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Deep learning-based parameter mapping for joint relaxation and diffusion tensor MR Fingerprinting [article]

Carolin M. Pirkl, Pedro A. Gómez, Ilona Lipp, Guido Buonincontri, Miguel Molina-Romero, Anjany Sekuboyina, Diana Waldmannstetter, Jonathan Dannenberg, Sebastian Endt, Alberto Merola, Joseph R. Whittaker, Valentina Tomassini (+4 others)
2020 arXiv   pre-print
and T1 and T2 relaxation.  ...  We bypass expensive dictionary matching by learning the implicit physical relationships between the spatiotemporal MRF data and the T1, T2 and diffusion tensor parameters.  ...  Jones is supported by a Wellcome Trust Investigator Award (096646/Z/11/Z) and a Wellcome Trust Strategic Award (104943/Z/14/Z).  ... 
arXiv:2005.02020v1 fatcat:znc47bxvhfazxerlb4vjv5luai

Characterizing the microstructural basis of "unidentified bright objects" in neurofibromatosis type 1: A combined in vivo multicomponent T2 relaxation and multi-shell diffusion MRI analysis

Thibo Billiet, Burkhard Mädler, Felice D'Arco, Ronald Peeters, Sabine Deprez, Ellen Plasschaert, Alexander Leemans, Hui Zhang, Bea Van den Bergh, Mathieu Vandenbulcke, Eric Legius, Stefan Sunaert (+1 others)
2014 NeuroImage: Clinical  
New in vivo MRI-based techniques (multi-exponential T2 relaxation (MET2) and diffusion MR imaging (dMRI)) provide measures relating to microstructural change.  ...  Myelin water imaging (MWI) Diffusion tensor imaging (DTI) Diffusion kurtosis imaging (DKI) Neurite orientation dispersion and density imaging (NODDI) Neurofibromatosis type 1 (NF1) Unidentified bright  ...  Acknowledgments The authors would like to thank and acknowledge Thomas Prasloski and colleagues at the UBC MRI Research Centre, for assisting with analysis of multi-echo data.  ... 
doi:10.1016/j.nicl.2014.04.005 pmid:24936416 pmcid:PMC4053637 fatcat:lxjyglsnr5du7bgdjdibajmfc4

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis

Pavel Filip, Alena Svatkova, Adam F Carpenter, Lynn E Eberly, Igor Nestrasil, Mikko J. Nissi, Shalom Michaeli, Silvia Mangia
2020 NeuroImage: Clinical  
Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense  ...  relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls.  ...  Acknowledgments and funding The authors are grateful to the patients and their families for their support of research activities.  ... 
doi:10.1016/j.nicl.2020.102234 pmid:32272373 pmcid:PMC7139162 fatcat:lzr6q3sfcfd7jk22wdasb6as7u

Age-related microstructural differences quantified using myelin water imaging and advanced diffusion MRI

Thibo Billiet, Mathieu Vandenbulcke, Burkhard Mädler, Ronald Peeters, Thijs Dhollander, Hui Zhang, Sabine Deprez, Bea R.H. Van den Bergh, Stefan Sunaert, Louise Emsell
2015 Neurobiology of Aging  
diffusion! MRI! and! multi%exponential! T2! relaxation! we! found!age%related!differences!in!multiple!MRI!measures!of!microstructure!across! the!brain!WM!that!predate!atrophy.!Commonly!reported!  ...  from!multi%exponential!T2!relaxation!(MET2,!or! "myelin! water! imaging,! MWI"),! and! magnetization! transfer! imaging! (MTI).! Studies! using! MTI! have! found! evidence! of! potential! age!  ... 
doi:10.1016/j.neurobiolaging.2015.02.029 pmid:25840837 fatcat:yegd6kqdijfmfenkzovrf64mbe

Magnetic Resonance Imaging Techniques: fMRI, DWI, and PWI

Samantha Holdsworth, Roland Bammer
2008 Seminars in neurology  
In addition to T1-and T2-weighted contrast achieved by regular anatomical MRI, other unique contrast mechanisms such as diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), and functional  ...  Magnetic resonance imaging (MRI) is a noninvasive technique which can acquire important quantitative and anatomical information from an individual in any plane or volume at comparatively high resolution  ...  The authors are grateful to Matus Straka and Stefan Skare for insightful discussions.  ... 
doi:10.1055/s-0028-1083697 pmid:18843569 pmcid:PMC3985850 fatcat:xorb52be5nc2lhflxuzo3kir3a

Modeling white matter microstructure

Tanguy Duval
2016 Functional Neurology  
This review explains the methodology behind microstructural modeling and imaging, and gives an overview of the breakthroughs and challenges associated with it.  ...  Non-invasive microstructural imaging has the potential to revolutionize neuroscience, and acquiring these measures in clinically feasible times would greatly improve patient monitoring and clinical studies  ...  T2 relaxations).  ... 
doi:10.11138/fneur/2016.31.4.217 fatcat:z7tvwmugr5g47lqcwn4i3ysz4e

Biomedical applications of sodium MRI in vivo

Guillaume Madelin, Ravinder R. Regatte
2013 Journal of Magnetic Resonance Imaging  
Sodium MRI is a subject of increasing interest in translational imaging research as it can give some direct and quantitative biochemical information on the tissue viability, cell integrity and function  ...  The article is divided in three parts: (1) the role of sodium in biological tissues, (2) a short review on sodium magnetic resonance, and (3) a review of some studies on sodium MRI on different organs/  ...  Acknowledgments Grant Support This work was partly supported by research grants (RO1 AR053133, RO1 AR056260, and RO1 AR060238), from the National Institute of Arthritis and Musculoskeletal and Skin Diseases  ... 
doi:10.1002/jmri.24168 pmid:23722972 pmcid:PMC3759542 fatcat:uc6bdpba3zcgdkk4vkeflgovvu

Skeletal Muscle Quantitative Nuclear Magnetic Resonance Imaging and Spectroscopy as an Outcome Measure for Clinical Trials

Pierre G. Carlier, Benjamin Marty, Olivier Scheidegger, Paulo Loureiro de Sousa, Pierre-Yves Baudin, Eduard Snezhko, Dmitry Vlodavets
2016 Journal of Neuromuscular Diseases  
Considerable efforts are being directed towards acceleration of image acquisitions using a variety of approaches, from the extraction of fat content and water T2 maps from one single acquisition to partial  ...  Diffusion NMR as well as texture analysis algorithms could generate complementary information on muscle organization at microscopic and mesoscopic scales, respectively. 31 P NMR spectroscopy is the reference  ...  Another approach to simultaneously measure water T2 and fat fraction is to use multi-component fitting of the standard MSME sequence by taking advantage of the differences in T1 and T2 relaxivities between  ... 
doi:10.3233/jnd-160145 pmid:27854210 pmcid:PMC5271435 fatcat:eolcxro4x5bbfeiov72wjbe5bq

Sodium Magnetic Resonance Imaging: Biomedical Applications [article]

Guillaume Madelin
2012 arXiv   pre-print
Sodium MRI is a subject of increasing interest in translational research as it can give some direct and quantitative biochemical information on the tissue viability, cell integrity and function, and therefore  ...  The article is divided in three parts: (1) the role of sodium in biological tissues, (2) a short review on sodium magnetic resonance, and (3) a review of some studies on sodium MRI on different organs/  ...  Multiple Sclerosis Another interesting application of sodium MRI in the brain would be for assessing multiple sclerosis (MS).  ... 
arXiv:1212.4400v3 fatcat:tmod4ku3gvfx3jrztorjxohnyi

Data fusion detects consistent relations between non-lesional white matter myelin, executive function, and clinical characteristics in multiple sclerosis

Tobias R. Baumeister, Sue-Jin Lin, Irenve Vavasour, Shannon Kolind, Brenda Kosaka, David K.B. Li, Anthony Traboulsee, Alex MacKay, Martin J. McKeown
2019 NeuroImage: Clinical  
Moreover, this consistent relation involves multiple white matter regions and is separate from the influence of lesions.  ...  We examined the influence of dysfunctional, non-lesional white matter on cognitive performance in multiple sclerosis (MS).  ...  Acknowledgements We thank all participants and their families for their cooperation as well as the MR technologists for the data collection.  ... 
doi:10.1016/j.nicl.2019.101926 pmid:31412310 pmcid:PMC6704047 fatcat:u4ijbepvvneojic6mamhwa2lte

Challenges for biophysical modeling of microstructure

Ileana O. Jelescu, Marco Palombo, Francesca Bagnato, Kurt G. Schilling
2020 Journal of Neuroscience Methods  
techniques, the development of a generalized standard model for any brain region and pathology, and the seamless communication between different parties involved in the development and application of  ...  biophysical models of diffusion.  ...  Acknowledgments The authors acknowledge support from the Center for Biomedical Imaging of the EPFL, Unil, CHUV, UniGE and HUG and the Swiss National Science Foundation grant no.  ... 
doi:10.1016/j.jneumeth.2020.108861 pmid:32692999 fatcat:bapfiafyqvcbtky3qggqibefsu

MRI and M/EEG studies of the White Matter Development in Human Fetuses and Infants: Review and Opinion

Jessica Dubois, Parvaneh Adibpour, Cyril Poupon, Lucie Hertz-Pannier, Ghislaine Dehaene-Lambertz, Bernard Zalc
2016 Brain Plasticity  
At the structural level, the early architecture and myelination of bundles have been assessed with diffusion and relaxometry MRI, recently integrated in multi-compartment models and multi-parametric approaches  ...  Only the recent use of non-invasive techniques such as magnetic resonance imaging (MRI) and magneto-and electroencephalography (M/EEG) has opened the possibility to understand the relationships between  ...  multiple sclerosis [105] .  ... 
doi:10.3233/bpl-160031 pmid:29765848 pmcid:PMC5928537 fatcat:6if7kwm3ejc5riwqzh7bjzgtgi

Abstracts from "Imaging in Neuromuscular Disease 2019: Second International Conference on Imaging in Neuromuscular Disease, 17th – 19th November 2019 | Berlin, Germany"

2019 Journal of Neuromuscular Diseases  
Aims: We hypothesized that a composite of MRI-T2 of fi ve lower leg muscles (LLC5-T2; soleus, medial gastrocnemius, tibialis anterior, tibialis posterior and peroneals) comprising muscles at different  ...  Based on natural history data of muscle MRI-T2 and fat fraction (FF) in DMD from the ImagingDMD Consortium, MoveDMD was designed as a proofof-concept trial with MRI in 4-7 year old boys with DMD not on  ...  A tri-exponential fi t was applied to the MSME images to quantify the muscle water T2 and FF.  ... 
doi:10.3233/jnd-199002 pmid:31744016 pmcid:PMC6918898 fatcat:c2q4eqos5racxibieebsslw2oe

2014 Joint ACTRIMS-ECTRIMS Meeting (MSBoston 2014) MS Journal Online: Poster Session 1

2014 Multiple Sclerosis  
Differences of SA/DP progression were assessed by examining the interactions between socio-demographics and time.  ...  Objectives: To describe the prevalence and predicting factors of caregiver burden in multiple sclerosis within a Mexican population.  ...  The MRI outcomes included lesion, atrophy magnetization transfer ratio (MTR) and diffusion-tensor imaging (DTI) measures. The analyses were corrected for multiple comparisons.  ... 
doi:10.1177/1352458514546077 pmid:25205048 pmcid:PMC4244172 fatcat:tzd6co2dijebfasgp6htmug2um

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

2014 Multiple Sclerosis  
Advanced MRI techniques such as diffusion tensor (DTI) and diffusional kurtosis imaging (DKI) provide information about tissue microstructure.  ...  P507 The nature of white matter tract injury in relapsingremitting multiple sclerosis: a diffusion-tensor imaging study in relation to disease duration A Background: Diffusion-tensor imaging (DTI) studies  ...  tensor imaging (DTI) and magnetization transfer imaging (MTI) are increasingly utilized in multiple sclerosis (MS) clinical trials.  ... 
doi:10.1177/1352458514547846 pmid:25205049 pmcid:PMC4244175 fatcat:gj757y4jlvejpnrfw22guoit7m
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