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Is angiogenesis a hallmark of prostate cancer?

Gianluigi Taverna, Fabio Grizzi, Piergiuseppe Colombo, Pierpaolo Graziotti
2013 Frontiers in Oncology  
Angiogenesis, the development of new branching vessels from existing vasculature, is a complex process observed in fetal growth, wound healing and endometrial hyperplasia associated with the menstrual  ...  The complex geometry of tumor vasculature and its structural and functional heterogeneity mean that vascular network cannot be measured on the basis of MVD estimates alone.  ... 
doi:10.3389/fonc.2013.00015 pmid:23390615 pmcid:PMC3565155 fatcat:ikqntvabizbvlmgu45hfr34psi

Regulation of Ocular Angiogenesis by Notch Signaling: Implications in Neovascular Age-Related Macular Degeneration

Iqbal Ahmad, Sudha Balasubramanian, Carolina B. Del Debbio, Sowmya Parameswaran, Allen R. Katz, Carol Toris, Robert N. Fariss
2011 Investigative Ophthalmology and Visual Science  
with microscopy, Thomas Gridley for critical review of the manuscript, and Timothy J.  ...  Acknowledgments The authors thank Mercedes Campos for laser-induced photocoagulation training, Anathbandhu Chaudhuri for contributing to CNV and retinal angiogenesis experiments, Parmender Mehta for help  ...  Q-PCR analysis of transcripts in the choroid-sclera complex of eyes with approximately 20 CNV lesions revealed that levels of those corresponding to genes positively associated with angiogenesis-Vegfr2  ... 
doi:10.1167/iovs.10-6608 pmid:21228388 pmcid:PMC3109005 fatcat:v2gvs5j3bbedlfvmu72bf4wxba

Tumor Angiogenesis: A Focus on the Role of Cancer Stem Cells [chapter]

Keiko Fujita, Masumi Akita
2017 Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy  
Angiogenesis is the process of growth of new blood vessels. Tumor angiogenesis plays pivotal roles in tumor development, progression, and metastasis.  ...  The conventional notion of tumor vasculature is that new tumor blood vessels sprout from preexisting vasculature near the tumor; hence, tumor endothelial cells are derived from normal endothelial cells  ...  (D) TEM analysis: CD133 was preferentially concentrated in the complex filopodial structure and at the leading edge of lamellipodia. The clustered particles form black spots; scale bar: 5 µm.  ... 
doi:10.5772/66402 fatcat:g3i5uk23abcipcfstcbmysbwze

New Gene Markers of Angiogenesis and Blood Vessels Development in Porcine Ovarian Granulosa Cells during Short-Term Primary Culture In Vitro

Błażej Chermuła, Maciej Brązert, Dariusz Iżycki, Sylwia Ciesiółka, Wiesława Kranc, Piotr Celichowski, Katarzyna Ożegowska, Mariusz J. Nawrocki, Maurycy Jankowski, Michal Jeseta, Paweł Antosik, Dorota Bukowska (+7 others)
2019 BioMed Research International  
From these, we have chosen the members of "angiogenesis," "blood vessel development," "blood vessel morphogenesis," "cardiovascular system development," and "vasculature development" for further selection  ...  They participate directly in the processes of oogenesis, building the cumulus-oocyte complex surrounding the ovum.  ...  Publication of this article was made possible by grants numbers UMO-2016/21/B/NZ9/03535 and UMO-2012/07/N/ NZ5/00069 from Polish National Centre of Science.  ... 
doi:10.1155/2019/6545210 fatcat:i577ckavnjg6rl4ujqsdasanca

Intermedin: A Novel Regulator for Vascular Remodeling and Tumor Vessel Normalization by Regulating Vascular Endothelial-Cadherin and Extracellular Signal-Regulated Kinase

W. Zhang, L.-J. Wang, F. Xiao, Y. Wei, W. Ke, H.-B. Xin
2012 Arteriosclerosis, Thrombosis and Vascular Biology  
Using RNA interference, real-time polymerase chain reaction, and Western blot analysis, we found that IMD alleviated the undesirable effects of vascular endothelial growth factor by restricting the excessive  ...  Conclusion-We demonstrated that IMD played a critical role in the vascular remodeling process and tumor angiogenesis and may serve as a novel target for the development of angiogenesis-based anticancer  ...  Hughes for kindly providing the detailed protocol of the fibrin bead assay. We thank Dr Matthew B. Veldman for critical reading of the manuscript. Sources of Funding Disclosures None.  ... 
doi:10.1161/atvbaha.112.300185 pmid:22922959 fatcat:krga5jfnhzbcho2mqn35doq5ua

Demystifying morphomolecular alterations of vasculature in interstitial lung diseases

Toyoshi Yanagihara, Kirk D. Jones
2020 European Respiratory Journal  
This is a comprehensive analysis with state-of-the-art technology focusing on remodelling-associated angiogenesis (figure 1).  ...  main subtypes of interstitial lung disease: UIP, NSIP and AFE http://bit.ly/2NtmV6D Interstitial lung diseases (ILDs) encompass a complex group of hundreds of lung disorders that affect lung tissue with  ... 
doi:10.1183/13993003.02446-2019 pmid:32165424 fatcat:xlpf7mb6yfdebepfgr32ih2mwa

Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature

M. E. Akerman, J. Pilch, D. Peters, E. Ruoslahti
2005 Proceedings of the National Academy of Sciences of the United States of America  
The role of the adhesion protein interaction apparently is to form integrin-binding complexes that deliver the antiangiogenic proteins to sites of angiogenesis.  ...  A group of angiogenesis inhibitors are derived from fragments of extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin are members of this group of substances.  ...  M.E.A. was supported by Department of Defense Fellowship DAMD17-02-1-0308.  ... 
doi:10.1073/pnas.0409844102 pmid:15687502 pmcid:PMC548558 fatcat:zxyl3b2gqzcw7m3icgmgudvmk4

Analysis of a Model for the Morphological Structure of Renal Arterial Tree: Fractal Structure

Aurora Espinoza-Valdez, Francisco C. Ordaz-Salazar, Edgardo Ugalde, Ricardo Femat
2013 Journal of Applied Mathematics  
The analysis can describe the complex structures of the development vasculature in kidney.  ...  Here we deal with the analysis of a model recently proposed by Espinoza-Valdez et al. (2010) for the kidney vasculature developed via angiogenesis.  ...  The complex structures of the renal arterial tree are consistent with previous fractal analysis of vascular structures [9, [11] [12] [13] [14] .  ... 
doi:10.1155/2013/396486 fatcat:tqlfwazp4vhgdawkdcqllrzc5q

A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth

L Arakelyan, V Vainstein, Z Agur
2002 Angiogenesis  
We put forward an algorithm describing the three principal interconnected sub-processes that influence tumor and vasculature dynamics: (i) tumor cell proliferation (ii) angiogenesis, that is, the formation  ...  Implementing this complex algorithm in a computer model, one can evaluate the correlations between various factors influencing angiogenesis and their influence on tumor progression at any given moment.  ...  Dr Arakelyan is a recipient of the Shapira Scholarship from the Center of Absorption in Science of the Israeli Ministry of Absorption.  ... 
pmid:12831061 fatcat:vxmlpez3yfds3gfdcjmjygi3pe

Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo

Magdalena Pruszko, Elisa Milano, Alicja Zylicz, Maciej Zylicz, Giovanni Blandino, Giulia Fontemaggi
2018 Journal of Thoracic Disease  
Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ...  ; a MAESTRO NZ1/00089 grant from the National Science Center of Poland to M Pruszko, A Zylicz, and M Zylicz.  ...  complex comprising mutant p53, ID4, SRSF1 proteins and lncRNA MALAT1 to the modulation of VEGFA isoforms and to tumor angiogenesis.  ... 
doi:10.21037/jtd.2018.03.86 pmid:29708138 pmcid:PMC5906282 fatcat:bcgfpdtxuvckble7wgrlhfehv4

Development of a Computationally Optimized Model of Cancer-induced Angiogenesis through Specialized Cellular Mechanics [article]

Dibya Jyoti Ghosh
2016 arXiv   pre-print
Angiogenesis, the development of new vasculature, is a critical process in the growth of new tumors.  ...  Analysis (DVSA) and experimentally observed data.  ...  Graphical analysis uses 3d space-filling models of the lattice structure, which allows for easy analysis of endothelial cell migration.  ... 
arXiv:1602.03244v1 fatcat:2jt5m4ayyndr7c6fyikxalusg4

Tumor Angiogenesis: Cause or Consequence of Cancer?

K. Shchors, G. Evan
2007 Cancer Research  
We identified the inflammatory cytokine interleukin-1B as an essential initiating trigger of vascular endothelial growth factor-dependent angiogenesis.  ...  However, whereas normal vasculature is hierarchically assembled into efficient networks of arteries, capillaries, and veins, the blood vessels of tumors are a mess-chaotic, leaky, inefficient, and barely  ...  Kinetic analysis of angiogenic factors present in islets following Myc activation indicated dramatic upregulation of soluble VEGFA by 72 h, consistent with the onset of angiogenesis we observed.  ... 
doi:10.1158/0008-5472.can-07-2053 pmid:17671171 fatcat:zkfg47vh5jbqtce6vjob4fxq2a

Development of the Pulmonary Vasculature: Current Understanding and Concepts for the Future

Tien Peng, Edward E. Morrisey
2013 Pulmonary Circulation  
We outline key questions on pulmonary vascular development that consider the role of heart-lung interaction in promoting the differentiation and patterning of the pulmonary vasculature.  ...  Prior studies into the role of angiogenesis and vasculogenesis in pulmonary vascular development have not clearly yielded the identity of pulmonary vascular precursors, or the signals coordinating vascular  ...  organ with a complex vasculature will be greatly increased.  ... 
doi:10.4103/2045-8932.109954 pmid:23662197 pmcid:PMC3641728 fatcat:flbtlfjclfg2fgmxj5dzy3np5a

Molecular imaging of vessels in mouse models of disease

Lyubomir Zagorchev, Mary J. Mulligan-Kehoe
2009 European Journal of Radiology  
For example, image analysis of vessel development in angiogenesis vs. arteriogenesis enables more accurate detection of biological variation between subjects and more robust and reliable diagnosis of disease  ...  This review highlights the capabilities of microCT, ultrasound and microPET for multimodal imaging of angiogenesis and molecular vascular targets in a mouse model of tumor angiogenesis.  ...  The complexity of the physiological processes involved in angiogenesis at the cellular level is enormous.  ... 
doi:10.1016/j.ejrad.2009.01.053 pmid:19304428 pmcid:PMC2757633 fatcat:zr6lxojmzncb3ibs7xz3eo3aum

Apelin Controls Angiogenesis-Dependent Glioblastoma Growth

Anne Frisch, Stefanie Kälin, Raymond Monk, Josefine Radke, Frank L. Heppner, Roland E. Kälin
2020 International Journal of Molecular Sciences  
By functional analysis of apelin in orthotopic GBM mouse models, we found that apelin/APLNR signaling is required for in vivo tumor angiogenesis.  ...  Knockdown of tumor cell-derived APLN massively reduced the tumor vasculature.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms21114179 pmid:32545380 fatcat:4le5o6fopvcthp6qad67fgp2du
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