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Competing endogenous RNA crosstalk at system level

Mattia Miotto, Enzo Marinari, Andrea De Martino, Erik Aurell
<span title="2019-11-01">2019</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
Experimental evidence, on the other hand, suggests that competing endogenous RNA (ceRNA) crosstalk is rather weak.  ...  microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules.  ...  In this respect, selection appears to have favoured the emergence of such features at system level.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1007474">doi:10.1371/journal.pcbi.1007474</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31675359">pmid:31675359</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6853376/">pmcid:PMC6853376</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3kqgrmifing5zhijqymakrdg6u">fatcat:3kqgrmifing5zhijqymakrdg6u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191214190916/https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007474&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0e/16/0e165c2ee0225083c0b4e011afe2042d4f2cd135.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1007474"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853376" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Competing endogenous RNA crosstalk at system level [article]

Mattia Miotto, Enzo Marinari, Andrea De Martino
<span title="2019-10-21">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Experimental evidence, on the other hand, suggests that competing endogenous RNA (ceRNA) crosstalk is rather weak.  ...  microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules.  ...  In this respect, selection appears to have favoured the emergence of such features at system level.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1910.09256v1">arXiv:1910.09256v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3pzszz2om5celiyvkdwawhvylq">fatcat:3pzszz2om5celiyvkdwawhvylq</a> </span>
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Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics

Avencia Sanchez-Mejias, Yvonne Tay
<span title="2015-03-28">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/iscxkayqx5enxdprqwzokjewbe" style="color: black;">Journal of Hematology &amp; Oncology</a> </i> &nbsp;
These competing endogenous RNAs (ceRNAs), or natural miRNA sponges, have an active role in regulating miRNA availability within the cell and form intertwined regulatory networks.  ...  A recently discovered dimension of post-transcriptional gene regulation involves co-regulatory crosstalk between RNA transcripts, which compete for common pools of microRNA (miRNA) molecules.  ...  Competing endogenous RNAs in cancer Several examples of MRE-containing non-coding RNA transcripts acting as ceRNAs have been described.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13045-015-0129-1">doi:10.1186/s13045-015-0129-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25888444">pmid:25888444</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4381443/">pmcid:PMC4381443</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sa2szb7vpbgqdfh4du3n2agms4">fatcat:sa2szb7vpbgqdfh4du3n2agms4</a> </span>
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The multilayered complexity of ceRNA crosstalk and competition

Yvonne Tay, John Rinn, Pier Paolo Pandolfi
<span title="">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/drfdii35rzaibj3aml5uhvr5xm" style="color: black;">Nature</a> </i> &nbsp;
These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges -they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small  ...  RNA-protein, RNA-RNA and protein-protein crosstalk.  ...  Table 1 | 1 List of validated non-coding competing endogenous RNAs Non-coding RNA species Competing endogenous RNAs Shared microRNAs Organism Reference Small non-coding RNA HSUR1 FOXO1 miR-27a  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nature12986">doi:10.1038/nature12986</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24429633">pmid:24429633</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4113481/">pmcid:PMC4113481</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5vmwh5i4szambczphmnl7repti">fatcat:5vmwh5i4szambczphmnl7repti</a> </span>
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Competing Endogenous RNA Regulations in Neurodegenerative Disorders: Current Challenges and Emerging Insights

Yifei Cai, Jun Wan
<span title="2018-10-05">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uc7xbcwzljashhncrlsxupx3em" style="color: black;">Frontiers in Molecular Neuroscience</a> </i> &nbsp;
The past decade has witnessed exciting breakthroughs that have contributed to the richness and complexity of a burgeoning modern RNA world, and one particular breakthrough-the competing endogenous RNA  ...  (ceRNA) hypothesis-has been described as the "Rosetta Stone" for decoding the RNA language used in regulating RNA crosstalk and modulating biological functions.  ...  COMPETING ENDOGENOUS RNA HYPOTHESIS: RNA CROSSTALK In 2011, Pier Paolo Pandolfi's group proposed the ceRNA hypothesis, positing that RNAs can engage in crosstalk with each other and manipulate biological  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnmol.2018.00370">doi:10.3389/fnmol.2018.00370</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30344479">pmid:30344479</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6182084/">pmcid:PMC6182084</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mlftgexllna7zioxm74bmlpbxe">fatcat:mlftgexllna7zioxm74bmlpbxe</a> </span>
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Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk

Claire L. Smillie, Tamara Sirey, Chris P. Ponting
<span title="2018-03-23">2018</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jf6xzofahfdgdpjb2zn6cikmli" style="color: black;">Critical reviews in biochemistry and molecular biology</a> </i> &nbsp;
Recent studies have proposed that some transcriptstermed competitive endogenous RNAs (ceRNAs)sequester a miRNA and diminish its repressive effects on other transcripts.  ...  Some question the relevance of ceRNA crosstalk, arguing that an individual transcript, when its abundance lies within a physiological range of gene expression, will fail to compete for miRNA binding due  ...  site has an effect on the abundance of other miRNA target transcripts when the ceRNA is expressed at endogenous levels.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/10409238.2018.1447542">doi:10.1080/10409238.2018.1447542</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29569941">pmid:29569941</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5935048/">pmcid:PMC5935048</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pel7u7enbrdkdisy7e36m6ei6u">fatcat:pel7u7enbrdkdisy7e36m6ei6u</a> </span>
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Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease

Yan Zhang, Fulong Yu, Siqi Bao, Jie Sun
<span title="2019-09-11">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tkuhrcyiufdxtkdmjqvay6f2ua" style="color: black;">Frontiers in Bioengineering and Biotechnology</a> </i> &nbsp;
The complexity and behavior of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) network remained poorly characterized in AD.  ...  Alzheimer's disease (AD), a degenerative disease of the central nervous system, is the most common form of dementia in old age.  ...  Therefore, we should investigate disease mechanism at the level of system biology and mine useful information from a vast network of interacting genes or RNAs (Zhang et al., 2018) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fbioe.2019.00222">doi:10.3389/fbioe.2019.00222</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31572720">pmid:31572720</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6749152/">pmcid:PMC6749152</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/px3lamd4pzc4fpo6jr64r3vmqy">fatcat:px3lamd4pzc4fpo6jr64r3vmqy</a> </span>
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Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story

Ugo Ala
<span title="2020-06-28">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3iichab3fbz7jq46o55l6trkq" style="color: black;">Cells</a> </i> &nbsp;
These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find new significance.  ...  They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs).  ...  Competing Endogenous RNA (ceRNA) Hypothesis Since miRNAs can recognize their target sites on different RNA molecules, it was suggested that miRNAs could be capable of mediating a regulatory crosstalk between  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells9071574">doi:10.3390/cells9071574</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32605220">pmid:32605220</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7407898/">pmcid:PMC7407898</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/u3lnokymsvc35ow3wxaecw6phi">fatcat:u3lnokymsvc35ow3wxaecw6phi</a> </span>
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PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

Tao Liu, Cai-Hua Zu, Shu-Sen Wang, Hong-Li Song, Zheng-Lu Wang, Xin-Nv Xu, Hong-Sheng Liu, Yu-Liang Wang, Zhong-Yang Shen
<span title="2016-05-30">2016</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yubgl6cdcrekxpjzhshpw23l3i" style="color: black;">OncoTarget</a> </i> &nbsp;
Competing endogenous RNAs (ceRNAs) are RNA transcripts that can crosstalk with each other by competing for shared microRNAs (miRNAs) through miRNA response elements (MREs).  ...  The MREs within PIK3C2A 3′UTR can independently stimulate CD151 expression level by acting as miR-124 decoys.  ...  These RNAs bearing a same set of MREs are known as competing endogenous RNAs (ceRNAs) [9] [10] [11] [12] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.9716">doi:10.18632/oncotarget.9716</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27270320">pmid:27270320</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5190030/">pmcid:PMC5190030</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/l5cbf52vm5c4fdmzh4phegcvfe">fatcat:l5cbf52vm5c4fdmzh4phegcvfe</a> </span>
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Regulatory Potential of Competing Endogenous RNAs in Myotonic Dystrophies

Edyta Koscianska, Emilia Kozlowska, Agnieszka Fiszer
<span title="2021-06-04">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3loumxx7kzamnlu4h6x3xoz6ay" style="color: black;">International Journal of Molecular Sciences</a> </i> &nbsp;
It has been proposed that the large-scale regulatory network across the whole transcriptome is mediated by competing endogenous RNA (ceRNA) activity attributed to both protein-coding and ncRNAs. ceRNAs  ...  crosstalk.  ...  These endogenous small (21-23 nucleotides in length) RNAs control gene expression at the posttranscriptional level.  ... 
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Network Approaches to Study Endogenous RNA Competition and Its Impact on Tissue-Specific microRNA Functions

Tânia Monteiro Marques, Margarida Gama-Carvalho
<span title="2022-02-19">2022</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/clnmwghhxzd35jr6jihmkh3gju" style="color: black;">Biomolecules</a> </i> &nbsp;
The competing endogenous RNA hypothesis suggests the presence of a new level of regulation, whereby a specific RNA transcript can indirectly influence the abundance of other transcripts by limiting the  ...  The focus of this review is to highlight recent developments and achievements made towards the process of characterizing competing endogenous RNA networks and their role in cellular function.  ...  When miRNAs are more abundant than the population of target RNA molecules, Figure 1 . The competing endogenous RNA hypothesis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biom12020332">doi:10.3390/biom12020332</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35204832">pmid:35204832</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8868585/">pmcid:PMC8868585</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ypokoxrhj5dhdih37kgwg54fpa">fatcat:ypokoxrhj5dhdih37kgwg54fpa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220505170258/https://mdpi-res.com/d_attachment/biomolecules/biomolecules-12-00332/article_deploy/biomolecules-12-00332.pdf?version=1645275666" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9d/7d/9d7df4b41091f21ceb546dfa502a1e07df9607b8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/biom12020332"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868585" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk

Tomasz M. Witkos, Wlodzimierz J. Krzyzosiak, Agnieszka Fiszer, Edyta Koscianska
<span title="2018-11-02">2018</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2gz5p7hhszcttc2a7kuvirxupu" style="color: black;">RNA Biology</a> </i> &nbsp;
MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept.  ...  Multiple protein-coding transcripts, transcribed pseudogenes, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) showing this potential were identified, and numerous miRNAs were predicted to bind  ...  According to the competing endogenous RNA (ceRNA) concept, multiple cellular transcripts communicate with and co-regulate each other by competing for binding to a shared pool of miRNAs [8] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/15476286.2018.1536593">doi:10.1080/15476286.2018.1536593</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30381983">pmid:30381983</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6284579/">pmcid:PMC6284579</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/equfxiucfnfeppbqa2j6az7ib4">fatcat:equfxiucfnfeppbqa2j6az7ib4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190219234704/http://pdfs.semanticscholar.org/1ca0/58f559901ce154077e648f9c5d83e103086b.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1c/a0/1ca058f559901ce154077e648f9c5d83e103086b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/15476286.2018.1536593"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> tandfonline.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284579" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Crosstalk and the Evolution of Specificity in Two-Component Signaling

Michael A. Rowland, Eric J. Deeds
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
proteins. 1906-Pos Board B636 Crosstalk and the Evolution of Specificity in Two-Component Signaling  ...  At physiologically realistic volume fractions, the mRNA output may be an increasing, decreasing, or non-monotonic function of drphid in these various regimes.  ...  endogenous RNAs (ceRNAs).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2013.11.2138">doi:10.1016/j.bpj.2013.11.2138</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jnxzacgh7ne4rpn4u5ijsprgxi">fatcat:jnxzacgh7ne4rpn4u5ijsprgxi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223140018/https://core.ac.uk/download/pdf/81966142.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/12/01/120128940558a07c72f922c7d9dc801cfabf4735.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2013.11.2138"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Metastatic EMT Phenotype Is Governed by MicroRNA-200-Mediated Competing Endogenous RNA Networks

Sara Uhan, Nina Hauptman
<span title="2021-12-28">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3iichab3fbz7jq46o55l6trkq" style="color: black;">Cells</a> </i> &nbsp;
The competing endogenous RNA (ceRNA) hypothesis proposes a competitive environment resembling a large-scale regulatory network of gene expression circuits where alterations in the expression of both protein-coding  ...  Upon acquiring more knowledge and clinical evidence on non-genetic factors affecting neoplasia, modulation of the expression levels of diverse ceRNAs may allow for the development of novel prognostic/diagnostic  ...  Network of competing endogenous RNAs (ceRNAs).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells11010073">doi:10.3390/cells11010073</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35011635">pmid:35011635</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8749983/">pmcid:PMC8749983</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/geixmkneafejdicn643vkkm5am">fatcat:geixmkneafejdicn643vkkm5am</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220430022101/https://mdpi-res.com/d_attachment/cells/cells-11-00073/article_deploy/cells-11-00073.pdf?version=1640668413" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fc/c0/fcc005ca7de4eecac8bab7f9748918991b021e3b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells11010073"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749983" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Health or Disease - Why Does "Dark Matter" Matter More?

Nicholas Tsinoremas
<span title="2014-05-02">2014</span> <i title="MedCrave Group, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vwitj35e3neipdj5bjhj56lnym" style="color: black;">Journal of Investigative Genomics</a> </i> &nbsp;
As such, they influence microRNA regulation in a network of RNA crosstalk focused on competing for mRNA binding, according the known 'sponging' [8] or also 'competing endogenous RNA' (ceRNA) law [9]  ...  effects of perturbations (i.e. treatments) at various complexity levels (single versus multiple targeted drugs).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.15406/jig.2014.01.00002">doi:10.15406/jig.2014.01.00002</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/v43hcxvv7ba2hff6v4ub2qdyvq">fatcat:v43hcxvv7ba2hff6v4ub2qdyvq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808142814/http://medcraveonline.com/JIG/JIG-01-00002.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.15406/jig.2014.01.00002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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