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A Canadian guideline on the use of next-generation sequencing in oncology

S. Yip, A. Christofides, S. Banerji, M. R. Downes, I. Izevbaye, B. Lo, A. MacMillan, J. McCuaig, T. Stockley, G. M. Yousef, A. Spatz
2019 Current Oncology  
Guidance on how to effectively use ngs technology is therefore needed to aid oncologists in applying the results of genomic tests.  ...  cancer.  ...  ACKNOWLEDGMENTS The authors acknowledge financial support from Hoffmann-La Roche, AstraZeneca, Pfizer, Illumina, and Thermo Fisher Scientific for medical writing services provided by Anna Christofides of  ... 
doi:10.3747/co.26.4731 pmid:31043833 pmcid:PMC6476432 fatcat:77tk4n5gbjg7jiaq6jjqka6u7e

Secondary acute myeloid leukemia and the role of allogeneic stem cell transplantation in a population-based setting

Christer Nilsson, Erik Hulegårdh, Hege Garelius, Lars Möllgård, Mats Brune, Anders Wahlin, Stig Lenhoff, Ulla Frödin, Mats Remberger, Martin Höglund, Gunnar Juliusson, Dick Stockelberg (+1 others)
2019 Biology of Blood and Marrow Transplantation  
We used the population-based Swedish AML Registry comprising 3337 intensively treated adult patients over a 17-year period to study the role of HCT within the group of patients with s-AML as well as compared  ...  At 5 years after diagnosis, there were no survivors among patients with previous myeloproliferative neoplasms who did not undergo HCT, and corresponding survival for patients with antecedent myelodysplastic  ...  Multiple imputation was used in study II to test the impact of missing data.  ... 
doi:10.1016/j.bbmt.2019.05.038 pmid:31176789 fatcat:izr2yszxunaxfdg5fekek3z57a

Diagnostics of hereditary malignancies

Karmen Stankov
2006 Jugoslovenska medicinska biohemija  
Cancer is a form of a complex genetic disease.  ...  The next frontier in cancer genetics is to find genes with high prevalence alleles conferring a low increase or decrease of cancer risk.  ...  Molecular genetic testing offers important opportunities for diagnosis and assessment of genetic risk for cancer.  ... 
doi:10.2298/jmb0604381s fatcat:hveundlhkjgphdonohuojm3vi4

Diagnostics of hereditary malignancies

Karmen Stankov
2006 Jugoslovenska medicinska biohemija  
Cancer is a form of a complex genetic disease.  ...  The next frontier in cancer genetics is to find genes with high prevalence alleles conferring a low increase or decrease of cancer risk.  ...  Molecular genetic testing offers important opportunities for diagnosis and assessment of genetic risk for cancer.  ... 
doi:10.2298/jmh0604381s fatcat:ttrcgdx4azhl7fov7bjawt4aky

Quality Assurance

2008 Laboratory Investigation  
Audit of 58 randomly selected cases from '06 demonstrated 100% compliance with CAP Cancer Protocols.  ...  Audit data of randomly selected oncologic SP reports for data elements from CAP Cancer Protocols was reviewed for '06.  ...  The aim of our study was to compare the two methods in the diagnosis of thyroid FNAB specimens.  ... 
doi:10.1038/sj.labinvest.3700743 fatcat:pvegl5cifnaqnji62snilgnizi

7thESACP Congress in Caen April 1–5, 2001

2001 Analytical Cellular Pathology  
parts, whereas in a uterine leiomyomatous process the necrotic parts only may lead to a diagnosis of sarcoma.  ...  breast cancer.  ...  Pairs of images of any diagnosis, magnification and staining  ... 
doi:10.1155/2001/414753 fatcat:7vxekd2dbjherbnpv5q7dshpsu

Undifferentiated Sarcomas: What to Do? And Does It Matter? A Surgical Pathology Perspective

Christopher D. M. Fletcher
2008 Ultrastructural Pathology  
is tested).  ...  , molecular genetic testing is often helpful.  ...  Applications of the DNA microarray technology to cancer diagnosis and prognosis Cancer is a disease of disturbed genome function.  ... 
doi:10.1080/01913120801896945 pmid:18446665 fatcat:7zr3wugsr5b4zf2q5lv5axq4ze

Identification of High Serum Apolipoprotein A1 as a Favorable Prognostic Indicator in Patients with Multiple Myeloma

Lifan Liang, Jing Li, Hangcheng Fu, Xinyang Liu, Peng Liu
2019 Journal of Cancer  
This study is to explore the prognostic significance of serum lipid profiles in patients with multiple myeloma (MM).  ...  We evaluated the prognostic significance of the pre-diagnostic serum lipid profile [cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), Apolipoprotein A1 (Apo A1)  ...  Acknowledgements This work was supported by the National Natural Science Foundation of China (81570123) and Academic Pacesetters Program of Shanghai Healthcare System (2017BR033).  ... 
doi:10.7150/jca.31357 pmid:31598156 pmcid:PMC6775509 fatcat:ux5y44phc5c45dy2gvgegrwjhy

Artificial Neural Networks in Medical Imaging Systems

C.S. Pattichis, C.I. Christodoulou, E.C. Kyriacou, M.S. Pattichis
2003 Zenodo  
A few selected case studies are presented, covering the application of neural networks in microscopy imaging in the analysis of cervicovaginal smears and breast cancer histopathology, in ultrasound imaging  ...  The aim of this paper is to provide a snapshot of the application of neural network systems in medical imaging.  ...  Computer-Aided Diagnosis in Mammography [30]-[34] Breast cancer is the most common malignancy in women and the second most common cause of death from malignancy in this population.  ... 
doi:10.5281/zenodo.2557707 fatcat:r6edgbp5ejgyzcqzh7tfadphh4

Epigenetics in Cancer: The Myelodysplastic Syndrome as a Model to Study Epigenetic Alterations as Diagnostic and Prognostic Biomarkers [chapter]

Teresa de Souza Fernandez, Andr Mencalha, Ceclia de Souza Fernandez
2012 Biomarker  
In these cases, important diagnostic tools, like the cytogenetics and the immunophenotyping, aid this diagnosis (Bennett & Orazi, 2009; Wong & So, 2002) .  ...  Statistical tests usually used in the medical literature. When we use a statistic test we compute a p-value.  ... 
doi:10.5772/38754 fatcat:3unaxhxi35gwjjiuw5pwhmsodm

NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology

Phillip G. Febbo, Marc Ladanyi, Kenneth D. Aldape, Angelo M. De Marzo, M. Elizabeth Hammond, Daniel F. Hayes, A. John Iafrate, R. Kate Kelley, Guido Marcucci, Shuji Ogino, William Pao, Dennis C. Sgroi (+1 others)
2011 The Journal of the National Comprehensive Cancer Network  
Hedvat, MD, PhD, and a molecular testing expert from the Centers for Medicare & Medicaid Services (CMS) for critical reading of sections of this manuscript.  ...  Diagnostic Markers A large category of molecular tests aid in the diagnosis or subclassification of a particular disease state.  ...  These guidelines were produced by a workgroup convened as part of the NCI-EORTC joint meeting on Cancer Diagnostics in Nyborg, Denmark, in 2000. 20 REMARK criteria include specification of patient populations  ... 
doi:10.6004/jnccn.2011.0137 pmid:22138009 fatcat:hvo3qypxczhddmgxaozlttmsza

Abstracts for the 34th HGSA Annual Scientific Meeting, Melbourne, Australia November 16-18, 2010

2010 Twin Research and Human Genetics  
Introduction: The congenital disorders of protein glycosylation are a family of enzyme defects in assembly (Type I), transfer, and remodeling (Type II) of glycan structures to proteins.  ...  Although the pathogenesis of CLN3 remains incomplete, it is now clear that at least part of the neuronal cell death is triggered by increased intracellular calcium content and the apoptosis pathway.  ...  Conclusion: TFGT is highly acceptable to many women, and they want to be informed about the testing around the time of their breast cancer diagnosis.  ... 
doi:10.1375/twin.13.6.620 fatcat:waz3wo2snrgdjigvmen5y2qtaq

Sensitivity and predictive value of criteria for p53germline mutation screening

A. CHOMPRET, A. ABEL, D. STOPPA-LYONNET, L. BRUGIERES, S. PAGES, J. FEUNTEUN, C. BONAITI-PELLIE
2001 Journal of Medical Genetics  
We acknowledge the financial support of the  ...  We are indebted to Thierry Frébourg for functional assays and helpful suggestions and to Céline Delouis for her help in p53 testing.  ...  on familial breast and colon cancer.  ... 
doi:10.1136/jmg.38.1.43 pmid:11332399 pmcid:PMC1734716 fatcat:3zpyumjay5ec5fpepakou4jvqe

Oral Presentation Abstracts

Scientific Committee
2016 Journal of cancer and allied specialties  
Material/Methods: Retrospectively pediatric HL patients between July 2010 and June 2015 who underwent staging 18 F-FDG PET-CT scan and BMB were analyzed.  ...  Purpose/Objective: To evaluate whether positron emission tomography/computed tomography using Flourine-18 fluro-deoxyglucose [ 18 F-FDG PET-CT] scan predicts bone marrow involvement[BMI] by Hodgkin's Lymphoma  ...  We expect broader utilization of this engineered nanomaterial as a signal transducer to develop a colorimetric assay towards cancer diagnostics through its conjugation with various recognition elements  ... 
doi:10.37029/jcas.v2i3.81 fatcat:xype6yidqvftnnpltadforrlqa

An unusual case of Primary Effusion Lymphoma with aberrant T-cell phenotype in a HIV-negative, HBV -positive, cirrhotic patient, and review of the literature

Charitini Nepka, Maria Samara, Spyridon Potamianos, Georgios Koukoulis, Dimitrios Kanakis, Andreas Kapsoritakis, Maria Karantana
2012 CytoJournal  
The presence of T-cell markers was consistent with the diagnosis of PEL with an aberrant T-cell phenotype.  ...  The combination of the immunohistochemistry results with the existence of a clonal rearrangement in the immunoglobulin heavy chain gene (identified by PCR), were compatible with the diagnosis of PEL.  ...  criteria  ... 
doi:10.4103/1742-6413.97766 pmid:22919423 pmcid:PMC3424686 fatcat:o7x7ma5wrnf3zczbq3xeosowhe
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