Two compounds, 7-hydroxystaurosporine and bafetinib, showed synergistic antiviral effects in our in vitro experiments, and strongly inhibited viral-induced syncytia formation.  ...  Moreover, since existing drug repositioning methods provide limited usable information for de novo drug design, we extracted and prioritized the chemical substructures of the identified drugs, providing  ...  and bafetinib synergistically block SARS-CoV-2-induced cell-cell fusion The ability of some pathogenic human viruses, including SARS-CoV-2, to induce cell-cell fusion, a phenomenon known as syncytia formation  ...