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Computational Issues in Mapping Variation Affecting Susceptibility to Complex Disorders: The Chicken and the Egg

Nancy J. Cox
2001 Theoretical Population Biology  
This paper focuses on how computational issues have impacted the design of studies on complex disorders and, conversely, how our study designs have influenced the computational issues that have been addressed  ...  Some of these constraints reflect the nature of complex disorders and are manifest in limitations on the kinds of data that can be collected, while others were (at least historically) strictly computational  ...  Here, we focus on how computational issues have influenced the choices investigators have made.  ... 
doi:10.1006/tpbi.2001.1535 pmid:11855956 fatcat:ewxhd2lvsregxb7hmbymfyy43i

High-performance computational biology

David A. Bader, Srinivas Aluru
2008 Parallel Computing  
However, research in high-performance computational biology has not grown as rapidly as computational biology itself.  ...  By bringing together research in this area as a special issue, we hope to provide a resource for Parallel Computing readers interested in this field and aid the entry of new researchers into the field.  ...  The Parallel Computing editorial staff has provided assistance throughout the process of bringing out the special issue.  ... 
doi:10.1016/j.parco.2008.10.001 pmid:19884965 pmcid:PMC2621331 fatcat:eldfm5xx2zctxajchvfnmdbgmq

Quantitative cell biology: transforming the conceptual, theoretical, instrumental, and methodological approaches to cell biology

Jennifer Lippincott-Schwartz, Jennifer Lippincott-Schwartz
2014 Molecular Biology of the Cell  
The Perspectives focus on how to bridge the wide gulf between collection of quantitative data and the use of physics, mathematics, and computers in providing causal relationships in cell biology.  ...  This special issue of Molecular Biology of the Cell recognizes this transformation in cell biology's methodologies and conceptual foundations and signals a broadening of the scope of MBoC to include papers  ...  The Perspectives focus on how to bridge the wide gulf between collection of quantitative data and the use of physics, mathematics, and computers in providing causal relationships in cell biology.  ... 
doi:10.1091/mbc.e14-08-1297 pmid:25368415 pmcid:PMC4230597 fatcat:ylirmlil7beixknw6pmztcqaxm

Editorial

W. Dubitzky
2009 Briefings in Bioinformatics  
I believe this issue of Briefings in Bioinformatics provides an interesting 'snapshot' of contemporary developments in bioinformatics and computational biology.  ...  I still believe that this issue is useful as a 'yardstick' to gage ongoing and anticipate future developments in the fields of bioinformatics, computational biology and even systems biology.  ... 
doi:10.1093/bib/bbp031 pmid:19505887 fatcat:gsxe6ojeyrgznjtxwzyp55gvjy

Special issue: Multi-agent systems for medicine, computational biology, and bioinformatics

Giuliano Armano
2007 Multiagent and Grid Systems  
As for the simulation and modeling of complex biological systems (see [Bosse et al.] , [Bandini et al.] , [Merelli and Young]), which are crucial issues in systems biology and computational biology,  ...  IOS Press Guest-editorial Special issue: Multi-agent systems for medicine, computational biology, and bioinformatics Recent progresses in the area of biomedical sciences, including medicine, bioinformatics  ...  of complex systems.  ... 
doi:10.3233/mgs-2007-3201 fatcat:kvzvzz73lfemxdagsvo22xvfze

Computationally Driven Experimental Biology

T M Murali
2012 Computer  
The complexity, diversity, and richness of experimental data on cellular systems are inspiring the development of computational analysis techniques that can directly prioritize and suggest new experiments  ...  of challenging computational issues that arise in the analysis of genomic, molecular, and network data and the algorithmic approaches for tackling them, and an article highlighting numerous computational  ...  biology.  ... 
pmid:24976642 pmcid:PMC4071611 fatcat:x42fgdto3zbyrfifv5on5lauti

Editorial

Luonan Chen, Xiang-Sun Zhang
2010 Journal of Systems Science and Complexity  
Systems Biology has been greatly boomed recently and attracted many leading scientists in Biology, Physics, Mathematics, Computer Science, Optimization, and Statistics.  ...  Fourteen papers in this special issue are selected from fifty nine papers in the OSB2009 proceedings. These papers cover a wide range of optimization and systems biology.  ... 
doi:10.1007/s11424-010-0003-8 fatcat:tqiskwayjverbkhgyfirtdz64e

Preface

Corrado Priami
2004 Theoretical Computer Science  
This special issue collects extended versions of papers presented at the international workshop on Computational Methods in Systems Biology held in Rovereto, 24-26 February 2003.  ...  This new way of doing research in biology is called systems biology. The approach of systems biology is very similar to the way in which computer scientists perform research.  ...  Antoniotti, Piazza, Policriti, Simeoni and Mishra use hybrid automata equipped with bisimulation and collapsing to model complex biological systems in the third paper of the issue.  ... 
doi:10.1016/j.tcs.2004.03.060 fatcat:xopeeenionhyhikacle52ci4rq

Modelling biological systems from molecules to dynamical networks

Yong Wang, Xiang-Sun Zhang, Luonan Chen
2012 BMC Systems Biology  
Acknowledgements We would like to thank all the authors who submitted their manuscripts to this Special Issue.  ...  This article has been published as part of BMC Systems Biology Volume 6 Supplement 1, 2012: Selected articles from The 5th IEEE International Conference on Systems Biology (ISB 2011).  ...  and computational research to understand the complex biological systems.  ... 
doi:10.1186/1752-0509-6-s1-s1 pmid:23046669 pmcid:PMC3403002 fatcat:m5va424wlvbtllbi2nu3bkzo2a

Computational cell biology

Ira Mellman, Tom Misteli
2003 Journal of Cell Biology  
This issue of the Journal of Cell Biology contains three reviews on computational cell biology. Further reviews on related topics will follow.  ...  In addition, the limited mathematical training of most cell biologists has slowed the wide acceptance of computation analysis in cell biology.  ...  This issue of the Journal of Cell Biology contains three reviews on computational cell biology. Further reviews on related topics will follow.  ... 
doi:10.1083/jcb.200303202 pmid:12743098 pmcid:PMC2172937 fatcat:jmjmkt4vmzeq5gpairtsggpgbi

Editorial (Thematic Issue: Protein Systems Biology: Method, Regulation, and Network)

Qingfeng Chen, Ming Chen
2014 Current protein and peptide science  
ACKNOWLEDGEMENTS We wish to thank all the authors who have contributed with their work to foster the dissemination of scientific excellence in the protein network biology field; all the reviewers for giving  ...  The work reported in this paper was partially supported by a National Natural Science Foundation of China project 61363025 and 31371328, and two key projects of Natural Science Foundation of Guangxi 053006  ...  It has been widely applied in both biological and biomedical studies to explore complex interactions between components within biology systems by virtue of biomedical studies to explore complex interactions  ... 
doi:10.2174/1389203715666140724091730 pmid:25135673 fatcat:liyexnkofndkhe2h3dzcpzfqli

Special Issue: Application of Machine Learning Methods in Bio-medical Informatics

Shahaboddin Shamshirband
2019 Figshare  
In fact, this special issue seeks the latest fundamental advances in thestate of the computational biology and data mining in biological complex data, biomarkerdiscovery and practice of pattern mining  ...  Machine learning methodsenable remarkable advances in the fields of drug discovery, healthcare, genome research,computational biology, etc.  ...  Infact, this special issue seeks the latest fundamental advances in the state of the computational biology and data mining in biological complex data, biomarker discovery and practice of pattern mining  ... 
doi:10.6084/m9.figshare.7763117 fatcat:g7yy2t5bwrczfeozn5hq2yf2py

Multiscale Systems Biology: A Special Issue Devoted to Understanding Biology and Medicine Across Multiple Scales

Michael R. King, Scott L. Diamond
2012 Annals of Biomedical Engineering  
The central goal of Systems Biology is to understand and quantitatively predict biological phenomena at a global level, where biological functions result from complex mechanisms that occur across diverse  ...  complex transport physics.  ...  In this Special Issue, a variety of approaches and methodologies are presented for the use of multiscale computational models to study and predict the behavior of complex systems.  ... 
doi:10.1007/s10439-012-0661-x pmid:23001360 fatcat:3rwsgc25hfds7lw6uhvi22klny

Biophysical Journal Special Issue: Focus on Quantitative Cell Biology

David W. Piston
2014 Biophysical Journal  
This special issue of the Biophysical Journal focusing on Quantitative Cell Biology highlights a broad range of biophysical approaches applied to mechanistic questions in cell biology.  ...  It is clearly an exciting time in cell biology research, and I hope our readers enjoy this special issue as much as we have enjoyed putting it together.  ...  This special issue of the Biophysical Journal focusing on Quantitative Cell Biology highlights a broad range of biophysical approaches applied to mechanistic questions in cell biology.  ... 
doi:10.1016/j.bpj.2014.10.038 pmid:25468353 pmcid:PMC4255198 fatcat:ljnjfcpqk5amnn6h72e3iipbju

In This Issue

2011 Cell  
It is in this context that we present our 2011 Special Review Issue on systems biology.  ...  In thinking about complexity, it's frequently invoked that the whole is greater than the sum of its parts.  ...  Finding Strength in Numbers (and Equations) As much as any discipline in modern biology, systems biology relies on computation and mathematics to collect data, build models, and make predictions.  ... 
doi:10.1016/j.cell.2011.03.011 fatcat:m7pybwttufahphuocbbvznsy44
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