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Neuroreceptor Mapping 2000

2000 NeuroImage  
The aim of this study was to evaluate in rats and monkeys the suitability of MPP-PTP for the in vivo imaging of adenosine A 2A receptors.  ...  PET studies in monkeys indicate that the tracer rapidly accumulates in brain where it reaches the maximum uptake between 5 and 10 minutes after injection and is cleared thereafter.  ...  For precisely setting of ROIs on PET and DHC images, we registrated both images using rigid-body registration with least-square error sum criteria.  ... 
doi:10.1006/nimg.2000.0622 fatcat:z7wjtrzb6jacva4vohw447zx2e

Poster Session I

2004 Neuropsychopharmacology  
Preclinical studies suggest that 5HT3 receptors mediate the stimulatory effects of cocaine, cocaine withdrawal, and cocaine-induced sensitization, and that chronic cocaine administration alters 5HT3 receptors  ...  The present study was therefore designed to specifically assess differences in the 5HT3 receptor systems in men and women with cocaine-dependence.  ...  Voxelwise analyses of the relationship of age to these FA maps were conducted in SPM2 (simple correlation model). Nonlinear effects were modeled using the square and square root of age.  ... 
doi:10.1038/sj.npp.1300646 fatcat:ee4zdyczlzc2pgxomn5ucq6cm4

Presentation abstracts

Laura Rice, JongHun Sung, Kathleen Keane, Elizabeth Peterson, Jacob Sosnoff, Gary Farkas, Ann Swartz, Scott Strath, Ashraf Gorgey, Arthur Berg, David Gater, Trevor Dyson-Hudson (+128 others)
2018 Journal of Spinal Cord Medicine (JSCM)  
3 | P a g e • Multiple lines of evidence support glutamatergic involvement in ADHD and autism (e.g., imaging and pharmacology studies in ADHD and autism populations as well as animal model studies).  ...  of the role of metabotropic glutamate receptors in the etiology and treatment of ADHD and Autism.  ...  Future work will assess the effect of slow brain entry on dopamine kinetics at a synaptic level using 11C-raclopride, a dopamine receptor antagonist PET radiotracer.  ... 
doi:10.1080/10790268.2018.1498262 pmid:30132748 fatcat:wxcohshv4zfkjapz4qfrpovp5u

Panel Session Co-Morbid Pain and Addiction: Novel Treatments

2006 Neuropsychopharmacology  
validation; (2) whether or not preclinical studies predicted clinical efficacy; and (3) whether the compound was of greater efficacy than "conventional treatment".  ...  had entered at least the later stages of preclinical research.  ...  The Time Course of Antipsychotics Versus Placebo: On Overall Efficacy, Positive, Negative and Cognitive Symptoms John M. Davis*  ... 
doi:10.1038/sj.npp.1301265 fatcat:6odqjmshuncm5muxk5g5knprui

Poster Session II

2005 Neuropsychopharmacology  
All 7 segments of the corpus callosum were compared between cocaine users and controls for using a Mixed Model ANOVA for λ1 and λ2.  ...  Based on prior animal and human studies suggesting that demyelination increases diffusion normal to the direction of fiber tracts λ2 with minimal effect on λ1 our findings are consistent with a reduction  ...  Peter S Talbot, Dah-Ren Hwang, Yiyun Huang, Thomas Cooper, Slifstein Mark and Anissa Abi-Dargham  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Poster Session II

2012 Neuropsychopharmacology  
It displayed at least a 30-fold functional selectivity over mu and delta OR as demonstrated by in vivo receptor occupancy (RO) and pharmacology.  ...  The anterior insula is rich in mu opioid receptors and is recruited during reward processing, so the effects of NTX that we observed could be a direct local effect of occupancy of mu opioid receptors.  ...  This effect size reduction was also nonlinear in relation to the degree of admixture.  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
The epidermal growth factor receptor (EGFR) is a biomarker heterogeneously expressed in high-grade gliomas (HGGs).  ...  EGFR immunohistochemical staining of tumor specimens from 35 HGG patients during 2006-2019 was scored by pathologists and expression levels were compared to that of mouse xenografts and subsequently stratified  ...  channel (Fig. 1f , and red arrows): microvascular sprouting (D3-D6, Fig. 1j,k ), anastomoses and flow establishment (D7-D9), and development of sinusoidal vessels (D7-D15).  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Poster Session II

2014 Neuropsychopharmacology  
Change from baseline in factor scores and individual PANSS item scores were evaluated based on least squares mean differences (LSMDs) between cariprazine and placebo using a mixed-effects model for repeated  ...  Rhythm parameters (amplitude, period and phase) were estimated using least squares fitting to a sine wave.  ...  Multivariate analyses and analyses of covariance were performed using SPSS v.22. Data were corrected for multiple comparisons using the false discovery rate method.  ... 
doi:10.1038/npp.2014.281 fatcat:al6onvo7vzhofpmlzfblnbaxha

Poster Session II

2015 Neuropsychopharmacology  
from depressed patients, and estimated the NMDA receptor occupancies at the doses used in the studies.  ...  Analyses were conducted using FMIRB's Local Analysis of Mixed Effects (FLAME) within the fMRI Expert Analysis Tool (FEAT).  ...  To assess and compare the rsFC, we examined and compared the normalized Z maps in group random effect analyses.  ... 
doi:10.1038/npp.2015.326 pmid:26632287 pmcid:PMC4672311 fatcat:ib64i5qmzngvxcpn5hznkcagie

ePresentation Sessions

2018 European Journal of Neurology  
Non-linear mixed effects modelling was used to characterize the PK/PD relationship, quantify intra-and inter-individual variability, and evaluate covariate effects.  ...  A mixed ANOVA assessed the effects of disease duration and medication.  ...  receptor (GABABR) encephalitis and optimise laboratory methods for the detection of GABABR antibodies.  ... 
doi:10.1111/ene.13700 fatcat:xk5co6xixzbs3n7wnhc5xjkpv4


2015 Journal of Thoracic Oncology  
The aim of our study is to determine if it is possible to distinguish between second primary versus metastases in patients with the same histological type and quantity any difference in survival.  ...  The detailed pathology reports of these patients were retrieved and the histology, subtype and pTNM of tumours documented.  ...  PRO questionnaire compliance was at least 91.2% up to cycle 9.  ... 
doi:10.1016/s1556-0864(16)30011-9 fatcat:nlhtgbimt5fu5dx4syerr2hjmu

Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, 30.09.–04.10. 2011, pp 90-184

2011 Onkologie (Basel)  
The goal of the present study is to analyse consecutive pts with HIV-HL who had at least one PET scan conducted during their course of primary chemotherapy (CT).  ...  This positive effect has been observed for both recreational and occupational activity.  ...  of at least 50%.  ... 
doi:10.1159/000333301 fatcat:rebrjglsybb7xn4lq53ouyjuci

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
Results: In all of the phantom and patients' MRI studies the post-processed images proved to have higher resolution and contrast as compared with images reconstructed by conventional methods.  ...  Body : Purpose: To demonstrate an application of fast iterative method to enhance contrast and image resolution in clinical MRI imaging.  ...  The nanocluster system with a high selectivity showed the potential for fluorescence imaging and the integrating of gold and MMAE demonstrated excellent concurrent chemotherapy-radiotherapy efficacy, which  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Methods: In a series of studies in healthy individuals and unaffected first-degree relatives of schizophrenia patients we have established and confirmed the link of these phenotypes to the genetic liability  ...  We have further explored the genetic contributions to these phenotypes using a broader array of imaging genetics methods including single-variant approaches exploring the effects of candidate genes and  ...  LC) produced mixed results, with some studies supporting and others refuting a reinforcing effect of NE.  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

ACNP 59th Annual Meeting: Poster Session III

2020 Neuropsychopharmacology  
In vivo pharmacokinetic studies are then used to measure plasma and brain exposures to guide the dose range and pretreatment times for the side effect profile, in vivo efficacy, and in vivo abuse liability  ...  Methods: Clinical assessments, serum CRP, and diffusion tensor imaging (DTI) data were collected from both a cross-sectional study of chronic trauma (GTP) and as part of a longitudinal study of acutely  ...  Sinusoidal curves were fitted to the expressed data using the nonlinear least-squares method and coefficient of determination (R^2) was used as a measure of goodness-of-fit.  ... 
doi:10.1038/s41386-020-00892-5 pmid:33279936 pmcid:PMC7735201 fatcat:mip4ywutfnfwvmye4u65i6vgg4
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