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Compounds In Literature (CIL): screening for compounds and relatives in PubMed

B. A. Gruning, C. Senger, A. Erxleben, S. Flemming, S. Gunther
2011 Bioinformatics  
Compounds In Literature (CIL) provides a web interface to automatically find names, structures, and similar structures in over 28 million compounds of PubChem and more than 18 million citations provided  ...  Furthermore, rarely investigated compounds may not be described in the available literature at all. In such cases, preceding searches for described similar compounds facilitate literature mining.  ...  Thus, Compounds In Literature (CIL) was developed, a webserver that combines the related tasks of compound and literature screening.  ... 
doi:10.1093/bioinformatics/btr130 pmid:21414988 fatcat:re454df6kjf4xpmnwsiogumc4q

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury

Kyunghee Yang, Cen Guo, Jeffrey L. Woodhead, Robert L. St. Claire, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Kim L.R. Brouwer
2016 Journal of Pharmaceutical Sciences  
SCH have been used widely to assess hepatobiliary disposition of endogenous and exogenous compounds and metabolites.  ...  modeling data for the same seven OATP substrates; they reported SFs of 55 for CL int, u, uptake , 0.019 for CL int, u, bile , and 0.092 for CL int, u, pass . 77 The difference in the estimated SF for  ...  compound 7-ethoxycoumarin, were estimated using mathematical modeling after co-incubation with human SCH for 48 hr. 20 , 21 The calculated intrinsic clearance was in accordance with literature reports  ... 
doi:10.1016/j.xphs.2015.11.008 pmid:26869411 pmcid:PMC4894499 fatcat:yqhmmdbzujh4nhsvmer4a3sgsi

Performance and storage integrity of dried blood spots for PCB, BFR and pesticide measurements

Stuart Batterman, Sergei Chernyak
2014 Science of the Total Environment  
Considering concentrations of contaminants for adults and children reported in the literature, and experimental values of detection limits and background contamination, DBS samples are suitable for quantifying  ...  Several of the target compounds and their degradation products have not been previously measured in DBS. All target compounds were detected in DBS samples collected from the volunteers.  ...  persistent organic contaminants, including chlorinated and brominated compounds, in human blood."  ... 
doi:10.1016/j.scitotenv.2014.06.142 pmid:25058892 pmcid:PMC4134318 fatcat:7sazf6ovibdkrflfugmpob6sba

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

Charles C. Bailey, Guocai Zhong, I-Chueh Huang, Michael Farzan
2014 Annual Review of Virology  
Murine Ifitm3 controls influenza A virus infection in vivo, and polymorphisms in human IFITM3 correlate with the severity of both seasonal and highly pathogenic avian influenza virus.  ...  These activities limit infection in cultured cells by many viruses, including dengue virus, Ebola virus, influenza A virus, severe acute respiratory syndrome coronavirus, and West Nile virus.  ...  First, once we understand the mechanism of restriction, we might be able screen for compounds that mimic this activity.  ... 
doi:10.1146/annurev-virology-031413-085537 pmid:25599080 pmcid:PMC4295558 fatcat:6l7avtlzyjbuhms2dmivfz2yaa

Carboxylic Acid Production

Gunnar Lidén
2017 Fermentation  
Acknowledgments: The author is grateful for research support in this field through the EU contracts BRIGIT (grant number FP7-311935) and Biorefine-2G (grant number FP7-613771).  ...  We also thank Nancy Dowe and Ed Wolfrum for helpful discussions and the reviewers for providing comments that improved the manuscript.  ...  The reason for the relatively low AD total could be explained by the majority of the COD present in the feed being constituted by phenolic compounds, LS, and other recalcitrant compounds, which are more  ... 
doi:10.3390/fermentation3030046 fatcat:7t3sdhpih5bjln66muf5uaxcby

Dual impact from coincide potential complications of cancer therapy and sarcopenia: a narrative review

Anmar Al-Taie, Aygül Koseoğlu
2021 Oncology in Clinical Practice  
By searching through data sets, all articles that focused on sarcopenia and cancer therapy were collected in the indexed journals between the years 2000 and 2021 that could provide findings for the potential  ...  In conclusion, the evaluation of sarcopenia in cancer patients should be considered a primary part of oncological care in cancer patients as there are potential complications and poor survival from the  ...  Introduction Sarcopenia term first took its place in medical literature in the late 1980s by Rosenberg and consists of two words: "sarx (muscle)" and "penia (loss)".  ... 
doi:10.5603/ocp.2021.0023 fatcat:24lh4mdwrza5vgjaocpmxj3sny

Assessing geographical distribution and accessibility of emergency obstetric care in sub-Saharan Africa: a systematic review

Aduragbemi Banke-Thomas, Kikelomo Wright, Lindsey Collins
2018 Journal of Global Health  
Two reviewers systematically searched multiple databases for articles published between January 2009 and June 2018. Both screened and selected studies based on the set inclusion criteria.  ...  Comprehensive assessments need to maximise recent advancements in mobile and GIS open-source technology to provide more realistic representation of EmOC access for service planners and policy-makers.  ...  Acknowledgements: The authors would like to acknowledge the support of Dr Oluwasola Banke-Thomas in the writing-up of this manuscript.  ... 
doi:10.7189/jogh.09.010414 pmid:30603080 pmcid:PMC6304172 fatcat:4xc4vlb73fepncojulykjme75u

Clinical translation of patient-derived tumour organoids- bottlenecks and strategies

Malia Alexandra Foo, Mingliang You, Shing Leng Chan, Gautam Sethi, Glenn K. Bonney, Wei-Peng Yong, Edward Kai-Hua Chow, Eliza Li Shan Fong, Lingzhi Wang, Boon-Cher Goh
2022 Biomarker Research  
These proposed solutions accelerate and optimize the workflow of a clinical organoid drug screening.  ...  Unsuitable methods of tissue acquisition, disparities in establishment rates and a lengthy timeline are the limiting factors for use of PDTOs in clinical application.  ...  Acknowledgements The authors would like to thank WONG HOCK BOON SOCIETY, National University of Singapore for kind support!  ... 
doi:10.1186/s40364-022-00356-6 pmid:35272694 pmcid:PMC8908618 fatcat:3g25pwaddjgknot3hklpxxxl3i

Weathering the storm: COVID-19 infection in patients with hematological malignancies

He HUANG, Arnon NAGLER, Yong-xian HU, Lin-qin WANG, Elaine TAN SU YIN
2020 Journal of Zhejiang University SCIENCE B  
In this review, we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs.  ...  In patients with COVID-19, underlying chronic diseases and comorbidities are associated with dismal treatment outcomes.  ...  Recently, detailed case reports and cohort studies of COVID-19 in patients with preexisting HMs have become increasingly available in databases like PubMed, Web of Science, and medRxiv.  ... 
doi:10.1631/jzus.b2000423 pmid:33843158 pmcid:PMC7759451 fatcat:w4w5wpkf6bae3oplm4igzuyjie

Meta-Analyses of Chemotherapy for Locally Advanced and Metastatic Pancreatic Cancer

Asma Sultana, Catrin Tudur Smith, David Cunningham, Naureen Starling, John P. Neoptolemos, Paula Ghaneh
2007 Journal of Clinical Oncology  
Neoptolemos, Paula Ghaneh published literature for survival endpoints. Stat Med 17:2815-2834, 1998 16.  ...  In the subgroup analysis for overall survival (Fig 6), platinum- based compounds (three trials, 1,077 patients; HR = 0.85; 95% CI, 0.74 to 0.96) and capecitabine (three trials, 935 patients; HR = 0.83;  ... 
doi:10.1200/jco.2006.09.2551 pmid:17577041 fatcat:yfa3yx2a3jfetbvypeofwkkj4a

Preclinical Pharmacokinetic/Pharmacodynamic Studies and Clinical Trials in the Drug Development Process of EMA-Approved Antibacterial Agents: A Review

Anselm Jorda, Markus Zeitlinger
2020 Clinical Pharmacokinetics  
In Europe, the European Medicines Agency has been guiding this development process for more than two decades.  ...  We confirmed the relevance of preclinical pharmacokinetic/pharmacodynamic studies in dosing optimization and decision making in antimicrobial drug development.  ...  However, the literature on this topic and the terminology are not always strictly consistent.  ... 
doi:10.1007/s40262-020-00892-0 pmid:32356105 fatcat:hzwp2x5ocrcgnjedkak52sp54u

Congress Abstracts*/Second ESPT Conference "Pharmacogenomics: From Cell to Clinic"

2013 Drug Metabolism and Drug Interactions  
Polymorphisms found in 2,3,4,11 and 17exons were already described in the literature.  ...  compounds.  ...  in genes encoding for xenobiotic metabolizing enzymes, such as the CYP2D6 and CYP2C19 isoforms of the cytochrome P450 (CYP450), and in genes encoding for proteins that mediate their efflux, such as the  ... 
doi:10.1515/dmdi-2013-0041 fatcat:tomi3ocjjbdklffkxo66ivgtva

Canadian Society of Plastic Surgeons

Howard Clarke, Peter Lennox, Murray Allen, Tracey Thomson
2016 Plastic Surgery  
Demonstrate an ability to formulate a list of treatment options and a preferred treatment for hand and wrist injuries in elite athletes; 5.  ...  DISCLOSURE: Paid consultant for the Calgary Flames; gifts in kind from the NHL and NHL Flames Association; paid travelling team doctor for Canada Snowboard Team; patent held on wrist cut resistant protectors  ...  METHODS: An electronic literature search was completed. Two independent reviewers completed the screening and data extraction process.  ... 
doi:10.1177/229255031602400206 pmcid:PMC4942236 fatcat:vuh7qiyzpng25bdwyuw2fk4o34

Canadian Society of Plastic Surgeons

Howard clarke, Peter Lennox, Murray allen Tracey thomson
2016 Plastic Surgery  
Demonstrate an ability to formulate a list of treatment options and a preferred treatment for hand and wrist injuries in elite athletes; 5.  ...  To recognize some of the pitfalls in treating sports-related hand and wrist injuries. disCLOsure: Paid consultant for the Calgary Flames; gifts in kind from the NHL and NHL Flames Association; paid travelling  ...  MethOds: An electronic literature search was completed. Two independent reviewers completed the screening and data extraction process.  ... 
doi:10.4172/plastic-surgery.1000960 fatcat:fq3gqtbx7reydikpk4yscou5rq

2021 Canadian Surgery Forum01. Design and validation of a unique endoscopy simulator using a commercial video game03. Is ethnicity an appropriate measure of health care marginalization?: A systematic review and meta-analysis of the outcomes of diabetic foot ulceration in the Aboriginal population04. Racial disparities in surgery — a cross-specialty matched comparison between black and white patients05. Starting late does not increase the risk of postoperative complications in patients undergoing common gene ...

G. Johnson, K. Hickey, A. Azin, K. Guidolin, K. Guidolin, F. Shariff, J. Gentles, M. Parapini, R. Guo, E. Ertel, T. Lenet, K. Nabata (+1419 others)
2021 Canadian journal of surgery  
Results: Experts outperformed novices for time to study completion (expert 944 s, novice 1515 s; p = 0.006) and number of hand movements (expert 1263.1 s, novice 2052.6 s; p = 0.004) using the novel colonoscope  ...  : A systematic review and metaanalysis of the outcomes of diabetic foot ulceration in the Aboriginal population. K. Hickey, D. Pace.  ...  Methods: A systematic literature search was performed using Embase, Google Scholar, Ovid Medline, PubMed and Web of Science (1990 Science ( -2020)) .  ... 
doi:10.1503/cjs.021321 pmid:35483046 pmcid:PMC8677574 fatcat:hiphvi35nrbszhqvmbydxuczte
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