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Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation [article]

Angela Serra, Michele Fratello, Antonio Federico, Ravi Ojha, Riccardo Provenzani, Ervin Tasnadi, Luca Cattelani, Giusy del Giudice, Pia Anneli Sofia Kinaret, Laura Aliisa Saarimaki, Alisa Pavel, Vincenzo Cerullo (+6 others)
2021 bioRxiv   pre-print
Two compounds, 7-hydroxystaurosporine and bafetinib, showed synergistic antiviral effects in our in vitro experiments, and strongly inhibited viral-induced syncytia formation.  ...  Moreover, since existing drug repositioning methods provide limited usable information for de novo drug design, we extracted and prioritized the chemical substructures of the identified drugs, providing  ...  and bafetinib synergistically block SARS-CoV-2-induced cell-cell fusion The ability of some pathogenic human viruses, including SARS-CoV-2, to induce cell-cell fusion, a phenomenon known as syncytia formation  ... 
doi:10.1101/2021.04.15.440004 fatcat:jvpshosxgvg4je7ioaatg2um4m