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Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance

Fuxiao Xin, Meng Li, Curt Balch, Michael Thomson, Meiyun Fan, Yunlong Liu, Scott M. Hammond, Sun Kim, Kenneth P. Nephew
2008 Computer applications in the biosciences : CABIOS  
These results suggest a significant role for miRNA-regulated gene expression in the onset of breast cancer antiestrogen resistance, and an improved understanding of this phenomenon could lead to better  ...  Motivation: Recent evidence shows significant involvement of microRNAs (miRNAs) in the initiation and progression of numerous cancers; however, the role of these in tumor drug resistance remains unknown  ...  The Center for Medical Genomics is supported in part by the Indiana Genomics Initiative of Indiana University, INGEN, which is supported in part by the Lilly Endowment, Inc.  ... 
doi:10.1093/bioinformatics/btn646 pmid:19091772 pmcid:PMC2642642 fatcat:exzmkahj2fh6tdqqp7ncv5dv3e

Antiestrogen resistance and the application of systems biology

Kerrie B Bouker, Yue Wang, Jianhua Xuan, Robert Clarke
2012 Drug Discovery Today : Disease Mechanisms  
We highlight recent advances in the field of antiestrogen resistance with a focus on transcriptomics, proteomics and methylomics.  ...  Previous methodologies for addressing this question have taken a single gene/pathway approach and the resulting gains have been limited in terms of their clinical impact.  ...  Acknowledgments This work was supported in part by awards from the US Department of Health and Human Services to Robert Clarke: R01-CA131465 and U54-CA149147.  ... 
doi:10.1016/j.ddmec.2012.10.003 pmid:23539064 pmcid:PMC3607389 fatcat:5bht4r4ocfdblhjeyeoen35qj4

An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells

Seungyoon Nam, Xinghua Long, ChangHyuk Kwon, Sun Kim, Kenneth P Nephew
2012 BMC Genomics  
Previously, we derived two drug-resistant breast cancer sublines (tamoxifen-and fulvestrant-resistant cell lines) from the MCF7 breast cancer cell line and performed genome-wide mRNA and microRNA profiling  ...  mechanism underlying antiestrogen resistance in breast cancer cells.  ...  Korea Institute of Science and Technology Information kindly provided SN with a computing resource. Drs. Yon Hui Kim and Hae Ryung Chang at NCC helped language editing and critical reading.  ... 
doi:10.1186/1471-2164-13-732 pmid:23270413 pmcid:PMC3560207 fatcat:ku55xicefzasjmvye45inry6bq

The molecular profile of luminal B breast cancer

Chad Creighton
2012 Biologics : Targets & Therapy  
Candidate pathways that might be targeted in luminal B include those involving growth factor receptors, including HER2 and EGFR, as well as PI3K/Akt/mTor.  ...  With the advent of DNA microarrays, global gene expression patterns were used to define the luminal A and luminal B subtypes of ER+ breast cancer, with luminal B cancers showing a more aggressive phenotype  ...  Acknowledgments The author is supported in part by NIH/NCI grants P30 CA125123, P50 CA58183-16, and U24CA143843. Disclosure The author reports no conflicts of interest in this work.  ... 
doi:10.2147/btt.s29923 pmid:22956860 pmcid:PMC3430090 fatcat:jumytlrqnbd5npwzq5x26rvrmy

Emerging Role of MicroRNAs in Drug-Resistant Breast Cancer

2011 Gene Expression  
Decades of research have unraveled several unique and common mechanisms that could contribute to drug resistance in breast cancer.  ...  In this review, we will discuss how miRNA profile is altered upon resistance development and the critical regulatory role miRNAs play in conferring resistance to commonly used therapeutic agents.  ...  In their analysis of the 77 human breast cancer tumor. specimens and 11 normal breast tissues, upregulation of miR-155 was detected in 55 breast cancers and one normal breast tissue.  ... 
doi:10.3727/105221611x13176664479287 pmid:22268296 pmcid:PMC6043828 fatcat:vplvdmzrirhmtaa5v6otufq4eq

An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma

Mariko Masuda, Yasuhiro Miki, Shuko Hata, Kiyoshi Takagi, Minako Sakurai, Katsuhiko Ono, Koyu Suzuki, Yang Yang, Eriko Abe, Hisashi Hirakawa, Takanori Ishida, Takashi Suzuki (+2 others)
2012 Journal of Translational Medicine  
Recently, several studies demonstrated a possible involvement of several micro RNAs (miRNAs) in the development of resistance to endocrine therapy in breast cancer patients, but the correlation between  ...  Conclusions: These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells.  ...  We also thank Ikumi Miura and Erina Iwabuchi (Department of Pathology, Tohoku University School of medicine, Sendai, Japan) for their skillful technical assistance.  ... 
doi:10.1186/1479-5876-10-s1-s2 pmid:23227519 pmcid:PMC3445861 fatcat:ddmiuah3qnedfbahm5ixbukjoi

Endoplasmic Reticulum Stress and Oncomir-Associated Chemotherapeutic Drug Resistance Mechanisms in Breast Cancer Tumors

2021 Turkish Journal of Biology  
Breast cancer, as a heterogenous malign disease among the top five leading causes of cancer death worldwide, is defined as by far the most common malignancy in women.  ...  Besides, ER stress-associated oncogenic microRNAs (miRNAs) induce chemoresistance in breast tumors.  ...  Identification of MDR-related genes and pathways in hormone receptor-positive breast cancer cells performed by KEGG analysis showed that target genes were supported in several pathways, with the inclusion  ... 
doi:10.3906/biy-2010-62 pmid:33597817 pmcid:PMC7877716 fatcat:brho7ukg5zhd7n6jiz272n5q34

Roles for miRNAs in endocrine resistance in breast cancer

Penn Muluhngwi, Carolyn M Klinge
2015 Endocrine-Related Cancer  
The role of microRNAs (miRNAs) in the progression of endocrine-resistant breast cancer is of keen interest in developing biomarkers and therapies to counter metastatic disease.  ...  This review focuses on miRNAs implicated as disruptors of antiestrogen therapies, their bona fide gene targets and associated pathways promoting endocrine resistance.  ...  and their targets in these pathways involved in endocrine resistance are shown.  ... 
doi:10.1530/erc-15-0355 pmid:26346768 pmcid:PMC4563344 fatcat:2ez7vp23trhzbeyopcdpvwn4im

MicroRNA in cancer: New hopes for antineoplastic chemotherapy

Gianpiero Di Leva, Daniel Briskin, Carlo M. Croce
2012 Upsala Journal of Medical Sciences  
Their major function is to negatively regulate mRNA target genes, and miRNA expression has been found to be deregulated in all human cancers, where miRNAs play critical roles in tumorigenesis, functioning  ...  This review provides a current overview of the connection between miRNAs and cancer by covering the recent advances in miRNA involvement in human cancer including initiation, growth, invasion, and metastasis  ...  , ARHGAP19 Breast and endometrial cancer miR-200c actively represses a program of mesenchymal and neuronal genes involved in cell motility and anoikis resistance p38a Ovarian cancer miR-200a-dependent  ... 
doi:10.3109/03009734.2012.660551 pmid:22348396 pmcid:PMC3339552 fatcat:oqkgecqhkvbk5lfhqpbzyeugqu

Inherited Variation in miR-290 Expression Suppresses Breast Cancer Progression by Targeting the Metastasis Susceptibility Gene Arid4b

N. Goldberger, R. C. Walker, C. H. Kim, S. Winter, K. W. Hunter
2013 Cancer Research  
Computational analysis identified breast cancer progression gene Arid4b as a top target of miR-290-3p, which was confirmed by luciferase reporter assay.  ...  Taken together, our results suggest miR-290 targets Arid4b while simultaneously enhancing ER signaling and increasing apoptosis, thereby suppressing breast cancer progression.  ...  The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C.  ... 
doi:10.1158/0008-5472.can-12-3513 pmid:23447578 pmcid:PMC3630248 fatcat:r4ikt3zrlzehrbytqzszvzctem

Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells

Tissa T. Manavalan, Yun Teng, Savitri N. Appana, Susmita Datta, Theodore S. Kalbfleisch, Yong Li, Carolyn M. Klinge
2011 Cancer Letters  
Microarrays identified miRNAs differentially expressed and 4-hydroxytamoxifen (4-OHT) regulated in MCF-7 endocrine-sensitive versus resistant LY2 human breast cancer cells. 97 miRNAs were differentially  ...  Bioinformatic analyses to impute the biological significance of these miRNAs identified 36 predicted gene targets from those regulated by 4-OHT in MCF-7 cells.  ...  Acknowledgments This work was supported by NIH R21 CA124811 and NIH R01 CA138410 to CMK and in part by P30ES01443 for Bioinformatic analysis by TSK. We thank Dr. Nalinie S.  ... 
doi:10.1016/j.canlet.2011.08.018 pmid:21955614 pmcid:PMC3214732 fatcat:pwnsoysxzrfe7gsqy4bhek3zgy

Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine

Lance D Miller, Edison T Liu
2007 Breast Cancer Research  
Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional  ...  Emerging 'hypothesis-driven' strategies that incorporate knowledge of pathways and other biological phenomena in the signature discovery process are linking prognosis and therapy prediction with transcriptional  ...  The authors apologize to colleagues whose work could not be cited because of space limitations.  ... 
doi:10.1186/bcr1662 pmid:17397520 pmcid:PMC1868923 fatcat:jvzoro26afeclj5cpa2jmaex74

Genome-Wide Identification of Estrogen Receptor Alpha Regulated miRNAs Using Transcription Factor Binding Data [chapter]

Jianzhen Xu, Xi Zhou, Chi-Wai Wong
2011 Bioinformatics - Trends and Methodologies  
In particular, ER is thought to be involved in the progression of breast cancer. Depending on the status of ER expression, breast cancer is classified into ER + and ER -subtypes.  ...  In previous analysis of mRNA targets, these two binding motifs were also shown to enriched in ER binding regions, suggesting their role in ER-regulated mRNAs transcription (Carroll et al. 2006 ).  ...  interested in current research in computational biology and bioinformatics including next generation sequencing, transcriptional analysis and drug design.  ... 
doi:10.5772/20696 fatcat:doafvelycrc7rksnjhidlh2vm4

Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers

Masashi Ninomiya, Yasuteru Kondo, Ryo Funayama, Takeshi Nagashima, Takayuki Kogure, Eiji Kakazu, Osamu Kimura, Yoshiyuki Ueno, Keiko Nakayama, Tooru Shimosegawa, Aftab A. Ansari
2013 PLoS ONE  
Finally, computer analysis was conducted to predict target genes and biological functions with MiRror 2.0 and DAVID v6.7.  ...  Comparing the differentially expressed miRNAs in the 4 groups, analysis of variance was performed on the number of sequence reads to evaluate the statistical significance.  ...  Accession number of DNA data bank of Japan (DDBJ) for the deepsequence data reported in this paper is DRA000933.  ... 
doi:10.1371/journal.pone.0066086 pmid:23776611 pmcid:PMC3680413 fatcat:hfyev56ulrdwjbdkwnfos6pm4u

Oestrogen receptors in breast cancer: basic mechanisms and clinical implications

Cecilia Williams, Chin-Yo Lin
2013 ecancermedicalscience  
Since the discovery of the connection between ovarian hormones and breast cancer, endocrine therapy has been an integral adjuvant treatment for patients with hormone-dependent breast cancers.  ...  A significant number of ER-positive patients, however, fail to respond to therapy or develop resistance over time.  ...  Small microRNAs (miRNAs) serve as key regulators of gene expression by targeting genes for degradation or by blocking their translation.  ... 
doi:10.3332/ecancer.2013.370 pmid:24222786 pmcid:PMC3816846 fatcat:d6sawuof35hhphx6zgstzupvc4
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