance metastasis, while anticoagulant therapies can interfere with metastasis formation  ... 
doi:10.1007/978-3-642-16483-5_4605 fatcat:keaft6ozlbclvnkyzcgrvcvud4
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