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Inorganic arsenic and human prostate cancer

Lamia Benbrahim-Tallaa, Michael Waalkes
2009 Ciência & Saúde Coletiva  
Whole animal studies were evaluated as were in vitro model systems of inorganic arsenic carcinogenesis in the prostate.  ...  Arsenic also appears to impact prostate cancer cell progression by precipitating events leading to androgen independence in vitro.  ...  Arsenic seems to have the potential for many mechanisms of action in the development of cancer, including prostate cancer.  ... 
doi:10.1590/s1413-81232009000100037 fatcat:jra624fjbffm3dy7l4jdcwvkjm

Inorganic Arsenic and Human Prostate Cancer

Lamia Benbrahim-Tallaa, Michael P. Waalkes
2008 Environmental Health Perspectives  
Arsenic seems to have the potential for many mechanisms of action in the development of cancer, including prostate cancer.  ...  Finally, additional research is clearly needed at all levels on the role of arsenic in prostate cancer development and progression.  ...  In vitro model of arsenic-induced prostatic carcinogenesis In vitro models can be invaluable for studies on carcinogenic mechanisms and can be applied to the various stages of oncogenesis including initiation  ... 
doi:10.1289/ehp.10423 pmid:18288312 pmcid:PMC2235216 fatcat:4laschkyffgmphv5dqfopuhy3q

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

Dennis J. Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L. Lakeland, Simon G. Coetzee, Brian E. Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A. Eeles, Douglas F. Easton (+5 others)
2014 PLoS Genetics  
Here we report the first step in such an endeavor for prostate cancer.  ...  Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified  ...  Models and computation Funci{SNP} analysis and assessment of SNP effects.  ... 
doi:10.1371/journal.pgen.1004102 pmid:24497837 pmcid:PMC3907334 fatcat:bpthhmmoabfxxd6s7g7jtllg24

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types

Anja van de Stolpe, Laurent Holtzer, Henk van Ooijen, Marcia Alves de Inda, Wim Verhaegh
2019 Scientific Reports  
Multiple pathway analysis of clinical prostate cancer (PCa) studies showed increased AR activity in hyperplasia and primary PCa but variable AR activity in castrate resistant (CR) PCa, loss of TGFβ activity  ...  We developed a method enabling quantitative measurement of functional pathway activity based on Bayesian computational model inference of pathway activity from measurements of mRNA levels of target genes  ...  Acknowledgements We acknowledge Kalyan Dulla for his initial work on identifying target genes for the AR pathway model.  ... 
doi:10.1038/s41598-018-38179-x pmid:30733525 pmcid:PMC6367506 fatcat:y7qzpixce5cnrbr54gwiqetopu

H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility [article]

Claudia Giambartolomei, Ji-Heui Seo, Tommer Schwarz, Malika Kumar Freund, Ruth Dolly Johnson, Sandor Spisak, Sylvan C. Baca, Alexander Gusev, Nicholas Mancuso, Bogdan Pasaniuc, Matthew L. Freedman
2020 bioRxiv   pre-print
Genome-wide association studies (GWAS) have identified more than 140 prostate cancer (PrCa) risk regions which provide potential insights into causal mechanisms.  ...  Multiple lines of evidence show that a significant proportion of PrCa risk can be explained by germline causal variants that dysregulate nearby target genes in prostate-relevant tissues thus altering disease  ...  Integrative Genomic Profiling of Human Prostate Cancer. Cancer Cell vol. 18 11-22 (2010). 48. Tindall, D. & Lonergan, P. Androgen receptor signaling in prostate cancer development and progression.  ... 
doi:10.1101/2020.10.23.352351 fatcat:adm45y2un5fgdlxnnixqejlccy

Physicochemical Characterization of Polymer‐stabilized Coacervate Protocells

N. Amy Yewdall, Bastiaan C. Buddingh', Wiggert J. Altenburg, Suzanne B. P. E. Timmermans, Daan F. M. Vervoort, Loai K.E.A. Abdelmohsen, Alexander F. Mason, Jan van Hest
2019 ChemBioChem  
to in dilute solutions, the buffering capacity of the core, the molecular organization of the polymer membrane, the permeability characteristics of this membrane towards a wide range of compounds, and  ...  Recently, complex coacervates have emerged as attractive protocellular models because their condensed interiors would be expected to mimic this crowding better.  ...  Acknowledgements We acknowledge Kalyan Dulla for his initial work on identifying target genes for the AR pathway model.  ... 
doi:10.1002/cbic.201900195 pmid:31012235 pmcid:PMC6851677 fatcat:eeumuwcy5rfetfbf7g5oiojlce

Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells

Robert E Bakin, Daniel Gioeli, Robert A Sikes, Eric A Bissonette, Michael J Weber
2003 Cancer Research  
Progression of prostate cancer ultimately results in a disease that is refractory to hormone ablation therapy but nevertheless continues to require the androgen receptor.  ...  This provides a common mechanism for prostate cancer progression driven by diverse agonists.  ...  Daniel Theodorescu for provision of plasmids and advice and the Paul Mellon Prostate Cancer Research Institute group for advice; Sharon Birdsall for immunohistochemical work; and all of the other members  ... 
pmid:12702592 fatcat:la677wl2nrgfzccgyrtkhiv3sq

Chronic Administration of Valproic Acid Inhibits Prostate Cancer Cell GrowthIn vitroandIn vivo

Qinghua Xia, Jennifer Sung, Wasim Chowdhury, Chien-lun Chen, Naseruddin Höti, Shabana Shabbeer, Michael Carducci, Ronald Rodriguez
2006 Cancer Research  
These effects are evident in both androgen receptor-positive (LNCaP and C4-2) and androgen receptor-negative (DU145 and PC3) prostate cancer cells.  ...  We conclude that acute treatment has nominal effects on prostate cancer cell survival and proliferation, but chronic VPA results in profound decreases in proliferation, independently of androgen regulation  ...  Acknowledgments The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C.  ... 
doi:10.1158/0008-5472.can-05-0487 pmid:16849572 fatcat:bi437g5vqrg6bdozxbr5xrdepi

The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model

Steffen E Eikenberry, John D Nagy, Yang Kuang
2010 Biology Direct  
We formulate a mathematical model of androgen regulated prostate growth to study the effects of abnormal androgen levels on selection for pre-malignant phenotypes in early prostate cancer development.  ...  The model represents a useful initial framework for understanding the role of androgens in prostate cancer etiology, and it suggests that low androgen levels can increase selection for phenotypes resistant  ...  As a one-time exception to the publishing policy of Biology Direct the articles in this series are being published with two reviewers.  ... 
doi:10.1186/1745-6150-5-24 pmid:20406442 pmcid:PMC2885348 fatcat:ded6yl2ljzbvhouey2yr7gb3xu

Hormone Status Selects for Spontaneous Somatic Androgen Receptor Variants That Demonstrate Specific Ligand and Cofactor Dependent Activities in Autochthonous Prostate Cancer

Guangzhou Han, Barbara A. Foster, Sandeep Mistry, Grant Buchanan, Jonathan M. Harris, Wayne D. Tilley, Norman M. Greenberg
2000 Journal of Biological Chemistry  
prostate cancer.  ...  We have used the autochthonous transgenic adenocarcinoma of mouse prostate (TRAMP) model to investigate the relationship between somatic mutation in the androgen receptor (AR) and the emergence of androgenindependent  ...  better understanding the causal relationships between AR variants and prostate cancer.  ... 
doi:10.1074/jbc.m008207200 pmid:11063747 fatcat:bdyapao43ne2jgsfp2kehggyry

Cixutumumab-Associated Pancolitis in a Patient With Prostate Cancer

Mehmet Asim Bilen, Jeri Kim, Huamin Wang, Shi-Ming Tu
2013 Clinical Genitourinary Cancer  
Several types of tumors, including prostate cancer (PC), overexpress the insulin-like growth factor 1 receptor (IGF1R). 1 The antitumor effect of IGF1R inhibition has been noted in both in vitro and in  ...  Introduction New therapies for cancer have emerged as we have gained better understanding of the molecular mechanisms that underlie those diseases.  ...  Acknowledgments Supported in part by the National Institutes of Health through The University of Texas MD Anderson Cancer Center Support Grant, CA016672-36. We thank Karen F.  ... 
doi:10.1016/j.clgc.2012.09.009 pmid:23083799 pmcid:PMC3579009 fatcat:2gvz656zhbacfdvu52xgfkmziu

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers

Suzan Stelloo, Andries M. Bergman, Wilbert Zwart
2019 Endocrine-Related Cancer  
The androgen receptor (AR) is commonly known as a key transcription factor in prostate cancer development, progression and therapy resistance.  ...  In this review, we provide an overview of the different factors that influence AR chromatin binding in prostate cancer specimens, which is complemented with knowledge from cell line studies.  ...  Acknowledgements The authors would like to thank Simon Linder for critical review of the manuscript.  ... 
doi:10.1530/erc-19-0032 pmid:30865928 fatcat:wxgize4ccfb3vgxz45hwlhwipu

Functional Analysis of Secreted Caveolin-1 in Mouse Models of Prostate Cancer Progression

M. Watanabe, G. Yang, G. Cao, S. A. Tahir, K. Naruishi, K.-i. Tabata, E. A. Fattah, K. Rajagopalan, T. L. Timme, S. Park, S. Kurosaka, K. Edamura (+4 others)
2009 Molecular Cancer Research  
These experimental data suggest a causal association of secreted cav-1 and prostate cancer growth and progression. (Mol Cancer Res  ...  Intraprostatic injection of androgen-sensitive, cav-1-secreting RM-9 mouse prostate cancer cells resulted in tumors that were larger in PBcav-1 mice than in nontransgenic littermates (P = 0.04).  ...  Anderson Cancer Center DNA Analysis Facility which is funded by National Cancer Institute grant CA16672 for mouse genotyping.  ... 
doi:10.1158/1541-7786.mcr-09-0071 pmid:19737975 pmcid:PMC2887686 fatcat:wnzlsnnxznazbgwjzo64cm53va

Joint effects of inflammation and androgen metabolism on prostate cancer severity

Timothy R. Rebbeck, Hanna Rennert, Amy H. Walker, Saarene Panossian, Teo Tran, Kyle Walker, Elaine Spangler, Margerie Patacsil‐Coomes, Rajeev Sachdeva, Alan J. Wein, S. Bruce Malkowicz, Charnita Zeigler‐Johnson
2008 International Journal of Cancer  
To explore the possible joint effects of these pathways in prostate cancer severity, we studied 1,090 Caucasian prostate cancer cases to evaluate whether tumor severity is influenced by a history of benign  ...  These pathways are not independent, and may act together in prostate cancer etiology: androgens promote both inflammatory processes and serve as mitogens in prostate tumor growth.  ...  Model of inflammatory and androgenic influences on prostate cancer etiology and outcome. Figure 1 . 1 Figure 1. for age and educational attainment.  ... 
doi:10.1002/ijc.23687 pmid:18566991 pmcid:PMC2700293 fatcat:vccao7gntvbqnabjmemc22bhbu

Discrepancies on the association between androgen deprivation therapy for prostate cancer and subsequent dementia: meta-analysis and meta-regression

Jae Heon Kim, Bora Lee, Deok Hyun Han, Kyoung Jin Chung, In Gab Jeong, Benjamin I. Chung
2017 OncoTarget  
Limited literature exists on the association between androgen deprivation therapy (ADT) for prostate cancer (PCa) and subsequent dementia and the study conclusions are in conflicts with one another.  ...  Seven studies were eligible for the meta-analysis, with the inclusion of a total of 90, 543 prostate cancer patients.  ...  CONFLICTS OF INTEREST All authors have no conflicts of interest to declare. GRANT SUPPORT This research was supported by Soonchunhyang University Fund.  ... 
doi:10.18632/oncotarget.20391 pmid:29069851 pmcid:PMC5641194 fatcat:mhhgcrs6ynefhjzafmzep44md4
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