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Subacute leukoencephalopathy complicating acute lymphoblastic leukemia

F M Filloux, J J Townsend
1987 Western Journal of Medicine  
A hypereosinophilic syndrome followed resulting in weight loss, lethargy and intermittent apnea, eventually leading to the diagnosis of non-B-, non-T-cell acute lymphoblastic leukemia.  ...  He became comatose with decerebrate posturing and asymmetric, unreactive pupils and (Filloux FM, Townsend JJ: Subacute leukoencephalopathy complicating acute lymphoblastic leukemia-University of Utah [  ...  is the delayed form of methotrexate neurotoxicity, also known as disseminated necrotizing leukoencephalopathy.22 This condition is primarily seen in children treated for acute leukemia with both CNS irradiation  ... 
pmid:3469814 pmcid:PMC1307240 fatcat:sfamxafxr5hghfjtpzoi3oot7i

Hyperperfusion on Magnetic Resonance Imaging in Acute Chemotherapy-Related Leukoencephalopathy

Lisa Michael El-Hakam, Melissa Beth Ramocki, James John Riviello, Anna Illner
2010 Journal of Child Neurology  
An 8-year-old male with acute lymphoblastic leukemia receiving chemotherapy, including intrathecal methotrexate, presented to our emergency center with 2 hours of expressive aphasia and flaccid right hemiplegia  ...  Magnetic resonance perfusion imaging proved valuable to rapidly distinguish acute chemotherapy-related leukoencephalopathy from ischemia, and the evaluation of perfusion alterations in this disorder may  ...  Funding The authors disclosed receipt of the following financial support for the research and/or authorship of this article: MBR acknowledges the support of NIH/NINDS grant 5K08NS062711-02.  ... 
doi:10.1177/0883073809346349 pmid:20363963 pmcid:PMC2936236 fatcat:lf7ilfcbivcfjkzgv76e5jdsoi

Preventing Neurocognitive Late Effects in Childhood Cancer Survivors

Martha A. Askins, Bartlett D. Moore
2008 Journal of Child Neurology  
Acknowledgment This article was presented at the Neurobiology of Disease in Children: Symposium on Central Nervous System Tumors, in conjunction with the 36th annual meeting of the Child Neurology Society  ...  acute lymphoblastic leukemia.  ...  Nevertheless, the survival rate approaches 90% for those diagnosed with acute lymphoblastic leukemia today, although less for children with brain tumors.  ... 
doi:10.1177/0883073808321065 pmid:18952582 pmcid:PMC3674758 fatcat:u7od6yrnbfbyze6nce3qj3qhxy

Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate

John O. Glass, Wilburn E. Reddick, Chin-Shang Li, Fred H. Laningham, Kathleen J. Helton, Ching-Hon Pui
2006 Magnetic Resonance Imaging  
into either leukoencephalopathy (LE) induced by chemotherapy or normal maturational processes in children treated for acute lymphoblastic leukemia without irradiation.  ...  These results suggest that subtle therapy-induced LE can be objectively and reproducibly detected in children treated for cancer using this CAD approach based on relative differences in quantitative signal  ...  Acknowledgments The authors thank Greg Bernstein for his efforts in the processing and analysis of MR examinations, and Vickey Simmons for the scheduling of examinations.  ... 
doi:10.1016/j.mri.2006.02.001 pmid:16824973 pmcid:PMC2396783 fatcat:iptbqyv3cnb5notf5zrvtfawi4

Central Nervous System Lymphoma

A. Lister
2002 Hematology ASH Education Program  
John Sandlund reviews the success of sequential clinical trials of overall therapy for acute lymphoblastic leukemia in childhood, identifying those patients at high risk of central nervous system leukemia  ...  In Section III, Dr. Andrew Lister discusses the issue of secondary central nervous system involvement with lymphoma and the indications for prophylaxis.  ...  John Sandlund reviews the success of sequential clinical trials of overall therapy for acute lymphoblastic leukemia in childhood, identifying those patients at high risk of central nervous system leukemia  ... 
doi:10.1182/asheducation-2002.1.283 fatcat:xsdddce4qjfxdbuqhdxvagpwpq

Late-Occurring Neurologic Sequelae in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study

Robert E. Goldsby, Qi Liu, Paul C. Nathan, Daniel C. Bowers, Amanda Yeaton-Massey, Shannon H. Raber, Daniel Hill, Gregory T. Armstrong, Yutaka Yasui, Lonnie Zeltzer, Leslie L. Robison, Roger J. Packer
2010 Journal of Clinical Oncology  
A B S T R A C T Purpose Children with acute lymphoblastic leukemia (ALL) are often cured, but the therapies they receive may be neurotoxic.  ...  Conclusion Children treated with regimens that include cranial radiation for ALL and those who suffer a relapse are at increased risk for late-onset neurologic sequelae.  ...  Children Cumulative incidence of selected chronic health conditions among 5-year survivors of acute lymphoblastic leukemia.  ... 
doi:10.1200/jco.2009.22.5060 pmid:19917844 pmcid:PMC2815720 fatcat:3fartqnyvvakvc5tw34egthzv4

Central nervous system malignancies in children

J R Geyer, M Berger
1990 New York state journal of medicine  
children were test- ed three years after diagnosis of medulloblastoma.* As in children treated for acute lymphoblastic leuke- mia, those treated for brain tumors appear to be at risk of developing specific  ...  Nonetheless, improvement in the treatment of child- hood brain tumors has not been as rapid as that seen for many other childhood cancers, such as Wilms’ tumor or acute lymphoblastic leukemia.  ... 
pmid:2277678 fatcat:emqcurd2dna6xjinixoybskoqy

Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia

Wilburn E. Reddick, Fred H. Laningham, John O. Glass, Ching-Hon Pui
2007 Neuroradiology  
Method and results-Computer-aided detection of changes on neuroimages enables us to objectively differentiate leukoencephalopathy from normal maturation of the developing brain.  ...  Introduction-Medical advances over the last several decades, including CNS prophylaxis, have greatly increased survival in children with leukemia.  ...  Acknowledgements This work was supported in part by R01-CA90246 and by Cancer Center Support (CORE) grant P30-CA21765 from the National Cancer Institute and by the American Lebanese Syrian Associated Charities  ... 
doi:10.1007/s00234-007-0262-9 pmid:17653705 pmcid:PMC2386666 fatcat:7oo7y2m535h4nigqr4z43myd5u

Neurocognitive late effects in pediatric cancer

Raymond K Mulhern, Shawna L Palmer
2003 Current Problems in Cancer  
We will then discuss methods of pharmacological, behavioral, and ecological intervention that may be helpful in reducing learning problems among surviving children.  ...  As survival rates for the most prevalent types of childhood cancer have dramatically improved over the past three decades, the concept of "cure" has evolved to include optimizing the quality of life among  ...  cancer, acute lymphoblastic leukemia (ALL) and brain tumors.  ... 
doi:10.1016/s0147-0272(03)00026-6 pmid:12855950 fatcat:dfzyd7i4rjdwdjqsmfxeqy735a

Accelerated Aging, Decreased White Matter Integrity, and Associated Neuropsychological Dysfunction 25 Years After Pediatric Lymphoid Malignancies

Ilse Schuitema, Sabine Deprez, Wim Van Hecke, Marita Daams, Anne Uyttebroeck, Stefan Sunaert, Frederik Barkhof, Eline van Dulmen-den Broeder, Helena J. van der Pal, Cor van den Bos, Anjo J.P. Veerman, Leo M.J. de Sonneville
2013 Journal of Clinical Oncology  
A B S T R A C T Purpose CNS-directed chemotherapy (CT) and cranial radiotherapy (CRT) for childhood acute lymphoblastic leukemia or lymphoma have various neurotoxic properties.  ...  Results CRT-treated survivors demonstrated significantly decreased FA compared with controls in frontal, parietal, and temporal WM tracts. Trends for lower FA were seen in the CT-treated survivors.  ...  Heinen and M. van Overveld (Academic Medical Center) for their valuable support in collecting and interpreting the data.  ... 
doi:10.1200/jco.2012.46.7050 pmid:23960182 fatcat:exejtbyjvjdgda4ssjsep7owny

Case Files of the New York City Poison Control Center: Paradichlorobenzene-Induced Leukoencephalopathy

Stephanie H. Hernandez, Sage W. Wiener, Silas W. Smith
2010 Journal of Medical Toxicology  
Tests of hepatic and renal function were: AST 53  ...  Hyperreflexia (without clonus) and cogwheel rigidity were noted in both lower extremities; upper extremities were normal. Plantar reflexes were normal bilaterally.  ...  Rathi B, Azad RK, Vasudha N, Hissaria P, Sawlani V, Gupta RK (2002) L-Asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia.  ... 
doi:10.1007/s13181-010-0053-2 pmid:20373064 pmcid:PMC3550295 fatcat:e5ua2ai7fre5zfgnzzwvxocuum

Index of subjects Volume 10 (1999)

1999 Annals of Oncology  
) 123 related mortality of patients with non-small-cell lung cancer (Short report) 605 results in Indian children with acute lymphoblastic leukemia 167 toxicity and mortality of patients with small-cell  ...  specific primary extranodal lymphomas (Editorial) 1405 factors for subdiaphragmatic involvement in clinical stage I -11 supra- diaphragmatic Hodgkin's disease 1343 of acute lymphoblastic leukemia  ... 
doi:10.1023/a:1017221630331 fatcat:olde4vnz5jd3ppfffdjqjep4ry

The Critically-Ill Pediatric Oncology Patients: What the Intensivist Needs to Know? Pediatric Critical Care Medicine

Manu Sundaram, Amin Al Haj Moussa, Ata Ur Rehman Maaz, Nesreen Faqih
2020 Indian Journal of Critical Care Medicine  
possible for the children with such disease.  ...  Cancer is an evolving cause of morbidity and mortality in children worldwide.  ...  as chimeric antigen receptor T-cell therapies have recently been approved for clinical practice after showing impressive therapeutic results in the treatment of refractory acute lymphoblastic B-cell leukemia  ... 
doi:10.5005/jp-journals-10071-23693 pmid:33446982 pmcid:PMC7775926 fatcat:twl5jz2iibebjfoh3hlkmo3qqm

The 62nd Annual Meeting of the Japanese Society of Pediatric Hematology/Oncology

2020 Pediatric Blood & Cancer  
S4 of S89 ABSTRACTS In the past, the second stem cell transplantation (SCT) was the only possible treatment for relapse after SCT for children with acute lymphoblastic leukemia (ALL).  ...  Second Hematopoietic Stem Cell Transplantation for Post-Transplantation Relapsed Acute Leukemia in Children: A Retrospective EBMT-PDWP Study.  ...  develop malignancies, such as acute lymphoblastic leukemia.  ... 
doi:10.1002/pbc.28797 pmid:33205885 fatcat:m5jeoj3l7fdbtjikanrxidv5gm

International Society of Paediatric Oncology SIOP XXXXII Congress Boston, United States October 21-24, 2010 SIOP Abstracts

2010 Pediatric Blood & Cancer  
for standard risk childhood acute lymphoblastic leukemia (SR-ALL).  ...  Method: We included 50 pediatric patients with confirmed diagnosis of Acute Lymphoblastic Leukemia treated at the National Institute of Pediatrics, Mexico.  ...  Three patients had acute lymphoblastic leukemia, 2 medulloblastoma, 1 acute myeloblastic leukemia, 1 osteosarcoma, 1 soft tissue sarcoma, 1 hepatoblastoma and 1 had hereditary spherocytosis.  ... 
doi:10.1002/pbc.22779 fatcat:6ydoygbkwvgxdkdfhmv7mvgzry
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