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A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle

Chitaranjan Mahapatra, Keith L. Brain, Rohit Manchanda, Agustín Guerrero-Hernandez
2018 PLoS ONE  
Over the past decades, computational modeling has been used widely towards these ends for neurons and for cardiac and skeletal muscle cells based on the Hodgkin-Huxley (HH) formulation [25] as well as  ...  For example, according to Li et al., 2017 [39], the elevated conductance of smallconductance calcium-dependent potassium channels (SK) hyperpolarizes the resting  ...  Shailesh Appukuttan for the gap junctional model used in our studies on AP propagation. We would also like to thank Dr.  ... 
doi:10.1371/journal.pone.0200712 pmid:30048468 pmcid:PMC6061979 fatcat:jlkycth2abdnhj7riursusikka

Kidney CLC-K Chloride Channels Inhibitors: Definition of Novel Structural Requirements and Efficacy in CLC-K Polymorphism Associated with Hypertension

Paola Imbrici, Antonella Liantonio, Giuseppe Fracchiolla, Giuseppe Carbonara, Maria Maddalena Dinardo, Michael Pusch, Diana Conte
2015 Biophysical Journal  
This phenomenon was unknown to date and may prove to be important in understanding the fine-tuning of T cell activation. 2963-Pos Board B393 Proton Channels are Present in Cell Membranes of the Breast  ...  Our measurements indicated that ion channel blockers and rapamycin had a negative dose-dependent effect on the amount of cell division.  ...  L1624P produced similar current density and similar voltage dependence of activation as those in wild-type channel.  ... 
doi:10.1016/j.bpj.2014.11.3203 fatcat:pdhv2mo6gbh23hedjsem3ru3ye

Table of Contents

1987 Journal of Physiology  
Calcium current and calcium-activated inward current in the oocyte of the starfish Leptasterias hexactis. 397 DUFFIN J. & LIPSKI J.  ...  Hodgkin-Huxley parameters TTX-sensitive and TTX-insensitive sodium channels in human myoballs. 78P NILIUS B.  ... 
doi:10.1113/jphysiol.1987.sp19873901toc fatcat:i67n5lfzjvezpoifvlptqgfqg4

Effect of Variations in Gap Junctional Coupling on the Frequency of Oscillatory Action Potentials in a Smooth Muscle Syncytium

Shailesh Appukuttan, Keith L. Brain, Rohit Manchanda
2021 Frontiers in Physiology  
Our study aims to computationally explore the effect of differences in gap junctional properties on oscillating action potentials in electrically coupled tissues.  ...  Gap junctions couple cells electrically, and therefore the electrical activity originating in one cell can affect and modulate the electrical activity in adjacent cells.  ...  ACKNOWLEDGMENTS We would like to thank Rohan Sathe (IIT Bombay, India) for his inputs in modeling of the various gap junction subtypes.  ... 
doi:10.3389/fphys.2021.655225 pmid:34658901 pmcid:PMC8517141 fatcat:co67aiz62zdy5memyep26cnaru

Numerical Bifurcation Analysis of Pacemaker Dynamics in a Model of Smooth Muscle Cells [article]

Hammed O. Fatoyinbo, Richard G. Brown, David J. W. Simpson, Bruce van Brunt
2020 arXiv   pre-print
We reveal a transition between Type I and Type II excitabilities with no external current required.  ...  Existing bifurcation analyses of the Morris-Lecar model concentrate on external applied current whereas we focus on parameters that model the response of the cell to changes in transmural pressure.  ...  Osinga (University of Auckland, New Zealand) for the support provided and useful discussion.  ... 
arXiv:2004.00343v1 fatcat:ub4okt6s4nfhbczq5lvlea7dcy

TWENTY-FIRST ANNUAL MEETING February 15–18, 1977 Braniff Place Hotel, New Orleans, Louisiana

1977 Biophysical Journal  
over a wide range of characteristic times.  ...  Sodium currents in voltage-clamped single fibers from rat sternomastoid (SM) and EDL muscles were studied at 120C using the vaseline gap method of Hille and Campbell (JGP 67:265, 1976).  ...  The results are inconsistent with a Hodgkin-Huxley type kinetic scheme.  ... 
doi:10.1016/s0006-3495(77)85640-3 fatcat:z6uiab6m5jf37jciuiikxqd44a

The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit

Jung Eun Lee, Christine Haewon Park, Hana Kang, Juyeon Ko, Suhan Cho, JooHan Woo, Mee Ree Chae, Sung Won Lee, Sung Joon Kim, Jinsung Kim, Insuk So
2020 Korean Journal of Physiology and Pharmacology  
KCNQ family constitutes slowly-activating potassium channels among voltage-gated potassium channel superfamily.  ...  Recent studies suggested that KCNQ4 and 5 channels are abundantly expressed in smooth muscle cells, especially in lower urinary tract including corpus cavernosum and that both channels can exert membrane  ...  ACKNOWLEDGEMENTS CONFLICTS OF INTEREST The authors declare no conflicts of interest.  ... 
doi:10.4196/kjpp.2020.24.6.503 pmid:33093272 pmcid:PMC7585595 fatcat:ejh7cgi2trdvhbp5dl7ltzible

Voltage-Gated Ion Channels and Hereditary Disease

Frank Lehmann-Horn, Karin Jurkat-Rott
1999 Physiological Reviews  
activation in the absence of intracellular calcium.  ...  That such a simple all-or-nothing signal should require highly complex proteins and ion channels, rather than just a particle within membrane bilayer, was unknown when Hodgkin and Huxley first described  ... 
doi:10.1152/physrev.1999.79.4.1317 pmid:10508236 fatcat:mttxoqsebzdd3oylyvamfekpoy

Substrates and triggers for the initiation of arrhythmias

David Auerbach, José Jalife
2012 Physiology News  
Acknowledgements Studies of PDGFRα + cells in the authors' laboratories are supported by a Pilot Project Grant from the University of Nevada and Core Facilities funded by the National Institute of Diabetes  ...  Acknowledgements We wish to acknowledge the financial support provided by the National Health and Medical Research Council (NH&MRC) of Australia to grant nos. 535033 and 535034.  ...  potassium channels were incorporated into Hodgkin-Huxley-type equations.  ... 
doi:10.36866/pn.85.15 fatcat:v6dvogkxojbftomixztxqrpxs4

Sodium flux ratio through the amiloride-sensitive entry pathway in frog skin

D. J. Benos
1983 The Journal of General Physiology  
The sodium flux ratio of the amiloride-sensitive Na + channel in the apical membrane of in vitro Rana catesbeiana skin has been evaluated at different sodium concentrations and membrane potentials in sulfate  ...  Amiloride-sensitive unidirectional influxes and effiuxes were determined as the difference between bidirectional ~Na and 24Na fluxes simultaneously measured in the absence and presence of 10 -4 M amiloride  ...  and rabbit colon, and toad urinary bladder (Macknight et al., 1980) .  ... 
doi:10.1085/jgp.81.5.667 pmid:6602864 pmcid:PMC2216559 fatcat:dvk3si2vorezxmc4mi6w7mp46q

The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons

S. G. Waxman
2000 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Voltage-gated sodium channels produce the depolarizations necessary for action potential activity in most neurons and, in this respect, lie close to the heart of the electrogenic machinery.  ...  Moreover, the transcription of these genes and the deployment of various types of sodium channels within neurons of the normal nervous system can change markedly as neurons respond to changing milieus  ...  The pivotal studies of Hodgkin & Huxley (1952) taught us that, in most neurons, voltage-gated sodium channels are responsible for the regenerative depolarization that underlies the action potential.  ... 
doi:10.1098/rstb.2000.0559 pmid:10724456 pmcid:PMC1692729 fatcat:nkzixnhywrfedcn6vp3wvitrze

Thirtieth Annual Meeting 9–13 February 1986 Brooks Hall/Convention Center, San Francisco, California

1986 Biophysical Journal  
Since removal of boundary water can perturb surface structure, we expect aqueous cavities of the inverted hexagonal phase to contain such perturbed water and cavity structure to depend on solvent activity  ...  In studies of the encapsulation of hemoglobin (Hb) by extrusion of an aqueous Hb/phospholipid/cholesterol dispersion, the concentration of Hb [Hb] inside the liposomes was always substantially less than  ...  The time-courses of both currents were fitted by Hodgkin-Huxley type equations and their kinetic parameters analyzed.  ... 
doi:10.1016/s0006-3495(86)83676-1 fatcat:5o46p2727zbz7ew6ijmnd47qdi

Thirty-first Annual Meeting 22–26 February 1987 Rivergate Convention Center, New Orleans, Louisiana

1987 Biophysical Journal  
We studied the kinetics of activation, relaxation and MgATP hydrolysis in contractions initiated by caged-ATP photolysis in guinea-pig ventricular trabeculae.  ...  The rate of the second relaxation is dependent upon the protein concentration and is compatible with a second order rate constant of 2X1Ob M-1 s-1.  ...  We measured the effects of phorbol myristate acetate (PMA) and 6oxytocin on osmotic water flow and impedance in toad urinary bladders.  ... 
doi:10.1016/s0006-3495(87)83344-1 fatcat:qxz4egh74vag7ce5dyh2hnr6um

Thirty-second Annual Meeting 28 February - 3 March 1988 Phoenix Civic Plaza, Phoenix, Arizona

1988 Biophysical Journal  
Study of the single-channel dwell time sequences revealed the existence of statistical dependency between adjacent open times.  ...  ,Vol.13, Part 2, 389.8,1987) the existence of an ion channel with a conductance of about 70 pS in 30 mM KC1, 30 mM NaCl, 2 mM CaC12, activated by cAMP (without ATP or GTP).  ...  We used impedance analysis to determine individual membrane conductances and areas of toad urinary bladder.  ... 
doi:10.1016/s0006-3495(88)83104-7 fatcat:wagbl733nnebfpnq7cszja4wcq

Thirty-eighth Annual Meeting March 6-10, 1994 New Orleans Convention Center New Orleans, Louisiana. Thursday Symposia and Posters, Part IV

1994 Biophysical Journal  
Th-Pos476 MODELING THE DYNAMIC FEATURES OFTHE SLOW INWARD CALCIUM CURRENT: FROM HODGKIN-HUXLEY TO MARKOV CHAIN MODELS.((D.R. Lemieux, S. Nattel and G.  ...  singleand double-pulse voltage-clamp protocols were applied to isolated human atrial cells in order to characterize the slow inward calcium current ('CaL)* We first modeled IC using the Hodgkin-Huxley  ... 
doi:10.1016/s0006-3495(94)80830-6 fatcat:faivk754ibesbbgcryvedzgbpa
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